Integrative genomic characterization and a genomic staging system for gastrointestinal stromal tumors.

abstract：BACKGROUND:Patients with familial adenomatous polyposis develop periampullary adenomas at a high rate. However, little is known regarding the factors that control the growth, the natural history, or the malignant potential of these tumors. METHODS:In this study, the authors systematically evaluated the expression of t...

journal_title：Cancer

authors： Resnick MB,Gallinger S,Wang HH,Odze RD

更新日期：1995-07-15 00:00:00

abstract：:Biopsy specimens from 62 human single primary squamous cell carcinomas (SCC) of the head and neck were xenografted into nude mice. To evaluate the prognostic significance of successful heterotransplantation, the 62 cases were retrospectively examined for survival, adjusting for possible confounders by multivariate ana...

journal_title：Cancer

authors： Zätterström UK,Wennerberg J,Attewell R,Ask A

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:EphA2 is overexpressed in the majority of ovarian cancers and predicts poor clinical outcome. Based on EphA2's emerging role in angiogenesis, we hypothesized that tumors overexpressing EphA2 demonstrate greater microvessel density (MVD) and matrix metalloproteinase (MMP) expression. METHODS:After Institutio...

journal_title：Cancer

authors： Lin YG,Han LY,Kamat AA,Merritt WM,Landen CN,Deavers MT,Fletcher MS,Urbauer DL,Kinch MS,Sood AK

更新日期：2007-01-15 00:00:00

abstract：:A case of acute renal failure secondary to bilateral renal vein occlusion by a retroperitoneal plasmacytoma is described. The use of low-risk radiographic techniques including radionuclide venography and a computerized axial tomography (CAT) scan made a rapid and accurate diagnosis possible. Fatal hemorrhage occurred ...

journal_title：Cancer

authors： Marks ES,Lee KM

更新日期：1984-03-01 00:00:00

abstract：:Ten consecutive diffuse histiocytic lymphoma (DHL) cell lines established in our laboratory were studied for the presence of Epstein-Barr virus (EBV) genomes, lysozyme, nonspecific esterase and other cytochemical reactions, phagocytic activity, cytoplasmic immunoglobulin light and heavy chains, and surface receptors t...

journal_title：Cancer

authors： Epstein AL,Levy R,Kim H,Henle W,Henle G,Kaplan HS

更新日期：1978-11-01 00:00:00

abstract：:Actuarial progression-free survival rate at 5 years of a series of 34 patients with medulloblastoma treated by combined surgery, radiotherapy, and chemotherapy was 71%. No relapses were observed in 14 patients followed for more than 5 years. Treatment consisted of a short postoperative course of vincristine (VCR) and ...

journal_title：Cancer

authors： Bellani FF,Gasparini M,Lombardi F,Zucali R,Luccarelli G,Migliavacca F,Moise S,Nicola G

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND:Angiogenesis in individuals with various solid tumors has provided useful information on tumor progression and prognosis, and many examples of mast cell (MC) accumulation coupled with angiogenesis can be found in the literature. METHODS:Utilizing monoclonal antibodies for tryptase that are specific markers ...

journal_title：Cancer

authors： Takanami I,Takeuchi K,Naruke M

更新日期：2000-06-15 00:00:00

abstract：BACKGROUND:To evaluate the immunologic activity of regional lymph nodes, the phenotype of lymphocytes and the functional expression of cell adhesion molecules (CAMs) on lymph node lymphocytes (LNL-: uninvolved, LNL+: involved) were investigated in patients with gastrointestinal carcinoma. METHODS:The lymphocyte subpop...

journal_title：Cancer

authors： Shinkal H,Kitayama J,Kimura W,Muto T,Shibata Y

更新日期：1996-10-15 00:00:00

abstract：BACKGROUND:Carcinoid tumors are unusual and most reports are anecdotal or limited in number. A series of 2837 cases was published in 1975. No recent large series is available. METHODS:The authors evaluated 5468 cases identified by the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer In...

journal_title：Cancer

authors： Modlin IM,Sandor A

更新日期：1997-02-15 00:00:00

abstract：:To determine the impact of pulmonary infections on survival in patients with lung cancer, a retrospective review of the records of 121 such patients treated at Howard University Hospital in Washington, DC, was done. There were 77 men and 44 women; 118 were black. The mean age was 63.5 years. Forty-three patients had s...

journal_title：Cancer

authors： Perlin E,Bang KM,Shah A,Hursey PD,Whittingham WL,Hashmi K,Campbell L,Kassim OO

