Abstract:
:The observation, in 1980, of a rapid increase in platelet counts as a result of administration of intravenous immunoglobulin (IVIG) in a patient with immune thrombocytopenic purpura (ITP) was followed by clinical studies confirming the efficacy of this new treatment alternative in ITP. Simultaneously, new sensitive assays using monoclonal antibodies against platelet glycoproteins showed that chronic ITP in adults and children is often an autoimmune disorder. There seem to be both immediate and long-term effects of IVIG in ITP which may be explained by mechanisms of action other than immunoglobulin G substitution. The mode of action of IVIG could correspond to interference with Fc receptors on phagocytes or be a result of antiidiotypic antibodies in IVIG that may induce secondary changes in the complex immunologic network. These immunomodulatory effects were the basis for the use of IVIG in the treatment of patients with other immune-related disorders. New aspects regarding definition and treatment of ITP, the possible mechanisms of action of IVIG, and the implications thereof are discussed and updated.
journal_name
Cancerjournal_title
Cancerauthors
Imbach Pdoi
10.1002/1097-0142(19910915)68:6+<1422::aid-cncr282subject
Has Abstractpub_date
1991-09-15 00:00:00pages
1422-5issue
6 Suppleissn
0008-543Xissn
1097-0142journal_volume
68pub_type
杂志文章,评审相关文献
CANCER文献大全abstract::The body composition of 23 patients with cachexia resulting from malignant or benign inflammatory disease was studied. Skinfold thickness and radioisotope tracer measurements enabled us to estimate total body fat, lean body mass, the ratio of fat loss to lean body loss, erythrocyte and plasma volumes, total body water...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801101)46:9<2041::aid-cncr2820
更新日期:1980-11-01 00:00:00
abstract::The authors reviewed clinical features, surgical extent of resection, histologic parameters, and DNA content in 55 children with medulloblastomas and found that complete or near total resection, absence of tumor dissemination, tumor DNA aneuploidy, and low proliferative index correlated with a favorable clinical outco...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.2820690539
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND:The authors had previously reported preliminary results of a treatment regimen of concurrent hyperfractionated radiation therapy and chemotherapy in patients with locally advanced head and neck carcinoma that demonstrated both feasibility and high local control. In an attempt to reduce acute mucosal and hema...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0142(19970715)80:2<266::aid-cnc
更新日期:1997-07-15 00:00:00
abstract::The abdominoinguinal incision is a new method for exposure and resection of tumors in the pelvis with lateral fixation that were previously called unresectable or were treated with hemipelvectomy. This procedure has been used in 22 patients referred from other centers following unsuccessful resection attempts. Twelve ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841201)54:11<2543::aid-cncr282
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) signaling is a target for antiangiogenic cancer therapy. The authors have previously observed that up to 40% of vessels in colorectal carcinoma (CRC) tumors are negative for VEGF receptor 2 (VEGFR2) expression. Differential activity of transforming growth factor beta...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26247
更新日期:2011-12-15 00:00:00
abstract::Survivors of pediatric and young adult cancers remain at risk for subsequent diseases, including those related to human papillomavirus (HPV) infection. Prevention of HPV acquisition through vaccination has become possible over the last decade. HPV vaccines have been shown to be safe and effective, yet rates of vaccina...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.29515
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Benign and malignant pancreatic mucinous tumors differ in proliferative activity, production of tumor markers, and expression of growth factors. DNA ploidy is a useful index of aggressiveness and poor survival in ductal adenocarcinoma, but has not been studied in pancreatic cystic tumors. METHODS:The DNA pl...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960101)77:1<58::AID-CNCR
更新日期:1996-01-01 00:00:00
abstract::Twenty-two patients with cancer of the colon and rectum were studied: preoperative and postoperative cell-mediated and humoral immune factors were assessed, and local concentration of immunoglobulins in tumor tissue and in normal mucosa were measured. Lymphocyte function was found to be reduced in 50% of stage A and B...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800815)46:4<700::aid-cncr28204
