Cognitive performance in survivors of breast cancer and markers of biological aging.

Abstract:

BACKGROUND:Biological aging pathways accelerated by cancer treatments may be a mechanism for cognitive impairment in cancer survivors. The goal of the current study was to examine whether indicators of biological aging, namely elevated levels of DNA damage, reduced telomerase enzymatic activity, and shorter peripheral blood mononuclear cell (PBMC) telomere length (TL) would be related to cognitive function in a cohort of survivors of breast cancer. METHODS:The authors evaluated a cross-sectional sample of 94 women aged 36 to 69 years who were treated for early-stage breast cancer 3 to 6 years previously. Leukocyte DNA damage, PBMC telomerase enzymatic activity, PBMC TL, and the inflammatory marker soluble tumor necrosis factor receptor II (sTNF-RII) were determined from blood samples. Cognitive function was assessed using a neuropsychological test battery and self-report. Linear regression models examined the relationship between biological aging predictors and cognitive outcomes. RESULTS:Both higher DNA damage and lower telomerase were found to be statistically significantly related to lower executive function scores adjusting for age, body mass index, race, years from treatment, and intelligence score (standardized coefficients [B], -0.23 and 0.30; all P values <.05). In addition, lower telomerase activity was associated with worse attention and motor speed scores (B values, 0.30 and 0.24; P <.05). sTNF-RII and TL were found to be unrelated to any of the neurocognitive domains. CONCLUSIONS:The results of the current study suggest a significant association between measures of biological aging and objective measures of cognitive performance in survivors of breast cancer. Future prospective studies are needed to confirm a causal role of biological aging as a driver of declines in cognitive function after cancer treatment.

journal_name

Cancer

journal_title

Cancer

authors

Carroll JE,Van Dyk K,Bower JE,Scuric Z,Petersen L,Schiestl R,Irwin MR,Ganz PA

doi

10.1002/cncr.31777

subject

Has Abstract

pub_date

2019-01-15 00:00:00

pages

298-306

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

125

pub_type

杂志文章

相关文献

CANCER文献大全
  • Laparoscopy and biopsy in malignant liver disease.

    abstract::Laparoscopy is highly effective in diagnosing malignant liver disease, with overall accuracy in the 90% range. Up to 80% of the liver surface can be inspected, and biopsies can be directed with precision. A major advantage over scan guided percutaneous techniques is the ability to detect and biopsy lesions only a few ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Lightdale CJ

    更新日期:1982-12-01 00:00:00

  • Malignant fibrous histiocytoma of soft tissue. A population-based epidemiologic and prognostic study of 137 patients.

    abstract::Epidemiology and prognosis were analyzed in a consecutive, population-based series of 137 patients with malignant fibrous histiocytoma of soft tissue in the extremities and trunk wall, with a complete follow-up of minimum 3 years. All but one patient were treated by surgery in 28 cases combined with adjuvant radiother...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910115)67:2<499::aid-cncr28206

    authors: Rööser B,Willén H,Gustafson P,Alvegård TA,Rydholm A

    更新日期:1991-01-15 00:00:00

  • DNA content and other prognostic features in childhood medulloblastoma. Proposal of a scoring system.

    abstract::The authors reviewed clinical features, surgical extent of resection, histologic parameters, and DNA content in 55 children with medulloblastomas and found that complete or near total resection, absence of tumor dissemination, tumor DNA aneuploidy, and low proliferative index correlated with a favorable clinical outco...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.2820690539

    authors: Schofield DE,Yunis EJ,Geyer JR,Albright AL,Berger MS,Taylor SR

    更新日期:1992-03-01 00:00:00

  • Positron emission tomography of patients with head and neck carcinoma before and after high dose irradiation.

    abstract:BACKGROUND:Positron emission tomography (PET) with labeled fluorodeoxyglucose (FDG) demonstrates increased tracer uptake in many neoplasms. This study was undertaken to define the patterns of FDG uptake in head and neck neoplasms before and after high dose irradiation. METHODS:Twenty-five patients were evaluated prosp...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940815)74:4<1355::aid-cncr2820

    authors: Greven KM,Williams DW 3rd,Keyes JW Jr,McGuirt WF,Watson NE Jr,Randall ME,Raben M,Geisinger KR,Cappellari JO

    更新日期:1994-08-15 00:00:00

  • The treatment of bilateral ulcerated lymph node metastases from carcinoma of the penis. A case report.

    abstract::A 44-year-old patient with histologically proven bilateral ulcerated lymph node metastases from a carcinoma of the penis was treated by sequenced combined chemotherapy and radical irradiation. Methotrexate and bleomycin were administered at weekly intervals for 5 weeks, followed by radiation with a split-course coning...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841015)54:8<1720::aid-cncr2820

    authors: Abratt RP

    更新日期:1984-10-15 00:00:00

  • An unusual presentation of a large tumor coexisting with an unusually high nonspecific immune responsiveness. A case report.

