Elevation of serum lactic dehydrogenase levels as an early marker of occult malignant lymphoma.

abstract：:Fifty-eight patients with 62 pathologic fractures secondary to metastatic disease were admitted to a rehabilitation hospital during a 5-year period. Thirty-four patients were discharged home, 7 were transferred to other facilities, and 17 died. The average hospital stay for the patients who went home (37 days) was onl...

journal_title：Cancer

authors： Bunting RW,Boublik M,Blevins FT,Dame CC,Ford LA,Lavine LS

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:The widespread use of anthracycline chemotherapy has contributed to improved outcomes in children with cancer. The most feared complication of the anthracyclines is cardiotoxicity. Routine echocardiographic monitoring typically is used before, during, and after treatment to minimize cardiotoxicity. The ideal...

journal_title：Cancer

authors： Watts RG,George M,Johnson WH Jr

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:The purpose of this study is to examine changes over time in survival for African American (AA) and white women diagnosed with cervical cancer (CC). METHODS:Surveillance, Epidemiology, and End Results (SEER) Program data from 1985 to 2009 were used for this analysis. Racial differences in survival were eval...

journal_title：Cancer

authors： Rauh-Hain JA,Clemmer JT,Bradford LS,Clark RM,Growdon WB,Goodman A,Boruta DM 2nd,Schorge JO,del Carmen MG

更新日期：2013-10-15 00:00:00

abstract：BACKGROUND:The authors hypothesized that insurance payer and race would influence the care and outcomes for patients with breast carcinoma. METHODS:The authors examined treatments and adjusted risk of death (through 1997) for all incident cases of breast carcinoma occurring in Florida in 1994 (n = 11,113) by using sta...

journal_title：Cancer

authors： Roetzheim RG,Gonzalez EC,Ferrante JM,Pal N,Van Durme DJ,Krischer JP

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Preclinical studies have demonstrated that the inhibition of the PI3K/Akt/mTOR pathway restores gefitinib sensitivity in resistant cancer cell lines. A phase 1 study was conducted of the combination of everolimus, an mTOR inhibitor, and gefitinib to determine a daily dose of everolimus with gefitinib in pati...

journal_title：Cancer

authors： Milton DT,Riely GJ,Azzoli CG,Gomez JE,Heelan RT,Kris MG,Krug LM,Pao W,Pizzo B,Rizvi NA,Miller VA

更新日期：2007-08-01 00:00:00

abstract：:Clinically benign whole, untrimmed prostates and pelvic lymph nodes were obtained from 105 patients at autopsy. All 105 patients had premortem serum from which prostate-specific antigen (PSA) levels were obtained. Sixty-eight did not have carcinoma of the prostate (CAP), 28 had CAP less than 1 ml and 9 had CAP larger ...

journal_title：Cancer

authors： Brawn PN,Speights VO,Kuhl D,Riggs M,Spiekerman AM,McCord RG,Coffield KS,Stewart DT,Lind ML

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Patients with renal cell carcinoma brain metastases (RCCBM) are frequently excluded from trials and to the authors' knowledge no guidelines currently exist regarding central nervous system (CNS) surveillance or treatment. The objective of the current study was to assist in the creation of treatment guideline...

journal_title：Cancer

authors： Shuch B,La Rochelle JC,Klatte T,Riggs SB,Liu W,Kabbinavar FF,Pantuck AJ,Belldegrun AS

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:The prognostic significance of molecular phenotype in breast cancer is well established in the literature. Recent studies have demonstrated that subgross lesion distribution (unifocal, multifocal, and diffuse) and disease extent also carry prognostic significance in this disease. However, the correlation of ...

journal_title：Cancer

authors： Pekar G,Hofmeyer S,Tabár L,Tarján M,Chen TH,Yen AM,Chiu SY,Hellberg D,Gere M,Tot T

更新日期：2013-03-15 00:00:00

abstract：BACKGROUND:Patients with human papillomavirus (HPV)-related oropharyngeal cancer (OPC) have improved survival when compared with those with HPV-negative OPC. Unfortunately, the American Joint Committee on Cancer seventh edition (AJCC-7ed) staging system does not account for the prognostic advantage observed with HPV-po...

journal_title：Cancer

authors： Malm IJ,Fan CJ,Yin LX,Li DX,Koch WM,Gourin CG,Pitman KT,Richmon JD,Westra WH,Kang H,Quon H,Eisele DW,Fakhry C

更新日期：2017-05-15 00:00:00

abstract：:The author reviewed the question of late side effects of cancer treatment. A late side effect was defined as an unwanted and deleterious effect observed for the first time 12 months or longer after treatment. In a survey of articles published by The New England Journal of Medicine and The Lancet from 1968 to 1988, nin...

