Successful treatment of metastatic extragonadal endodermal sinus (yolk sac) tumor in childhood.

Abstract:

:Two children with metastatic extragonadal endodermal sinus tumor who had failed VAC chemotherapy were treated with combination chemotherapy consisting of cis-platinum, vinblastine, doxorubicin HCl (Adriamycin) and bleomycin (cis-VAB). There was a complete response in both patients with one child remaining tumor-free 3 1/2 years after metastasis and 2 1/2 years after stopping therapy. The main toxic reactions encountered were associated with the use of cis-platinum, but these were manageable and resolved upon completion of therapy. Cis-VAB appears to be a safe and effective regimen for the treatment of metastatic endodermal sinus tumor. A study of the efficacy of cis-VAB in a larger group of children with endodermal sinus tumor of poor prognosis seems indicated.

journal_name

Cancer

journal_title

Cancer

authors

Thomas WJ,Kelleher JF,Duval-Arnould B

doi

10.1002/1097-0142(19811201)48:11<2371::aid-cncr282

subject

Has Abstract

pub_date

1981-12-01 00:00:00

pages

2371-4

issue

11

eissn

0008-543X

issn

1097-0142

journal_volume

48

pub_type

杂志文章

相关文献

CANCER文献大全
  • Isolated marrow lymphoma: an entity of possible T-cell derivation.

    abstract::Seven adults had a distinct clinicopathologic type of lymphoproliferative disorder of the bone marrow. All patients presented with weakness and pancytopenia; no evidence of gross extramedullary involvement was found. In 5 cases severe and prolonged bone marrow hypoplasia was associated with combination chemotherapy; 1...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19801015)46:8<1767::aid-cncr2820

    authors: Barton JC,Conrad ME,Vogler LB,Parmley RT

    更新日期:1980-10-15 00:00:00

  • Pineoblastoma: an electron microscopic study.

    abstract::The ultrastructure of a human pineoblastoma is described. Tumor cells formed nests, palisading row and rosettes. Cells within nests were undifferentiated. Palisade and rosette forming cells had polarized cytoplasms and showed signs of differentiation and surface membrane specialization which included surface end-bulb-...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197911)44:5<1692::aid-cncr282044

    authors: Kline KT,Damjanov I,Katz SM,Schmidek H

    更新日期:1979-11-01 00:00:00

  • Clinical and pathologic factors that predict lymph node yield from surgical specimens in colorectal cancer: a population-based study.

    abstract:BACKGROUND:The National Quality Forum endorses the recommendation of examining at least 12 lymph nodes (LNs) from colorectal cancer (CRC) specimens. However, heterogeneity in LN harvest exists. The objective of this study was to investigate the clinicopathologic factors that influence LN yield. METHODS:The authors use...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25032

    authors: Chou JF,Row D,Gonen M,Liu YH,Schrag D,Weiser MR

    更新日期:2010-06-01 00:00:00

  • The impact of breast reconstruction on the delivery of chemotherapy.

    abstract:BACKGROUND:: The purpose of this study was to evaluate the impact of postmastectomy breast reconstruction on the timing of chemotherapy. METHODS:: The authors included stage I-III breast cancer patients from 8 National Comprehensive Cancer Network institutions for whom guidelines recommended chemotherapy. Surgery type...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24891

    authors: Alderman AK,Collins ED,Schott A,Hughes ME,Ottesen RA,Theriault RL,Wong YN,Weeks JC,Niland JC,Edge SB

    更新日期:2010-04-01 00:00:00

  • Preirradiation gemcitabine chemotherapy for newly diagnosed glioblastoma. A phase II study.

    abstract:BACKGROUND:The median survival for patients with glioblastoma is reported to be 12 months. To improve the outcome for glioblastoma patients, the authors evaluated the therapeutic efficacy of preirradiation gemcitabine chemotherapy followed by standard radiotherapy. METHODS:Twenty-one patients with newly diagnosed glio...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(20010115)91:2<423::aid-cncr1017>

    authors: Weller M,Streffer J,Wick W,Kortmann RD,Heiss E,Küker W,Meyermann R,Dichgans J,Bamberg M

