Mucin 1 antigens in the serum and bronchial lavage fluid of patients with lung cancer.

Abstract:

BACKGROUND:Lung cancer (LC) is the most common fatal malignancy, but there are no useful tumor markers for diagnosis or monitoring. Mucin 1 has an established role as a marker in other malignancies, but has undergone limited assessment in LC. METHODS:Serum from 86 patients with LC and 24 with benign pulmonary disease (BPD), and bronchial lavage fluid from 55 LC patients and 21 BPD patients were tested using the Mucin 1 assays mammary serum antigen (MSA) and cancer-associated serum antigen (CASA). RESULTS:For LC, serum CASA achieved sensitivity of 57%, specificity of 93% relative to normals, and 63% specificity relative to BPD. For MSA the same parameters were 19%, 95%, and 92%. Serum CASA levels were significantly higher in LC patients compared with BPD (P = 0.024) but there was no difference for MSA (P = 0.635). CASA showed excellent correlation with tumor stage and in patients with changing status of disease, while MSA did not. By contrast there was no difference in bronchial lavage fluid tumor marker levels from LC and BPD patients (CASA, P = 0.87; MSA, P = 0.89). CONCLUSIONS:In a small series serum CASA appears to be a useful agent in detecting LC because it is elevated in all types and stages of LC, and its level correlates with stage and progress of disease. Some patients with BPD have elevated levels suggesting a greater value for monitoring rather than diagnosis. Both serum MSA testing and measurements of either marker in bronchial lavage fluid are of no value.

journal_name

Cancer

journal_title

Cancer

authors

Willsher PC,Xing PX,Clarke CP,Ho DW,McKenzie IF

doi

10.1002/1097-0142(19931115)72:10<2936::aid-cncr282

subject

Has Abstract

pub_date

1993-11-15 00:00:00

pages

2936-42

issue

10

eissn

0008-543X

issn

1097-0142

journal_volume

72

pub_type

杂志文章

相关文献

CANCER文献大全
  • Acupressure bands do not improve chemotherapy-induced nausea control in pediatric patients receiving highly emetogenic chemotherapy: A single-blinded, randomized controlled trial.

    abstract:BACKGROUND:Chemotherapy-induced nausea and vomiting remain common, distressing side effects of chemotherapy. It has been reported that acupressure prevents chemotherapy-induced nausea in adults, but it has not been well studied in children. METHODS:In this multicenter, prospective, randomized, single-blind, sham-contr...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/cncr.31198

    authors: Dupuis LL,Kelly KM,Krischer JP,Langevin AM,Tamura RN,Xu P,Chen L,Kolb EA,Ullrich NJ,Sahler OJZ,Hendershot E,Stratton A,Sung L,McLean TW

    更新日期:2018-03-15 00:00:00

  • Characterization of adolescent and pediatric renal cell carcinoma: A report from the Children's Oncology Group study AREN03B2.

    abstract:BACKGROUND:The current study was conducted to characterize the epidemiology, histology, and radiographic features of as well as the surgical approach to pediatric and adolescent renal cell carcinoma (pRCC). METHODS:pRCC cases prospectively enrolled on the Children's Oncology Group study AREN03B2 underwent central path...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.29368

    authors: Geller JI,Ehrlich PF,Cost NG,Khanna G,Mullen EA,Gratias EJ,Naranjo A,Dome JS,Perlman EJ

    更新日期:2015-07-15 00:00:00

  • Latent Epstein-Barr virus infection is an unlikely event in the pathogenesis of immunoproliferative small intestinal disease.

    abstract:BACKGROUND:The observed seasonal and geographic variations in the incidence of immunoproliferative small intestinal disease (IPSID) suggest that environmental factors contribute to its pathogenesis. One such environmental factor, the Epstein-Barr virus (EBV), has been associated with other B-cell lymphoproliferative di...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940915)74:6<1699::aid-cncr2820

    authors: Baddoura FK,Unger ER,Mufarrij A,Nassar VH,Zaki SR

    更新日期:1994-09-15 00:00:00

  • Primary malignant lymphoma of the breast. Lymphoma of the mucosa-associated lymphoid tissue.

