Chemoimmunotherapy of metastatic large bowel cancer: nonspecific stimulation with BCG and levamisole.

Abstract:

:The administration of two chemoimmunotherapy programs to 103 consecutive patients with metastatic colorectal cancer resulted in improved survival for patients who achieved either objective tumor regressions or disease stabilization for more than 8 weeks. Objective tumor regression was observed in 47% of patients treated with the Ftorafur-methyl-CCNU-methotrexate-Bacillus Calmette-Guerin (FTOR-MeM-BCG) program and in 34% of patients treated with the 5-fluorouracil-methotrexate-Baker's antifol (FU-M-BAF) +/- Levamisole program. The combinated median duration of survival for patients who achieved objective tumor regression and disease stabilization with FTOR-MeM-BCG was 13 months compared with 6 months for patients who had progression of disease (p = 0.001). The corresponding values for patients treated with FU-M-BAF +/- levamisole were 11 months and seven months, respectively (p = 0.001). While the role of BCG immunotherapy in these results remains speculative, the administration of levamisole immunotherapy did not appear to have influenced results significantly. Patients who presented at diagnosis with Dukes A, B and C lesions, and therefore had longer disease-free intervals, responded more frequently to chemoimmunotherapy and survived longer than patients who presented at diagnosis with Dukes D lesions. Similarly, greater antitumor effect was observed in patients with lower pretreatment plasma CEA levels evaluation of these pretreatment characteristics may have insignificant implications for the design of future clinical trials.

journal_name

Cancer

journal_title

Cancer

authors

Valdivieso M,Bedikian A,Burgess MA,Rodriguez V,Hersh EM,Bodey GP,Mavligit GM

doi

10.1002/1097-0142(197711)40:5+<2731::aid-cncr28204

subject

Has Abstract

pub_date

1977-11-01 00:00:00

pages

2731-9

issue

5 Suppl

eissn

0008-543X

issn

1097-0142

journal_volume

40

pub_type

杂志文章

相关文献

CANCER文献大全
  • Prognostic value of intratumoral natural killer cells in gastric carcinoma.

    abstract:BACKGROUND:Natural killer (NK) cells are a group of effector cells that act nonspecifically against tumor cells. The correlation between intratumoral NK cell infiltration and clinicopathologic features remains unclear. METHODS:The authors selected 146 patients with gastric carcinoma who underwent gastrectomy at Kagosh...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Ishigami S,Natsugoe S,Tokuda K,Nakajo A,Che X,Iwashige H,Aridome K,Hokita S,Aikou T

    更新日期:2000-02-01 00:00:00

  • Clinical characteristics of 45 patients with invasive pulmonary aspergillosis: retrospective analysis of 1711 lung cancer cases.

    abstract:BACKGROUND:: Invasive aspergillosis (IA) is a common complication in patients with hematologic malignancies. Patients with solid tumors also are at risk for IA because they may develop neutropenia as a result of chemotherapy and radiotherapy. However, studies of IA in patients with solid tumors are rare. In this study,...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24559

    authors: Yan X,Li M,Jiang M,Zou LQ,Luo F,Jiang Y

    更新日期:2009-11-01 00:00:00

  • The metabolic syndrome and risk of incident colorectal cancer.

    abstract:BACKGROUND:The authors tested the hypothesis that the metabolic syndrome (> or =3 of the following components: high blood pressure, increased waist circumference, hypertriglyceridemia, low levels of high-density lipoprotein cholesterol, or diabetes/hyperglycemia) is a risk factor for colorectal cancer. METHODS:Data fr...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.21950

    authors: Ahmed RL,Schmitz KH,Anderson KE,Rosamond WD,Folsom AR

    更新日期:2006-07-01 00:00:00

  • Mixed-phenotype acute leukemia: A cohort and consensus research strategy from the Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force.

    abstract:BACKGROUND:Optimal chemotherapy for treating mixed-phenotype acute leukemia (MPAL) and the role of hematopoietic stem cell transplantation (HSCT) remain uncertain. Major limitations in interpreting available data are MPAL's rarity and the use of definitions other than the currently widely accepted criteria: the World H...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32552

    authors: Orgel E,Alexander TB,Wood BL,Kahwash SB,Devidas M,Dai Y,Alonzo TA,Mullighan CG,Inaba H,Hunger SP,Raetz EA,Gamis AS,Rabin KR,Carroll AJ 3rd,Heerema NA,Berman JN,Woods WG,Loh ML,Zweidler-McKay PA,Horan JT,Children's

    更新日期:2020-02-01 00:00:00

  • Multiple cancers in the prostate. Morphologic features of clinically recognized versus incidental tumors.

