Prognostic significance of cytomorphology in the cutaneous T-cell lymphomas.

Abstract:

:In this retrospective study, the degree of differentiation of atypical lymphoid cells was assessed in pretreatment cutaneous biopsy specimens from 248 patients with cutaneous T-cell lymphomas (mycosis fungoides and Sézary syndrome) and the findings were correlated with the subsequent therapeutic results. Overall, patients with a predominance of cells with hyperchromatic nuclei (well-differentiated lymphoid cells) in cutaneous infiltrates responded better to treatment with improved survival rates than patients with infiltrates composed predominantly of cells with pale vascular nuclei (poorly differentiated lymphoid cells). Infiltrates with a predominance of poorly differentiated lymphoid cells were observed primarily in patients with advanced (tumor) stages of disease. However, comparison of the therapeutic results achieved for the two cytomorphologic patterns in patients at comparable stages of advanced disease did not reveal significant differences, indicating that the presence of poorly differentiated cells in large proportions does not have additional prognostic implications beyond those obtained from usual staging procedures. We speculate that the atypical cells with large, pale vesicular nuclei found in lesions of cutaneous T-cell lymphoma are not a more malignant cell population but rather evolve from more hyperchromatic cellular forms, perhaps a byproduct of malignant dedifferentiation.

journal_name

Cancer

journal_title

Cancer

authors

Vonderheid EC,Tam DW,Johnson WC,Van Scott EJ,Wallner PE

doi

10.1002/1097-0142(19810101)47:1<119::aid-cncr28204

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

119-25

issue

1

eissn

0008-543X

issn

1097-0142

journal_volume

47

pub_type

杂志文章

相关文献

CANCER文献大全
  • Flow cytometric analysis of deparaffinized nuclei in urinary bladder carcinoma. Comparison with cytogenetic analysis.

    abstract::Both cytogenetic analysis and flow cytometry (FCM) have prognostic efficacy in the analysis of transitional cell carcinoma (TCC) of urinary bladder. To correlate results of the two methods, we studied a unique group of patients whose tumors had undergone prospective conventional cytogenetic analysis. Paraffin blocks o...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860415)57:8<1594::aid-cncr2820

    authors: Coon JS,Schwartz D,Summers JL,Miller AW 3rd,Weinstein RS

    更新日期:1986-04-15 00:00:00

  • Kaposi's sarcoma in immunosuppression. Possibly the result of a dual viral infection.

    abstract::Kaposi's sarcoma of the gingiva and skin developed in an HIV-negative renal transplant patient while he was receiving cyclosporine therapy. The Kaposi's sarcoma developed shortly after the patient had an acute infection with cytomegalovirus (CMV). Electron microscopy of the tumor's established cell line showed two typ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900201)65:3<492::aid-cncr28206

    authors: Siegal B,Levinton-Kriss S,Schiffer A,Sayar J,Engelberg I,Vonsover A,Ramon Y,Rubinstein E

    更新日期:1990-02-01 00:00:00

  • The significance of bone and cartilage formation in malignant fibrous histiocytoma of soft tissue.

    abstract::Malignant fibrous histiocytoma of soft tissues (MFH), a mesenchymal tumor of varied morphologic patterns and cell types, sometimes contains bone and cartilage. Such bony and cartilaginous elements in a pleomorphic MFH may pose a difficult diagnostic challenge. An MFH with bone and cartilage can be distinguished from e...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820201)49:3<480::aid-cncr28204

    authors: Bhagavan BS,Dorfman HD

    更新日期:1982-02-01 00:00:00

  • Prophylactic cranial irradiation in limited-stage small cell lung cancer.

    abstract:BACKGROUND:The role of prophylactic cranial irradiation (PCI) for patients with limited-stage small cell lung cancer (LSSCLC) remains a controversial issue. This study evaluated PCI in patients with LSSCLC who achieved a complete response to initial chemotherapy. METHODS:A retrospective case study of all nonprotocol p...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950315)75:6<1302::aid-cncr2820

    authors: Liengswangwong V,Bonner JA,Shaw EG,Foote RL,Frytak S,Richardson RL,Creagan ET,Eagan RT,Su JQ

