Abstract:
BACKGROUND:Obesity has been shown to affect breast carcinoma prognosis, with the heaviest women having a higher mortality due to breast carcinoma. Few studies have focused on premenopausal women or the correlation of body mass index (BMI) to tumor characteristics related to prognosis. METHODS:The authors conducted a population-based follow-up study for mortality of 1177 women younger than 45 years of age who had invasive ductal breast carcinoma diagnosed from 1983 through 1992. Histologic slides and/or tumor tissue were collected for pathologic review, immunohistochemistry assays, and bivariate flow cytometric analysis. RESULTS:Women with breast carcinoma who were in the highest quartile of BMI were 2.5 times as likely (95% confidence interval [CI], 1.6-3.9) to die of their disease within 5 years of diagnosis compared with women in the lowest quartile of BMI. The tumors of the women in the highest quartile of BMI were more likely to be estrogen receptor negative (odds ratio [OR], 1.5; 95% CI, 1.0-2.2) and to have a high S-phase fraction (OR, 1.9; 95% CI, 1.2-3.1), high histologic grade (OR, 1.7; 95% CI, 1.0-2.9), high mitotic cell count (OR, 2.0; 95% CI, 1.2-3.1), and large tumor size (2 to < 5 cm: OR, 2.3; 95% CI, 1.5-3.1; or > or = 5 cm: OR, 2.7; 95% CI, 1.5-4.8) compared with the tumors of women whose BMI was in the first quartile. Relative to the large tumors (> or = 2 cm) in women in the lowest BMI quartile, the large tumors in women in the highest BMI quartile were more likely to express markers of high proliferation, indicating they may have grown faster than similar size tumors of the thinnest women. In a multivariate analysis including the tumor characteristics, obesity, as measured by being in the highest quartile of BMI, remained an independent prognostic factor for mortality (hazard ratio, 1.7; 95% CI, 1.0-2.9; P < 0.05. CONCLUSIONS:Our study results indicated that being in the highest quartile of BMI was a strong predictor of mortality in women with breast carcinoma diagnosed at a young age. The tumors of the heavy women were larger and more likely to have markers of high cellular proliferation than those of thinner women.
journal_name
Cancerjournal_title
Cancerauthors
Daling JR,Malone KE,Doody DR,Johnson LG,Gralow JR,Porter PLdoi
10.1002/1097-0142(20010815)92:4<720::aid-cncr1375>subject
Has Abstractpub_date
2001-08-15 00:00:00pages
720-9issue
4eissn
0008-543Xissn
1097-0142pii
10.1002/1097-0142(20010815)92:4<720::AID-CNCR1375>journal_volume
92pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:9-Aminocamptothecin (9AC) and its parent compound, camptothecin, have shown outstanding preclinical activity against colorectal carcinoma. Irinotecan (CPT-11), another camptothecin derivative, has demonstrated clinical activity in patients with 5-fluorouracil (5-FU)-refractory colorectal carcinoma. METHODS:...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0142(19971101)80:9<1727::aid-cn
更新日期:1997-11-01 00:00:00
abstract::Desmosomes, gap junctions and tight junctions are intercellular specializations which have been described in human meningiomas. We report, in five of five meningiomas, including a pulmonary metastasis from a malignant intracranial meningioma, a fourth type of intercellular specialization which is similar to but not id...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197806)41:6<2242::aid-cncr282041
更新日期:1978-06-01 00:00:00
abstract:BACKGROUND:The authors evaluated the efficacy of adjuvant chemotherapy with 5-fluorouracil (5-FU) plus doxorubicin in gastric carcinoma after D2-3 curative resection. They also evaluated the effect of dose-related factors (delivered total dose/m(2), actual dose intensity [ADI], relative dose intensity [RDI]) of this re...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(20010601)91:11<2016::aid-cncr122
更新日期:2001-06-01 00:00:00
abstract::Twenty patients with malignant hepatoma were treated with sequential intraarterial doxorubicin (72-hour continuous infusion) followed by systemic 5-fluorouracil (5-FU) and semustine (methyl CCNU). Objective tumor responses were seen in three patients (15%). The durations of response were 6, 19, and 27+ months, respect...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880915)62:6<1041::aid-cncr2820
更新日期:1988-09-15 00:00:00
abstract::The validity of current staging systems for malignant melanoma was analyzed in a prospective study on 220 patients with extremity melanoma. Patients were followed 2 to 9 years after a wide excision of the primary, regional cytostatic perfusion and dissection of regional lymph nodes. The "original three-stage" system y...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900715)66:2<396::aid-cncr28206
更新日期:1990-07-15 00:00:00
abstract:BACKGROUND:Combined transperineal prostate brachytherapy and external beam radiation therapy (EBRT) is widely used for treatment of prostate cancer. Long-term efficacy and toxicity results of a multicenter phase 2 trial assessing combination of EBRT and transperineal prostate brachytherapy boost with androgen deprivati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26203
更新日期:2011-12-15 00:00:00
