Phase II randomized study of daily gefitinib treatment alone or with vinorelbine every 2 weeks in patients with adenocarcinoma of the lung who failed at least 2 regimens of chemotherapy.

abstract：:Eighty-one primary ovarian carcinoids and intraovarian metastases from six mid-gut carcinoids were examined for the presence of tumor cells immunoreactive with antisera raised against various neurohormonal peptides, mostly of gastroenteropancreatic (GEP) origin. Twenty of the primary and two of the metastatic carcinoi...

journal_title：Cancer

authors： Sporrong B,Falkmer S,Robboy SJ,Alumets J,Håkanson R,Ljungberg O,Sundler F

更新日期：1982-01-01 00:00:00

abstract：:A number of problems inherent to quality of care evaluation have been described above. Although issues such as limited resources and clinical staff resistance may not be specific to cancer care, they certainly impact on the evaluation of the quality of care offered to cancer patients. Other issues such as complexity o...

journal_title：Cancer

authors： Miransky LJ

更新日期：1989-07-01 00:00:00

abstract：:A short-term differential staining cytotoxicity (DiSC) assay was used to assess the sensitivity of tumor cells in vitro from patients with chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma to various cytotoxic drugs. The results have been correlated with drug sensitivities of the tumors in vivo. The chemos...

journal_title：Cancer

authors： Bird MC,Bosanquet AG,Forskitt S,Gilby ED

更新日期：1988-03-15 00:00:00

abstract：:The experience of 260 patients with endometrial carcinoma was reviewed. The influence of factors such as age, stage of disease, grade and degree of myometrial penetration on the survival was presented, showing that survival decreases in elderly patients, in patients with advanced stage of disease, when the tumor is un...

journal_title：Cancer

authors： Tavares MA,Patricio MB,Vilhena M,Da Silva JN

更新日期：1977-02-01 00:00:00

abstract：BACKGROUND:Karyotypic abnormalities in sporadic Burkitt lymphoma (BL) have been described extensively. However, to the authors' knowledge, very limited studies have focused on the secondary chromosomal abnormalities in pediatric BL as compared with those of adult BL and on their prognostic impact. METHODS:A retrospect...

journal_title：Cancer

authors： Onciu M,Schlette E,Zhou Y,Raimondi SC,Giles FJ,Kantarjian HM,Medeiros LJ,Ribeiro RC,Pui CH,Sandlund JT

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate the long-term survival and late toxicities of concurrent-adjuvant chemotherapy in patients with stage III through IVB nasopharyngeal carcinoma (NPC) from endemic regions of China. METHODS:Patients with stage III to IVB NPC were assigned randomly to receive radioth...

journal_title：Cancer

authors： Chen Y,Sun Y,Liang SB,Zong JF,Li WF,Chen M,Chen L,Mao YP,Tang LL,Guo Y,Lin AH,Liu MZ,Ma J

更新日期：2013-06-15 00:00:00

abstract：BACKGROUND:Assessment of tissue specimens obtained with common immersion-fixation followed by dehydration (IMDH) is affected by artifacts, which hinder precise evaluation of the histology and microenvironment of tumor tissues. The technical characteristics of cryobiopsy and in vivo cryotechnique (IVCT) where target org...

journal_title：Cancer

authors： Ohno N,Terada N,Bai Y,Saitoh S,Nakazawa T,Nakamura N,Naito I,Fujii Y,Katoh R,Ohno S

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Angiotropic large cell lymphoma (ALCL) is characterized by the intravascular proliferation of malignant lymphoid cells in small and medium-sized blood vessels. In the current study, the authors report an unusual case in which the initial presentation of the ALCL was that of superior vena cava (SVC) syndrome....

journal_title：Cancer

authors： Savarese DM,Zavarin M,Smyczynski MS,Rohrer MJ,Hutzler MJ

更新日期：2000-12-15 00:00:00

abstract：BACKGROUND:Although ascites cytology is important for therapeutic strategies, it is difficult to distinguish cancer infiltration from reactive mesothelial proliferation in some patients. In this study, the authors applied CDX2 immunocytochemistry to improve diagnostic accuracy. METHODS:The authors examined the distrib...

journal_title：Cancer

authors： Kobayashi M,Ueyama Y,Nakanishi H,Ishida H,Takahashi E,Nakamura S,Koshikawa T,Yatabe Y