    更新日期:2001-01-15 00:00:00

  • The value of serial carcinoembryonic antigen (CEA) in predicting response rate and survival of patients with gastrointestinal cancer treated with chemotherapy.

    abstract::Elevated serum levels of carcinoembryonic antigen (CEA) were found in 70% of 141 patients with advanced gastrointestinal (GI) cancers. Serial CEA measurements were performed on 70 patients before and during chemotherapy. The majority were treated with 5-FU and Methyl-CCNU (33 patients), 5-FU (19 patients), or 5-FU and...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197910)44:4<1222::aid-cncr282044

    authors: Al-Sarraf M,Baker L,Talley RW,Kithier K,Vaitkevicius VK

    更新日期:1979-10-01 00:00:00

  • Fine structural characterization of melanosomes in dysplastic nevi.

    abstract::This study characterized the fine structure of melanosomes in melanocytes of the dysplastic nevi in six cases with lentiginous melanocytic dysplasia and one case with epithelioid-cell melanocytic dysplasia, and compared that structure with those of common melanocytic nevi and malignant melanoma. It was found that: fin...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850701)56:1<111::aid-cncr28205

    authors: Takahashi H,Horikoshi T,Jimbow K

    更新日期:1985-07-01 00:00:00

  • The prevalence of polyps of the large intestine in Oslo: an autopsy study.

    abstract::The colon and rectum were removed from 445 consecutive autopsies and examined for the presence of polypoid lesions under an illuminating magnifying lens. There were seven clinically undiagnosed carcinomas, 329 adenomas, 174 hyperplastic polyps, 59 mucosal tags, 34 other polypoid lesions, and 54 polyps in which no hist...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820215)49:4<819::aid-cncr28204

    authors: Vatn MH,Stalsberg H

    更新日期:1982-02-15 00:00:00

  • Type 73 human papillomavirus in esophageal squamous cell carcinoma: a novel association.

    abstract:BACKGROUND:Human papillomaviruses (HPVs) commonly cause proliferative lesions of squamous epithelia, and infection with certain HPV types carries a high risk of malignant transformation, especially in the uterine cervix but also at other sites, including the esophagus. We used molecular techniques to detect and type HP...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960615)77:12<2440::AID-C

    authors: West AB,Soloway GN,Lizarraga G,Tyrrell L,Longley JB

    更新日期:1996-06-15 00:00:00

  • A centralized mailed program with stepped increases of support increases time in compliance with colorectal cancer screening guidelines over 5 years: A randomized trial.

    abstract:BACKGROUND:Screening over many years is required to optimize reductions in colorectal cancer (CRC) mortality. However, no prior trials have compared strategies for obtaining long-term adherence. METHODS:Systems of Support to Increase Colorectal Cancer Screening and Follow-Up was implemented in an integrated health car...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/cncr.30908

    authors: Green BB,Anderson ML,Cook AJ,Chubak J,Fuller S,Meenan RT,Vernon SW

    更新日期:2017-11-15 00:00:00

  • Clinical and economic burden associated with stage III to IV triple-negative breast cancer: A SEER-Medicare historical cohort study in elderly women in the United States.

    abstract:BACKGROUND:The current study was performed to describe patient characteristics, treatment patterns, survival, health care resource use (HRU), and costs among older women in the United States with advanced (American Joint Committee on Cancer stage III/IV) triple-negative breast cancer (TNBC) in the Surveillance, Epidemi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31299

    authors: Schwartz KL,Simon MS,Bylsma LC,Ruterbusch JJ,Beebe-Dimmer JL,Schultz NM,Flanders SC,Barlev A,Fryzek JP,Quek RGW

