Surgical adjuvant chemotherapy with mitomycin C and cyclophosphamide in Japanese patients with breast cancer.

Abstract:

:A controlled trial of surgical adjuvant chemotherapy for breast cancer was carried out using 551 Japanese patients. Single or combined treatment with mitomycin C (0.2 mg/kg i.v. three times within five days postoperatively) and cyclophosphamide (100 mg postoperatively daily for four months or longer) was used after radical surgery. In patients of the chemotherapy group with one to three lymph nodes involved in the axilla, the five-year cancer-free survival rate was 84.8% compared with 57.3% in the control group (P < 0.05), and the five-year cumulative recurrence in distant sites was 5.1% compared with 31.1% in the control (P < 0.05). The effectiveness of chemotherapy was much less marked in patients without nodal metastasis and with four or more nodes involved. Histologically, scirrhous cancer was the type that responded most favorably to chemotherapy, even in patients without axillary involvement. Premenopausal patients benefited more than postmenopausal patients from chemotherapy. A combination of mitomycin C and cyclophosphamide was more effective than their use singly. The present chemotherapy regimen was effective primarily in moderately advanced stages of breast cancer with decreased incidence of distant metastasis.

journal_name

Cancer

journal_title

Cancer

authors

Koyama H,Wada T,Takahashi Y,Nishizawa Y,Iwanaga T,Aoki Y,Terasawa T,Kosaki G,Kajita A,Wada A

doi

10.1002/1097-0142(19801201)46:11<2373::aid-cncr282

subject

Has Abstract

pub_date

1980-12-01 00:00:00

pages

2373-9

issue

11

eissn

0008-543X

issn

1097-0142

journal_volume

46

pub_type

临床试验,杂志文章

相关文献

CANCER文献大全
  • Oncocytic neoplasms of salivary glands: a report of fifteen cases including two malignant oncocytomas.

    abstract::Fifteen oncocytic (oxyphilic granular cell) neoplasms of the salivary glands collected from three large university medical centers are presented. The histologic and ultrastructural criteria that characterize oncocytes are presented and electron micrographs of two of our cases are discussed. Included in the series are ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197609)38:3<1306::aid-cncr282038

    authors: Gray SR,Cornog JL Jr,Seo IS

    更新日期:1976-09-01 00:00:00

  • Familial prostate cancer in Sweden. A nationwide register cohort study.

    abstract:BACKGROUND:Although prostate carcinoma is not widely recognized as a familial cancer, familial aggregation of this disease has been shown in some retrospective case-control studies. To study familial prostate cancer in Sweden, a population-based cohort study was performed, that attempted to avoid possible bias connecte...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/(SICI)1097-0142(19960101)77:1<138::AID-CNC

    authors: Grönberg H,Damber L,Damber JE

    更新日期:1996-01-01 00:00:00

  • Chemotherapy of malignant hepatomas with sequential intraarterial doxorubicin and systemic 5-fluorouracil and semustine.

    abstract::Twenty patients with malignant hepatoma were treated with sequential intraarterial doxorubicin (72-hour continuous infusion) followed by systemic 5-fluorouracil (5-FU) and semustine (methyl CCNU). Objective tumor responses were seen in three patients (15%). The durations of response were 6, 19, and 27+ months, respect...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880915)62:6<1041::aid-cncr2820

    authors: O'Connell MJ,Hahn RG,Rubin J,Moertel CG

    更新日期:1988-09-15 00:00:00

  • Prognostic significance of cytomorphology in the cutaneous T-cell lymphomas.

    abstract::In this retrospective study, the degree of differentiation of atypical lymphoid cells was assessed in pretreatment cutaneous biopsy specimens from 248 patients with cutaneous T-cell lymphomas (mycosis fungoides and Sézary syndrome) and the findings were correlated with the subsequent therapeutic results. Overall, pati...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810101)47:1<119::aid-cncr28204

    authors: Vonderheid EC,Tam DW,Johnson WC,Van Scott EJ,Wallner PE

    更新日期:1981-01-01 00:00:00

  • Serious hyponatremia in patients with cancer: management with demeclocycline.

