Replacement estrogens and risk of gynecologic cancers and breast cancer.

Abstract:

:The two cancers specific to women for which substantial research on their relationship to exogenous estrogens has been reported are endometrial cancer and breast cancer. With the former, the link to estrogen use is well established. The estrogen use patterns associated with increased risk of endometrial cancer are characteristic of a promotional agent. The example serves as a prototype model for the study of an adverse health effect subsequent to a prescribed medication. However, modification in estrogen prescribing patterns have lowered significantly the endometrial cancer risk for patients. A relationship between estrogen replacement therapy and breast cancer is difficult to assess. Despite biologic plausibility, large epidemiologic studies have shown no association between estrogen use and breast cancer occurrence. Those studies suggesting a relationship find it concentrated in the high dose estrogen products and possibly among women who have had a prior bilateral oophorectomy. A convincing resolution to the current uncertainty is likely to require new approaches in laboratory, clinical, and epidemiologic research. Larger studies investigating more refined hypotheses within the same conceptual confines are unlikely to be productive.

journal_name

Cancer

journal_title

Cancer

authors

Hulka BS

doi

10.1002/1097-0142(19901015)60:8+<1960::aid-cncr282

subject

Has Abstract

pub_date

1987-10-15 00:00:00

pages

1960-4

issue

8 Suppl

eissn

0008-543X

issn

1097-0142

journal_volume

60

pub_type

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