    abstract::Eight cases of primary non-Hodgkin's lymphoma of the breast found in the pathology files of the Institute of Oncology, Ljubljana, Yugoslavia, for a period of 25 years (from 1961 to 1985) were analyzed. During the same period 5711 cases of breast carcinoma were seen. Seven cases were diffuse lymphomas, and one case was...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19871215)60:12<3033::aid-cncr282

    authors: Lamovec J,Jancar J

    更新日期:1987-12-15 00:00:00

  • Risk factors for primary central nervous system lymphoma: a case-control study.

    abstract:BACKGROUND:The incidence of primary central nervous system lymphoma (PCNSL) has increased over time in both immunocompetent and immunodeficient individuals. The reasons for the increase among immunocompetent patients are unclear. METHODS:The authors conducted a case-control study of PCNSL at the Mayo Clinic based on c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Schiff D,Suman VJ,Yang P,Rocca WA,O'Neill BP

    更新日期:1998-03-01 00:00:00

  • Patterns and predictors of cancer-related fatigue in ovarian and endometrial cancers: 1-year longitudinal study.

    abstract:BACKGROUND:Fatigue is a common and distressing symptom for patients with gynecologic cancers. Few studies have empirically examined whether it spontaneously resolves. This study was aimed at identifying longitudinal patterns of fatigue and predictors of clinically significant fatigue 1 year after treatment completion. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32927

    authors: Poort H,de Rooij BH,Uno H,Weng S,Ezendam NPM,van de Poll-Franse L,Wright AA

    更新日期:2020-08-01 00:00:00

  • Accelerated fractionation for high-grade cerebral astrocytomas. Preliminary treatment results.

    abstract::A Phase I/II accelerated fractionation study for high-grade cerebral astrocytomas began in October 1987. Forty-two patients, 25 men and 17 women, were entered in the study. Median age was 58.5 years of age (range, 32 to 78 years). Performance status was 0, 1, 2, and 3 on Eastern Cooperative Oncology Group (ECOG) scale...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19910501)67:9<2247::aid-cncr2820

    authors: Shenouda G,Souhami L,Freeman CR,Hazel J,Lehnert S,Joseph L

    更新日期:1991-05-01 00:00:00

  • Cytogenetic and molecular responses and outcome in chronic myelogenous leukemia: need for new response definitions?

    abstract:BACKGROUND:Response rates in chronic myeloid leukemia (CML) are now reported based on the cumulative incidence of a single-time best response. The study aim was to examine the significance of different response criteria for CML on imatinib therapy. METHODS:In all, 276 patients with chronic phase CML on imatinib therap...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23238

    authors: Kantarjian H,O'Brien S,Shan J,Huang X,Garcia-Manero G,Faderl S,Ravandi-Kashani F,Verstovsek S,Beth Rios M,Cortes J

    更新日期:2008-02-15 00:00:00

  • Disseminated intravascular coagulation in childhood acute lymphocytic leukemia with poor prognostic features.

    abstract::Three children with ALL having poor prognostic features developed clinical and laboratory evidence of disseminated intravascular coagulation (DIC). Two developed a bleeding diathesis associated temporally with a rapid drop in blast cell counts during induction therapy with L-asparaginase, prednisone, and vincristine. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197804)41:4<1642::aid-cncr282041

    authors: Champion LA,Luddy RE,Schwartz AD

    更新日期:1978-04-01 00:00:00

  • 2b or not 2b? Shoulder function after level 2b neck dissection: A double-blind randomized controlled clinical trial.

    abstract:BACKGROUND:Selective neck dissection (SND) is a mainstay of head and neck cancer treatment. A common sequela is shoulder syndrome from spinal accessory nerve (SAN) trauma. Extensive dissection in neck levels 2 and 5 leads to SAN dysfunction. However, it is not known whether limited level 2 dissection reduces SAN injury...