更新日期：2006-04-25 00:00:00

abstract：BACKGROUND:Cell kinetics studies performed with immunohistochemical techniques to estimate the S-phase fraction have elucidated the proliferative potential of individual brain tumors. METHODS:The authors developed a new double-labeling method that enables other cell kinetics variables, including the duration of the S-...

journal_title：Cancer

authors： Shibuya M,Ito S,Davis RL,Wilson CB,Hoshino T

更新日期：1993-05-15 00:00:00

abstract：:The hematologic factors of 16 female patients with breast carcinoma who had received adjuvant chemotherapy with L-phenylalanine-based programs for two years were compared with those for 13 normal female volunteers of similar age. The findings include significant suppression of the mean hemoglobin level, of leukocyte c...

journal_title：Cancer

authors： Corder MP,Jochimsen PR

更新日期：1982-06-15 00:00:00

abstract：:The records of all 27 adult patients (age, greater than or equal to 16 years) diagnosed with cerebellar medulloblastoma between 1968 and 1986 were reviewed. Twenty-four patients (89%) were treated with postoperative megavoltage irradiation. Twenty of these patients underwent craniospinal irradiation. Sixteen patients ...

journal_title：Cancer

authors： Hazuka MB,DeBiose DA,Henderson RH,Kinzie JJ

更新日期：1992-04-15 00:00:00

abstract：BACKGROUND:Ovarian dysplasia has been defined by histologic and morphometric studies focusing on architectural and nuclear profile changes. A new technique is used to enhance the accuracy of this diagnosis by a quantitative evaluation of the nuclear texture that represents the nuclear chromatin pattern on which convent...

journal_title：Cancer

authors： Deligdisch L,Miranda C,Barba J,Gil J

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Inferior vena cava obstruction (IVCO) is a poorly characterized complication of metastatic germ cell tumor (GCT). The authors identified 31 cases to describe the clinical features, radiologic findings, complications, and treatment of this clinical entity. METHODS:Patients with GCT and IVCO were identified f...

journal_title：Cancer

authors： Hassan B,Tung K,Weeks R,Mead GM

更新日期：1999-02-15 00:00:00

abstract：BACKGROUND:More cases of bronchogenic carcinoma have been reported in recent years, and these patients are more prone to secondary aspergillosis. However, the frequency of secondary aspergillosis in bronchogenic carcinoma still has not been defined clearly in the literature. METHODS:The current study population was co...

journal_title：Cancer

authors： Shahid M,Malik A,Bhargava R

更新日期：2008-08-01 00:00:00

abstract：:111Indium-Bleomycin (111In-Blm), a new radiopharmaceutical, was administered intravenously to 37 patients with benign and malignant breast lesions. Early and delayed images of both the breasts and axillae were made, and results were correlated with physical examination, histopathology of the excised lesion, mammograph...

journal_title：Cancer

authors： Silverstein MJ,Verma RC,Greenfield L,Morton DL

更新日期：1976-01-01 00:00:00

abstract：:During the past decade, one of the major changes in the field of oncology has been in the surgical approach to primary and secondary cancer of the liver. As a result of data and experience gained in liver transplantation programs and with the application of vascular surgical principles, resectability rates have been i...

journal_title：Cancer

authors： Fortner JG,MacLean BJ,Kim DK,Howland WS,Turnbull AD,Goldiner P,Carlon G,Beattie EJ Jr

更新日期：1981-05-01 00:00:00

abstract：:Biologicals and biological response modifiers (BRMs) represent a new class of agents for cancer therapy. Historically, there have been many attempts to stimulate the immune response with nonspecific immunomodulators in the form of bacterial extracts, viruses, and chemicals. Although these approaches have occasionally ...

journal_title：Cancer

authors： Oldham RK,Thurman GB,Talmadge JE,Stevenson HC,Foon KA

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:The authors examined the "real-world" effectiveness of rituximab (R) maintenance therapy (R-maintenance) compared with observation after R-based induction therapy in patients with previously untreated follicular lymphoma (FL) in the United States. METHODS:The National LymphoCare Study is a prospective, mult...

journal_title：Cancer

authors： Nastoupil LJ,Sinha R,Byrtek M,Zhou X,Taylor MD,Friedberg JW,Link BK,Cerhan JR,Dawson K,Flowers CR

更新日期：2014-06-15 00:00:00

abstract：BACKGROUND:The ability of screening mammography programs serving women of different socioeconomic status (SES) to diagnose early stage breast carcinoma in a comparably effective fashion has been questioned. METHODS:Results of screening 50,653 women of lower SES were compared with those of screening 45,923 more socioec...

