Health-related quality of life of cancer and noncancer patients in Medicare managed care.

Abstract:

BACKGROUND:Data from the Health Care Financing Administration's (HCFA) Medicare Health Outcomes Survey (MHOS) of patients enrolled in managed care services through Medicare were analyzed. The MHOS provided baseline estimates of quality of life of cancer survivors in comparison to a frequency age-matched cohort of noncancer patients. METHOD:In 1998, the MHOS was mailed to a random sample of 279,135 beneficiaries. Completed surveys were received from 167,096 respondents (60%). Some 22,747 respondents who had been diagnosed with cancer were frequency age matched to an equal number of noncancer patients. RESULTS:Cancer survivors had statistically significantly poorer scores than noncancer patients on all eight subscales as well as on the Physical Component and Mental Component summary measures of the Medical Outcomes Study Short Form-36 (MOS SF-36). Comparisons by type and number of cancers for which an individual was currently in treatment showed lowest quality of life for those in treatment for lung carcinoma, followed by those who were in treatment for more than one type of cancer. CONCLUSION:The data suggest that cancer shows negative effects on health-related quality of life that are not explainable by simple effects of age because frequency age-matched cancer survivors had statistically significantly lower scores on all 10 scores of the MOS SF-36. Effect sizes are evaluated to determine the clinical significance of these differences in health-related quality of life. The MHOS offers useful data for planning and improving cancer policy and programs.

journal_name

Cancer

journal_title

Cancer

authors

Baker F,Haffer SC,Denniston M

doi

10.1002/cncr.11085

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

674-81

issue

3

eissn

0008-543X

issn

1097-0142

journal_volume

97

pub_type

杂志文章

相关文献

CANCER文献大全
  • Nonrandom expression of polypeptide hormones in pancreatic endocrine tumors. An immunohistochemical study in a case of multiple islet cell neoplasia.

    abstract::One hundred four endocrine tumors found in the body and tail of the pancreas of a patient with the Zollinger-Ellison syndrome (ZES) and multiple endocrine neoplasia (MEN-I) were investigated by immunohistochemistry for insulin, glucagon, somatostatin, pancreatic polypeptide (PP), and gastrin. The results for each tumo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880501)61:9<1815::aid-cncr2820

    authors: Pilato FP,D'Adda T,Banchini E,Bordi C

    更新日期:1988-05-01 00:00:00

  • Survival after hepatic resection in metastatic colorectal cancer: a population-based study.

    abstract:BACKGROUND:Hepatectomy is the standard of care for patients with colorectal cancer who have isolated hepatic metastases; however, the long-term survival benefits of hepatectomy in this population have not been characterized well outside of case series. For the current study, a population-based database was used to comp...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22448

    authors: Cummings LC,Payes JD,Cooper GS

    更新日期:2007-02-15 00:00:00

  • Bladder cancer as seen in giant histologic sections.

    abstract::Giant sections from cystectomy specimens in 45 cases of bladder cancer were examined microscopically after en bloc fixation and processing. There were 35 transitional cell, seven squamous cell, and three mixed transitional cell and squamous carcinomas. Broad front invasion was associated with papillary and superficial...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197702)39:2<447::aid-cncr2820390

    authors: Soto EA,Friedell GH,Tiltman AJ

    更新日期:1977-02-01 00:00:00

  • Relation of body mass index to tumor markers and survival among young women with invasive ductal breast carcinoma.

    abstract:BACKGROUND:Obesity has been shown to affect breast carcinoma prognosis, with the heaviest women having a higher mortality due to breast carcinoma. Few studies have focused on premenopausal women or the correlation of body mass index (BMI) to tumor characteristics related to prognosis. METHODS:The authors conducted a p...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20010815)92:4<720::aid-cncr1375>

    authors: Daling JR,Malone KE,Doody DR,Johnson LG,Gralow JR,Porter PL

    更新日期:2001-08-15 00:00:00

  • Combined modality therapy of gynecologic cancer.

