Flow cytometry of breast carcinoma: I. Relation of DNA ploidy level to histology and estrogen receptor.

Abstract:

:Flow cytometry studies of the DNA distribution of tumor cells from 92 human breast cancers showed measurable aneuploidy (hyperploidy) in 83 cases (92%). The DNA ploidy values were unimodal in each case, but there was a bimodal distribution for the entire series. One group of tumors had a diploid or near diploid DNA distribution and a second group had ploidy levels from triploid to tetraploid or higher. The tumors with lower DNA ploidy (at or near diploid) tended to be histologically low grade, cytologically more orderly and estrogen-binding positive; those with higher DNA ploidy were more likely to be higher grade, more anaplastic, and estrogen-binding negative.

journal_name

Cancer

journal_title

Cancer

authors

Olszewski W,Darzynkiewicz Z,Rosen PP,Schwartz MK,Melamed MR

doi

10.1002/1097-0142(19810815)48:4<980::aid-cncr28204

subject

Has Abstract

pub_date

1981-08-15 00:00:00

pages

980-4

issue

4

eissn

0008-543X

issn

1097-0142

journal_volume

48

pub_type

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