Potential impact on tumor control and organ preservation with cisplatin and 5-fluorouracil for patients with advanced tumors of the paranasal sinuses and nasal fossa. A prospective pilot study.


METHODS:Twelve patients with advanced epithelial nonadenocarcinoma of the paranasal sinuses and nasal fossa were treated with three cycles of cisplatin (100 mg/m2, day 1) and 5-fluorouracil (1000 mg/m2/24 hours on days 1-5 by continuous infusion), followed by preoperative external radiation therapy of 48 Gy and limited surgery, clearing the paranasal sinuses and nasal fossa. RESULTS:After chemotherapy, 11 of 12 patients were free of the previous symptoms of disease. Clinical response rates were different, however, with an overall response rate of approximately 70% with no complete responses. Histopathologic analysis of resected specimens showed no vital tumor in eight patients, minimal microscopic disease in three patients, and infiltrating tumor in one patient. Local control was achieved in 11 of 12 patients. Ten patients are alive with no evidence of disease (mean follow-up, 27 months). Surgical mutilation was avoided, with no functional or cosmetic loss. CONCLUSIONS:The results of this small pilot study seem to indicate a high chemosensitivity of carcinomas of the paranasal sinuses and nasal fossa, which, in this study, has meant significant relief of symptoms and an unusually high rate of local control (90%) without mutilation.






Björk-Eriksson T,Mercke C,Petruson B,Ekholm S




Has Abstract


1992-12-01 00:00:00














  • PEG-IFN-alpha-2b therapy in BCR-ABL-negative myeloproliferative disorders: final result of a phase 2 study.

    abstract:BACKGROUND:Interferon-alpha (IFN-alpha) has shown significant activity in the treatment of BCR-ABL-negative myeloproliferative disorders (MPDs), particularly essential thrombocythemia (ET) and polycythemia vera (PV). PEG-IFN-alpha-2b is a pegylated IFN-alpha-2b with a significant advantage over nonpegylated form in tha...


    pub_type: 杂志文章


    authors: Jabbour E,Kantarjian H,Cortes J,Thomas D,Garcia-Manero G,Ferrajoli A,Faderl S,Richie MA,Beran M,Giles F,Verstovsek S

    更新日期:2007-11-01 00:00:00

  • Genetic testing and counseling for hereditary forms of colorectal cancer.

    abstract::The discovery of genes responsible for inherited forms of colorectal cancer have the potential to improve cancer risk assessment and counseling. Germline mutations (nonsense, frameshift) of APC are associated with familial adenomatous polyposis, an autosomal dominant syndrome, clinically characterized by young onset, ...


    pub_type: 杂志文章,评审


    authors: Petersen GM,Brensinger JD,Johnson KA,Giardiello FM

    更新日期:1999-12-01 00:00:00

  • Manual dissection of adenocarcinoma of the lower third of the rectum specimens for detection of lymph node metastases smaller than 5 mm.

    abstract:BACKGROUND:The question of whether manual dissection when searching for metastatic lymph nodes from rectal cancer (less than 5 mm) is a reliable method remains controversial. METHODS:We examined 50 consecutive cases of primary adenocarcinoma of the rectum treated with a sphincter-sparing total rectum resection, total ...


    pub_type: 杂志文章


    authors: Andreola S,Leo E,Belli F,Bufalino R,Tomasic G,Lavarino C,Baldini MT,Meroni E

    更新日期:1996-02-15 00:00:00

  • The pathophysiology of undernutrition in the child with cancer.

    abstract::The physiologic consequences of malnutrition in children with cancer are reviewed. It is stressed that the child with cancer has a nutritional state that is no different from the average population from which the child comes. What little malnutrition is seen is calorie malnutrition. The physiologic consequences are th...


    pub_type: 杂志文章


    authors: van Eys J

    更新日期:1986-10-15 00:00:00

  • Chondrosarcoma with additional mesenchymal component (dedifferentiated chondrosarcoma). II. An immunohistochemical and electron microscopic study.