    abstract::In the treatment of gynecologic malignancies, various combinations of surgery, drugs, and radiation therapy are used with increasing frequency. An examination is made of data dealing with combined modalities in the treatment of tumors of the cervix, endometrium, and ovary. Although the efficacy of such treatments has ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197501)35:1<76::aid-cncr28203501

    authors: Brady LW

    更新日期:1975-01-01 00:00:00

  • Thymoma in a 12-year-old boy.

    abstract::A case of thymoma in a 12-year-old boy is presented. The patient had a history of thymic irradiation in infancy, and a family history of leukemia. The mass was readily resected and the patient is well 10 years later. The tumor contained an unusual admixture of normal thymic tissue with the neoplastic epithelial elemen...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197602)37:2<953::aid-cncr2820370

    authors: Chatten J,Katz SM

    更新日期:1976-02-01 00:00:00

  • Dual-tracer scintigraphy and subtraction studies in the diagnosis of hepatocellular carcinoma.

    abstract::Dual tracer scintigraphy (DTS) (technetium 99m [99mTc] sulfur colloid and gallium 67 citrate [67 gallium citrate]) of the liver and computer subtraction studies (SS) were performed in 26 patients subsequently proven to have hepatocellular carcinoma (HCC) and 32 patients with cirrhosis and focal defects on the colloid ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880215)61:4<667::aid-cncr28206

    authors: Sostre S,Villagra D,Morales NE,Rivera JV

    更新日期:1988-02-15 00:00:00

  • Immunologic evaluation of patients with advanced head and neck cancer receiving weekly chemoimmunotherapy.

    abstract::Patients with advanced head and neck cancer have significant reduction in their circulating lymphocyte mass which is reflected in decreased numbers of T cells, Fc receptor cells, and in derangements of T lymphocyte functions, i.e., decreased responsiveness to several dilutions of phytohemagglutinin and lack of develop...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197907)44:1<117::aid-cncr2820440

    authors: Zighelboim J,Dorey F,Parker NH,Calcaterra T,Ward P,Fahey JL

    更新日期:1979-07-01 00:00:00

  • Pathobiology of preoperative chemotherapy: findings from the National Surgical Adjuvant Breast and Bowel (NSABP) protocol B-18.

    abstract:BACKGROUND:Examination was performed on pathologic material from patients enrolled in the National Surgical Adjuvant Breast Project (NSABP) protocol B-18, in which the clinical effects of preoperative (preop) and postoperative (postop) doxorubicin and cyclophosphamide (AC) were compared. METHODS:Of the total number of...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/cncr.10741

    authors: Fisher ER,Wang J,Bryant J,Fisher B,Mamounas E,Wolmark N

    更新日期:2002-08-15 00:00:00

  • Antibody response to Epstein-Barr virus Rta protein in patients with nasopharyngeal carcinoma: a new serologic parameter for diagnosis.

    abstract:BACKGROUND:Nasopharyngeal carcinoma (NPC) is associated closely with Epstein-Barr virus (EBV). The authors previously reported that an EBV immediate-early gene, BRLF1, was expressed frequently in NPC tumors, and a significant elevation in immunoglobulin G (IgG) antibodies directed against BRLF1 gene product Rta was det...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20011001)92:7<1872::aid-cncr1704

    authors: Feng P,Chan SH,Soo MY,Liu D,Guan M,Ren EC,Hu H

    更新日期:2001-10-01 00:00:00

  • Solitary plasmacytoma of bone vs. extramedullary plasmacytoma and their relationship to multiple myeloma.

    abstract::Solitary plasmacytoma of bone (SPB) and extramedullary plasmacytoma (EMPC) are unusual solitary tumors of plasma cell origin. The clinical differences between these tumors and multiple myeloma are the subject of continued study. This review examines the radiotherapy experience at M. D. Anderson Hospital. Between 1948 ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197903)43:3<1007::aid-cncr282043

    authors: Corwin J,Lindberg RD

    更新日期:1979-03-01 00:00:00

  • Cost-effectiveness of alternating magnetic resonance imaging and digital mammography screening in BRCA1 and BRCA2 gene mutation carriers.