    abstract::The authors present the case of a 40-year-old white man with an obstructing laryngeal mass. Despite considerable tumor size, results of repeated biopsies revealed widespread carcinoma in situ with chronic inflammation within the subcutaneous tissues, and only after extensive endoscopic "debulking" of the mass was a sm...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850801)56:3<490::aid-cncr28205

    authors: Eskinazi DP,Mihail R,Dichtel WG

    更新日期:1985-08-01 00:00:00

  • Racial differences in time from prostate cancer diagnosis to treatment initiation: a population-based study.

    abstract:BACKGROUND:Timely delivery of care has been identified by the Institute of Medicine as an indicator for quality health care, and treatment delay is a potentially modifiable obstacle that can contribute to the disparities among African American (AA) and Caucasian patients in prostate cancer recurrence and mortality. Usi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27975

    authors: Stokes WA,Hendrix LH,Royce TJ,Allen IM,Godley PA,Wang AZ,Chen RC

    更新日期:2013-07-01 00:00:00

  • Intensity-modulated radiotherapy improves survival and reduces treatment time in squamous cell carcinoma of the anus: A National Cancer Data Base study.

    abstract:BACKGROUND:Chemoradiation with 5-fluorouracil and mitomycin remains the standard of care for squamous cell carcinoma (SCC) of the anal canal. A prolonged treatment time is associated with inferior disease-specific outcomes. Radiation Therapy Oncology Group trial 0529 demonstrated decreased toxicity and fewer treatment ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31721

    authors: Elson JK,Kachnic LA,Kharofa JR

    更新日期:2018-11-15 00:00:00

  • Non-Hodgkin's lymphoma in children: an analysis of 122 cases from Argentina.

    abstract::One hundred twenty two children with non-Hodgkin's lymphoma were studied from January 1966 to December 1975. The first group (1966-1972) did not receive an uniform treatment. The second group (1973-1975) entered in a G.A.T.L.A. protocol consisting of: vincristine-prednisone plus surgery and/or radiotherapy as inductio...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(197806)41:6<2372::aid-cncr282041

    authors: Cebrian-Bonesana A,Schvartzman E,Roca-Garcia C,Pependieck C,Sackmann-Muriel S,Ojeda FG,Kvicala R,Pavlovsky S,Lein JM,Penchansky L

    更新日期:1978-06-01 00:00:00

  • An analysis of abnormalities of the retinoblastoma gene in human ovarian and endometrial carcinoma.

    abstract::The altered expression of the human retinoblastoma (RB) gene has been demonstrated to play an important role in the pathogenesis of RB and other tumors. To determine whether the RB gene might be involved in the pathogenesis of human ovarian and endometrial cancer, DNA from 24 human ovarian tumors, 3 normal ovaries, 3 ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19901115)66:10<2150::aid-cncr282

    authors: Sasano H,Comerford J,Silverberg SG,Garrett CT

    更新日期:1990-11-15 00:00:00

  • Radiation treatment of primary carcinoma of the female urethra.

    abstract::Because of the rarity of the primary carcinoma of the female urethra, there has been limited experience of individual institutions in management of this disease. Treatment by radiation alone required radium implant skill in early cases and individualized consideration for integrating external and internal irradiation ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197809)42:3<1177::aid-cncr282042

    authors: Prempree T,Wizenberg MJ,Scott RM

    更新日期:1978-09-01 00:00:00

  • Fatal hepatic vascular toxicity of DTIC. Is it really a rare event?

    abstract::A fatal massive hepatic necrosis with widespread thrombotic occlusion of the small hepatic veins developed in two of 68 patients treated with DTIC for advanced melanoma in a randomized study. Thirteen similar reactions, in patients treated with single-agent DTIC, are reported in the literature. Several clinical and pa...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880515)61:10<1988::aid-cncr282

    authors: Ceci G,Bella M,Melissari M,Gabrielli M,Bocchi P,Cocconi G

    更新日期:1988-05-15 00:00:00

  • Chemotherapy in patients with recurrent and progressive central neurocytoma.

    abstract:BACKGROUND:Recurrent central neurocytoma is very rare and to the authors' knowledge data regarding its response to chemotherapy currently are not available. METHODS:Three patients with progressive neurocytoma received chemotherapy after their informed consent was obtained. Disease recurred in two patients after surger...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(20000101)88:1<169::aid-cnc

    authors: Brandes AA,Amistà P,Gardiman M,Volpin L,Danieli D,Guglielmi B,Carollo C,Pinna G,Turazzi S,Monfardini S

    更新日期:2000-01-01 00:00:00

  • Phase II study of doxorubicin plus ifosfamide/mesna in patients with advanced breast cancer.