    更新日期:1995-03-15 00:00:00

  • "Locked-in syndrome" after intrathecal cytosine arabinoside therapy for malignant immunoblastic lymphoma.

    abstract::A 22-year-old man with malignant immunoblastic lymphoma had "locked-in" syndrome within 48 hours of receiving a single (100 mg) dose of intrathecal cytosine arabinoside (ara-C) in conjunction with intravenous ara-C, cisplatin, and doxorubicin. Eight hours after therapy, the patient had central hypoventilation and blur...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19921115)70:10<2504::aid-cncr282

    authors: Kleinschmidt-DeMasters BK,Yeh M

    更新日期:1992-11-15 00:00:00

  • A nonfunctioning paraganglioma of vagus nerve: an ultrastructural study.

    abstract::The clinical, histological, and ultrastructural aspects of a cervical paraganglioma of the vagus nerve, in a 66-year-old white man, have been discussed in detail. Ultrastructurally, the tumor chief cells contained characteristic membrane-bound and dense-cored neurosecretory granules which ranged in size from 85 millim...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197905)43:5<1689::aid-cncr282043

    authors: Chaudhry AP,Haar JG,Koul A,Nickerson PA

    更新日期:1979-05-01 00:00:00

  • Fine-needle aspiration of chromophobe renal cell carcinoma. Analysis of six cases.

    abstract:BACKGROUND:The chromophobe variant of renal cell carcinoma is a recently described and frequently unrecognized tumor. Because the prognosis of the chromophobe variant appears to be intermediate between that of oncocytoma and the clear cell variant of renal cell carcinoma, accurate diagnosis may be important for appropr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19970425)81:2<122::aid-cnc

    authors: Granter SR,Renshaw AA

    更新日期:1997-04-25 00:00:00

  • Cancer in collagen disease. A statistical analysis by reviewing the Annual of Pathological Autopsy Cases (Nippon Boken Shuho) in Japan.

    abstract::Cases of systemic lupus erythematosus, systemic sclerosis, periarteritis nodosa, and dermato- and polymyositis autopsied in Japan during a recent, 7-year period (1972-1978) were studied to assess the incidence of cancer as a complication. In comparison with the other three groups, cases of dermato- and polymyositis (D...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841101)54:9<1841::aid-cncr2820

    authors: Okayasu I,Mizutani H,Kurihara H,Yanagisawa F

    更新日期:1984-11-01 00:00:00

  • Hyperfractionated cyclophosphamide with high-doses of arabinosylcytosine and methotrexate (HyperCHiDAM Verona 897).

    abstract:BACKGROUND:Patients who have aggressive, refractory or recurrent non-Hodgkin lymphomas (NHLs) that are refractory to first-line anthracycline-containing regimens (ACRs) have a dismal outcome. Achieving complete remission (CR) is essential for a favorable outcome. To improve the CR rate in these patients, the authors de...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21150

    authors: Todeschini G,Tecchio C,Pasini F,Benedetti F,Cantini M,Crippa C,Draisci M,Pizzolo G

    更新日期:2005-08-01 00:00:00

  • Malignant large cell lymphoma of B-cell type with multilobated nuclei. Report of a case and review of the literature.

    abstract::Malignant lymphomas with multilobated nuclei are rare, recently recognized neoplasms of the immune system initially thought to be of T-cell type. Reported is a case of large cell lymphoma with multilobated nuclei in which immunologic marker studies demonstrated that the neoplastic cells had characteristics of B-lympho...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850501)55:9<1913::aid-cncr2820

    authors: Parfrey NA,Mann RB,Selonick SE,Beschorner WE

    更新日期:1985-05-01 00:00:00

  • Plasma ribonuclease: a marker for the detection of ovarian cancer.

