Abstract:
:The case of a 71-year-old woman who developed generalized weakness, lymphadenopathy, and a skin rash during methyldopa therapy is described. The prompt disappearance of symptoms following the discontinuation of the drug implicates it in the initial triggering of the abnormal lymphoid proliferation. Shortly thereafter, florid immunoblastic lymphadenopathy developed, and the patient subsequently responded to corticosteroid therapy. The frequent occurrence of immunoblastic lymphadenopathy during or shortly after the administration of various therapeutic medications is emphasized. The nature of the disorder and its differential diagnosis are discussed.
journal_name
Cancerjournal_title
Cancerauthors
Weisenburger DDdoi
10.1002/1097-0142(197811)42:5<2322::aid-cncr282042subject
Has Abstractpub_date
1978-11-01 00:00:00pages
2322-7issue
5eissn
0008-543Xissn
1097-0142journal_volume
42pub_type
杂志文章相关文献
CANCER文献大全abstract::A pathology review of breast cancers in Japanese and Caucasian women indicates more numerous in situ carcinomas in the Japanese. Carcinomas with uniform nuclei were also more numerous among Japanese. Japanese women showed more extensive lymphocytic infiltrates adjacent to their tumors than did Caucasian women, and als...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850701)56:1<206::aid-cncr28205
更新日期:1985-07-01 00:00:00
abstract:BACKGROUND:The first analysis of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial (median follow-up, 33 months) demonstrated that in adjuvant endocrine therapy for postmenopausal patients with early-stage breast cancer, anastrozole was superior to tamoxifen in terms of disease-free survival (DFS), time to r...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/cncr.11745
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Gastrointestinal stromal tumors (GISTs) are KIT-positive mesenchymal tumors of the gastrointestinal tract that are driven by activated KIT-signalling or platelet-derived growth factor receptor-alpha (PDFGRA) signaling. These tumors most commonly occur in the stomach and small intestine and encompass a clinic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23216
更新日期:2008-02-01 00:00:00
abstract::The authors studied 11 pediatric intrathoracic neoplasms that share clinicopathologic features and constitute a specific tumor in children. These neoplasms were intrapulmonary, mediastinal, or pleural-based masses. A common histologic feature was the presence of small, primitive cells with blastematous qualities separ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19881015)62:8<1516::aid-cncr2820
更新日期:1988-10-15 00:00:00
abstract:BACKGROUND:Discrimination and trust are known barriers to accessing health care. Despite well-documented racial disparities in the ovarian cancer care continuum, the role of these barriers has not been examined. This study evaluated the association of everyday discrimination and trust in physicians with a prolonged int...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32451
更新日期:2019-12-15 00:00:00
abstract:BACKGROUND:Primary cardiac tumors are infrequent, and few cardiac surgeons have extensive experience in treating them. The majority of the tumors are benign. As noninvasive diagnostic imaging of cardiac masses continues to improve, the number of these tumors that are seen by clinicians will increase. More of the malign...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970501)79:9<1809::aid-cn
更新日期:1997-05-01 00:00:00
abstract::We report on an 89-year-old female admitted with signs of intestinal obstruction in whom three independent adenocarcinomas of the proximal jejunum were found. Multiple foci of pyloric gland metaplasia, glandular hyperplasia and dysplasia, carcinoma-in-situ, and several varieties of adenocarcinoma were identified on mi...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197909)44:3<1142::aid-cncr282044
更新日期:1979-09-01 00:00:00
abstract:BACKGROUND:If some adenomas do not bleed over several years, they will cause systematic false-negative fecal immunochemical test (FIT) results. The long-term effectiveness of FIT screening has been estimated without accounting for such systematic false-negativity. There are now data with which to evaluate this issue. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29952
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Severe fatigue is a common and distressing symptom affecting approximately one in four survivors of breast cancer. The current study examined the efficacy of Internet-based cognitive behavioral therapy (ICBT) for severe fatigue in survivors of breast cancer compared with care as usual (CAU). METHODS:The aut...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.30815
更新日期:2017-10-01 00:00:00
abstract::The presence of hepatitis B virus (HBV) has been evaluated in liver specimens from 11 children with primary liver tumors and negative results of serologic testing for HBV markers. HBV-DNA sequences were detected by the polymerase chain reaction procedure, using different sets of oligonucleotide primers from highly con...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920601)69:11<2731::aid-cncr282
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:Recently, peripheral lung adenocarcinomas (PLA) measuring < or = 3 cm in greatest dimension often have been diagnosed using diagnostic radiology. The objective of the current study was to determine which cytologic factors are associated with a favorable outcome and an unfavorable outcome in patients with PLA...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20686
更新日期:2005-02-25 00:00:00
abstract:BACKGROUND:American Indians/Alaskan Natives (AI/ANs) have the worst 5-year cancer survival of all racial/ethnic groups in the United States. Causes for this disparity are unknown. The authors of this report examined the receipt of cancer treatment among AI/AN patients compared with white patients. METHODS:This was a r...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28683
更新日期:2014-07-15 00:00:00
abstract::A collaborative study of the humoral and cellular immune status of patients with carcinoma of the Head and Neck (H&N) was conducted at the West Virginia University (WVU) hospital. In addition, blind-coded serum panels were supplied on H&N cancer patients being treated at the National Cancer Institute (NCI). Serum prot...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860615)57:12<2295::aid-cncr282
更新日期:1986-06-15 00:00:00
abstract:BACKGROUND:Gene expression profiling (GEP) has been rapidly adopted for early breast cancer and can aid in chemotherapy decision making. Study results regarding racial disparities in testing are conflicting, and may reflect different care settings. To the authors' knowledge, data regarding the influence of provider fac...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31222