    abstract::Light microscopic, immunocytochemical and ultrastructural studies were performed on chondrosarcomas which contained a second, noncartilagenous mesenchymal component. Attention was focused on the nonchondroid portion of each tumor in an attempt to elucidate the histogenesis of this mixed variant of chondrosarcoma. The ...


    pub_type: 杂志文章


    authors: Têtu B,Ordóñez NG,Ayala AG,Mackay B

    更新日期:1986-07-15 00:00:00

  • Determinants of the recommended phase 2 dose of molecular targeted agents.

    abstract:BACKGROUND:The recommended phase 2 dose (RP2D) of anticancer agents is determined traditionally by dose-limiting toxicities. Nontoxicity or biological endpoints such as pharmacokinetics, pharmacodynamics, and efficacy can also be used to identify RP2D, which may be relevant to molecularly targeted agents (MTAs). METHO...


    pub_type: 杂志文章,meta分析


    authors: Hansen AR,Cook N,Amir E,Siu LL,Abdul Razak AR

    更新日期:2017-04-15 00:00:00

  • Disparities in participation in cancer clinical trials in the United States : a symptom of a healthcare system in crisis.

    abstract::Disparities in minorities' representation in cancer clinical trials have been shown only in adult populations, which suggest that the main causes of these disparities relate to health system-based barriers, including issues of poverty (lack of insurance), poor access to trials, and an inadequate number of clinical tri...


    pub_type: 杂志文章


    authors: Colon-Otero G,Smallridge RC,Solberg LA Jr,Keith TD,Woodward TA,Willis FB,Dunn AN

    更新日期:2008-02-01 00:00:00

  • A phase 2 study of glembatumumab vedotin, an antibody-drug conjugate targeting glycoprotein NMB, in patients with advanced melanoma.

    abstract:BACKGROUND:Glembatumumab vedotin is an antibody-drug conjugate that produced preliminary clinical activity against advanced melanoma in a phase 1 dose-escalation trial. The objective of the current study was to investigate further the antitumor activity of glembatumumab vedotin at the recommended phase 2 dose in heavil...


    pub_type: 杂志文章


    authors: Ott PA,Pavlick AC,Johnson DB,Hart LL,Infante JR,Luke JJ,Lutzky J,Rothschild NE,Spitler LE,Cowey CL,Alizadeh AR,Salama AK,He Y,Hawthorne TR,Bagley RG,Zhang J,Turner CD,Hamid O

    更新日期:2019-04-01 00:00:00

  • Active immunotherapy of human solid tumor with autologous cells treated with cholesteryl hemisuccinate. A Phase I study.

    abstract::A marked increase in specific immunogenicity of tumor cells is induced upon incorporation of cholesteryl hemisuccinate (CHS) into the cell membrane, which presumably promotes the expression of latent tumor-associated antigens. Immunotherapy with CHS-treated and irradiated tumor cells as vaccine was found to be very ef...


    pub_type: 临床试验,杂志文章


    authors: Skornick YG,Rong GH,Sindelar WF,Richert L,Klausner JM,Rozin RR,Shinitzky M

    更新日期:1986-08-01 00:00:00

  • Clinical impact of sedentary behaviors in adult survivors of acute lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort study.

    abstract:BACKGROUND:Sedentary behaviors are associated with poor health outcomes in the general population, but their clinical impact on adult survivors of childhood acute lymphoblastic leukemia (ALL) has not been characterized to date. In the current study, we described the prevalence of sedentary behaviors in survivors of ALL...


    pub_type: 杂志文章


    authors: Howell CR,Wilson CL,Ehrhardt MJ,Partin RE,Kaste SC,Lanctot JQ,Pui CH,Robison LL,Hudson MM,Ness KK