更新日期:1980-08-15 00:00:00
abstract::Doxorubicin is an effective antineoplastic agent, but it frequently causes dose-related cardiotoxic effects. Because the atrial natriuretic peptide (ANP) level is elevated in children with heart defects, the authors measured the ANP levels in children to determine whether ANP might serve as a simple diagnostic indicat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920315)69:6<1492::aid-cncr2820
更新日期:1992-03-15 00:00:00
abstract:BACKGROUND:Two randomized trials have demonstrated improved progression-free survival (PFS) with lenalidomide maintenance after autologous transplantation for multiple myeloma (MM). Overall survival (OS) results are conflicting, and quality-of-life (QOL) data are lacking. The authors conducted a systematic survey of pa...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.28340
更新日期:2013-12-15 00:00:00
abstract:BACKGROUND:The value of surgical staging and treatment of the axillary lymph nodes with either surgery or radiotherapy in the initial management of patients with Stage I or II invasive breast cancer is controversial. METHODS:A review of retrospective and prospective clinical studies was performed to assess the risks o...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19951101)76:9<1491::aid-cncr2820
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Although caspase recruitment domain (CARD) membrane-associated guanylate kinase (MAGUK) protein 1 (CARMA1) and CARD9 play important roles in lymphocyte activation, the significance of CARMA1 and CARD9 in the pathogenesis of gastric mucosa-associated lymphoid tissue (MALT) lymphoma remains to be elucidated. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21421
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:Lung cancer (LC) is the most common fatal malignancy, but there are no useful tumor markers for diagnosis or monitoring. Mucin 1 has an established role as a marker in other malignancies, but has undergone limited assessment in LC. METHODS:Serum from 86 patients with LC and 24 with benign pulmonary disease ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931115)72:10<2936::aid-cncr282
更新日期:1993-11-15 00:00:00
abstract:BACKGROUND:The causal relation between high-risk human papillomavirus (HPV) and cervical cancer and its precursor lesions has led to the use of sensitive HPV molecular tests for screening. This study examined the impact of the baseline HPV status on the future risk of cervical intraepithelial neoplasia grade 2 or worse...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31788
更新日期:2019-01-15 00:00:00
abstract::Patients with a localized primary liposarcoma of the extremity who were treated in Memorial Sloan-Kettering Cancer Center between 1968 and 1978 were studied. The prognosis of patients with extremity liposarcoma was analyzed according to histopathologic subtypes. A system of five subtypes was used; well-differentiated,...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891001)64:7<1514::aid-cncr2820
更新日期:1989-10-01 00:00:00
abstract::An 11-year-old female with a large embryonal carcinoma of the left ovary was treated by unilateral salpingo-oophorectomy combined with a systemic chemotherapy of a total dose of 1.9 mg of dactinomycin. The preoperative serum alpha-fetoprotein (AFP) level of 70,350 ng/ml decreased to 270 ng/ml 5 weeks after the operati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19831015)52:8<1470::aid-cncr2820
更新日期:1983-10-15 00:00:00
abstract:BACKGROUND:This report evaluated whether biochemical recurrence (BCR) as a time-dependent covariate (t) after radical prostatectomy (RP) for prostate cancer was associated with the risk of death and whether salvage therapy with radiotherapy (RT) and/or hormonal therapy (HT) can lessen this risk METHODS:This was a retr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25013
更新日期:2010-04-15 00:00:00
abstract::Two siblings succumbed to glioblastoma multiforme, associated with hepatic focal nodular hyperplasia and cafe-au-lait spots. One sibling had syndactyly and multiple colonic polyps, while the other had an angiomatous malformation in the brain. Their mother died of myasthenia gravis. The findings suggest a hamartomatous...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197607)38:1<310::aid-cncr2820380
更新日期:1976-07-01 00:00:00
abstract::The difficulties encountered in establishing a diagnosis of a malignant peritoneal mesothelioma are emphasized in a patient who developed the lesion 16 years after radiation therapy for a seminoma of the testis. Historically, histologically, electron microscopically, and by microincineration, there was no evidence of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197909)44:3<914::aid-cncr2820440
