Renal cell carcinoma clinically involving adjacent organs: experience with aggressive surgical management.

abstract：BACKGROUND:Several of the large studies addressing prognosis and survival from hepatocellular carcinoma (HCC) have been from Europe and Asia, but only a few have emanated from North America. Survival statistics from other parts of the world may not be applicable to the North American population because of etiologic, de...

journal_title：Cancer

authors： Nzeako UC,Goodman ZD,Ishak KG

更新日期：1995-08-15 00:00:00

abstract：BACKGROUND:Increased pretreatment serum interleukin (IL)-6 levels among patients with head and neck squamous cell carcinoma (HNSCC) have been shown to correlate with poor prognosis, but sample sizes in prior studies have been small and thus unable to control for other known prognostic variables. METHODS:A longitudinal...

journal_title：Cancer

authors： Duffy SA,Taylor JM,Terrell JE,Islam M,Li Y,Fowler KE,Wolf GT,Teknos TN

更新日期：2008-08-15 00:00:00

abstract：BACKGROUND:In the past 4 years, the weekly 24-hour infusion of high dose 5-fluorouracil (5-FU) and leucovorin in the treatment of patients with advanced gastric carcinoma has been prospectively studied at the authors' institution. This has enabled them to explore the possibility that the level of expression of thymidyl...

journal_title：Cancer

authors： Yeh KH,Shun CT,Chen CL,Lin JT,Lee WJ,Lee PH,Chen YC,Cheng AL

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Ifosfamide has previously been shown to be active as a single agent and in combination with doxorubicin, etoposide, and teniposide in pediatric solid tumors and adult acute leukemia. The authors performed a dose-escalation trial of ifosfamide with a fixed dosage of etoposide, with mesna uroprotection, in chi...

journal_title：Cancer

authors： Bernstein ML,Whitehead VM,Devine S,Grier H,Kung F,Krischer J,Dreyer Z,Bell B,Land V,Buchanan GR

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:The current study was conducted to evaluate the maximum tolerable dose of weekly gemcitabine administered simultaneously with radiation and cisplatin in patients with locally advanced nonsmall cell lung cancer (NSCLC). METHODS:Patients with stage IIIA/B NSCLC received concurrently 63 grays radiation and 20 ...

journal_title：Cancer

authors： Momm F,Kaden M,Tannock I,Schumacher M,Hasse J,Henke M

更新日期：2010-10-15 00:00:00

abstract：BACKGROUND:Pathologically, benign prostatic hyperplasia (BPH) is not considered a precursor for prostate carcinoma. However, because the two conditions share not only a similar hormonal environment within the prostate but also several common risk factors, it is possible that men with BPH may be at increased risk of pro...

journal_title：Cancer

authors： Chokkalingam AP,Nyrén O,Johansson JE,Gridley G,McLaughlin JK,Adami HO,Hsing AW

更新日期：2003-10-15 00:00:00

abstract：BACKGROUND:Idarubicin, a new anthracycline analogue, is available in an oral preparation, and responses have been observed using relatively aggressive therapy in patients with myelodysplastic syndromes (MDS). The authors studied whether a chronic low-dose schedule would be effective but less myelotoxic. METHODS:Forty-...

journal_title：Cancer

authors： Greenberg BR,Reynolds RD,Charron CB,Squillace KM,Lessin LS,Case DC Jr,Gams RA

更新日期：1993-03-15 00:00:00

abstract：BACKGROUND:Excessive risk of cutaneous melanoma as a second cancer has been associated with benign or malignant tumors of the nervous system. Cutaneous melanoma and nervous system tumors may independently aggregate in families. There are, however, no previous reports of increased likelihood of tumors of the nervous sys...

journal_title：Cancer

authors： Azizi E,Friedman J,Pavlotsky F,Iscovich J,Bornstein A,Shafir R,Trau H,Brenner H,Nass D

更新日期：1995-11-01 00:00:00

abstract：:Sixty-one patients with essential thrombocythemia (ET) were followed from 1974 through 1987 at the Medizinische Poliklinik. Fifty-one patients (84%) presented with thromboembolic complications, and eight patients (13%) with hemorrhages. In seven patients (12%), a thrombocytosis was detected accidentally. Disturbances ...

journal_title：Cancer

authors： Hehlmann R,Jahn M,Baumann B,Köpcke W

更新日期：1988-06-15 00:00:00

abstract：:We synthesized doxorubicin (Adriamycin, Adria Laboratories, Columbus, OH)-loaded human albumin microspheres (containing approximately 1% doxorubicin w/w) between 15 and 20 micron in diameter. Intrarenal arterial administration of 99mTC-labeled microspheres demonstrated a high renal entrapment ratio (97% of recovered r...

