Establishment of an Epstein-Barr virus-negative B-cell lymphoma line from a Japanese Burkitt's lymphoma and its serial passage in hamsters.

Abstract:

:An Epstein-Barr virus (EBV)-negative lymphoma line (JBL) was established in vitro from pleural effusion of an EBV-seropositive 29-year-old Japanese female with Burkitt's lymphoma. JBL cells as well as her original lymphoma cells bore monoclonal surface IgM with lambda light chains. The JBL line grew in single cell suspension with a doubling time of 30 hours. Attempts were made to serially transplant JBL cells in antilymphocyte serum-treated newborn hamsters; intraperitoneal implantation of 1-3 X 10(7) cells gave rise to invasive tumors in all recipients with death after 10 to 14 days. The hamster-passage line, now in the 9th passage, has been converted to an ascitic form with progression to leukemia in some animals. A "starry sky" pattern closely resembling the human tumor material was preserved in every tumor through serial animal passage.

journal_name

Cancer

journal_title

Cancer

authors

Miyoshi I,Hiraki S,Kubonishi I,Matsuda Y,Kishimoto H,Nakayama T,Tanaka T,Masuji H,Kimura I

doi

10.1002/1097-0142(197712)40:6<2999::aid-cncr282040

subject

Has Abstract

pub_date

1977-12-01 00:00:00

pages

2999-3003

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

40

pub_type

杂志文章

相关文献

CANCER文献大全
  • Radiation therapy at the end of life in patients with incurable nonsmall cell lung cancer.

    abstract:BACKGROUND:Receipt of chemotherapy at the end of life (EOL) is considered an indicator of poor quality of care for medical oncology. The objective of this study was to characterize the use of radiotherapy (RT) in patients with nonsmall cell lung cancer (NSCLC) during the same period. METHODS:Treatment characteristics ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27401

    authors: Kapadia NS,Mamet R,Zornosa C,Niland JC,D'Amico TA,Hayman JA

    更新日期:2012-09-01 00:00:00

  • Lymphoplasmacytic lymphoma. Report of a case with three monoclonal proteins derived from a single neoplastic clone.

    abstract::The unique case of a 60-year-old patient with a non-Hodgkin's B-cell lymphoma of the lymphoplasmacytic type and three associated monoclonal proteins, is described. The patient also exhibited various autoimmune phenomena that were consistent with the diagnoses of Sjögren's syndrome and autoimmune thyroiditis. The evolu...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860501)57:9<1794::aid-cncr2820

    authors: Berg AR,Weisenburger DD,Linder J,Armitage JO

    更新日期:1986-05-01 00:00:00

  • Clostridial septicemia complicating the course of leukemia.

    abstract::The authors report an analysis of 47 leukemia patients (including 9 from our own medical center) whose courses were complicated by 48 episodes of clostridial septicemia. There were 36 adults and 11 children; acute myelogenous leukemia and acute lymphoblastic leukemia accounted for 61.7% and 14.9% of cases, respectivel...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860515)57:10<2045::aid-cncr282

    authors: Caya JG,Farmer SG,Ritch PS,Wollenberg NJ,Tieu TM,Oechler HW,Spivey M

    更新日期:1986-05-15 00:00:00

  • Logistic regression model of fotemustine toxicity combining independent phase II studies.

    abstract:BACKGROUND:To optimize fotemustine chemotherapy, the authors considered how to combine independent Phase II trials to predict the risk of first occurrence of severe toxicity as a function of initial patient characteristics. METHODS:Clinical data from six Phase II trials were collected. Of the 478 patients enrolled 442...

    journal_title:Cancer

    pub_type: 杂志文章,meta分析

    doi:

    authors: Raymond E,Haon C,Boaziz C,Coste M

    更新日期:1996-11-01 00:00:00

  • The impact of underinsurance on bladder cancer diagnosis, survival, and care delivery for individuals under the age of 65 years.

    abstract:BACKGROUND:Health insurance is a key mediator of health care disparities. Outcomes in bladder cancer, one of the costliest diseases to treat, may be especially sensitive to a patient's insurance status. METHODS:The Surveillance, Epidemiology, and End Results registry and the National Cancer Data Base were used to iden...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32562

    authors: Fletcher SA,Cole AP,Lu C,Marchese M,Krimphove MJ,Friedlander DF,Mossanen M,Kilbridge KL,Kibel AS,Trinh QD

    更新日期:2020-02-01 00:00:00

  • Thyroid abnormalities following neck irradiation for Hodgkin's disease.

