Abstract:
:K-ras gene mutation in colorectal tumors from patients with familial polyposis coli were investigated using oligonucleotide probes specific for a mutation at codon 12, 13, or 61 of the K-ras gene. The authors examined 22 colorectal carcinomas and 51 colorectal adenomas from 41 familial polyposis coli patients and observed mutations at codons 12 and 13 in eight of 22 colorectal carcinomas (36%) and six of 51 colorectal adenomas (12%). Thus, the frequency and sites of K-ras gene mutation in colorectal carcinoma from familial polyposis coli patients are similar to those in cases of sporadic colorectal carcinoma and may not be the first genetic event linked to the tumorigenesis.
journal_name
Cancerjournal_title
Cancerauthors
Sasaki M,Sugio K,Sasazuki Tdoi
10.1002/1097-0142(19900601)65:11<2576::aid-cncr282subject
Has Abstractpub_date
1990-06-01 00:00:00pages
2576-9issue
11eissn
0008-543Xissn
1097-0142journal_volume
65pub_type
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