    abstract::Seventeen patients with cancer or aplastic anemia received demeclocycline as treatment for hyponatremia. Prior to demeclocycline therapy no patients showed clinical signs of fluid overload or saline depletion. In all patients inappropriately concentrated urine (mean urine osmolality = 548 mOSM/kg H2O) or increased uri...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810615)47:12<2908::aid-cncr282

    authors: Trump DL

    更新日期:1981-06-15 00:00:00

  • Acute myocardial infarction with normal coronary arteriogram after mantle field radiation therapy for Hodgkin's disease.

    abstract::A case of an acute myocardial infarction occurring in a 19-year-old woman, 27 months after mantle radiotherapy for Stage II-A Hodgkin's disease is described. The coronary arteriogram demonstrated patent and normal coronary arteries, but the echocardiogram revealed pericarditis. The clinical course was further complica...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830815)52:4<637::aid-cncr28205

    authors: Yahalom J,Hasin Y,Fuks Z

    更新日期:1983-08-15 00:00:00

  • Late effects of treatment for Wilms' tumor. A report from the National Wilms' Tumor Study Group.

    abstract::The National Wilms' Tumor Study (NWTS) was initiated in 1969. One of its objectives was to modulate treatments according to risk factors to minimize the number and severity of treatment-related short-term and long-term iatrogenic complications. The NWTS has therefore incorporated a Long Term Follow-up Study (LTFS) wit...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910115)67:2<331::aid-cncr28206

    authors: Evans AE,Norkool P,Evans I,Breslow N,D'Angio GJ

    更新日期:1991-01-15 00:00:00

  • Pleomorphic liposarcoma: clinical observations and molecular variables.

    abstract:BACKGROUND:Pleomorphic liposarcoma (PLS) is a rare high-grade sarcoma that has lipoblastic differentiation. In this study, the authors evaluated PLS natural history, patient outcomes, and commonly deregulated protein biomarkers. METHODS:Medical records from patients (n = 155) who had PLS from 1993 to 2010 were reviewe...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26195

    authors: Ghadimi MP,Liu P,Peng T,Bolshakov S,Young ED,Torres KE,Colombo C,Hoffman A,Broccoli D,Hornick JL,Lazar AJ,Pisters P,Pollock RE,Lev D

    更新日期:2011-12-01 00:00:00

  • Medullary carcinoma of the breast. An unusual cytologic finding in cyst fluid aspirates.

    abstract::Cystic medullary carcinoma of the breast is unusual. This report describes five patients with medullary carcinoma who presented clinically with a breast cyst. Fine-needle aspiration biopsy (NAB) was performed as part of the initial physical examination and the retrieved cyst fluid was examined cytologically. Four of t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900115)65:2<277::aid-cncr28206

    authors: Howell LP,Kline TS

    更新日期:1990-01-15 00:00:00

  • Adjuvant immunotherapy and chemoimmunotherapy in colorectal cancer (Dukes' class C): prolongation of disease-free interval and survival.

    abstract::The poor postsurgical prognosis in patients with colorectal cancer of the Dukes' C classification has prompted a clinical trial of adjuvant immunotherapy versus chemoimmunotherapy intended to prolong either the disease-free interval or the overall survival or both. One hundred and twenty-one patients have been entered...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197711)40:5+<2726::aid-cncr28204

    authors: Mavligit GM,Gutterman JU,Malahy MA,Burgess MA,McBride CM,Jubert A,Hersh EM

    更新日期:1977-11-01 00:00:00

  • Telomerase activity in bladder carcinoma and its implication for noninvasive diagnosis by detection of exfoliated cancer cells in urine.