    abstract::Four courses of ifosfamide with mesna given by intravenous infusions were combined with bolus doxorubicin in a phase II trial to treat patients with breast cancer. Ifosfamide can deplete intracellular glutathione levels and because doxorubicin resistance may be associated with elevated levels of intracellular glutathi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900601)65:11<2421::aid-cncr282

    authors: Millward MJ,Harris AL,Cantwell BM

    更新日期:1990-06-01 00:00:00

  • The prognostic significance of nuclear DNA content in malignant epithelial tumors of the ovary.

    abstract::Recent studies have indicated that the nuclear DNA content of certain malignant neoplasms can be used as an adjunct in predicting their biologic behavior. The DNA content of 99 ovarian carcinomas was determined by flow cytometric analysis of nuclei obtained from paraffin-embedded tissue. Of the 99 tumors, 51 were dipl...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900101)65:1<141::aid-cncr28206

    authors: Brescia RJ,Barakat RA,Beller U,Frederickson G,Suhrland MJ,Dubin N,Demopoulos RI

    更新日期:1990-01-01 00:00:00

  • Short term treatment with Escherichia coli recombinant human granulocyte-macrophage-colony stimulating factor prior to chemotherapy for Hodgkin disease.

    abstract:BACKGROUND:Granulocyte-macrophage-colony stimulating factor (GM-CSF) administration stimulates the proliferation of hemopoietic progenitors. Shortly (48-96 hours) after its discontinuation, feedback phenomena occur and the progenitor proliferation rate drops below baseline levels. As the quiescence of hyperplastic bone...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/(sici)1097-0142(20000115)88:2<454::aid-cnc

    authors: Aglietta M,Montemurro F,Fagioli F,Volta C,Botto B,Cantonetti M,Racanelli V,Teofili L,Ferrara R,Amadori S,Castoldi GL,Dammacco F,Levis A

    更新日期:2000-01-15 00:00:00

  • A consensus review on malignancy-associated hemophagocytic lymphohistiocytosis in adults.

    abstract::Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of severe immune activation and dysregulation resulting in extreme and often life-threatening inflammation. HLH has been well recognized in pediatric populations, and most current diagnostic and therapeutic guidelines are based on pediatric HLH. Recently there has...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.30826

    authors: Daver N,McClain K,Allen CE,Parikh SA,Otrock Z,Rojas-Hernandez C,Blechacz B,Wang S,Minkov M,Jordan MB,La Rosée P,Kantarjian HM

    更新日期:2017-09-01 00:00:00

  • Principles of early detection of cancer.

    abstract::Screening for the early detection of cancer offers the potential of increasing the number of patients whose cancer is diagnosed in a localized, curable stage. The operation of an efficient and effective early detection program requires that a number of conditions be fulfilled, some of which are difficult to attain. Fi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810301)47:5+<1142::aid-cncr282

    authors: Miller DG

    更新日期:1981-03-01 00:00:00

  • Immunocytochemical estrogen and progestin receptor assays in breast cancer with monoclonal antibodies. Histopathologic, demographic, and biochemical correlations and relationship to endocrine response and survival.

    abstract::Breast cancer specimens from 600 women were assayed for estrogen receptors (ER) using an immunocytochemical assay (ICA) employing the monoclonal antiestrophilin antibody H222 Sp gamma. Results showed significant correlation with biochemical ER determinations as well as with tumor grade and menopausal status. In 449 ca...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19901015)66:8<1663::aid-cncr2820

    authors: Pertschuk LP,Kim DS,Nayer K,Feldman JG,Eisenberg KB,Carter AC,Rong ZT,Thelmo WL,Fleisher J,Greene GL

    更新日期:1990-10-15 00:00:00

  • Dose intensity analysis of high-dose carboplatin in refractory ovarian carcinoma relative to age.

    abstract:BACKGROUND:Cisplatin and carboplatin are essential to management of advanced-stage epithelial ovarian carcinoma. No published data exist regarding carboplatin dose intensity importance in ovarian cancer, nor are there data for the effect of age on the ability to deliver dose-intensive carboplatin. METHODS:Retrospectiv...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.2820710225

    authors: Cornelison TL,Reed E

    更新日期:1993-01-15 00:00:00

  • Incidence of thrombocytopenia and serious hemorrhage among patients with solid tumors.

    abstract::To evaluate the incidence of thrombocytopenia and bleeding among patients with solid tumors treated intensively with chemotherapy, the records of 1274 patients treated between 1972 and 1980 on protocols known to produce significant myelosuppression were reviewed. Three hundred one patients with solid tumors (breast, l...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840201)53:3<557::aid-cncr28205

    authors: Dutcher JP,Schiffer CA,Aisner J,O'Connell BA,Levy C,Kendall JA,Wiernik PH

    更新日期:1984-02-01 00:00:00

  • Vascular-targeting therapies for treatment of malignant disease.