    更新日期:2018-05-15 00:00:00

  • Clinical outcome of patients with Ewing sarcoma family of tumors of bone in Japan: the Japanese Musculoskeletal Oncology Group cooperative study.

    abstract:BACKGROUND:Ewing sarcoma family of tumors (ESFT) of bone is extremely rare in Japan. The objectives of the current study were to assess the clinical outcome and prognostic factors of patients with ESFT of bone in Japan and to compare them between Euro-American and Japanese populations. METHODS:The authors conducted a ...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.22481

    authors: Obata H,Ueda T,Kawai A,Ishii T,Ozaki T,Abe S,Tanaka K,Tsuchiya H,Matsumine A,Yabe H,Japanese Musculoskeletal Oncology Group.

    更新日期:2007-02-15 00:00:00

  • Intensity-modulated radiotherapy reduces toxicity with similar biochemical control compared with 3-dimensional conformal radiotherapy for prostate cancer: A randomized clinical trial.

    abstract:BACKGROUND:The objective of this article was to report the results from a randomized clinical trial comparing intensity-modulated radiotherapy (IMRT) with 3-dimensonal conformal radiotherapy (3DCRT) for the treatment of prostate cancer on a hypofractionated schedule. METHODS:The authors randomly assigned 215 men who h...

    journal_title:Cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/cncr.29983

    authors: Viani GA,Viana BS,Martin JE,Rossi BT,Zuliani G,Stefano EJ

    更新日期:2016-07-01 00:00:00

  • Immunohistochemical identification of tissue factor in solid tumors.

    abstract::Patients with cancer experience a much higher than expected incidence of thromboembolic disorders, commonly referred as Trousseau syndrome. Although this association has been well documented, the etiology of the hypercoagulable state is not known. The expression on tumor cells of tissue factor (TF), a membrane-bound l...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920901)70:5<1194::aid-cncr2820

    authors: Callander NS,Varki N,Rao LV

    更新日期:1992-09-01 00:00:00

  • DNA ploidy of ovarian granulosa cell tumors. Lack of correlation between DNA index or proliferative index and outcome in 40 patients.

    abstract:BACKGROUND:Most cases of granulosa cell tumor of the ovary are characterized by relatively good outcome; however, some tumors behave aggressively, and some tend to recur many years after the initial diagnosis. Because DNA ploidy has been shown to predict biologic behavior better than conventional prognostic variables i...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950501)75:9<2295::aid-cncr2820

    authors: Evans MP,Webb MJ,Gaffey TA,Katzmann JA,Suman VJ,Hu TC

    更新日期:1995-05-01 00:00:00

  • c-KIT mutation analysis for diagnosis of gastrointestinal stromal tumors in fine needle aspiration specimens.

    abstract:BACKGROUND:Gastrointestinal stromal tumors (GISTs) are a specific clinicopathologic entity characterized by activating mutations in the c-KIT gene. These mutations are associated with increased immunohistochemical staining for the c-KIT protein. Because many GISTs display a definitive response to the KIT inhibitor imat...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21064

    authors: Willmore-Payne C,Layfield LJ,Holden JA

    更新日期:2005-06-25 00:00:00

  • Thomsen-Friedenreich antigen presents as a prognostic factor in colorectal carcinoma: A clinicopathologic study of 264 patients.

    abstract:BACKGROUND:Up to now, the expression of the tumor-associated Thomsen-Friedenreich (TF) antigen in colorectal carcinoma has not been thoroughly investigated with particular emphasis on its correlation with established clinicopathologic characteristics and classifications as well as its prognostic relevance. METHODS:For...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Baldus SE,Zirbes TK,Hanisch FG,Kunze D,Shafizadeh ST,Nolden S,Mönig SP,Schneider PM,Karsten U,Thiele J,Hölscher AH,Dienes HP

    更新日期:2000-04-01 00:00:00

  • Clinical and radiologic features of hepatocellular carcinoma originating in the caudate lobe.