更新日期:1979-09-01 00:00:00
abstract::The case of a 49-year-old man with the diagnosis of angioimmunoblastic lymphadenopathy is reported. The patient survived a stormy clinical course. The corticosteroids improved dramatically the clinical picture although the patient developed a staphylococcal septicemia. Before treatment immunological studies were done ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197808)42:2<447::aid-cncr2820420
更新日期:1978-08-01 00:00:00
abstract::There is now considerable interest in gastrointestinal stromal tumor (GIST) because it can be treated effectively with a targeted molecular agent. The majority of GISTs contain an activating mutation in the KIT protooncogene or, occasionally, in the platelet-derived growth factor-alpha (PDGFRA) gene. Five years ago, i...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.21419
更新日期:2005-11-01 00:00:00
abstract::A prospective study was performed on 84 patients with neuroendocrine pancreatic tumors. Fifty-nine (70%) had malignant tumors and received causal medical treatment. Streptozotocin in combination with 5-fluorouracil or doxorubicin was used as first-line treatment and produced overall objective responses in 20 of 44 (45...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900501)65:9<1883::aid-cncr2820
更新日期:1990-05-01 00:00:00
abstract:BACKGROUND:Patient navigation may reduce cancer disparities associated with socioeconomic status (SES) and household factors. This study examined whether these factors were associated with delays in diagnostic resolution among patients with cancer screening abnormalities and whether patient navigation ameliorated these...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29612
更新日期:2015-11-15 00:00:00
abstract:BACKGROUND:Complementary medicine has become an important aspect of palliative cancer care. This overview is primarily aimed at providing guidance to clinicians regarding some commonly used complementary therapies. METHODS:Several complementary therapies were identified as particularly relevant to palliative cancer ca...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(20010601)91:11<2181::aid-cncr124
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Surgical resection with adjuvant chemotherapy is the standard of care for patients with pancreatic cancer, but to the authors' knowledge, little is known regarding the temporal relationship between chemotherapy initiation and survival. The current study analyzed the impact of time to the initiation of adjuva...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30163
更新日期:2016-10-01 00:00:00
abstract::Head and neck cancer (H&N CA) patients have known depression of cell-mediated immunity. There is suggestive evidence that prostaglandin (PGE2)-secreting cells may be a major factor. The authors have sought to determine the role of PGE2-releasing monocytes-macrophages in this immune depression by determining the effect...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880201)61:3<462::aid-cncr28206
更新日期:1988-02-01 00:00:00
abstract::Identification of BCR-ABL as the defining leukemogenic event in chronic myelogenous leukemia (CML) revolutionized the treatment of the disease. Imatinib, a potent BCR-ABL inhibitor, is the standard of care for the first-line treatment of patients with chronic-phase CML because of its high long-term response rates and ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.24928
更新日期:2010-03-15 00:00:00
abstract:BACKGROUND:Increasingly, the quality of life (QOL) of women diagnosed with breast carcinoma is being studied. However, there is little information regarding long term survivors among ethnic minority women. The purpose of this study was to describe the QOL of long term breast carcinoma survivors (BCS) and to examine the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990115)85:2<418::aid-cnc
更新日期:1999-01-15 00:00:00
abstract:BACKGROUND:Significant antitumor effects were previously observed with radioimmunotherapy (RIT) using an anti-carcinoembryonic antigen (CEA) monoclonal antibody (F6) labeled with iodine-131 in medullary thyroid cancer (MTC)-bearing nude mice. Nevertheless, no complete response was achieved. Because angiogenesis is crit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24792
更新日期:2010-02-15 00:00:00
abstract:BACKGROUND:Disseminated intravascular coagulation (DIC) and primary fibrinolysis have both been reported in association with prostate carcinoma. The correct diagnosis of the coagulopathy can be difficult and the appropriate management controversial. METHODS:A case is presented of a man in whom DIC and soft tissue hemo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920801)70:3<656::aid-cncr28207
更新日期:1992-08-01 00:00:00