    abstract:BACKGROUND:Tumor endothelium represents a valuable target for cancer therapy. The vasculature plays a critical role in the survival and continued growth of solid tumor masses; in addition, the inherent differences between tumor blood vessels and blood vessels associated with normal tissue make the tumor vasculature a u...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.20299

    authors: Siemann DW,Chaplin DJ,Horsman MR

    更新日期:2004-06-15 00:00:00

  • Chemotherapy for adenocystic carcinoma.

    abstract::Seventeen patients with adenocystic carcinoma have received 34 adequate trials of chemotherapy at Princess Margaret Hospital since 1969. There have been five objective responses to chemotherapy in 4 cases, lasting from five to 24 months, and 3 other patients have had stabilized disease for a period of five to seven mo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800801)46:3<452::aid-cncr28204

    authors: Tannock IF,Sutherland DJ

    更新日期:1980-08-01 00:00:00

  • Anaerobic liver abscess and intrahepatic metastases: a case report and review of the literature.

    abstract::A patient is described in whom the first recurrence of a cloacogenic carcinoma of the rectum was an intrahepatic metastasis associated with an hepatic abscess caused by the anaerobic bacterium Peptococcus prevotii. Three previously reported cases of infection associated with hepatic tumor nodules have been found in wh...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197802)41:2<682::aid-cncr2820410

    authors: Trump DL,Fahnestock R,Cloutier CT,Dickman MD

    更新日期:1978-02-01 00:00:00

  • Spinal cord compression in breast cancer.

    abstract::Myelography was performed on 78 patients with breast cancer who had signs or symptoms compatible with spinal cord compression. Of 42 patients (54%) with extradural defects, 21 (50%) had a complete block. All patients with positive myelograms (M+) had a positive bone scan and 41 of 42 (97%) had positive skeletal x-rays...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850615)55:12<2839::aid-cncr282

    authors: Harrison KM,Muss HB,Ball MR,McWhorter M,Case D

    更新日期:1985-06-15 00:00:00

  • Supratentorial gangliogliomas: histopathologic grading and tumor recurrence in 184 patients with a median follow-up of 8 years.

    abstract:BACKGROUND:Supratentorial gangliogliomas (GGs) are rare tumors of the central nervous system and are commonly associated with chronic seizures. To date, only case reports and small series of patients with short-term follow-up have been available for the assessment of the potential of GGs to recur and progress. METHODS...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20332

    authors: Luyken C,Blümcke I,Fimmers R,Urbach H,Wiestler OD,Schramm J

    更新日期:2004-07-01 00:00:00

  • Imaging in gynecologic malignancies.

    abstract::Cross-sectional imaging is often a useful complement to clinical examination in patients with gynecologic malignancies. Patients with ovarian cancer will benefit less from the use of computed tomography and magnetic resonance imaging (MRI); however, extensive intraperitoneal disease may be evaluated and followed with ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.2820710431

    authors: Bragg DG,Hricak H

    更新日期:1993-02-15 00:00:00

  • Splenic alterations in hairy-cell leukemia: II. an electron microscopic study.

    abstract::Spleen from nine patients with hairy-cell leukemia (HCL) were studied for ultrastructural alterations. In all cases, hairy cells with typical ultrastructural characteristics were observed within splenic cords and sinuses. Hairy cells had numerous cytoplasmic processes that interdigitated with cytoplasmic processes of ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820415)49:8<1617::aid-cncr2820

    authors: Pilon VA,Davey FR,Gordon GB,Jones DB

    更新日期:1982-04-15 00:00:00

  • Reduced-intensity conditioning with fludarabine and busulfan versus fludarabine and melphalan for patients with acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation.

    abstract:BACKGROUND:Fludarabine plus busulfan (FB) and fludarabine plus melphalan (FM) are 2 widely used reduced-intensity conditioning (RIC) regimens for allogeneic hematopoietic stem cell transplantation (allo-SCT). METHODS:The current survey compared transplantation outcomes for a cohort of 394 acute myeloid leukemia (AML) ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29163

    authors: Baron F,Labopin M,Peniket A,Jindra P,Afanasyev B,Sanz MA,Deconinck E,Nagler A,Mohty M

    更新日期:2015-04-01 00:00:00

  • Synovial sarcoma. A DNA flow cytometric study.

    abstract::The relationship between DNA content, clinicopathologic findings, and patient survival in synovial sarcoma was investigated. Patient age at diagnosis (P less than 0.001), tumor size (P less than 0.001), and ploidy status (P less than 0.003) correlated significantly with patient survival. A marginally significant corre...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900515)65:10<2295::aid-cncr282

    authors: el-Naggar AK,Ayala AG,Abdul-Karim FW,McLemore D,Ballance WW,Garnsey L,Ro JY,Batsakis JG

    更新日期:1990-05-15 00:00:00