    abstract::There were no significant differences between the mean blood plasma (leukocyte-free) RNAase activity among 128 healthy women volunteers age 13-70 and 49 women with benign gynecological tumors. Exceptions to this finding were three apparently healthy women volunteers who had plasma enzyme activity which was higher than...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197705)39:5<2204::aid-cncr282039

    authors: Sheid B,Lu T,Pedrinan L,Nelson JH Jr

    更新日期:1977-05-01 00:00:00

  • The treatment of Wilms' tumor: results of the Second National Wilms' Tumor Study.

    abstract::One-hundred-eighty-eight children up to 16 years of age were randomized in the second National Wilms' Tumor Study (NWTS) with tumors that were confined to the kidney and that had been totally excised (Group I). Most fared well whether treated for six or for 15 months with both actinomycin D (AMD) and vincristine (VCR)...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19810501)47:9<2302::aid-cncr2820

    authors: D'Angio GJ,Evans A,Breslow N,Beckwith B,Bishop H,Farewell V,Goodwin W,Leape L,Palmer N,Sinks L,Sutow W,Tefft M,Wolff J

    更新日期:1981-05-01 00:00:00

  • Aggressive angiomyxoma: a clinicopathologic study of 29 female patients.

    abstract:BACKGROUND:Aggressive angiomyxoma is an uncommon mesenchymal tumor that preferentially involves the pelvic and perineal regions of females. Since its initial description in 1983, approximately 65 cases have been reported in the English literature. METHODS:The clinical and pathologic features of 29 cases of aggressive ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960701)78:1<79::AID-CNCR

    authors: Fetsch JF,Laskin WB,Lefkowitz M,Kindblom LG,Meis-Kindblom JM

    更新日期:1996-07-01 00:00:00

  • Validation of the caregiver Pediatric Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events measure.

    abstract:BACKGROUND:Despite improvements in survival rates, cancer treatments have significant side effects that affect the quality of life of children and their families. When an ill child cannot self-report symptoms (eg, he or she is too ill), caregiver (parent) reporting becomes critical. This study evaluates the validity an...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33389

    authors: Reeve BB,McFatrich M,Lin L,Lucas NR,Mack JW,Jacobs SS,Withycombe JS,Baker JN,Freyer DR,Hinds PS

    更新日期:2020-12-17 00:00:00

  • A case of primary B-cell lymphoma of the breast. Light and electron microscopy, and immunologic cell markers.

    abstract::A case of primary non-Hodgkin's lymphoma of the breast was studied with light and electron microscopy and for immunologic cell markers. With light microscopy, the tumor was seen to be a poorly differentiated lymphocytic lymphoma, diffuse, according to Rappaport's classification. With electron microscopy, the tumor was...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830815)52:4<671::aid-cncr28205

    authors: Tateno M,Yoshiki T,Itoh T,Takamuro M,Saito C

    更新日期:1983-08-15 00:00:00

  • Assessing symptom distress in cancer patients: the M.D. Anderson Symptom Inventory.

    abstract:BACKGROUND:The purpose of this project was to develop the M. D. Anderson Symptom Inventory (MDASI), a brief measure of the severity and impact of cancer-related symptoms. METHODS:A list of symptoms was generated from symptom inventories and by panels of clinicians. Twenty-six symptoms and 6 interference items were rat...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20001001)89:7<1634::aid-cncr29>3

    authors: Cleeland CS,Mendoza TR,Wang XS,Chou C,Harle MT,Morrissey M,Engstrom MC

    更新日期:2000-10-01 00:00:00

  • Quality of care received and patient-reported regret in prostate cancer: Analysis of a population-based prospective cohort.

    abstract:BACKGROUND:Meeting quality of care standards in oncology is recognized as important by physicians, professional organizations, and payers. Data from a population-based cohort of patients with prostate cancer were used to examine whether receipt of care was consistent with published consensus metrics and whether receivi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30315

    authors: Holmes JA,Bensen JT,Mohler JL,Song L,Mishel MH,Chen RC

    更新日期:2017-01-01 00:00:00

  • Phase II randomized study of daily gefitinib treatment alone or with vinorelbine every 2 weeks in patients with adenocarcinoma of the lung who failed at least 2 regimens of chemotherapy.