    abstract::Thyroid function and scans were evaluated in fifty disease-free patients 2 to 16 years after receiving neck irradiation for the treatment of Hodgkin's disease. Twenty-five of 50 patients had abnormal thyroid studies: eight were hypothyroid, two were hypothyroid and had abnormal scans, and fifteen had abnormal scans. O...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197812)42:6<2553::aid-cncr282042

    authors: Nelson DF,Reddy KV,O'Mara RE,Rubin P

    更新日期:1978-12-01 00:00:00

  • Cognitive performance in survivors of breast cancer and markers of biological aging.

    abstract:BACKGROUND:Biological aging pathways accelerated by cancer treatments may be a mechanism for cognitive impairment in cancer survivors. The goal of the current study was to examine whether indicators of biological aging, namely elevated levels of DNA damage, reduced telomerase enzymatic activity, and shorter peripheral ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31777

    authors: Carroll JE,Van Dyk K,Bower JE,Scuric Z,Petersen L,Schiestl R,Irwin MR,Ganz PA

    更新日期:2019-01-15 00:00:00

  • Vincristine, dactinomycin, and cyclophosphamide in the treatment of malignant germ cell tumors of the ovary. A Gynecologic Oncology Group Study (a final report).

    abstract::Seventy-six patients with malignant germ cell tumors of the ovary received vincristine, dactinomycin, and cyclophosphamide (VAC) postoperatively. Fifty-four were treated after removal of all gross disease. The majority of these remain disease-free. Indeed, only 15 (28%) have failed, including 11 of 24 with pure endode...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850715)56:2<243::aid-cncr28205

    authors: Slayton RE,Park RC,Silverberg SG,Shingleton H,Creasman WT,Blessing JA

    更新日期:1985-07-15 00:00:00

  • A functioning catecholamine-secreting vagal body tumor. A case report and review of the literature.

    abstract::There are few cases of catecholamine-secreting paragangliomas of the neck reported in the literature, most of these being of the carotid body and glomus-jugulare type. This report cites the second case of a functioning vagal body tumor secreting norepinephrine predominantly and producing labile hypertension and sympto...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19830901)52:5<932::aid-cncr28205

    authors: Tannir NM,Cortas N,Allam C

    更新日期:1983-09-01 00:00:00

  • Molecular genetic alterations as potential prognostic indicators in colorectal carcinoma.

    abstract::The molecular genetic alterations in colorectal carcinoma are among the best understood of any common human cancer. Identified abnormalities include both dominant-acting oncogenes (ras, myc, src) and suppressor genes which undergo inactivation or deletion (deleted in colorectal carcinoma gene [DCC], p53, adenomatous p...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19920315)69:6+<1589::aid-cncr282

    authors: Hamilton SR

    更新日期:1992-03-15 00:00:00

  • Characterization of metastatic urothelial carcinoma via comprehensive genomic profiling of circulating tumor DNA.

    abstract:BACKGROUND:Biomarker-guided clinical trials are increasingly common in metastatic urothelial carcinoma (mUC), yet patients for whom contemporary tumor tissue is not available are not eligible. Technological advancements in sequencing have made cell-free circulating DNA (cfDNA) next-generation sequencing (NGS) readily a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31314

    authors: Agarwal N,Pal SK,Hahn AW,Nussenzveig RH,Pond GR,Gupta SV,Wang J,Bilen MA,Naik G,Ghatalia P,Hoimes CJ,Gopalakrishnan D,Barata PC,Drakaki A,Faltas BM,Kiedrowski LA,Lanman RB,Nagy RJ,Vogelzang NJ,Boucher KM,Vaishampa

    更新日期:2018-05-15 00:00:00

  • Laboratory aids to diagnosis--enzymes.

    abstract::A summary is presented of those organ specific enzyme assays traditionally used in evaluation of the patient with cancer. In addition, the use of certain serum enzymes such as gamma-glutamyl transpeptidase, phosphohexose isomerase or 5'-nucleotidase as aids in following the course of the disease, particularly in patie...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197601)37:1+<542::aid-cncr282037

    authors: Schwartz MK

    更新日期:1976-01-01 00:00:00

  • Studies in variation associated with the measurement of solid tumors.

    abstract::The existing system for solid tumor evaluation is criticized and revised criteria are proposed. The foundation for this analysis is a tumor stimulation experiment to determine the distribution associated with measurement of solid tumors. This tumor simulation experiment was conducted among 26 oncologists in order to a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800901)46:5<1286::aid-cncr2820

    authors: Lavin PT,Flowerdew G

    更新日期:1980-09-01 00:00:00

  • The effect of Medicaid expansion among adults from low-income communities on stage at diagnosis in those with screening-amenable cancers.