    abstract:BACKGROUND:Current clinical guidelines recommend earlier, more intensive breast cancer screening with both magnetic resonance imaging (MRI) and mammography for women with breast cancer susceptibility gene (BRCA) mutations. Unspecified details of screening schedules are a challenge for implementing guidelines. METHODS:...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27864

    authors: Cott Chubiz JE,Lee JM,Gilmore ME,Kong CY,Lowry KP,Halpern EF,McMahon PM,Ryan PD,Gazelle GS

    更新日期:2013-03-15 00:00:00

  • Expression of neurofilament and neuron-specific enolase in small cell tumors of skin using immunohistochemistry.

    abstract::Trabecular carcinoma of the skin (Merkel cell tumor), a neoplasm of putative neural origin, must be differentiated from other small cell tumors primary or metastatic to skin. In order to provide more objective diagnostic criteria, four were examined using monoclonal antibodies against neurofilament proteins (NF) and a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850801)56:3<625::aid-cncr28205

    authors: Leff EL,Brooks JS,Trojanowski JQ

    更新日期:1985-08-01 00:00:00

  • Isolated marrow lymphoma: an entity of possible T-cell derivation.

    abstract::Seven adults had a distinct clinicopathologic type of lymphoproliferative disorder of the bone marrow. All patients presented with weakness and pancytopenia; no evidence of gross extramedullary involvement was found. In 5 cases severe and prolonged bone marrow hypoplasia was associated with combination chemotherapy; 1...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19801015)46:8<1767::aid-cncr2820

    authors: Barton JC,Conrad ME,Vogler LB,Parmley RT

    更新日期:1980-10-15 00:00:00

  • Interferon decreases hepatocellular carcinogenesis in patients with cirrhosis caused by the hepatitis B virus: a pilot study.

    abstract:BACKGROUND:To elucidate the influence of long term interferon administration on the rate of occurrence of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV)-related cirrhosis, the authors analyzed 313 consecutive patients with cirrhosis. METHODS:Of the 313 patients, 94 underwent long term intermit...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19980301)82:5<827::aid-cnc

    authors: Ikeda K,Saitoh S,Suzuki Y,Kobayashi M,Tsubota A,Fukuda M,Koida I,Arase Y,Chayama K,Murashima N,Kumada H

    更新日期:1998-03-01 00:00:00

  • Effects of high-intensity aerobic interval training on cardiovascular disease risk in testicular cancer survivors: A phase 2 randomized controlled trial.

    abstract:BACKGROUND:Testicular cancer survivors (TCS) have an increased risk of treatment-related cardiovascular disease (CVD), which may limit their overall survival. We evaluated the effects of high-intensity aerobic interval training (HIIT) on traditional and novel CVD risk factors and surrogate markers of mortality in a pop...

    journal_title:Cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/cncr.30859

    authors: Adams SC,DeLorey DS,Davenport MH,Stickland MK,Fairey AS,North S,Szczotka A,Courneya KS

    更新日期:2017-10-15 00:00:00

  • Elimination of dose limiting toxicities of cisplatin, 5-fluorouracil, and leucovorin using a weekly 24-hour infusion schedule for the treatment of patients with nasopharyngeal carcinoma.

    abstract:BACKGROUND:Cisplatin, 5-flourouracil (5-FU), and leucovorin (PFL) chemotherapy has been reported to be effective in the treatment of cancers but severe mucositis or neutropenia are dose limiting toxicities. This Phase II study evaluated the anticancer effect and the toxicities of a new weekly 24-hour infusional PFL che...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19951201)76:11<2186::aid-cncr282

    authors: Chi KH,Chan WK,Shu CH,Law CK,Chen SY,Yen SH,Chen KY

    更新日期:1995-12-01 00:00:00

  • Molecular epidemiology of HTLV-I-associated non-Hodgkin's lymphomas in Jamaica.

