Adult acute leukemia. Aggressive treatment improves survival.

Abstract:

:Although improvements in the management of adults with acute leukemia have lagged behind those seen in the treatment of children, there are clear reasons for optimism. Combination chemotherapy for acute myeloblastic leukemia (AML) and acute lymphoblastic leukemia (ALL) in adults results in complete remissions in 50-85% of patients. An increasing number of these patients remain in continuous remission for over two years with a significant proportion (15-25%) disease-free after five years. Those who remain in remission for more than five years have a low incidence of relapse and many may be cured. Nevertheless, there are still many problems to be solved. Improved, less toxic induction regimens are needed. The roles of maintenance, late intensification, and central nervous system prophylaxis remain unresolved. The results of bone marrow transplantation for adults with AML in remission are encouraging enough to make this an attractive form of therapy for any patient younger than age 40 with a histocompatible sibling. New forms of treatment, such as immunotherapy and monoclonal antibodies, remain investigational.

journal_name

Cancer

journal_title

Cancer

authors

Eyre HJ,Ward JH,Priebat DA

doi

10.1002/1097-0142(19830615)51:12+<2460::aid-cncr28

subject

Has Abstract

pub_date

1983-06-15 00:00:00

pages

2460-8

issue

12 Suppl

eissn

0008-543X

issn

1097-0142

journal_volume

51

pub_type

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