    abstract:BACKGROUND:Several states have opted to expand Medicaid under the Patient Protection and Affordable Care Act (ACA), which offers insurance coverage to low-income individuals up to 138% of the federal poverty level. This expansion of Medicaid to a medically vulnerable population potentially can reduce cancer outcome dis...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32895

    authors: Kim U,Koroukian S,Statler A,Rose J

    更新日期:2020-09-15 00:00:00

  • Molecular targeting and pharmacogenomics in the management of advanced bladder cancer.

    abstract::Bladder cancer is one of the malignancies for which considerable information is available regarding molecular pathogenesis and genetic predictors of natural history, as well as response to treatment. Loss of heterozygosity of chromosome 9 appears to be essential to the genesis of superficial bladder cancer, and mutati...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.11281

    authors: Raghavan D

    更新日期:2003-04-15 00:00:00

  • Cancer in the respiratory organs of Swedish farmers.

    abstract::In a cohort of 254,417 male Swedish farmers (4,330,717 person-years) the incidence of cancer of the respiratory organs was compared to a reference cohort of 1,725,845 men (30,131,664 person-years) employed in other economic activities than agriculture or forestry. In the study cohort 1450 cases of cancer in the respir...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880301)61:5<1055::aid-cncr2820

    authors: Wiklund K,Steineck G

    更新日期:1988-03-01 00:00:00

  • Detection of humoral immune response to human brain tumors: specificity and reliability of microcytotoxicity assay.

    abstract::A humoral microcytotoxicity assay has been used to study the immune response to human malignant astrocytic tumors. Two series are described. When the assay was performed under uniform, ideal conditions, the sera from 36 of 45 patients with these tumors (80%) produced significant cytotoxicity against allogeneic astrocy...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197901)43:1<86::aid-cncr28204301

    authors: Wood WC,Kornblith PL,Quindlen EA,Pollock LA

    更新日期:1979-01-01 00:00:00

  • Biologic distinctions between cure and time to death in 2892 patients with intraocular melanoma.

    abstract:BACKGROUND:For certain types of cancer, resection alone rarely achieves a cure, but patients nevertheless tend to have a prolonged survival before they die of the tumor. For other types of cancer, the opposite scenario prevails, suggesting that those biologic mechanisms that allow a curative resection are not identical...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930401)71:7<2299::aid-cncr2820

    authors: Gamel JW,McLean IW,McCurdy JB

    更新日期:1993-04-01 00:00:00

  • Characterization of pathologic complete response after preoperative chemoradiotherapy in carcinoma of the esophagus and outcome after pathologic complete response.

    abstract:BACKGROUND:The purpose of the current study was to test the hypothesis that a lower clinical TNM stage is associated with a higher rate of pathologic complete response (pathCR) in patients with esophageal carcinoma receiving preoperative chemoradiotherapy and to determine whether outcome after pathCR is related to clin...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21439

    authors: Rohatgi P,Swisher SG,Correa AM,Wu TT,Liao Z,Komaki R,Walsh GL,Vaporciyan AA,Rice DC,Roth JA,Ajani JA

    更新日期:2005-12-01 00:00:00

  • Reappraisal of trimodal combination therapy for maxillary sinus carcinoma.

    abstract::The introduction of trimodal combination therapy (surgery + radiation + intraarterial infusion) for maxillary carcinoma resulted in a change in the sites of recurrence and no satisfactory improvement in the local control rate. To examine the cause of these phenomena, external carotid angiography was performed on 51 pa...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19821215)50:12<2790::aid-cncr282

    authors: Shibuya H,Suzuki S,Horiuchi J,Takagi M,Okuyama T,Suzuki H,Takeda M

    更新日期:1982-12-15 00:00:00

  • Favorable response to maintenance therapy of second or subsequent remissions in childhood acute lymphocytic leukemia.

    abstract::Twenty-two children with acute lymphocytic leukemia (ALL) who had relapsed while on therapy and for whom remissions were successfully reinduced were maintained with a combination of methotrexate, daunomycin, 6-mercaptopurine, prednisone, and vincristine (Djerassi-methotrexate with BOMB). The median duration of remissi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800901)46:5<1093::aid-cncr2820

    authors: Kimball JC,Herson J,Sullivan MP

    更新日期:1980-09-01 00:00:00

  • 5'-Nucleotide phosphodiesterase isozyme-V as a marker for liver metastases in breast cancer patients.