    journal_title:Cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/cncr.32681

    authors: Dziegielewski PT,McNeely ML,Ashworth N,O'Connell DA,Barber B,Courneya KS,Debenham BJ,Seikaly H

    更新日期:2020-04-01 00:00:00

  • Patterns of Care Study quantitative evaluation of the quality of radiotherapy in Japan.

    abstract:BACKGROUND:Quality assurance (QA) of clinical practice is important for any medical specialty. Programs based on the Patterns of Care Study (PCS) have been developed to compare the quality of radiotherapeutic care at individual institutions, with the national average representing the process and outcome of radiotherapy...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10633

    authors: Tanisada K,Teshima T,Ohno Y,Inoue T,Abe M,Ikeda H,Owen JB,Hanks GE,Masuda K,Honke Y

    更新日期:2002-07-01 00:00:00

  • Kaposi's sarcoma in immunosuppression. Possibly the result of a dual viral infection.

    abstract::Kaposi's sarcoma of the gingiva and skin developed in an HIV-negative renal transplant patient while he was receiving cyclosporine therapy. The Kaposi's sarcoma developed shortly after the patient had an acute infection with cytomegalovirus (CMV). Electron microscopy of the tumor's established cell line showed two typ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900201)65:3<492::aid-cncr28206

    authors: Siegal B,Levinton-Kriss S,Schiffer A,Sayar J,Engelberg I,Vonsover A,Ramon Y,Rubinstein E

    更新日期:1990-02-01 00:00:00

  • Chemotherapy of malignant hepatomas with sequential intraarterial doxorubicin and systemic 5-fluorouracil and semustine.

    abstract::Twenty patients with malignant hepatoma were treated with sequential intraarterial doxorubicin (72-hour continuous infusion) followed by systemic 5-fluorouracil (5-FU) and semustine (methyl CCNU). Objective tumor responses were seen in three patients (15%). The durations of response were 6, 19, and 27+ months, respect...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880915)62:6<1041::aid-cncr2820

    authors: O'Connell MJ,Hahn RG,Rubin J,Moertel CG

    更新日期:1988-09-15 00:00:00

  • Primary adenocarcinoma of the urinary bladder. A clinicopathologic and prognostic study.

    abstract::The study is a clinicopathologic report on 64 patients with primary adenocarcinoma of the urinary bladder and urachus, with particular reference to important prognostic and therapeutic factors. All tumors exhibited adenocarcinomatous features in at least two thirds of the examined tumor area. Pure forms of the differe...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19831001)52:7<1273::aid-cncr2820

    authors: Anderström C,Johansson SL,von Schultz L

    更新日期:1983-10-01 00:00:00

  • Microsatellite instability and expression of MLH1 and MSH2 in carcinomas of the small intestine.

    abstract:BACKGROUND:Carcinomas of the small intestine are rare, but the risk is greatly increased in patients with hereditary nonpolyposis colorectal cancer (HNPCC) due to an inherited mismatch repair (MMR) gene mutation, most commonly affecting the genes MLH1 or MSH2. Defective MMR is characterized by microsatellite instabilit...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11197

    authors: Planck M,Ericson K,Piotrowska Z,Halvarsson B,Rambech E,Nilbert M

    更新日期:2003-03-15 00:00:00

  • Elevation of serum lactic dehydrogenase levels as an early marker of occult malignant lymphoma.

    abstract::Elevated serum lactic dehydrogenase (LDH) levels, 595 to 615 microns/ml (normal less than 225 microns/ml) with predominance of LDH isoenzymes 2 and 3 was the early and only sign of occult malignant lymphoma in three patients. In the first patient, overt lymphoma appeared clinically only 2 months after the finding of e...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841001)54:7<1379::aid-cncr2820

    authors: Rotenberg Z,Weinberger I,Fuchs Y,Erdberg A,Davidson E,Agmon J

    更新日期:1984-10-01 00:00:00

  • Primary seminoma of the mediastinum. Cancer Control Agency of British Columbia experience.