    abstract:BACKGROUND:Telomerase is an enzyme that can reconstitute the ends (telomeres) of chromosomes after cell division and thus circumvent the cumulative damage that occurs in normal adult somatic cells during successive mitotic cycles. Recently, it has been proposed that this enzyme should, therefore, be detectable in immor...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19970115)79:2<362::aid-cnc

    authors: Yoshida K,Sugino T,Tahara H,Woodman A,Bolodeoku J,Nargund V,Fellows G,Goodison S,Tahara E,Tarin D

    更新日期:1997-01-15 00:00:00

  • Breast conservation therapy in the United States following the 1990 National Institutes of Health Consensus Development Conference on the treatment of patients with early stage invasive breast carcinoma.

    abstract:BACKGROUND:A National Institutes of Health (NIH) Consensus Development Conference on the treatment of patients with early stage invasive breast carcinoma, held in June 1990, recommended breast conservation therapy for the majority of women with Stage I or II breast carcinoma. The authors evaluated the national use of b...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Lazovich D,Solomon CC,Thomas DB,Moe RE,White E

    更新日期:1999-08-15 00:00:00

  • Are patients of low socioeconomic status receiving suboptimal management for pancreatic adenocarcinoma?

    abstract:BACKGROUND:The objective of this study was to define the effects of socioeconomic status (SES) and other demographic variables on outcomes for patients with pancreatic adenocarcinoma. METHODS:Florida cancer registry and inpatient hospital data were queried for pancreatic adenocarcinoma diagnosed from 1998 to 2002. RE...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24758

    authors: Cheung MC,Yang R,Byrne MM,Solorzano CC,Nakeeb A,Koniaris LG

    更新日期:2010-02-01 00:00:00

  • Religion, spirituality, and health outcomes in cancer: A case for a meta-analytic investigation.

    abstract::A growing body of research shows that a majority of patients with cancer report having religious and spiritual (R/S) beliefs, engaging in R/S behaviors, or deriving comfort from R/S experiences. These studies have been reviewed but not subjected to rigorous critical analysis. A meta-analytic approach is needed to prov...

    journal_title:Cancer

    pub_type: 杂志文章,meta分析

    doi:10.1002/cncr.29349

    authors: Salsman JM,Fitchett G,Merluzzi TV,Sherman AC,Park CL

    更新日期:2015-11-01 00:00:00

  • Trends, patterns, and outcomes in the management of malignant colonic polyps in the general population of the United States.

    abstract:BACKGROUND:Colonoscopic screening has increased detection of malignant colonic polyps (MPs). The goal of this study was to analyze trends and patterns in the surgical treatment of MPs and to assess outcomes as measured by lymph node retrieval and patient survival. METHODS:The Surveillance, Epidemiology, and End Result...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25657

    authors: Wasif N,Etzioni D,Maggard MA,Tomlinson JS,Ko CY

    更新日期:2011-03-01 00:00:00

  • Use of tamoxifen in the treatment of malignant melanoma.

    abstract:BACKGROUND:Tamoxifen has been used in the treatment of patients with metastatic malignant melanoma either as a single agent or, more commonly, in combination with other chemotherapeutic agents. The aim of the current study was to summarize the available clinical evidence on the role of the tamoxifen in different combin...

    journal_title:Cancer

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/cncr.11644

    authors: Lens MB,Reiman T,Husain AF

    更新日期:2003-10-01 00:00:00

  • Fibrosis in the peritoneum induced by scirrhous gastric cancer cells may act as "soil" for peritoneal dissemination.

    abstract:BACKGROUND:Peritoneal metastases are one reason for the poor prognosis of scirrhous gastric cancer. However, the mechanism of peritoneal metastasis remains unclear. We therefore investigated the interaction between gastric cancer cells and peritoneal fibroblasts, in vivo and in vitro. METHODS:A human scirrhous gastric...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960415)77:8<1668::AID-CN

    authors: Yashiro M,Chung YS,Nishimura S,Inoue T,Sowa M

    更新日期:1996-04-15 00:00:00

  • Phase II study of oxaliplatin in children with recurrent or refractory medulloblastoma, supratentorial primitive neuroectodermal tumors, and atypical teratoid rhabdoid tumors: a pediatric brain tumor consortium study.