    abstract::Five patients with hepatocellular carcinoma in the caudate lobe were evaluated. Computed tomography (CT) scan and/or angiography clearly demonstrated multiple intrahepatic metastases in four (80%), and tumor thrombi in the portal vein in two (40%), and in the inferior vena cava in one. Even though there was no recogni...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19861001)58:7<1557::aid-cncr2820

    authors: Takayasu K,Muramatsu Y,Shima Y,Goto H,Moriyama N,Yamada T,Makuuchi M,Kaneko A,Itabashi M,Shimamura Y

    更新日期:1986-10-01 00:00:00

  • Decreased risk of radiation-associated second malignant neoplasms in actinomycin-D-treated patients.

    abstract::One hundred two long-term survivors of childhood cancers with second malignant neoplasms (SMNs) were collected from 10 institutions. Forty-seven cases fulfilling study criteria were studied to determine the risk of developing a SMN in irradiated fields after exposure to various chemotherapeutic agents. The case contro...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197602)37:2+<1177::aid-cncr28203

    authors: D'Angio GJ,Meadows A,Miké V,Harris C,Evans A,Jaffe N,Newton W,Schweisguth O,Sutow W,Morris-Jones P

    更新日期:1976-02-01 00:00:00

  • Reproducibility of the diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study.

    abstract:BACKGROUND:Most gynecologists determine therapy based on current International Society of Gynecologic Pathologists (ISGP)/World Health Organization classification of endometrial hyperplasia, the reproducibility of which has been questioned. The Gynecologic Oncology Group (GOG) initiated a protocol to assess the efficac...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.21649

    authors: Zaino RJ,Kauderer J,Trimble CL,Silverberg SG,Curtin JP,Lim PC,Gallup DG

    更新日期:2006-02-15 00:00:00

  • MAGE, BAGE, and GAGE gene expression in patients with esophageal squamous cell carcinoma and adenocarcinoma of the gastric cardia.

    abstract:BACKGROUND:The MAGE, BAGE, and GAGE gene families code for distinct, tumor specific antigens that are recognized by cytotoxic T lymphocytes in the context of HLA molecules. The purpose of this study was to analyze MAGE, BAGE, and GAGE gene expression in the two major histologic types of esophageal carcinoma, squamous c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Zambon A,Mandruzzato S,Parenti A,Macino B,Dalerba P,Ruol A,Merigliano S,Zaninotto G,Zanovello P

    更新日期:2001-05-15 00:00:00

  • Association of the -160 C --> a promoter polymorphism of E-cadherin gene with gastric carcinoma risk.

    abstract:BACKGROUND:A -160 C --> A polymorphism in the promoter region of E-cadherin has been shown to decrease gene transcription. This allelic variation might be a potential genetic marker for identifying individuals at risk for cancer. There remains no report regarding the polymorphism of E-cadherin in gastric carcinoma (GC)...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10371

    authors: Wu MS,Huang SP,Chang YT,Lin MT,Shun CT,Chang MC,Wang HP,Chen CJ,Lin JT

    更新日期:2002-03-01 00:00:00

  • Medullary carcinoma of the breast. An unusual cytologic finding in cyst fluid aspirates.

    abstract::Cystic medullary carcinoma of the breast is unusual. This report describes five patients with medullary carcinoma who presented clinically with a breast cyst. Fine-needle aspiration biopsy (NAB) was performed as part of the initial physical examination and the retrieved cyst fluid was examined cytologically. Four of t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900115)65:2<277::aid-cncr28206

    authors: Howell LP,Kline TS

    更新日期:1990-01-15 00:00:00

  • Integrative genomic characterization and a genomic staging system for gastrointestinal stromal tumors.