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND:Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) tests are commonly used to assess human epidermal growth factor 2 (HER2) status of tumors in patients with breast cancer. This analysis evaluates the likely cost-effectiveness of expanded retesting to assess HER2 tumor status in women w...

journal_title：Cancer

authors： Garrison LP Jr,Lalla D,Brammer M,Babigumira JB,Wang B,Perez EA

更新日期：2013-09-01 00:00:00

abstract：:The responses of 23 patients with agnogenic myeloid metaplasia (AMM) to androgen therapy were studied. Various clinical and laboratory parameters were analyzed for their value in determining response to therapy and length of survival. Fifty-seven percent of patients responded, as determined by a sustained increase in ...

journal_title：Cancer

authors： Besa EC,Nowell PC,Geller NL,Gardner FH

更新日期：1982-01-15 00:00:00

abstract：BACKGROUND:The increasing incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) highlights the need for simple and effective tools to evaluate head and neck lesions and their HPV status. The main objective of the current study was to investigate the association between abnormal c...

journal_title：Cancer

authors： Donà MG,Giuliani M,Vocaturo A,Spriano G,Pichi B,Rollo F,Ronchetti L,Covello R,Pescarmona E,Benevolo M

更新日期：2014-11-15 00:00:00

abstract：BACKGROUND:The authors sought to determine whether the availability of highly active antiretroviral therapy (HAART) coincided with changes in the epidemiology of acquired immunodeficiency syndrome (AIDS)-related non-Hodgkin lymphoma (NHL). METHODS:Cancer registry data from 1988-2000 were linked with AIDS registry data...

journal_title：Cancer

authors： Diamond C,Taylor TH,Aboumrad T,Anton-Culver H

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Although increasing rates of breast carcinoma incidence have been observed in Asian countries, appropriate strategies for detecting early stage breast carcinoma in such communities have been difficult to formulate, particularly because no large population screening trial specifically involving Asian women ha...

journal_title：Cancer

authors： Ng EH,Ng FC,Tan PH,Low SC,Chiang G,Tan KP,Seow A,Emmanuel S,Tan CH,Ho GH,Ng LT,Wilde CC

更新日期：1998-04-15 00:00:00

abstract：:A case report is presented, believed to be the first documented example of pleomorphic rhabdomyosarcoma developing in the larynx of a child. A review of the literature then follows, with evaluation of the epidemiology, treatment options, and survival of patients with this disease. Cure of this malignancy is more likel...

journal_title：Cancer

authors： Dodd-o JM,Wieneke KF,Rosman PM

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:p53 gene mutations at codon 249 have been reported in hepatocellular carcinoma (HCC) from China and South Africa, a phenomenon shown to be closely associated with food contamination by aflatoxin. There have been few reports, however, in regard to p53 gene mutations in HCC from other geographic areas. METHOD...

journal_title：Cancer

authors： Nose H,Imazeki F,Ohto M,Omata M

更新日期：1993-07-15 00:00:00

abstract：:Sixty patients with advanced prostatic carcinoma were treated with monthly subcutaneous injections of a depot formulation of goserelin, a luteinizing hormone-releasing hormone (LHRH) analogue (Zoladex, ICI Pharma, Destelbergen, Belgium). All patients were regularly evaluated with measurements of luteinizing hormone (L...

journal_title：Cancer

authors： Mahler C,Verhelst J,Chaban M,Denis L

更新日期：1991-02-01 00:00:00

abstract：:The anniversary of the first publication of Cancer provides an opportunity to review the progress in liver cancer surgery in the past 60 years. Indeed, the past half century has been witness to remarkable advances in liver surgery that have provided benefit to so many patients afflicted with primary or secondary liver...

journal_title：Cancer

authors： Tanabe KK

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Although caspase recruitment domain (CARD) membrane-associated guanylate kinase (MAGUK) protein 1 (CARMA1) and CARD9 play important roles in lymphocyte activation, the significance of CARMA1 and CARD9 in the pathogenesis of gastric mucosa-associated lymphoid tissue (MALT) lymphoma remains to be elucidated. ...

journal_title：Cancer

authors： Nakamura S,Nakamura S,Matsumoto T,Yada S,Hirahashi M,Suekane H,Yao T,Goda K,Iida M

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Salivary gland carcinomas (SGCs) are a rare malignancy with unknown etiology. The objective of the current study was to identify genetic variants modifying the risk of SGC and its major subtypes: adenoid cystic carcinoma and mucoepidermoid carcinoma. METHODS:The authors conducted a genome-wide association s...