    abstract::As part of epidemiologic studies of human T-lymphotropic virus (HTLV)-I-associated malignancies in Jamaica, the authors evaluated 26 patients with non-Hodgkin's lymphoma for the presence of integrated HTLV-I provirus in their malignant cells. Fifteen of 26 patients had integrated provirus. All 15 also were HTLV-I anti...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880401)61:7<1477::aid-cncr2820

    authors: Clark JW,Gurgo C,Franchini G,Gibbs WN,Lofters W,Neuland C,Mann D,Saxinger C,Gallo RC,Blattner WA

    更新日期:1988-04-01 00:00:00

  • Hereditary diffuse gastric cancer: diagnosis, genetic counseling, and prophylactic total gastrectomy.

    abstract:BACKGROUND:A subset of patients with diffuse gastric cancer harbor deleterious cancer-causing germline mutations in the type 1 E-cadherin (epithelial) gene (CDH1), which predisposes to the autosomal dominantly inherited hereditary diffuse gastric cancer (HDGC) syndrome. These mutations are associated with a 70% life-ti...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23501

    authors: Lynch HT,Kaurah P,Wirtzfeld D,Rubinstein WS,Weissman S,Lynch JF,Grady W,Wiyrick S,Senz J,Huntsman DG

    更新日期:2008-06-15 00:00:00

  • Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S.

    abstract:BACKGROUND:Heavy alcohol consumption, viral hepatitis, and diabetes are risk factors for hepatocellular carcinoma (HCC). However, to the authors' knowledge, the information concerning their interaction effect in patients with risk of HCC is sparse. METHODS:A population-based, case-control study of HCC was conducted du...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20427

    authors: Yuan JM,Govindarajan S,Arakawa K,Yu MC

    更新日期:2004-09-01 00:00:00

  • Comparison of Akt/mTOR signaling in primary breast tumors and matched distant metastases.

    abstract:BACKGROUND:The Akt/mammalian target of the rapamycin (mTOR) signaling pathway represents a promising target for cancer therapy. The phosphorylation status of Akt and of mTOR's phosphorylation target eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) is often used to assess the activity of Akt and mTOR signaling...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23456

    authors: Akcakanat A,Sahin A,Shaye AN,Velasco MA,Meric-Bernstam F

    更新日期:2008-06-01 00:00:00

  • JAK2 (V617F) as an acquired somatic mutation and a secondary genetic event associated with disease progression in familial myeloproliferative disorders.

    abstract:BACKGROUND:A somatic gain-of-function mutation of the Janus kinase 2 (JAK2) gene has been identified in chronic myeloproliferative disorders, which appear to have a sporadic occurrence in most individuals. The authors studied the biologic significance of the JAK2 (V617F) mutation in familial myeloproliferative disorder...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22240

    authors: Rumi E,Passamonti F,Pietra D,Della Porta MG,Arcaini L,Boggi S,Elena C,Boveri E,Pascutto C,Lazzarino M,Cazzola M

    更新日期:2006-11-01 00:00:00

  • An Eastern Cooperative Oncology Group phase II trial of trimetrexate in the treatment of advanced urothelial carcinoma.

    abstract:BACKGROUND:Trimetrexate is an antifol that differs from methotrexate in ways that may be clinically important. Because methotrexate has activity in advanced bladder cancer, this trial was initiated. METHODS:Ambulatory patients with advanced urothelial carcinoma were treated with the nonclassic antifol trimetrexate at ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/1097-0142(19940201)73:3<688::aid-cncr28207

    authors: Witte RS,Elson P,Khandakar J,Trump DL

    更新日期:1994-02-01 00:00:00

  • Salvage combination chemotherapy with 5-fluorouracil and actinomycin D for patients with refractory, high-risk gestational trophoblastic tumors.

    abstract:BACKGROUND:The objective of this study was to evaluate the efficacy and toxicity of a high-dose 5-fluorouracil and actinomycin D regimen (the FA regimen) as salvage chemotherapy for patients with high-risk gestational trophoblastic tumors (GTTs). METHODS:From 1985 to 1997, 10 patients with refractory, high-risk GTTs w...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10790

    authors: Matsui H,Suzuka K,Iitsuka Y,Yamazawa K,Tanaka N,Mitsuhashi A,Seki K,Sekiya S