abstract::The relative value of each lactic dehydrogenase isoenzyme (iso LDH) was measured by electrophoretic separation in the serum and the pleural fluid of 100 patients. In each case, the cause of the pleural effusion was known. Two types of LDH isoenzyme pattern were found in the serum: a normal type with a low value of LDH...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840801)54:3<507::aid-cncr28205
更新日期:1984-08-01 00:00:00
abstract:BACKGROUND:Overall survival (OS) is considered the gold standard for determining treatment efficacy in oncology trials, but the relation between treatment and OS can be challenging to assess because of long study durations and the impact of subsequent therapies on outcome. Using OS can be particularly difficult for new...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30622
更新日期:2017-05-15 00:00:00
abstract:BACKGROUND:The impact of cancer on socioeconomic outcomes is attracting attention as the number of survivors of cancer in young age continues to rise. This study examines economic independence in a national cohort of survivors of cancer at a young age in Norway. METHODS:Through the linkage of several national registri...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30253
更新日期:2016-12-15 00:00:00
abstract:BACKGROUND:The relationship between serum levels of matrix metalloproteinase-2 (MMP-2) and MMP-3 and recurrence in patients with urothelial carcinoma after complete resection was studied to determine whether the enzymes could be a new predictor of recurrence. METHODS:Serum levels of MMP-2 and MMP-3 in 146 healthy cont...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract::Thirty-seven lymphomas of bone were studied, including 33 diffuse large cell lymphomas, three undifferentiated (small noncleaved cell) lymphomas, and one well-differentiated (small) lymphocytic lymphoma. The large cell lymphomas were subclassified as large cleaved, large noncleaved, multilobated cell, and immunoblasti...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871115)60:10<2494::aid-cncr282
更新日期:1987-11-15 00:00:00
abstract::In malignant melanoma, using Sephadex G-200 chromatography and polyacrylamide gel electrophoresis (PAGE), it has been possible to separate two types of skin reactive antigens. The first, found in Sephadex fraction II and PAGE region a appears specific for melanoma. Allogeneic extracts have produced positive reactions ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197510)36:4<1282::aid-cncr282036
更新日期:1975-10-01 00:00:00
abstract:BACKGROUND:Current research is inconclusive regarding the relation between alcohol consumption and prostate cancer risk. In this study, the authors examined the associations of total alcohol, type of alcoholic beverage, and drinking pattern with the risk of total, low-grade, and high-grade prostate cancer. METHODS:Dat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24423
更新日期:2009-08-15 00:00:00
abstract:BACKGROUND:The identification of the BRCA1 gene is a powerful tool for predicting a patient's lifetime risk for carcinoma of the breast and ovary when she has hereditary breast/ovarian carcinoma (HBOC) syndrome. The process of BRCA1 testing and genetic counseling and participants' reactions to test results, are describ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970601)79:11<2219::aid-c
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:Cancer cell expression of costimulatory molecule B7-H1 has been implicated as a potent inhibitor of T-cell-mediated antitumoral immunity. The authors recently reported that B7-H1 is aberrantly expressed in primary renal cell carcinoma (RCC). Blockade of B7-H1, as demonstrated in several murine cancer models,...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21470
更新日期:2005-11-15 00:00:00
abstract:BACKGROUND:In addition to possessing many physiologic functions, human growth hormone-1 (GH1) has been shown in recent in vitro and in vivo experiments to induce malignant disease, including breast carcinoma. The authors investigated the association of breast carcinoma with genetic polymorphisms in the GH1 gene in the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20375
更新日期:2004-07-15 00:00:00
abstract::A primary fibrosarcoma of the thyroid occurring in a patient with a nodular goiter is described. Light microscopy showed interwoven bundles of spindle cells admixed with plump ovoid cells, and foci of multinucleated giant cells. Remnants of distorted thyroid follicles were found only at the periphery of the tumor. "Tr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197908)44:2<584::aid-cncr2820440
更新日期:1979-08-01 00:00:00
abstract::Single meningiomas are histologically classified as benign tumors, but clearly malignant types have been encountered. The standard mode of management is total macroscopic removal with excision of the dural attachment and abnormal bone, if there is any. Despite this aggressive surgery, recurrence rates of approximately...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19880401)61:7<1447::aid-cncr2820
更新日期:1988-04-01 00:00:00