journal_title：Cancer

authors： Boivin JF

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Estrogen receptor-alpha (ERalpha) is variably expressed in hepatocellular carcinoma (HCC) and is believed to be correlated with prognosis and survival. Recently, another estrogen receptor (ERbeta) has been identified, but its relevance in liver diseases is unknown. METHODS:The expression of ERbeta in the li...

journal_title：Cancer

authors： Iavarone M,Lampertico P,Seletti C,Francesca Donato M,Ronchi G,del Ninno E,Colombo M

更新日期：2003-08-01 00:00:00

abstract：:Vitamin B6 is involved in many biological processes of potential relevance to carcinogenesis and tumor growth, including DNA synthesis and maintenance of immunocompetence, yet very little information exists on B6 nutritional status in childhood leukemia. Using a radioenzymatic assay, the authors measured plasma pyrido...

journal_title：Cancer

authors： Pais RC,Vanous E,Hollins B,Faraj BA,Davis R,Camp VM,Ragab AH

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:A somatic gain-of-function mutation of the Janus kinase 2 (JAK2) gene has been identified in chronic myeloproliferative disorders, which appear to have a sporadic occurrence in most individuals. The authors studied the biologic significance of the JAK2 (V617F) mutation in familial myeloproliferative disorder...

journal_title：Cancer

authors： Rumi E,Passamonti F,Pietra D,Della Porta MG,Arcaini L,Boggi S,Elena C,Boveri E,Pascutto C,Lazzarino M,Cazzola M

更新日期：2006-11-01 00:00:00

abstract：:Lobular carcinoma in situ (LCIS) has uncertain malignant potential; biologic markers that will identify patients at risk for a poor clinical outcome have been sought actively. Amplification of the c-erbB-2 protooncogene has been correlated with poor prognosis in invasive mammary carcinoma, and immunohistochemical eval...

journal_title：Cancer

authors： Porter PL,Garcia R,Moe R,Corwin DJ,Gown AM

更新日期：1991-07-15 00:00:00

abstract：:An unusual tumor of the cystic duct in a 28-year-old woman is described. The patient presented with a painful distended gallbladder due to a small tumor occluding the cystic duct. Microscopically the tumor cells showed a nesting pattern suggestive of endocrine differentiation, but contained numerous lipid vacuoles and...

journal_title：Cancer

authors： Goodman ZD,Albores-Saavedra J,Lundblad DM

更新日期：1984-02-01 00:00:00

abstract：:Estradiol and testosterone levels in the peripheral and ovarian circulation of patients with endometrial cancer and of postmenopausal women were studied. These levels proved to be the same in the two groups. The ovaries of neither group secreted estradiol. The testosterone level in the ovarian circulation of all exami...

journal_title：Cancer

authors： Schenker JG,Weinstein D,Okon E

更新日期：1979-11-01 00:00:00

abstract：:Testicular function was studied in 26 men with sarcoma who received adjuvant treatment with doxorubicin, cyclophosphamide, and high-dose methotrexate (with or without radiotherapy). Testicular size, sperm output, and serum FSH, LH and testosterone levels were assessed after treatment. Five of 17 men who received chemo...

journal_title：Cancer

authors： Shamberger RC,Sherins RJ,Rosenberg SA

更新日期：1981-05-15 00:00:00

abstract：BACKGROUND:Parathyroid hormone-related protein (PTHrP) is the predominant cause of humoral hypercalcemia of malignancy (HHM). METHODS:Using a PTHrP-specific monoclonal antibody (MoAb), 4B3, the authors investigated the immunohistochemical localization of PTHrP in formalin-fixed and paraffin-embedded sections of normal...

journal_title：Cancer

authors： Gotoh A,Kitazawa S,Mizuno Y,Takenaka A,Arakawa S,Matsumoto O,Kitazawa R,Fujimori T,Maeda S,Kamidono S

更新日期：1993-05-01 00:00:00

abstract：:The records of 314 children with acute lymphocytic leukemia (ALL) were reviewed to determine the frequency, clinical and laboratory features; contributing factors; and prognosis of cyclophosphamide-induced hemorrhagic cystitis. Twenty-five well-documented cases of hemorrhagic cystitis were identified. While most of th...

journal_title：Cancer

authors： Lawrence HJ,Simone J,Aur RJ

更新日期：1975-11-01 00:00:00

abstract：:Chlorozotocin was administered by rapid intravenous infusion to 35 patients with advanced cancer on either single-day of five-consecutive-day schedules. Total doses per course ranged from 12.5 to 200 mg/m2. On either administration schedule, dose limiting toxicities were thrombocytopenia and leukopenia at total doses ...