    更新日期:2002-09-01 00:00:00

  • Chemotherapy versus chemotherapy plus hormonotherapy in postmenopausal advanced breast cancer patients. A randomized trial.

    abstract::One hundred seventeen postmenopausal advanced breast cancer patients previously untreated with chemotherapy were randomized to receive: cyclophosphamide, methotrexate, and 5-fluorouracil (CMF), CMF and tamoxifen (TMX), and CMF and medroxyprogesterone (MAP). Treatments B and C induced a greater proportion of responses ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19851215)56:12<2745::aid-cncr282

    authors: Viladiu P,Alonso MC,Avella A,Beltrán M,Borrás J,Ojeda B,Bosch FX

    更新日期:1985-12-15 00:00:00

  • Predictors and outcomes of surgeons' referral of older breast cancer patients to medical oncologists.

    abstract:BACKGROUND:Older women are less likely than younger women to receive definitive care for a new diagnosis of breast cancer, but the reasons are not well understood. Although coordination of referral among specialists is an important component of quality of care, it has not been studied as a factor that contributes to ob...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21256

    authors: Thwin SS,Fink AK,Lash TL,Silliman RA

    更新日期:2005-09-01 00:00:00

  • Impact of the coronavirus disease 2019 (COVID-19) pandemic on pediatric oncology care in the Middle East, North Africa, and West Asia region: A report from the Pediatric Oncology East and Mediterranean (POEM) group.

    abstract:BACKGROUND:Childhood cancer is a highly curable disease when timely diagnosis and appropriate therapy are provided. A negative impact of the coronavirus disease 2019 (COVID-19) pandemic on access to care for children with cancer is likely but has not been evaluated. METHODS:A 34-item survey focusing on barriers to ped...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33075

    authors: Saab R,Obeid A,Gachi F,Boudiaf H,Sargsyan L,Al-Saad K,Javakhadze T,Mehrvar A,Abbas SS,Abed Al-Agele YS,Al-Haddad S,Al Ani MH,Al-Sweedan S,Al Kofide A,Jastaniah W,Khalifa N,Bechara E,Baassiri M,Noun P,El-Houdzi J,K

    更新日期:2020-09-15 00:00:00

  • Chondrosarcoma of the foot. A case report and review of the literature.

    abstract::Chondrosarcoma of the foot is a very unusual entity. A case arising from a solitary osteocartilagenous exostosis is presented and the literature is reviewed and discussed. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197508)36:2<586::aid-cncr2820360

    authors: Lewis MM,Marcove RC,Bullough PG

    更新日期:1975-08-01 00:00:00

  • Nucleolar organizer regions in precancerous and cancerous lesions of the bronchus.

    abstract::Using a silver staining technique, nucleolar organizer region-associated proteins (Ag-NOR) were studied in paraffin sections of five specimens of normal bronchial epithelium, eight of atypical squamous metaplasia, five of carcinoma in situ, and seven of microinvasive squamous cell carcinoma. The mean number of Ag-NOR ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910115)67:2<472::aid-cncr28206

    authors: Abe S,Ogura S,Kunikane H,Suko N,Watanabe N,Nakajima I,Kawakami Y,Inoue K

    更新日期:1991-01-15 00:00:00

  • Role of fine needle aspiration in the diagnosis of lesions of the oral cavity, oropharynx, and nasopharynx.

    abstract::The oral cavity, oropharynx and nasopharynx are readily accessible to fine needle aspiration (FNA). This study reviews the author's experience with 93 FNA from these sites: 76 from the oral cavity, eight from the oropharynx, and eight from the nasopharynx. Thirty-nine (42%) of the FNA were positive for malignancy with...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19881215)62:12<2602::aid-cncr282

    authors: Scher RL,Oostingh PE,Levine PA,Cantrell RW,Feldman PS

    更新日期:1988-12-15 00:00:00