Comparison of intensive versus moderate chemotherapy of lymphocytic lymphomas: a progress report.

Abstract:

:In an Easter Cooperative Oncology Group trial, Cytoxan-prednisone (CP) Induction was compared to BCNU-prednisone (BP) in 273 patients with lymphocytic lymphoma. Response rates were comparable, with 21% achieving complete response and 40%, partial response. Patients with a nodular pattern responded better. Maintenance phase comparing cyclic intensive therapy (BCVP) with intermittent chlorambucil revealed the superiority of BCVP as demonstrated by improvement of the quality of response and somewhat longer remissions. The value of the Rappaport classification in the evaluation of lymphoma chemotherapy results is discussed. It is suggested tha NHL be separated into "favorable" and "unfavorable" groups, based on the presence or absence of nodularity and treatment schedules devised accordingly.

journal_name

Cancer

journal_title

Cancer

authors

Ezdinli E,Pocock S,Berard CW,Aungst CW,Silverstein M,Horton J,Bennett J,Bakemeier R,Stolbach L,Perlia C,Brunk SF,Lenhard RE,Klaassen DJ,Richter P,Carbone P

doi

10.1002/1097-0142(197609)38:3<1060::aid-cncr282038

subject

Has Abstract

pub_date

1976-09-01 00:00:00

pages

1060-8

issue

3

eissn

0008-543X

issn

1097-0142

journal_volume

38

pub_type

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