journal_title：Cancer

authors： Kovach JS,Moertel CG,Schutt AJ,Frytak S,O'Connell MJ,Rubin J,Ingle JN

更新日期：1979-06-01 00:00:00

abstract：BACKGROUND:The prognosis of patients with clinically staged hilar nodal involvement (Stage N1) or clinical Stage II non-small cell lung cancer (NSCLC, Stage T1-2N1M0) treated with radiation therapy (RT) alone is not well established. METHODS:Records of 758 patients with clinical Stage I-III NSCLC treated with RT were ...

journal_title：Cancer

authors： Rosenthal SA,Curran WJ Jr,Herbert SH,Hughes EN,Sandler HM,Stafford PM,McKenna WG

更新日期：1992-11-15 00:00:00

abstract：:The two cancers specific to women for which substantial research on their relationship to exogenous estrogens has been reported are endometrial cancer and breast cancer. With the former, the link to estrogen use is well established. The estrogen use patterns associated with increased risk of endometrial cancer are cha...

journal_title：Cancer

authors： Hulka BS

更新日期：1987-10-15 00:00:00

abstract：:Plasminogen activator is a serine protease which exists in two forms, known as tissue-type plasminogen activator and urokinase-type plasminogen activator. Here, we show that urokinase-type plasminogen activator activity in primary breast carcinomas correlates with both size of tumor and number of axillary nodes with m...

journal_title：Cancer

authors： Duffy MJ,O'Grady P,Devaney D,O'Siorain L,Fennelly JJ,Lijnen HJ

更新日期：1988-08-01 00:00:00

abstract：:Two children with metastatic extragonadal endodermal sinus tumor who had failed VAC chemotherapy were treated with combination chemotherapy consisting of cis-platinum, vinblastine, doxorubicin HCl (Adriamycin) and bleomycin (cis-VAB). There was a complete response in both patients with one child remaining tumor-free 3...

journal_title：Cancer

authors： Thomas WJ,Kelleher JF,Duval-Arnould B

更新日期：1981-12-01 00:00:00

abstract：:Seventeen cases of pulmonary scar carcinomas were found in 112 surgically resected pulmonary carcinomas from 1985 through 1988 in a hospital situated in a histoplasmosis endemic area. These carcinomas can be divided into two types: Type I, mucinous; and Type II, non-mucinous (Clara cell). Each type of carcinoma consti...

journal_title：Cancer

authors： Yoneda K

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Current clinical guidelines recommend earlier, more intensive breast cancer screening with both magnetic resonance imaging (MRI) and mammography for women with breast cancer susceptibility gene (BRCA) mutations. Unspecified details of screening schedules are a challenge for implementing guidelines. METHODS:...

journal_title：Cancer

authors： Cott Chubiz JE,Lee JM,Gilmore ME,Kong CY,Lowry KP,Halpern EF,McMahon PM,Ryan PD,Gazelle GS

更新日期：2013-03-15 00:00:00

abstract：:Seventy patients with poor prognosis, metastatic breast cancer were treated with FUVAC induction chemotherapy (5-fluorouracil, vinblastine, Adriamycin [doxorubicin] and cyclophosphamide). Consolidation therapy was given to 30 of 48 responders (63%), of whom 23 received sequential hemibody irradiation (HBI) at 8 cGy, c...

journal_title：Cancer

authors： Livingston RB,Schulman S,Griffin BR,Tranum BL,Rivkin SE,Goldberg RS,Fabian CJ,Hammond N,Hynes H

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:Although cutaneous desmoplastic malignant melanoma (DMM) has been well characterized, those arising from the oral mucosa have been less well defined. METHODS:We evaluated the clinical and pathologic features of three patients with biopsy-proven DMM examined at the North Carolina Baptist Hospital. Routine he...

journal_title：Cancer

authors： Kilpatrick SE,White WL,Browne JD

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Genes involved in the angiopoietin and pericyte pathways may become escape mechanisms under antivascular endothelial growth factor (anti-VEGF) therapy. The authors investigated whether variations within genes in these pathways are associated with clinical outcome in patients with colorectal liver metastases ...

journal_title：Cancer

authors： Stremitzer S,Zhang W,Yang D,Ning Y,Stintzing S,Sebio A,Sunakawa Y,Yamauchi S,Matsusaka S,El-Khoueiry R,Stift J,Wrba F,Gruenberger T,Lenz HJ

更新日期：2015-06-01 00:00:00

abstract：:We have tested methyl glyoxal bis-guanyl hydrazone (NSC 32946) for antitumor activity in patients with colorectal carcinoma and non-small cell bronchogenic carcinoma. The drug dose was 500 mg/m2 administered by single weekly injection, and with a provision dose escalation. No responses were seen in 38 evaluable patien...

journal_title：Cancer

authors： Killen JY,Mitchell EP,Hoth DF,Willis LL,Gullo JJ,Smith FP,Schein PS,Woolley PV

更新日期：1982-10-01 00:00:00