Transgenic mice as models of hemopoiesis.

Abstract:

:A useful approach to establishing the biologic actions, in vivo, of granulocyte-macrophage colony-stimulating factor (GM-CSF) is to assess the consequences of long-term elevation of the factor in transgenic mice. Two lines of transgenic GM-CSF mice were analyzed. The major abnormality exhibited was an elevation in the number of macrophages, eosinophils, and polymorphs in the peritoneal and pleural cavities. Disease states exhibited by the lines were dependent on the insertion site of the GM-CSF gene. These disease states seem best explained on the basis of CSF-mediated macrophage activation and may provide valuable clues as to the cause of comparable human diseases such as malignant histiocytosis, polymyositis, or rheumatoid arthritis.

journal_name

Cancer

journal_title

Cancer

authors

Metcalf D

doi

10.1002/1097-0142(19910515)67:10+<2695::aid-cncr28

subject

Has Abstract

pub_date

1991-05-15 00:00:00

pages

2695-9

issue

10 Suppl

eissn

0008-543X

issn

1097-0142

journal_volume

67

pub_type

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