journal_title：Cancer

authors： Kerr DJ,Willmott N,McKillop JH,Cummings J,Lewi HJ,McArdle CS

更新日期：1988-09-01 00:00:00

abstract：:The quantitative analysis on glycosaminoglycan (GAG) in the tumor tissues of five patients with malignant pleural mesothelioma and in the pleural fluid of two patients was performed with the use of biochemical methods. In the tumor tissues, it was found that the average of the total amount of GAG was more than 7.9 tim...

journal_title：Cancer

authors： Nakano T,Fujii J,Tamura S,Amuro Y,Nabeshima K,Horai T,Hada T,Higashino K

更新日期：1986-01-01 00:00:00

abstract：:Many investigators have regarded Stage III lymphomas as a generalized form of disease and have accordingly recommended systemic treatment programs. Between 1961 and 1973, 68 patients with clinical or pathologic Stage III non-Hodgkin's lymphomas were seen in the Division of Radiation Therapy at Stanford University Medi...

journal_title：Cancer

authors： Glatstein E,Fuks Z,Goffinet DR,Kaplan HS

更新日期：1976-06-01 00:00:00

abstract：:The prolonged administration of bisphosphonates can reduce the frequency of morbid skeletal events in patients with metastatic breast carcinoma or multiple myeloma. The development of more potent bisphosphonates will simplify current therapeutic schemes and could improve the therapeutic effectiveness of bisphosphonate...

journal_title：Cancer

authors： Body JJ

更新日期：1997-10-15 00:00:00

abstract：BACKGROUND:Adult T-cell leukemia/lymphoma (ATLL) is a neoplasm of the mature helper T-lymphocyte. Human T-lymphotropic virus type 1 (HTLV-1) has been shown to be the cause of this neoplasm. Recently, however, the HTLV-1 genome has been found in some patients with cutaneous T-cell lymphoma (CTCL), which suggests a causa...

journal_title：Cancer

authors： Kikuchi A,Ohata Y,Matsumoto H,Sugiura M,Nishikawa T

更新日期：1997-01-15 00:00:00

abstract：BACKGROUND:The authors performed a case-control analysis of local control, progression free survival, and overall survival in patients with Stage I-II aggressive lymphomas measuring > or = 7 cm in greatest dimension who were treated initially with or without surgical debulking: All patients then received cyclophosphami...

journal_title：Cancer

authors： Wilder RB,Romaguera JE,Tucker SL,Ha CS,Hess MA,Cabanillas F,Cox JD

更新日期：2002-02-01 00:00:00

abstract：:The accumulation of large amounts of fluid in the pleural space is a common sequela of disseminated carcinomatosis. Traditional management has included therapeutic thoracentesis or the placement of a large bore chest tube for drainage with the subsequent installation of a sclerosing agent in an attempt to achieve pleu...

journal_title：Cancer

authors： Parker LA,Charnock GC,Delany DJ

更新日期：1989-09-15 00:00:00

abstract：BACKGROUND:Single-walled carbon nanotubes (SWNTs) have remarkable physicochemical properties that may have several medical applications. The authors have discovered a novel property of SWNTs-heat release in a radiofrequency (RF) field-that they hypothesized may be used to produce thermal cytotoxicity in malignant cells...

journal_title：Cancer

authors： Gannon CJ,Cherukuri P,Yakobson BI,Cognet L,Kanzius JS,Kittrell C,Weisman RB,Pasquali M,Schmidt HK,Smalley RE,Curley SA

更新日期：2007-12-15 00:00:00

abstract：:Ependymomas originating in the sacrum or extraspinal parasacral soft tissues are rare tumors. The majority are of the myxopapillary type and may be locally destructive. Even though metastases are not uncommon in retrosacral ependymomas, they have been rarely described in intrasacral locations. A case is reported of a ...

journal_title：Cancer

authors： Miralbell R,Louis DN,O'Keeffe D,Rosenberg AE,Suit HD

更新日期：1990-05-15 00:00:00

abstract：:Flow cytometry studies of the DNA distribution of tumor cells from 92 human breast cancers showed measurable aneuploidy (hyperploidy) in 83 cases (92%). The DNA ploidy values were unimodal in each case, but there was a bimodal distribution for the entire series. One group of tumors had a diploid or near diploid DNA di...

journal_title：Cancer

authors： Olszewski W,Darzynkiewicz Z,Rosen PP,Schwartz MK,Melamed MR

更新日期：1981-08-15 00:00:00

abstract：:Although improvements in the management of adults with acute leukemia have lagged behind those seen in the treatment of children, there are clear reasons for optimism. Combination chemotherapy for acute myeloblastic leukemia (AML) and acute lymphoblastic leukemia (ALL) in adults results in complete remissions in 50-85...