journal_title：Cancer

authors： Dershaw DD,Loring L,True SJ,Momrow DC,Liberman L,Morris EA

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:In the past 4 years, the weekly 24-hour infusion of high dose 5-fluorouracil (5-FU) and leucovorin in the treatment of patients with advanced gastric carcinoma has been prospectively studied at the authors' institution. This has enabled them to explore the possibility that the level of expression of thymidyl...

journal_title：Cancer

authors： Yeh KH,Shun CT,Chen CL,Lin JT,Lee WJ,Lee PH,Chen YC,Cheng AL

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Hispanics comprise almost one-third of the population of California, are the most rapidly increasing racial/ethnic group in the state, and represent almost one-third of all Hispanics in the U.S. California has among the highest rates of melanoma in the world, yet little is known about trends in melanoma in i...

journal_title：Cancer

authors： Cockburn MG,Zadnick J,Deapen D

更新日期：2006-03-01 00:00:00

abstract：:To assess the efficacy of performing both computed tomography (CT) of the thorax and upper abdomen and whole-body gallium scintigraphy for staging lung cancer, the results of each test were compared with those obtained by chest radiography and clinical examination in 100 patients. Clinical efficacy was defined in term...

journal_title：Cancer

authors： MacMahon H,Scott W,Ryan JW,Montner SM,Little AG,Hoffman PC,Ferguson MK,Golomb HM

更新日期：1989-10-01 00:00:00

abstract：:The case of a 49-year-old man with the diagnosis of angioimmunoblastic lymphadenopathy is reported. The patient survived a stormy clinical course. The corticosteroids improved dramatically the clinical picture although the patient developed a staphylococcal septicemia. Before treatment immunological studies were done ...

journal_title：Cancer

authors： Kosmidis PA,Axelrod AR,Palacas C,Stahl M

更新日期：1978-08-01 00:00:00

abstract：:Five hundred and sixty-nine patients with breast cancer presenting for treatment at a community hospital were studied. The results showed no significant change in tumor size at presentation or reported patient delay over a 12-year span. This was in spite of considerable national discussion and increasing public concer...

journal_title：Cancer

authors： Buttlar CA,Templeton AC

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:Because patients with germ cell tumors expect an additional life span of around 50 years after successful treatment, attention is now focused on potential long term toxicity. Limited data are available on Leydig cell function in long term survivors. METHODS:The authors measured testosterone, sex hormone bin...

journal_title：Cancer

authors： Gerl A,Mühlbayer D,Hansmann G,Mraz W,Hiddemann W

更新日期：2001-04-01 00:00:00

abstract：:A useful approach to establishing the biologic actions, in vivo, of granulocyte-macrophage colony-stimulating factor (GM-CSF) is to assess the consequences of long-term elevation of the factor in transgenic mice. Two lines of transgenic GM-CSF mice were analyzed. The major abnormality exhibited was an elevation in the...

journal_title：Cancer

authors： Metcalf D

更新日期：1991-05-15 00:00:00

abstract：BACKGROUND:Proliferating cell nuclear antigen (PCNA) is an intranuclear protein that is linked closely to the cell cycle. An immunohistochemical study was performed on the expression of PCNA in various sized hepatocellular carcinomas (HCCs) to determine the relation between the proliferative activity of cancer cells an...

journal_title：Cancer

authors： Suehiro T,Matsumata T,Itasaka H,Yamamoto K,Kawahara N,Sugimachi K

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:The aim of this retrospective study was to determine those prognostic factors associated with response to a second-line chemotherapy in patients with metastatic breast carcinoma (MBC) that was previously responsive to a first-line chemotherapy. METHODS:The 70 MBC patients studied had previously responded to...

journal_title：Cancer

authors： Brun B,Benchalal M,Lebas C,Piedbois P,Lin M,Lebourgeois JP

更新日期：1997-06-01 00:00:00

abstract：:From November 1973 to May 1986, 50 patients with Stage I epithelial ovarian cancer were treated at the University of Kentucky Medical Center (Lexington, KY) with oral Alkeran (melphalan) chemotherapy after primary surgery. Twenty-two patients had Grade 1 tumors, 23 patients had Grade 2 tumors, and five patients had Gr...

journal_title：Cancer

authors： Gallion HH,van Nagell JR,Donaldson ES,Higgins RV,Powell DE,Kryscio RJ

更新日期：1989-03-15 00:00:00