Abstract:
BACKGROUND:The aim of this study was to evaluate a regimen of sequential chemotherapy and radiotherapy for patients with Hodgkin disease. METHODS:The Cancer and Leukemia Group B conducted a Phase II study of three cycles of etoposide, vinblastine, and doxorubicin (EVA) chemotherapy followed by subtotal lymph node radiation for patients with localized Hodgkin disease and unfavorable prognostic features. Fifty-nine patients were enrolled in the study. Fifty-three patients met all study eligibility criteria; 48 of them (91%) had mediastinal disease and 29 (55%) had bulky mediastinal disease. RESULTS:A complete response (CR) occurred in 35 of the patients (66%). Of all patients who had CR, 26% had the CR after the chemotherapy and before the radiation, and 74% after the chemotherapy and radiation. Twenty percent of the patients who had CR experienced disease progression; in these patients, the progression was outside the radiotherapy field in the lung and involved widespread disease. CONCLUSIONS:EVA offers a nonbleomycin-containing alternative for patients in whom preexisting pulmonary disease may be exacerbated by bleomycin and radiation therapy. EVA, as given in this study (in three cycles), was insufficient chemotherapy for patients who had disease in areas outside the radiation fields (occult disease).
journal_name
Cancerjournal_title
Cancerauthors
Wasserman TH,Petroni GR,Millard FE,Chung CT,Barcos M,Johnson JL,Canellos GP,Peterson BAdoi
10.1002/(sici)1097-0142(19991015)86:8<1590::aid-cnsubject
Has Abstractpub_date
1999-10-15 00:00:00pages
1590-5issue
8eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19991015)86:8<1590::AID-CNjournal_volume
86pub_type
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