    abstract::Multiple independent tumors were identified in specimens from 117 of 234 prostatectomies for clinical adenocarcinoma; there were 266 incidental cancers in these 117 prostates. The clinically detected carcinoma was the largest (or only) tumor in all 202 Stage B cases. However, among 32 Stage A cases (detection by trans...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19921101)70:9<2313::aid-cncr2820

    authors: Villers A,McNeal JE,Freiha FS,Stamey TA

    更新日期:1992-11-01 00:00:00

  • ThinPrep Pap Test: performance and biopsy follow-up in a university hospital.

    abstract:BACKGROUND:The ThinPrep Pap Test (TP), a liquid-based cervical cytology preparation, was approved for use in the U.S. in 1996. The purpose of this study was to compare TP performance and biopsy follow-up studies with a similar population of high risk patients sampled by conventional Papanicolaou (Pap) smear (CS). METH...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19990625)87:3<105::aid-cnc

    authors: Carpenter AB,Davey DD

    更新日期:1999-06-25 00:00:00

  • Replacement estrogens and risk of gynecologic cancers and breast cancer.

    abstract::The two cancers specific to women for which substantial research on their relationship to exogenous estrogens has been reported are endometrial cancer and breast cancer. With the former, the link to estrogen use is well established. The estrogen use patterns associated with increased risk of endometrial cancer are cha...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19901015)60:8+<1960::aid-cncr282

    authors: Hulka BS

    更新日期:1987-10-15 00:00:00

  • Prognostic significance of mast cells in soft tissue sarcoma.

    abstract::We counted the number of toluidine blue positive mast cells within and around the tumor in 44 patients with soft tissue sarcomas (STS). Irrespective of their histologic types, these cases were broadly divided into the following two groups: (1) low count (less than 20 mast cells/10 high-power fields [HPF]) and (2) high...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19881201)62:11<2416::aid-cncr282

    authors: Ueda T,Aozasa K,Tsujimoto M,Yoshikawa H,Kato T,Ono K,Matsumoto K

    更新日期:1988-12-01 00:00:00

  • Urokinase-plasminogen activator, a marker for aggressive breast carcinomas. Preliminary report.

    abstract::Plasminogen activator is a serine protease which exists in two forms, known as tissue-type plasminogen activator and urokinase-type plasminogen activator. Here, we show that urokinase-type plasminogen activator activity in primary breast carcinomas correlates with both size of tumor and number of axillary nodes with m...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880801)62:3<531::aid-cncr28206

    authors: Duffy MJ,O'Grady P,Devaney D,O'Siorain L,Fennelly JJ,Lijnen HJ

    更新日期:1988-08-01 00:00:00

  • Cancers of the large bowel: associated disorders in individuals.

    abstract::The individual medical histories in the files of the Oxford Record Linkage Study for the years 1963 to 1967 were analyzed to ascertain any previously unsuspected associations between cancers of the large bowel and other diseases in individuals, and to quantify the relative risks of disorders already known to be associ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197906)43:6<2553::aid-cncr282043

    authors: Adelstein P,Baldwin JA,Fedrich J

    更新日期:1979-06-01 00:00:00

  • Survivorship after lower gastrointestinal cancer: Patient-reported outcomes and planning for care.

    abstract:BACKGROUND:There is significant need for quality follow-up care to optimize long-term outcomes for the growing population of lower gastrointestinal (GI) cancer survivors. Patient-reported outcomes (PROs) provide valuable information regarding late and long-term effects (LLTEs). METHODS:A convenience sample from 1129 c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30527

    authors: Frick MA,Vachani CC,Hampshire MK,Bach C,Arnold-Korzeniowski K,Metz JM,Hill-Kayser CE

    更新日期:2017-05-15 00:00:00

  • A simple rapid autoradiography for 3H-thymidine labeling index and its application to therapy of adult acute leukemia.

    abstract::Our simple rapid autoradiography for 3H-thymidine (3H-TdR) labeling index (LI) of leukemic cells was introduced. Thirty-nine adult patients with acute nonlymphocytic leukemia were treated under a new protocol using 3H-TdR LI as a parameter and inserting a trial of partial synchronization by Ara-C. The success rate of ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19801115)46:10<2298::aid-cncr282

    authors: Yoshida T,Hattori KI,Nakamura S,Mitamura E,Kobayashi S,Ohtake S,Tanimoto K

    更新日期:1980-11-15 00:00:00

  • Survival of patients with carcinoma in situ of the urinary bladder.

    abstract:BACKGROUND:To the authors' knowledge, the long term follow-up of patients with carcinoma in situ of the urinary bladder is limited. METHODS:The authors studied 138 patients diagnosed with urothelial carcinoma in situ of the bladder at the Mayo Clinic between 1972-1979. All the histologic slides were reviewed and fulfi...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Cheng L,Cheville JC,Neumann RM,Leibovich BC,Egan KS,Spotts BE,Bostwick DG

