Abstract:
:A useful approach to establishing the biologic actions, in vivo, of granulocyte-macrophage colony-stimulating factor (GM-CSF) is to assess the consequences of long-term elevation of the factor in transgenic mice. Two lines of transgenic GM-CSF mice were analyzed. The major abnormality exhibited was an elevation in the number of macrophages, eosinophils, and polymorphs in the peritoneal and pleural cavities. Disease states exhibited by the lines were dependent on the insertion site of the GM-CSF gene. These disease states seem best explained on the basis of CSF-mediated macrophage activation and may provide valuable clues as to the cause of comparable human diseases such as malignant histiocytosis, polymyositis, or rheumatoid arthritis.
journal_name
Cancerjournal_title
Cancerauthors
Metcalf Ddoi
10.1002/1097-0142(19910515)67:10+<2695::aid-cncr28subject
Has Abstractpub_date
1991-05-15 00:00:00pages
2695-9issue
10 Suppleissn
0008-543Xissn
1097-0142journal_volume
67pub_type
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