journal_title：Cancer

authors： Xu L,Tang H,Chen DW,El-Naggar AK,Wei P,Sturgis EM

更新日期：2015-07-15 00:00:00

abstract：BACKGROUND:To compare the diagnostic value of thoracoscopic biopsy, fluid cytology, and Abrams needle biopsy, the authors analyzed prospectively the records of 188 patients with malignant pleural mesothelioma examined between 1973 and 1990. Symptoms were pleural effusion in 173 patients, empyema in 1, spontaneous pneum...

journal_title：Cancer

authors： Boutin C,Rey F

更新日期：1993-07-15 00:00:00

abstract：BACKGROUND:The purpose of the current study was to examine the surgical management of women with borderline ovarian tumors and the adequacy of initial staging according to the guidelines of the International Federation of Gynecology and Obstetrics; to evaluate the impact of restaging operations; and to identify risk fa...

journal_title：Cancer

authors： Fauvet R,Boccara J,Dufournet C,David-Montefiore E,Poncelet C,Daraï E

更新日期：2004-03-15 00:00:00

abstract：:The effectiveness of combination therapy with diethylstilbestrol, cyclophosphamide, and 5-fluorouracil (DES + CTx + FU) was compared with DES alone or CTx + FU in 87 postmenopausal women with advanced breast cancer. Therapy was randomized according to the tumor estrogen-receptor (ER) status. In 30 patients with ER-ric...

journal_title：Cancer

authors： Kiang DT,Frenning DH,Gay J,Goldman AI,Kennedy BJ

更新日期：1981-02-01 00:00:00

abstract：:The cellular DNA content of 15 benign and 34 malignant primary bone tumors was analyzed by means of flow cytophotometry. All benign tumors except one of questionable histologic type exhibited a normal DNA content (diploid), whereas 23 of 34 malignant tumors showed an abnormal DNA content (aneuploid). Closer analysis r...

journal_title：Cancer

authors： Kreicbergs A,Silvferswärd C,Tribukait B

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:The frequency of RET rearrangements (RET/PTC) in papillary thyroid carcinomas varies significantly according to geographic area, with the greatest incidence reported in the Belarus region, which is iodine-deficient and was contaminated severely after the Chernobyl reactor accident, and with the lowest incide...

journal_title：Cancer

authors： Nakazawa T,Kondo T,Kobayashi Y,Takamura N,Murata S,Kameyama K,Muramatsu A,Ito K,Kobayashi M,Katoh R

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:To the authors' knowledge there is little information available regarding the effectiveness of standard antiemetic therapy among cancer patients who receive emetogenic chemotherapy in clinical practice, especially in the pediatric population. The current study was undertaken to determine the effectiveness of...

journal_title：Cancer

authors： Holdsworth MT,Raisch DW,Frost J

更新日期：2006-02-15 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate a regimen of sequential chemotherapy and radiotherapy for patients with Hodgkin disease. METHODS:The Cancer and Leukemia Group B conducted a Phase II study of three cycles of etoposide, vinblastine, and doxorubicin (EVA) chemotherapy followed by subtotal lymph node radi...

journal_title：Cancer

authors： Wasserman TH,Petroni GR,Millard FE,Chung CT,Barcos M,Johnson JL,Canellos GP,Peterson BA

更新日期：1999-10-15 00:00:00

abstract：BACKGROUND:Recently, invasion of vascular spaces by endometrial carcinoma has received particular attention as a prognostic factor. The goal of the current investigation was to re-examine the effect of vascular invasion on tumor recurrence and survival in patients with endometrial carcinoma. METHODS:Surgical specimens...

journal_title：Cancer

authors： Inoue Y,Obata K,Abe K,Ohmura G,Doh K,Yoshioka T,Hoshiai H,Noda K

更新日期：1996-10-01 00:00:00

abstract：:The authors treated 32 patients with Stage IIIB or IV non-small cell lung cancer (NSCLC) with an outpatient regimen of edatrexate (10-ethyl-10-deaza-aminopterin) (10-EdAM) on days 1 and 8, cyclophosphamide on day 1, and cisplatin on day 1, repeated every 3 weeks with dose modification. The 22 men and 10 women (median ...

journal_title：Cancer

authors： Lee JS,Libshitz HI,Fossella FV,Murphy WK,Pang AC,Lippman SM,Shin DM,Dimery IW,Glisson BS,Hong WK

更新日期：1991-09-01 00:00:00