    abstract::Six patients with primary seminoma of the mediastinum were treated at the Cancer Control Agency of British Columbia during the period from 1970 to 1982. Primary treatment used was external beam radiotherapy. Only one patient received both radiotherapy and chemotherapy. Tumor dose ranged from 3000 cGy in 16 daily fract...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850115)55:2<450::aid-cncr28205

    authors: Lee YM,Jackson SM

    更新日期:1985-01-15 00:00:00

  • Pancreatic cancer: approach to diagnosis, selection for surgery and choice of operation.

    abstract::The physician must suspect pancreatic cancer in patients older than age 40 years who present with minimal vague symptoms. The presence of common disorders such as gallstones, hiatal hernia and diverticulosis coli, does not exclude pancreatic cancer. Ultrasonography, computed tomography, ERCP and cytology are the essen...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Moossa AR

    更新日期:1982-12-01 00:00:00

  • Remission of rapidly growing desmoid tumors after tamoxifen therapy.

    abstract::A patient is described with Gardner's syndrome manifested initially by an extra-abdominal desmoid which was resected. The case was complicated by metastatic adenocarcinoma of the colon and recurrence of several large painful desmoid lesions. In view of the predilection of desmoids to occur in women in their childbeari...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19831215)52:12<2201::aid-cncr282

    authors: Kinzbrunner B,Ritter S,Domingo J,Rosenthal CJ

    更新日期:1983-12-15 00:00:00

  • Histopathologic studies on carcinoma in pleomorphic adenoma of the parotid gland.

    abstract::Five-hundred-eighteen cases of primary epithelial tumors of the parotid gland were examined. The incidence of carcinomas in pleomorphic adenoma was 9.3% (48 cases). In addition to cellular atypism, the following histological findings were thought to be important criteria for the diagnosis of carcinomas: (1) capsular i...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810701)48:1<113::aid-cncr28204

    authors: Nagao K,Matsuzaki O,Saiga H,Sugano I,Shigematsu H,Kaneko T,Katoh T,Kitamura T

    更新日期:1981-07-01 00:00:00

  • The use of oncofetal ferritin-bearing lymphocytes as a marker for the screening, diagnosis, and follow-up of patients with early breast malignancy screening of 3400 women.

    abstract::The potential of using a blood test enumerating oncofetal ferritin-bearing lymphocytes (FBL) as a biomarker for early breast cancer was further explored. Nine hundred women attending a high-risk breast cancer clinic and 2500 normal-risk women were physically examined and their blood drawn for FBL determination using a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890801)64:3<691::aid-cncr28206

    authors: Moroz C,Kahn M,Ron E,Luria H,Chaimoff C

    更新日期:1989-08-01 00:00:00

  • Results of a multicenter, randomized, double-blind phase 2/3 study of lenalidomide in the treatment of pretreated relapsed or refractory metastatic malignant melanoma.

    abstract:BACKGROUND:The results of an international, multicenter, randomized, double-blind, controlled study assessing the efficacy and safety of lenalidomide treatment in patients with refractory stage IV metastatic malignant melanoma are reported. METHODS:The study compared treatment with lenalidomide (25 mg/d on Days 1-21 o...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/cncr.24686

    authors: Eisen T,Trefzer U,Hamilton A,Hersey P,Millward M,Knight RD,Jungnelius JU,Glaspy J

    更新日期:2010-01-01 00:00:00

  • Spontaneous remission of recurring disseminated intravascular coagulation associated with prostatic carcinoma.

    abstract::A 58-year-old patient with metastatic prostatic carcinoma had two well-documented episodes of disseminated intravascular coagulation (DIC) occurring 1 year apart and resolving without heparin therapy. This case illustrates that DIC need not have a poor prognosis and may resolve spontaneously despite progressive cancer...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197602)37:2<928::aid-cncr2820370

    authors: Alving BM,Abeloff MD,Bell W

    更新日期:1976-02-01 00:00:00

  • Patient-controlled analgesic administration. A comparison of steady-state morphine infusions with bolus doses.