    abstract::A 2-year prospective study testing 258 breast cancer patients for the presence of 5'-nucleotide phosphodiesterase isozyme-V (5'-NPD-V) as a marker for liver metastases was undertaken. Despite the difficulty associated with such a study in obtaining data from biopsy (only 12 patients) and autopsy (only 18 patients), th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841101)54:9<1788::aid-cncr2820

    authors: Tsou KC,Creech RH,Inouye WY,Lo KW

    更新日期:1984-11-01 00:00:00

  • Neurologic complications of patients with small cell prostate carcinoma. Report of two cases.

    abstract:BACKGROUND:Primary small cell carcinoma arising in organs other than the lung were thought to be relatively rare. However, with the increasing technical sophistication of pathology departments, tumors with foci of small cell neuroendocrine components are being identified more frequently. The pattern of disease involvem...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19941215)74:12<3159::aid-cncr282

    authors: Lyster MT,Kies MS,Kuzel TM

    更新日期:1994-12-15 00:00:00

  • New diagnostic, staging, and therapeutic aspects of early breast cancer.

    abstract::Many advances have occurred in breast cancer through research and clinical trials. More confidence in new biological consumptions about invasive breast cancer indicate that: (1) details of the primary breast cancer do not control survival; (2) breast-only failures after local excision do not bias against survival; and...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19900201)65:3+<634::aid-cncr2820

    authors: Cady B

    更新日期:1990-02-01 00:00:00

  • Combination versus successive single agent chemotherapy in lymphocytic lymphoma.

    abstract::Fifty-three patients with advanced lymphocytic lymphoma were randomly assigned to treatment with the combination cyclophosphamide, vincristine, and prednisone (CVP) or the same agents used successively in maximal doses (C-V-P). Complete remissions occurred in 68% with CVP and 48% with C-V-P. For patients with nodular ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(197801)41:1<23::aid-cncr28204101

    authors: Kennedy BJ,Bloomfield CD,Kiang DT,Vosika G,Peterson BA,Theologides A

    更新日期:1978-01-01 00:00:00

  • Feasibility and early results of accelerated radiotherapy for head and neck carcinoma in the elderly.

    abstract:BACKGROUND:Accelerated radiotherapy (RT) represents a promising method with which to improve the treatment outcome in patients with head and neck carcinoma. However, its applicability to elderly patients has not been well established. This study assessed treatment toxicities, patient compliance, and oncologic results i...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Allal AS,Maire D,Becker M,Dulguerov P

    更新日期:2000-02-01 00:00:00

  • Preoperative experience for public hospital patients with gynecologic cancer: Do structural barriers widen the gap?

    abstract:BACKGROUND:Widespread disparities in care have been documented in women with gynecologic cancer in the United States. This study was designed to determine whether structural barriers to optimal care were present during the preoperative period for patients with gynecologic cancer. METHODS:A retrospective review was con...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29859

    authors: Frey MK,Moss HA,Musa F,Rolnitzky L,David-West G,Chern JY,Boyd LR,Curtin JP

    更新日期:2016-03-15 00:00:00

  • DNA flow cytometric analysis of serous ovarian tumors of low malignant potential.

    abstract:BACKGROUND:Ovarian serous tumors of low malignant potential (STLMP) occasionally progress; a small percentage of patients die of the tumor. There is no known way to predict which tumors will progress. METHODS:Forty STLMP were analyzed by DNA flow cytometry and compared with 26 serous carcinomas. RESULTS:Forty percent...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930615)71:12<3947::aid-cncr282

    authors: Seidman JD,Norris HJ,Griffin JL,Hitchcock CL

    更新日期:1993-06-15 00:00:00

  • Histology and DNA contents of a secondary malignancy arising in a mature residual lesion six years after chemotherapy for a disseminated nonseminomatous testicular tumor.

    abstract::The current report describes a secondary malignancy developing in a retroperitoneal mature residual lesion 6 years after chemotherapeutic treatment of a disseminated nonseminomatous testicular tumor. The histologically malignant component was not present in the primary tumor and consisted of polygonal and fusiform cel...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860715)58:2<264::aid-cncr28205

    authors: Molenaar WM,Oosterhuis JW,Meiring A,Sleyfer DT,Schraffordt Koops H,Cornelisse CJ

    更新日期:1986-07-15 00:00:00

  • Cost effectiveness of proton therapy compared with photon therapy in the management of pediatric medulloblastoma.

    abstract:BACKGROUND:Proton therapy has been a hotly contested issue in both scientific publications and lay media. Proponents cite the modality's ability to spare healthy tissue, but critics claim the benefit gained from its use does not validate its cost compared with photon therapy. The objective of this study was to evaluate...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28322

    authors: Mailhot Vega RB,Kim J,Bussière M,Hattangadi J,Hollander A,Michalski J,Tarbell NJ,Yock T,MacDonald SM

    更新日期:2013-12-15 00:00:00