    abstract:BACKGROUND:The objective of this study was to assess the efficacy of adding chronic, intermittent, low-dose vinorelbine to gefitinib treatment for patients who had adenocarcinoma of the lung who failed>or=2 regimens of chemotherapy. METHODS:Patients were randomized into 2 arms: Oral gefitinib 250 mg daily (the G arm) ...

    journal_title:Cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/cncr.22616

    authors: Chen YM,Liu JM,Chou TY,Perng RP,Tsai CM,Whang-Peng J

    更新日期:2007-05-01 00:00:00

  • Phase II trial of tamoxifen, etoposide, mitoxantrone, and cisplatin in patients with metastatic breast carcinoma.

    abstract:BACKGROUND:Based on previous data demonstrating a potentially synergistic interaction between tamoxifen and cisplatin in metastatic melanoma therapy, a Phase II study was performed to assess the activity of tamoxifen, etoposide, mitoxantrone, and cisplatin (TEMP) in patients with metastatic breast carcinoma. METHODS:F...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-0142(19961101)78:9<1906::aid-cn

    authors: Conzen SD,Kaufman PA,Arvizu C,LeMarbre P,Maurer LH,Mott LA,Mills LE

    更新日期:1996-11-01 00:00:00

  • Cancer risks among Missouri farmers.

    abstract::A series of case-control studies was conducted to investigate cancer risks among farmers. These studies were based on Missouri Cancer Registry data for 15,000 white male patients, including 1720 subjects classified as farmers, registered between 1984 and 1988. For each cancer site, all other cancer registrations forme...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891201)64:11<2381::aid-cncr282

    authors: Brownson RC,Reif JS,Chang JC,Davis JR

    更新日期:1989-12-01 00:00:00

  • Prognostic significance of Wilms tumor gene (WT1) mRNA expression in soft tissue sarcoma.

    abstract:BACKGROUND:There have been several recent reports that Wilms tumor gene (WT1) mRNA is overexpressed in many types of neoplasms, and those results suggested that WT1 has oncogenic properties. The objective of the current study was to evaluate the prognostic significance of WT1 mRNA expression in patients with soft tissu...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21861

    authors: Sotobori T,Ueda T,Oji Y,Naka N,Araki N,Myoui A,Sugiyama H,Yoshikawa H

    更新日期:2006-05-15 00:00:00

  • The treatment of tumors by the induction of anemia and irradiation in hyperbaric oxygen.

    abstract::Because increased effects have been achieved when murine tumors are irradiated after a period of hypoxia and because of anecdotal clinical experiences of an improved result after irradiation of previously anemic patients in hyperbaric oxygen, the relationship between irradiation and increased survival was investigated...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890801)64:3<646::aid-cncr28206

    authors: Sealy R,Jacobs P,Wood L,Levin W,Barry L,Boniaszczuk J,Blekkenhorst G

    更新日期:1989-08-01 00:00:00

  • Cell proliferative activity in adenomatous hyperplasia of the liver and small hepatocellular carcinoma. An immunohistochemical study demonstrating proliferating cell nuclear antigen.

    abstract:BACKGROUND:Recently, adenomatous hyperplasia (AH) of the liver, a sizable parenchymal nodule in the cirrhotic liver, has been considered a preneoplastic lesion in human hepatocarcinogenesis. METHODS:The authors evaluated cell proliferative activity by immunostaining for proliferating cell nuclear antigen (PCNA) in AH ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920801)70:3<591::aid-cncr28207

    authors: Terada T,Nakanuma Y

    更新日期:1992-08-01 00:00:00

  • Castleman's disease in POEMS syndrome with elevated interleukin-6.