    abstract::The authors have shown previously that bone marrow transplant (BMT) patients who self-administered bolus doses of morphine gained equal oral mucositis pain relief while using less drug compared with similar patients receiving morphine by staff-controlled continuous infusion. In a follow-up study they compared the effi...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19910215)67:4<873::aid-cncr28206

    authors: Hill HF,Mackie AM,Coda BA,Iverson K,Chapman CR

    更新日期:1991-02-15 00:00:00

  • Ocular and orbital complications following radiation therapy of paranasal sinus malignancies and review of literature.

    abstract::During the period from March 1963 through March 1978, 30 patients with malignant neoplasms of the paranasal sinuses were treated with supervoltage technique at the University of Rochester Medical Center. Twenty-one patients had at least the medial portion of the orbit within the effective treatment volume and the rest...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19830315)51:6<980::aid-cncr28205

    authors: Nakissa N,Rubin P,Strohl R,Keys H

    更新日期:1983-03-15 00:00:00

  • Preventable and mitigable adverse events in cancer care: Measuring risk and harm across the continuum.

    abstract:BACKGROUND:Patient safety is a critical concern in clinical oncology, but the ability to measure adverse events (AEs) across cancer care is limited by a narrow focus on treatment-related toxicities. The objective of this study was to assess the nature and extent of AEs among cancer patients across inpatient and outpati...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30916

    authors: Lipitz-Snyderman A,Pfister D,Classen D,Atoria CL,Killen A,Epstein AS,Anderson C,Fortier E,Weingart SN

    更新日期:2017-12-01 00:00:00

  • Production of extracellular matrix-degrading proteinases by primary cultures of human epithelial ovarian carcinoma cells.

    abstract:BACKGROUND:The authors analyzed the secretion of extracellular matrix-degrading proteinases, including urinary-type plasminogen activator (u-PA), matrix metalloproteinase-2 (MMP-2, gelatinase A), and MMP-9 (gelatinase B), by short term primary cultures of epithelial ovarian carcinoma cells derived from primary ovarian ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19971015)80:8<1457::aid-cn

    authors: Fishman DA,Bafetti LM,Banionis S,Kearns AS,Chilukuri K,Stack MS

    更新日期:1997-10-15 00:00:00

  • High expression of thymidylate synthase is associated with the drug resistance of gastric carcinoma to high dose 5-fluorouracil-based systemic chemotherapy.

    abstract:BACKGROUND:In the past 4 years, the weekly 24-hour infusion of high dose 5-fluorouracil (5-FU) and leucovorin in the treatment of patients with advanced gastric carcinoma has been prospectively studied at the authors' institution. This has enabled them to explore the possibility that the level of expression of thymidyl...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-0142(19980501)82:9<1626::aid-cn

    authors: Yeh KH,Shun CT,Chen CL,Lin JT,Lee WJ,Lee PH,Chen YC,Cheng AL

    更新日期:1998-05-01 00:00:00

  • Development of a brief screening interview for adjustment disorders and major depression in patients with cancer.

    abstract:BACKGROUND:Adjustment disorders and major depression are common psychiatric disorders in patients with cancer and have a serious impact on quality of life. The problem in clinical oncology settings is underrecognition of these disorders; as a result, screening is recommended to detect them. The goal of the current stud...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11358

    authors: Akizuki N,Akechi T,Nakanishi T,Yoshikawa E,Okamura M,Nakano T,Murakami Y,Uchitomi Y

    更新日期:2003-05-15 00:00:00

  • Prognostic factors in elderly women with metastatic breast cancer treated with tamoxifen: an analysis of patients entered on four prospective clinical trials.

    abstract:BACKGROUND:Information regarding prognostic factors and survival in elderly women with metastatic breast cancer treated with tamoxifen is limited. METHODS:The data from 4 prospective clinical trials were analyzed, including information on 396 postmenopausal women with advanced breast cancer who received tamoxifen as i...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/(sici)1097-0142(19960215)77:4<683::aid-cnc

    authors: Dhodapkar MV,Ingle JN,Cha SS,Mailliard JA,Wieand HS

    更新日期:1996-02-15 00:00:00