    abstract:BACKGROUND:An open-label Phase II study of oxaliplatin was conducted to evaluate its safety and efficacy in children with recurrent or refractory medulloblastoma (MB), supratentorial primitive neuroectodermal tumors (SPNET), and atypical teratoid rhabdoid tumor (ATRT). METHODS:Patients were stratified as follows: stra...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22241

    authors: Fouladi M,Blaney SM,Poussaint TY,Freeman BB 3rd,McLendon R,Fuller C,Adesina AM,Hancock ML,Danks MK,Stewart C,Boyett JM,Gajjar A

    更新日期:2006-11-01 00:00:00

  • Uroplakin as a marker for typing metastatic transitional cell carcinoma on fine-needle aspiration specimens.

    abstract:BACKGROUND:Immunohistological markers specific for a single type of epithelium are rare. Recently, urothelium tissue-specific genes were cloned. The genes encoded a family of transmembrane proteins, uroplakins, that are expressed only in urothelial mucosa. Using uroplakin antibodies on paraffin-embedded tissue, a previ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.9032

    authors: Xu X,Sun TT,Gupta PK,Zhang P,Nasuti JF

    更新日期:2001-06-25 00:00:00

  • Plasma immunoglobulin levels in patients with breast cancer.

    abstract::The plasma levels of the immunoglobulins IgA, IgG and IgM have been measured in 55 patients with benign breast disease, 28, 68 and 22 patients with early breast cancer one day before, 10-14 days after and three-six months after mastectomy, respectively, and 35 normal healthy control women. The mean levels of IgA, IgG ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197705)39:5<2190::aid-cncr282039

    authors: Wang DY,Goodwin PR,Bulbrook RD,Hayward JL

    更新日期:1977-05-01 00:00:00

  • An aggressive therapeutic approach to carcinoma of the body and tail of the pancreas.

    abstract:BACKGROUND:Prognosis of patients with adenocarcinoma of the pancreatic body and tail is extremely poor. Anatomically, this part of the pancreas is thin, and cancerous invasion to the retropancreatic structures occurs easily. The majority of patients have residual tumor in the retroperitoneal tissues after conventional ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960601)77:11<2240::AID-C

    authors: Ozaki H,Kinoshita T,Kosuge T,Yamamoto J,Shimada K,Inoue K,Koyama Y,Mukai K

    更新日期:1996-06-01 00:00:00

  • Treatment of recurrent epithelial ovarian cancer.

    abstract::The majority of patients with advanced ovarian cancer progress after first-line therapy and require further treatment. Tumor biology, prior chemotherapy, responses to previous therapy, performance status, and toxicity are the characteristics that influence treatment choice. These criteria have been linked to the time ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.32500

    authors: Pignata S,Pisano C,Di Napoli M,Cecere SC,Tambaro R,Attademo L

    更新日期:2019-12-15 00:00:00

  • Positron emission tomography of patients with head and neck carcinoma before and after high dose irradiation.

    abstract:BACKGROUND:Positron emission tomography (PET) with labeled fluorodeoxyglucose (FDG) demonstrates increased tracer uptake in many neoplasms. This study was undertaken to define the patterns of FDG uptake in head and neck neoplasms before and after high dose irradiation. METHODS:Twenty-five patients were evaluated prosp...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940815)74:4<1355::aid-cncr2820

    authors: Greven KM,Williams DW 3rd,Keyes JW Jr,McGuirt WF,Watson NE Jr,Randall ME,Raben M,Geisinger KR,Cappellari JO

    更新日期:1994-08-15 00:00:00

  • Analgesics and cancer of the renal pelvis in New South Wales.