journal_title：Cancer

authors： Eyre HJ,Ward JH,Priebat DA

更新日期：1983-06-15 00:00:00

abstract：:The authors investigated the level of lipid peroxidation and possible related phenomena in the activation of phospholipase A2 and the infiltration of granulocyte neutrophils in human colorectal cancer tissue samples. Malondialdehyde (an index of lipid peroxidation), phospholipase A2 activity, and myeloperoxidase activ...

journal_title：Cancer

authors： Otamiri T,Sjödahl R

更新日期：1989-07-15 00:00:00

abstract：:Balloon-mesh cytologic screening for esophageal cancer done in 255 asymptomatic high-risk United States veterans (age greater than 40 years, ethanol abuse for greater than 20 years, and cigarette smoking greater than 20 pack years) identified 37 patients with squamous cell dysplasia. Of the 37 patients with dysplasia,...

journal_title：Cancer

authors： Jacob P,Kahrilas PJ,Desai T,Hidvegi D,Walloch J,Yokoo H,Gurley AM,Ostrow JD

更新日期：1990-06-15 00:00:00

abstract：BACKGROUND:Clinical guidelines recommend against routine prostate-specific antigen (PSA) screening for older men and for those with lower life expectancies. The authors of this report examined providers' decision-making regarding discontinuing PSA screening. METHODS:A survey of primary providers from a large, universi...

journal_title：Cancer

authors： Pollack CE,Platz EA,Bhavsar NA,Noronha G,Green GE,Chen S,Carter HB

更新日期：2012-11-15 00:00:00

abstract：BACKGROUND:Kaiser Permanente (KP) is a large health maintenance organization (HMO) operating in 14 states and caring for 8,000,000 members in hundreds of facilities staffed by thousands of physicians and support personnel. Cancer care is provided to these KP members as part of the health care package. METHODS:KP insur...

journal_title：Cancer

authors： Glass A

更新日期：1998-05-15 00:00:00

abstract：:The case of a 71-year-old woman who developed generalized weakness, lymphadenopathy, and a skin rash during methyldopa therapy is described. The prompt disappearance of symptoms following the discontinuation of the drug implicates it in the initial triggering of the abnormal lymphoid proliferation. Shortly thereafter,...

journal_title：Cancer

authors： Weisenburger DD

更新日期：1978-11-01 00:00:00

abstract：:The prognostic significance of histologic tumor grade has been evaluated in 1537 women entered into the Ludwig Trials I-IV of adjuvant therapy for node-positive breast cancer. Tumor grade was determined on histologic review of primary tumor sections by two central review pathologists using a modification of the Bloom ...

journal_title：Cancer

authors： Davis BW,Gelber RD,Goldhirsch A,Hartmann WH,Locher GW,Reed R,Golouh R,Säve-Söderbergh J,Holloway L,Russell I

更新日期：1986-12-15 00:00:00

abstract：:One hundred thirty-nine consecutive unselected adults with acute nonlymphoblastic leukemia were treated with a high-dose chemotherapeutic remission-induction regimen consisting of daunomycin (70 mg/m2 IV on days 1, 2, 3), cytosine arabinoside (100 mg/m2 IV every 12 hours), 6-thioguanine (100 mg/m2 orally every 12 hour...

journal_title：Cancer

authors： Glucksberg H,Cheever MA,Farewell VT,Fefer A,Sale GE,Thomas ED

更新日期：1981-09-01 00:00:00

abstract：:In view of increasing debate over possible benefit of more complete surgery compared to conservative procedures, a randomized controlled trial contrasting the then standard Halsted radical (RDL) operation with the more complete extended radical (EXT) mastectomy was initiated in 1973. Between November 1973 and July 198...

journal_title：Cancer

authors： Meier P,Ferguson DJ,Karrison T

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Aberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic therapy. Decitabine indirectly depletes methylcytosine and causes hypomethylation of target gene promoters. METHODS:A total of 170 patients with...

journal_title：Cancer

authors： Kantarjian H,Issa JP,Rosenfeld CS,Bennett JM,Albitar M,DiPersio J,Klimek V,Slack J,de Castro C,Ravandi F,Helmer R 3rd,Shen L,Nimer SD,Leavitt R,Raza A,Saba H

更新日期：2006-04-15 00:00:00

abstract：:A clinicopathologic study of 51 patients with endoscopically removed large bowel polyps showing histologic evidence of malignancy, either focally, to a massive extent, or comprising the entire polyp, revealed only one absolute finding capable of predicting residual disease, namely, the presence of cancer at the resect...

journal_title：Cancer

authors： Lipper S,Kahn LB,Ackerman LV

更新日期：1983-11-01 00:00:00