更新日期:2018-04-15 00:00:00
abstract:BACKGROUND:The prognosis of pediatric patients with nonpilocytic astrocytoma, and in particular those with anaplastic astrocytoma, is somewhat unpredictable. This study used MIB-1 monoclonal antibody, a proliferative marker that can be used in formalin fixed paraffin embedded tissues, to study nonpilocytic pediatric as...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980615)82:12<2459::aid-c
更新日期:1998-06-15 00:00:00
abstract:BACKGROUND:Glioblastoma multiforme (GBM) is the most frequent primary brain tumor in adults. Temozolomide was rapidly incorporated into first-line treatment following the publication of the pivotal European Organization for Research and Treatment of Cancer-National Cancer Institute of Canada phase 3 trial in 2005. Howe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26685
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:The Early Lung Cancer Action Project (ELCAP) is designed to evaluate baseline and annual repeat screening by low radiation dose computed tomography (low-dose CT) in persons at high-risk for lung cancer. The authors report on the baseline screening experience. For full evaluation of screening, they await the ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(20001201)89:11+<2474::aid-cncr26
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Initial clinic studies revealed that the overexpression of proline-directed protein kinase F(A) (PDPK F(A)) is associated conversely with various stages of tumor tissue differentiation. However, the role of overexpressed PDPK F(A) in tumor cell differentiation remains unknown and needs to be established. In ...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:Rural residence has been associated with increased risk of late stage cancer diagnosis, but it is unknown if this is related to lower socioeconomic status (SES) of rural residents or to other factors. This study examined the impacts of SES and urban/rural status on colorectal cancer (CRC) stage at diagnosis ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22016
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:This Phase III trial was performed to compare the roles of oral etoposide and intravenous (i.v.) vinblastine in the treatment of Mediterranean Kaposi's Sarcoma (MEKS) in elderly patients with severe disease (Stages II, Ac/B, III, and IV). PATIENTS AND METHODS:Sixty-five patients were randomized to receive e...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19941115)74:10<2873::aid-cncr282
更新日期:1994-11-15 00:00:00
abstract::To additionally understand the molecular mechanisms and biologic indicators of colonic tumorigenesis through the adenoma-carcinoma sequence, protein kinase C (PKC) activity was examined in the cytosol and particulate fraction of specimen homogenates from 18 human colonic carcinomas and seven coexisting colonic adenoma...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920101)69:1<24::aid-cncr282069
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:The long-term impact of breast carcinoma and its treatment was assessed in 153 breast carcinoma survivors previously treated on a Phase III randomized trial (Cancer and Leukemia Group B [CALGB 7581]) a median of 20 years after entry to CALGB 7581. METHODS:Survivors were interviewed by telephone using the fo...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/cncr.11531
更新日期:2003-08-15 00:00:00
abstract:BACKGROUND:The goal of this study was to examine the clinical significance of ZNF217 amplification and assess whether ZNF217 could be a potential therapeutic target in ovarian clear cell carcinoma (OCCC). METHODS:ZNF217 expression and amplification in OCCC was assessed by immunohistochemistry, fluorescence in situ hyb...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26598
更新日期:2012-06-01 00:00:00
abstract::Approximately 25% of women with early stage breast cancer and negative axillary nodes will eventually die of metastatic disease. Some studies have shown a recurrence rate of 40% or more at 10 years in this relatively good prognostic group. The incidence of breast cancer continues to increase approximately 1% per year ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:1991-03-15 00:00:00
abstract:BACKGROUND:Fortunately, primary malignant mucosal melanoma of the head and neck is a rare entity. A paucity of data elucidating the predictive factors as well as the unpredictable and aggressive biologic behavior of mucosal melanoma compound the vexing clinical situation. This review summarizes what the literature reve...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19971015)80:8<1373::aid-cn
更新日期:1997-10-15 00:00:00
abstract::Epidemiologic and laboratory data suggest that cervical cancer typically arises from a series of causal steps. Each step can be studied separately in the hope of better etiologic understanding and improved cancer prevention. The earliest identified etiologic step is infection of young women with specific types of vene...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19951115)76:10+<1888::aid-cncr28
更新日期:1995-11-15 00:00:00
abstract:BACKGROUND:The purpose of the current analysis was to evaluate the impact of local recurrence (LR) on the development of distant metastases (DM), overall survival (OS), and cause specific survival (CSS) in patients with early-stage breast carcinoma who underwent conservative surgery (CS) and received postoperative radi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11143
更新日期:2003-02-15 00:00:00
abstract:BACKGROUND:Breast carcinoma commonly metastasizes to the skeleton in patients with advanced disease to cause bone destruction and the associated pain, hypercalcemia, fracture, and nerve-compression syndromes. In this scenario, the bone destruction is mediated by the osteoclast. Tumor-produced parathyroid hormone-relate...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(20000615)88:12+<2892::aid-cncr2>
更新日期:2000-06-15 00:00:00
abstract::With increasing numbers of survivors from cancer at a young age, the issue of fertility preservation has assumed greater importance. This review describes normal ovarian and testicular function and summarizes what is known about the effect of chemotherapy and radiotherapy on the gonads and uterus. All young patients w...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.26045
更新日期:2011-05-15 00:00:00
abstract:BACKGROUND:Gastric carcinoma with lymphoid stroma (GCLS) has been reported to have a more favorable prognosis than ordinary gastric carcinoma, however, the precise mechanism of the pathogenesis for GCLS remains unclear. METHODS:The authors analyzed 99 GCLS in 94 patients for Epstein-Barr virus (EBV) sequences using po...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940501)73:9<2239::aid-cncr2820
更新日期:1994-05-01 00:00:00