    abstract::POEMS syndrome is a rare multisystem affliction known for its signs, from which it also takes its acronym name "peripheral neuropathy, organomegaly, endocrinopathy, monoclonal (M) protein, and skin lesions." Our study chronicles the course of this syndrome in a young woman with Castleman's disease (angiofollicular lym...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920601)69:11<2697::aid-cncr282

    authors: Mandler RN,Kerrigan DP,Smart J,Kuis W,Villiger P,Lotz M

    更新日期:1992-06-01 00:00:00

  • Mixed Brenner and adenomatoid tumor of the testis: an ultrastructural study and histogenetic considerations.

    abstract::A previously unreported association of Brenner and adenomatoid tumor found in the tunica vaginalis testis is presented. Many ultrastructural features found in mesothelial cells such as intercellular spaces, deeply indented nuclei, tonofilaments and tight desmosomes, were also shared by cells present in both neoplastic...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197902)43:2<539::aid-cncr2820430

    authors: Nogales FF Jr,Matilla A,Ortega I,Alvarez T

    更新日期:1979-02-01 00:00:00

  • 67Ga accumulation in pulmonary lesions associated with bleomycin toxicity.

    abstract::The radionuclide, gallium-67, accumulates in a wide variety of neoplastic and inflammatory lesions. Diffuse bilateral lung localization of 67Ga occurred in two cases of interstitial pneumonitis associated with bleomycin therapy. Clinical symptoms and laboratory evaluation of pulmonary status correlated with scintigrap...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.2820360906

    authors: Richman SD,Levenson SM,Bunn PA,Flinn GS,Johnston GS,DeVita VT

    更新日期:1975-12-01 00:00:00

  • Gauging the impact of breast carcinoma screening in terms of tumor size and death rate.

    abstract:BACKGROUND:While the question of whether the trials of breast cancer screening have resulted in a reduction in breast cancer death has been the subject of much scrutiny, there has been less attention to the reduction in tumor size achieved by screening. METHODS:Size data for invasive breast tumors were assembled from ...

    journal_title:Cancer

    pub_type: 杂志文章,meta分析

    doi:10.1002/cncr.11766

    authors: Michaelson JS,Satija S,Kopans D,Moore R,Silverstein M,Comegno A,Hughes K,Taghian A,Powell S,Smith B

    更新日期:2003-11-15 00:00:00

  • Reliability of computer image analysis of pigmented skin lesions of Australian adolescents.

    abstract:BACKGROUND:The diagnosis of melanomas at an early stage is associated with improved survival, so the recognition of changes in pigmented skin lesions over time is important. We have developed a computer imaging system with the aim of assisting clinicians in differentiating early melanomas from benign pigmented skin les...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960715)78:2<252::AID-CNC

    authors: Aitken JF,Pfitzner J,Battistutta D,O'Rourke PK,Green AC,Martin NG

    更新日期:1996-07-15 00:00:00

  • Multifocal adenocarcinoma of the jejunum.

    abstract::We report on an 89-year-old female admitted with signs of intestinal obstruction in whom three independent adenocarcinomas of the proximal jejunum were found. Multiple foci of pyloric gland metaplasia, glandular hyperplasia and dysplasia, carcinoma-in-situ, and several varieties of adenocarcinoma were identified on mi...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197909)44:3<1142::aid-cncr282044

    authors: Warner TF,Peralta J

    更新日期:1979-09-01 00:00:00

  • Acute myocardial infarction with normal coronary arteriogram after mantle field radiation therapy for Hodgkin's disease.

    abstract::A case of an acute myocardial infarction occurring in a 19-year-old woman, 27 months after mantle radiotherapy for Stage II-A Hodgkin's disease is described. The coronary arteriogram demonstrated patent and normal coronary arteries, but the echocardiogram revealed pericarditis. The clinical course was further complica...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830815)52:4<637::aid-cncr28205

    authors: Yahalom J,Hasin Y,Fuks Z

    更新日期:1983-08-15 00:00:00