    更新日期:1999-06-01 00:00:00

  • B-cell lymphoma in severe combined immunodeficiency not associated with the Epstein-Barr virus.

    abstract::Patients with congenital and acquired immunodeficiencies are at increased risk for the development of B-cell lymphoproliferative disorders. When the appropriate tests have been performed, the Epstein-Barr virus (EBV) nuclear antigen (EBNA) or EBV DNA has been found in tissues from these tumors. These data have provide...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19871215)60:12<2941::aid-cncr282

    authors: Garcia CR,Brown NA,Schreck R,Stiehm ER,Hudnall SD

    更新日期:1987-12-15 00:00:00

  • Flow cytometric analysis of nuclear DNA content of renal cell carcinoma correlated with histologic and clinical features.

    abstract:BACKGROUND:The prognostic value of flow cytometric analysis of DNA content is contradictory in renal cell carcinoma (RCC). METHODS:Flow cytometric analysis was performed on 72 patients with RCC, and the relationship between the DNA content and pathologic or clinical features was investigated. RESULTS:Aneuploidy was o...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930815)72:4<1319::aid-cncr2820

    authors: Nakano E,Kondoh M,Okatani K,Seguchi T,Sugao H

    更新日期:1993-08-15 00:00:00

  • Prognostic factors in laryngeal carcinoma. Experience in 296 male patients.

    abstract:BACKGROUND:Laryngeal cancer is the primary cause of death among patients with head and neck cancer in Argentina. Different prognostic factors have been incidentally dealt with in a number of articles, but there are few studies of prognostic variables, such as age, tobacco, and alcohol, using multifactorial analysis. M...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930415)71:8<2472::aid-cncr2820

    authors: Pradier R,González A,Matos E,Loria D,Adan R,Saco P,Califano L

    更新日期:1993-04-15 00:00:00

  • Ovarian dysplasia: nuclear texture analysis.

    abstract:BACKGROUND:Ovarian dysplasia has been defined by histologic and morphometric studies focusing on architectural and nuclear profile changes. A new technique is used to enhance the accuracy of this diagnosis by a quantitative evaluation of the nuclear texture that represents the nuclear chromatin pattern on which convent...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19931201)72:11<3253::aid-cncr282

    authors: Deligdisch L,Miranda C,Barba J,Gil J

    更新日期:1993-12-01 00:00:00

  • Extremity and trunk desmoid tumors: a multifactorial analysis of outcome.

    abstract:BACKGROUND:The natural history of desmoid tumors remains an enigma. Previous reports attempting to identify their biology have included recurrent and primary tumors as well as tumors from both intra- and extra-abdominal sites. The purpose of this study was to analyze patients with primary extremity and trunk desmoid tu...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Merchant NB,Lewis JJ,Woodruff JM,Leung DH,Brennan MF

    更新日期:1999-11-15 00:00:00

  • Cognitive functioning in breast cancer survivors: a controlled comparison.

    abstract:BACKGROUND:The current study was performed to determine whether neuropsychologic functioning differs in breast cancer survivors 6 months after the completion of adjuvant treatment compared with women without cancer. METHODS:Participants were 187 women who were diagnosed with ductal carcinoma in situ or stage I or stag...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24192

    authors: Jim HS,Donovan KA,Small BJ,Andrykowski MA,Munster PN,Jacobsen PB

    更新日期:2009-04-15 00:00:00

  • Tn, a carcinoma-associated antigen, reacts with anti-Tn of normal human sera.

    abstract::Tn antigen is the immediate precursor of the carcinoma (CA)-associated T antigen; both are masked in non-CA tissues. Tn antigen was detected by absorption of human anti-Tn antibody in 46 of 50 primary breast CAs and in all 6 metastases originating from Tn-positive primary CAs. Thirteen of 25 (52%) anaplastic CAs, but ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850201)55:3<561::aid-cncr28205

    authors: Springer GF,Taylor CR,Howard DR,Tegtmeyer H,Desai PR,Murthy SM,Felder B,Scanlon EF

    更新日期:1985-02-01 00:00:00

  • Adolescents' preferences for treatment decisional involvement during their cancer.

    abstract:BACKGROUND:This qualitative study investigated the medical decision-making preferences of adolescent oncology patients and the parental and clinician behaviors that adolescents report to be supportive of their preferred level of decision-making involvement. METHODS:Interviews were conducted with 40 adolescents between...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29663

    authors: Weaver MS,Baker JN,Gattuso JS,Gibson DV,Sykes AD,Hinds PS

    更新日期:2015-12-15 00:00:00

  • Combination teletherapy and iridium implantation in the treatment of locally advanced breast cancer.

