Abstract:
:In an Easter Cooperative Oncology Group trial, Cytoxan-prednisone (CP) Induction was compared to BCNU-prednisone (BP) in 273 patients with lymphocytic lymphoma. Response rates were comparable, with 21% achieving complete response and 40%, partial response. Patients with a nodular pattern responded better. Maintenance phase comparing cyclic intensive therapy (BCVP) with intermittent chlorambucil revealed the superiority of BCVP as demonstrated by improvement of the quality of response and somewhat longer remissions. The value of the Rappaport classification in the evaluation of lymphoma chemotherapy results is discussed. It is suggested tha NHL be separated into "favorable" and "unfavorable" groups, based on the presence or absence of nodularity and treatment schedules devised accordingly.
journal_name
Cancerjournal_title
Cancerauthors
Ezdinli E,Pocock S,Berard CW,Aungst CW,Silverstein M,Horton J,Bennett J,Bakemeier R,Stolbach L,Perlia C,Brunk SF,Lenhard RE,Klaassen DJ,Richter P,Carbone Pdoi
10.1002/1097-0142(197609)38:3<1060::aid-cncr282038subject
Has Abstractpub_date
1976-09-01 00:00:00pages
1060-8issue
3eissn
0008-543Xissn
1097-0142journal_volume
38pub_type
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