abstract::Esophageal prothesis (EP) is a palliative treatment for inoperable neoplastic stenosis. Ninety-one patients were candidates for EP placement between 1978 and 1983. EP placement was successful in 77 patients. Of these: 85% had primary esophageal cancer; 15% had bronchial or mediastinal carcinoma; 83% had stenosis in th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860401)57:7<1426::aid-cncr2820
更新日期:1986-04-01 00:00:00
abstract::A series of consecutive trials were undertaken to determine whether higher doses of intravenous metoclopramide and combinations of metoclopramide, dexamethasone, and diphenhydramine would improve antiemetic control or decrease treatment-related side effects in patients receiving cisplatin at 120 mg/m2. Metoclopramide ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19850201)55:3<527::aid-cncr28205
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND:A crossover in breast carcinoma incidence at ages 45-49 years has been observed between black and white women, with blacks experiencing higher incidence at younger ages and lower incidence after age 50 years. Can this phenomenon be partially explained by the differences in the distributions of reproductive r...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(20000301)88:5+<1230::aid-c
更新日期:2000-03-01 00:00:00
abstract::Six patients with Hodgkin's disease (HD) and demonstrable serum antibodies to human immunodeficiency virus (HIV) and two additional patients with HD belonging to HIV-associated high-risk groups but with negative HIV serology were studied. All patients were men and ranged in age from 21 to 45 years. The HIV risk factor...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19910401)67:7<1865::aid-cncr2820
更新日期:1991-04-01 00:00:00
abstract::The hemoptysis which occurs following lymphography typically consists of one or more episodes of blood-tinged sputum, and generally requires no treatment. In contradistinction to this "mild" form of hemoptysis, the current report describes a case of hemoptysis following lymphography--hemoptysis so severe as to require...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197902)43:2<482::aid-cncr2820430
更新日期:1979-02-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate a regimen of sequential chemotherapy and radiotherapy for patients with Hodgkin disease. METHODS:The Cancer and Leukemia Group B conducted a Phase II study of three cycles of etoposide, vinblastine, and doxorubicin (EVA) chemotherapy followed by subtotal lymph node radi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0142(19991015)86:8<1590::aid-cn
更新日期:1999-10-15 00:00:00
abstract::Of the remote effects of cancer on the neurologic system, paraneoplastic cerebellar degeneration (PCD), characterized by global cerebellar dysfunction, is second only to paraneoplastic neuropathies in frequency. Recent evidence, including the finding of anti-Purkinje cell (now termed anti-Yo) antibodies directed again...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19911015)68:8<1835::aid-cncr2820
更新日期:1991-10-15 00:00:00
abstract:BACKGROUND:Cisplatin is one of the single drugs that has shown the best documented effect in treating patients with locally recurrent or metastatic urothelial cancer. To the authors' knowledge, the effect of the combination of different platinum analogues in treating transitional cell carcinoma has not been evaluated p...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19951115)76:10<1797::aid-cncr282
更新日期:1995-11-15 00:00:00
abstract::The 4F2 antigen is a cell-membrane glycoprotein which arises early in the G0-G1 phases of the cell cycle. This molecule is present in all established human cell lines and most malignant human cells. The authors used an indirect immunophosphatase method to study 50 squamous cell carcinomas of the larynx and ten lymph-n...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19901001)66:7<1493::aid-cncr2820
更新日期:1990-10-01 00:00:00
abstract::A case is reported of a patient with pancreatic carcinoma who developed pancreatic ascites after intraoperative fine-needle aspiration cytology (FNAC) biopsy. This complication of FNAC has not previously been reported to the authors' knowledge. The literature is reviewed, and FNAC is shown to be the safest method of p...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900601)65:11<2537::aid-cncr282
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:Telomerase is a ribonucleoprotein that maintains telomeric base pair repeats at the ends of mammalian chromosomes during DNA replication. Telomerase is expressed in various human tumors, some normal tissues, and immortalized cell lines. The assay of telomerase activity has potential as an adjunct for cancer ...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1999-04-25 00:00:00
abstract:BACKGROUND:Although almost half of all incidents of breast carcinoma occur in women age > or = 65 years, not enough is known about appropriate care for patients in this age group. The objective of the current study was to evaluate the role of breast conservation therapy in the management of breast carcinoma in women ag...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010901)92:5<1092::aid-cncr1425
更新日期:2001-09-01 00:00:00