Abstract:
:Actuarial progression-free survival rate at 5 years of a series of 34 patients with medulloblastoma treated by combined surgery, radiotherapy, and chemotherapy was 71%. No relapses were observed in 14 patients followed for more than 5 years. Treatment consisted of a short postoperative course of vincristine (VCR) and intrathecal (IT) methotrexate (MTX) followed by irradiation to the entire cranio spinal axis. Maintenance chemotherapy (CCNU, VCR, and IT MTX) was then continued to encompass 2 years from surgery. Failure occurred in nine patients: four had local recurrence, four dissemination within the central nervous system, and one widespread skeletal metastases. Poor prognostic factors such as presence of malignant cells in the cerebrospinal fluid, non-radical surgery, young age, and radiation doses less than 50 Gy to the tumor bed, did not adversely affect the outcome of patients in this series. Long-term sequelae from the treatment program could be observed in all patients, and in 58% they were severe enough to interfere with normal, active life.
journal_name
Cancerjournal_title
Cancerauthors
Bellani FF,Gasparini M,Lombardi F,Zucali R,Luccarelli G,Migliavacca F,Moise S,Nicola Gdoi
10.1002/1097-0142(19841101)54:9<1956::aid-cncr2820subject
Has Abstractpub_date
1984-11-01 00:00:00pages
1956-61issue
9eissn
0008-543Xissn
1097-0142journal_volume
54pub_type
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