    abstract:BACKGROUND:Gastrointestinal stromal tumors (GISTs) historically were grouped with leiomyosarcomas (LMSs) based on their morphologic similarities; however, recently, GIST was established unequivocally as a distinct type of sarcoma based on its molecular features and response to imatinib treatment. METHODS:To gain furth...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25594

    authors: Ylipää A,Hunt KK,Yang J,Lazar AJ,Torres KE,Lev DC,Nykter M,Pollock RE,Trent J,Zhang W

    更新日期:2011-01-15 00:00:00

  • A clinicopathologic study of 92 cases of granulosa cell tumor of the ovary with special reference to the factors influencing prognosis.

    abstract::Ninety-two cases of granulosa cell tumor of the ovary have been studied. The clinical and pathologic data from this group were similar to that obtained in previous series. Because of the long natural history of many granulosa cell tumors, crude death rates over a relatively short period give little indication of the t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197501)35:1<231::aid-cncr2820350

    authors: Fox H,Agrawal K,Langley FA

    更新日期:1975-01-01 00:00:00

  • Preoperative evaluation of patients with primary colorectal cancer.

    abstract::Preoperative evaluation should focus on techniques that either preclude surgery entirely, alter the planned operation either preoperatively or intraoperatively, or suggest the need for preoperative adjuvant therapy. The presence of a synchronous colonic neoplasia should be excluded by colonoscopy or air-contrast bariu...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19920901)70:3+<1328::aid-cncr282

    authors: Cohen AM

    更新日期:1992-09-01 00:00:00

  • Pathomorphologic evaluation of pulmonary radiofrequency ablation: proof of cell death is characterized by DNA fragmentation and apoptotic bodies.

    abstract:BACKGROUND:Radiofrequency (RF) ablation is an increasingly applied technique. Promising results of hepatic RF ablation raised expectations of its capabilities for treatment of primary and secondary lung tumors. Because of different thermal and electrical properties of lung tissue, compared with liver tissue, a simple a...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.23882

    authors: Clasen S,Krober SM,Kosan B,Aebert H,Fend F,Bomches A,Claussen CD,Pereira PL

    更新日期:2008-12-01 00:00:00

  • The significance of bone and cartilage formation in malignant fibrous histiocytoma of soft tissue.

    abstract::Malignant fibrous histiocytoma of soft tissues (MFH), a mesenchymal tumor of varied morphologic patterns and cell types, sometimes contains bone and cartilage. Such bony and cartilaginous elements in a pleomorphic MFH may pose a difficult diagnostic challenge. An MFH with bone and cartilage can be distinguished from e...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820201)49:3<480::aid-cncr28204

    authors: Bhagavan BS,Dorfman HD

    更新日期:1982-02-01 00:00:00

  • Conservative treatment versus mastectomy in breast cancer tumors with macroscopic diameter of 20 millimeters or less. The experience of the Institut Gustave-Roussy.

    abstract::A clinical trial was conducted at the Institut Gustave Roussy between October 1972 and December 1980 to compare mastectomy with local excision plus Cobalt-irradiation, in patients with breast cancer tumors of 20 mm in diameter or less at macroscopic examination. Low-axillary dissection and extemporaneous histologic ex...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19840301)53:5<1209::aid-cncr2820

    authors: Sarrazin D,Lê M,Rouëssé J,Contesso G,Petit JY,Lacour J,Viguier J,Hill C

    更新日期:1984-03-01 00:00:00

  • Midkine and pleiotrophin expression in normal and malignant breast tissue.

    abstract:BACKGROUND:Some growth factors may promote tumor growth by affecting tumor angiogenesis. The angiogenic growth factor, pleiotrophin, was demonstrated previously in human breast carcinoma tissues; however, the pattern of pleiotrophin expression in normal breast tissues has not been established. METHODS:The expression o...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940901)74:5<1584::aid-cncr2820

    authors: Garver RI Jr,Radford DM,Donis-Keller H,Wick MR,Milner PG

    更新日期:1994-09-01 00:00:00