    abstract::A lifetime history of analgesics and tobacco consumption was obtained by a questionnaire completed at interview from 67 patients with carcinoma of the renal pelvis (40 women, 27 men) and 180 control subjects drawn from two sources, friends of patients and persons attending a health screening clinic. Regular consumptio...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820615)49:12<2617::aid-cncr282

    authors: McCredie M,Ford JM,Taylor JS,Stewart JH

    更新日期:1982-06-15 00:00:00

  • Prognostic factors in laryngeal carcinoma. Experience in 296 male patients.

    abstract:BACKGROUND:Laryngeal cancer is the primary cause of death among patients with head and neck cancer in Argentina. Different prognostic factors have been incidentally dealt with in a number of articles, but there are few studies of prognostic variables, such as age, tobacco, and alcohol, using multifactorial analysis. M...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930415)71:8<2472::aid-cncr2820

    authors: Pradier R,González A,Matos E,Loria D,Adan R,Saco P,Califano L

    更新日期:1993-04-15 00:00:00

  • Management of adult acute leukemia. A Southwest Oncology Group study.

    abstract::Five hundred forty three adult patients with acute leukemia were entered on the study designed to: (1) test efficacy of vincristine and prednisone used as primary drug therapy in patients with good prognosis as judged by a circulating blast cell count less than 30,000 cm2; (2) investigate the use of either simultaneou...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830915)52:6<958::aid-cncr28205

    authors: McCredie KB,Gehan EA,Freireich EJ,Hewlett JS,Coltman CA Jr,Hussein KK,Balcerzak SP,Chen TT

    更新日期:1983-09-15 00:00:00

  • Multiple visceral and cutaneous granular cell tumors. Ultrastructural and immunocytochemical evidence of Schwann cell origin.

    abstract::Granular cell tumor of the stomach is rare and may occur in association with similar tumors in the skin. Two such tumors were found in association with cutaneous granular cell tumors in two black females. Infiltrating carcinoma of the stomach was suspected at surgery in one case. All of the lesions were typical granul...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840515)53:10<2104::aid-cncr282

    authors: Seo IS,Azzarelli B,Warner TF,Goheen MP,Senteney GE

    更新日期:1984-05-15 00:00:00

  • Role of ultrasound-guided fine-needle aspiration of indeterminate and suspicious axillary lymph nodes in the initial staging of breast carcinoma.

    abstract:BACKGROUND:Ultrasound (US) is more sensitive than physical examination alone in determining axillary lymph node involvement during preliminary staging of breast carcinoma. Due to occasional overlap of sonographic features of benign and indeterminate lymph nodes, fine-needle aspiration (FNA) of sonographically indetermi...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.10786

    authors: Krishnamurthy S,Sneige N,Bedi DG,Edieken BS,Fornage BD,Kuerer HM,Singletary SE,Hunt KK

    更新日期:2002-09-01 00:00:00

  • Impact of lung cancer screening results on participant health-related quality of life and state anxiety in the National Lung Screening Trial.

    abstract:BACKGROUND:Low-dose computed tomography (LDCT) lung screening has been associated with a 20% reduction in lung cancer mortality. A major barrier to the adoption of lung screening is the potential negative psychological impact of a false-positive (FP) screen, occurring in 20% to 50% of those screened. The objective of t...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/cncr.28833

    authors: Gareen IF,Duan F,Greco EM,Snyder BS,Boiselle PM,Park ER,Fryback D,Gatsonis C

    更新日期:2014-11-01 00:00:00

  • Whole-body protein metabolism in cancer-bearing patients. Effect of total parenteral nutrition and associated serum insulin response.

    abstract::Aggressive nutritional support of the cancer patient undergoing treatment has become widespread standard practice. In order to evaluate the effect of total parenteral nutrition (TPN) on protein metabolism, 11 patients with localized squamous cell carcinoma of the distal esophagus were studied in the postabsorptive sta...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840315)53:6<1246::aid-cncr2820

    authors: Burt ME,Stein TP,Schwade JG,Brennan MF

    更新日期:1984-03-15 00:00:00