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Impact of lung cancer screening results on participant health-related quality of life and state anxiety in the National Lung Screening Trial.

Abstract：

BACKGROUND:Low-dose computed tomography (LDCT) lung screening has been associated with a 20% reduction in lung cancer mortality. A major barrier to the adoption of lung screening is the potential negative psychological impact of a false-positive (FP) screen, occurring in 20% to 50% of those screened. The objective of this study was to assess the impact of abnormal findings on health-related quality of life (HRQoL) and anxiety in the American College of Radiology (ACRIN)/National Lung Screening Trial (NLST). METHODS:The NLST was a randomized screening trial comparing LDCT with chest X-ray screening (CXR). This study was part of the original protocol. A total of 2812 participants at 16 of 23 ACRIN sites who had baseline HRQoL assessments were asked to complete the Short Form-36 and the State Trait Anxiety Inventory (form Y-1) questionnaires to assess short-term (1 month) and long-term (6 months) effects of screening. FP were lung cancer-free at 1 year, and true-positives (TP) were not. RESULTS:Of the total participants, 1024 (36.4%) participants were FP, 63 (2.2%) were TP, 344 (12.2%) had significant incidental findings (SIFs), and 1381 (49.1%) had negative screens. Participants had been randomized to LDCT (n = 1947) and CXR (n = 865). Short-term and long-term HRQoL and state anxiety did not differ across participants with FP, SIF, or negative screens. Short-term and long-term HRQoL were lower and anxiety was higher for TP participants compared to participants with FP, SIF, and negative screens. CONCLUSIONS:In a large multicenter lung screening trial, participants receiving a false-positive or SIF screen result experienced no significant difference in HRQoL or state anxiety at 1 or at 6 months after screening relative to those receiving a negative result.

journal_name

Cancer

journal_title

Cancer

authors

Gareen IF,Duan F,Greco EM,Snyder BS,Boiselle PM,Park ER,Fryback D,Gatsonis C

doi

10.1002/cncr.28833

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

3401-9

issue

eissn

0008-543X

issn

1097-0142

journal_volume

120

pub_type

杂志文章,多中心研究,随机对照试验

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Impact of lung cancer screening results on participant health-related quality of life and state anxiety in the National Lung Screening Trial.