    abstract::Combined teletherapy and interstitial iridium 192 implantation can control locally advanced breast cancer in a consistent fashion without causing significant morbidity. Moreover, in the absence of clinically evident distant metastases, patients who undergo this treatment can survive comfortably for long periods of tim...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197611)38:5<1936::aid-cncr282038

    authors: Alderman SJ

    更新日期:1976-11-01 00:00:00

  • Low-dose Adriamycin remission maintenance therapy for pediatric solid tumors.

    abstract::A low-dose maintenance schedule of Adriamycin was evaluated in six children whose metastatic solid tumors regressed following toxic induction therapy with Adriamycin. Three of these children are now disease-free more than one year following discontinuation of therapy. Adriamycin can be given on a low-dose maintenance ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197706)39:6<2411::aid-cncr282039

    authors: Hvizdala EV,Komp DM,Arnold JB

    更新日期:1977-06-01 00:00:00

  • Breast-conserving surgery and radiation after augmentation mammoplasty.

    abstract:BACKGROUND:Although breast-conserving therapy (tumor excision, axillary node dissection, and postoperative radiation) for women with breast cancer yields survival and local recurrence rates comparable with those of modified radical mastectomy, studies suggest that postoperative radiation leads to capsular contractures ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940515)73:10<2613::aid-cncr282

    authors: Guenther JM,Tokita KM,Giuliano AE

    更新日期:1994-05-15 00:00:00

  • Increased lipid peroxidation in malignant tissues of patients with colorectal cancer.

    abstract::The authors investigated the level of lipid peroxidation and possible related phenomena in the activation of phospholipase A2 and the infiltration of granulocyte neutrophils in human colorectal cancer tissue samples. Malondialdehyde (an index of lipid peroxidation), phospholipase A2 activity, and myeloperoxidase activ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890715)64:2<422::aid-cncr28206

    authors: Otamiri T,Sjödahl R

    更新日期:1989-07-15 00:00:00

  • Integration of human papillomavirus vaccination, cytology, and human papillomavirus testing.

    abstract::There is justifiable excitement about the recent introduction of prophylactic vaccines against human papillomavirus (HPV) types 16 (HPV-16) and HPV-18. Preventing these infections theoretically could avert approximately 70% of cervical cancer cases worldwide. In the U.S., numerous influential advocates are calling for...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.22751

    authors: Schiffman M

    更新日期:2007-06-25 00:00:00

  • Expression of aldehyde dehydrogenase 1 as a marker of mammary stem cells in benign and malignant breast lesions of Ghanaian women.

    abstract:BACKGROUND:Breast cancers that are negative for the estrogen receptor (ER), the progesterone receptor (PR), and the HER2 (human epidermal growth factor receptor 2) marker are more prevalent among African women, and the biologically aggressive nature of these triple-negative breast cancers (TNBCs) may be attributed to t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27737

    authors: Schwartz T,Stark A,Pang J,Awuah B,Kleer CG,Quayson S,Kingman S,Aitpillah F,Abantanga F,Jiagge E,Oppong JK,Osei-Bonsu E,Martin I,Yan X,Toy K,Adjei E,Wicha M,Newman LA

    更新日期:2013-02-01 00:00:00

  • Cost-effectiveness of a patient navigation intervention to increase colonoscopy screening among low-income adults in New Hampshire.

    abstract:BACKGROUND:Colonoscopy is the most widely used colorectal cancer (CRC) screening test in the United States. Through the detection and removal of potentially precancerous polyps, it can prevent CRC. However, CRC screening remains low among adults who are recommended for screening. The New Hampshire Colorectal Cancer Scr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31864

    authors: Rice K,Sharma K,Li C,Butterly L,Gersten J,DeGroff A

    更新日期:2019-02-15 00:00:00

  • Squamous cell carcinoma antigen in the diagnosis and treatment follow-up of oral and facial squamous cell carcinoma.

    abstract::The squamous cell carcinoma (SCC) antigen was determined by radioimmunoassay in the serum of 40 untreated patients with SCC of the oromaxillofacial region. The mean (+/- SEM) serum concentration for these patients (3.8 +/- 0.8 ng/ml) was significantly higher than that of 52 disease-free patients coming to routine post...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900315)65:6<1321::aid-cncr2820

    authors: Fischbach W,Meyer T,Barthel K

    更新日期:1990-03-15 00:00:00

  • Role of fine needle aspiration in the diagnosis of lesions of the oral cavity, oropharynx, and nasopharynx.

    abstract::The oral cavity, oropharynx and nasopharynx are readily accessible to fine needle aspiration (FNA). This study reviews the author's experience with 93 FNA from these sites: 76 from the oral cavity, eight from the oropharynx, and eight from the nasopharynx. Thirty-nine (42%) of the FNA were positive for malignancy with...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19881215)62:12<2602::aid-cncr282

    authors: Scher RL,Oostingh PE,Levine PA,Cantrell RW,Feldman PS

    更新日期:1988-12-15 00:00:00