    更新日期:2018-03-01 00:00:00

  • Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice: analyses of tumor heterogenity in relation to the immunohistochemical levels of expression of cyclooxygenase-2, ornithine decarboxylase, lung-related resista

    abstract:BACKGROUND:Nonsmall cell lung carcinomas (NSCLCs) are associated with very dismal prognoses, and adjuvant chemotherapy, including irinotecan, taxanes, platin, and vinca alkaloid derivatives, offer patients only slight clinical benefits. Part of the chemoresistance of NSCLC results from the expression in NSCLC cells of ...


    pub_type: 杂志文章


    authors: Mathieu A,Remmelink M,D'Haene N,Penant S,Gaussin JF,Van Ginckel R,Darro F,Kiss R,Salmon I

    更新日期:2004-10-15 00:00:00

  • Treatment of the patient with cancer using parenteral electronic drug administration.

    abstract::Oncologic therapy demands technologic sophistication to meet the clinical challenges of proper drug administration for chemotherapeutic agents, pain management, antibiotics, hydration, antiemetic drugs, and total parenteral nutrition. Drug administration systems for patient-controlled analgesia include benefits of imp...


    pub_type: 杂志文章,评审


    authors: Shaw HL

    更新日期:1992-08-15 00:00:00

  • Primary combined malignant melanoma and ductal carcinoma of the breast. A report of two cases.

    abstract:BACKGROUND:Tumors consisting of a combination of malignant melanoma and carcinoma are very rare. The authors report two such cases occurring as primary breast tumors. METHODS:The breast tumors were analyzed by histologic, immunohistochemical, and ultrastructural techniques. RESULTS:Histologically, the tumors were com...


    pub_type: 杂志文章


    authors: Padmore RF,Lara JF,Ackerman DJ,Gales T,Sigurdson ER,Ehya H,Cooper HS,Patchefsky AS

    更新日期:1996-12-15 00:00:00

  • The role of radiation therapy in the multidisciplinary management of recurrent and metastatic breast cancer.

    abstract::Carcinoma of the breast is a disease that is associated with 10-year recurrence rates of 25% in operable patients with no spread to the axillary nodes and 75% in patients in whom the tumor has extended to the axillary nodes. Locoregional recurrence rates of close to 50% have been reported in patients with Stage III di...


    pub_type: 杂志文章


    authors: Marcial VA

    更新日期:1994-07-01 00:00:00

  • The Breast and Cervical Cancer Early Detection Program, Medicaid, and breast cancer outcomes among Ohio's underserved women.

    abstract:BACKGROUND:As an organized screening program, the national Breast and Cervical Cancer Early Detection Program (BCCEDP) was launched in the early 1990s to improve breast cancer outcomes among underserved women. To analyze the impact of the BCCEDP on breast cancer outcomes in Ohio, this study compared cancer stages and m...


    pub_type: 杂志文章


    authors: Koroukian SM,Bakaki PM,Htoo PT,Han X,Schluchter M,Owusu C,Cooper GS,Rose J,Flocke SA

    更新日期:2017-08-15 00:00:00

  • Diagnostic utility of bilateral bone marrow examination: significance of morphologic and ancillary technique study in malignancy.

    abstract:BACKGROUND:To retrospectively evaluate the significance of morphologic examination and ancillary studies performed on bilateral bone marrow biopsy specimens, 1864 bone marrow samples were studied. METHODS:Bilateral bone marrow biopsy specimens included 883 specimens that were evaluated for involvement by non-Hodgkin l...


    pub_type: 杂志文章


    authors: Wang J,Weiss LM,Chang KL,Slovak ML,Gaal K,Forman SJ,Arber DA

    更新日期:2002-03-01 00:00:00

  • Comparison of clinical schemas and morphologic features in predicting Lynch syndrome in mutation-positive patients with endometrial cancer encountered in the context of familial gastrointestinal cancer registries.

    abstract:BACKGROUND:Endometrial cancer (EC) is the most common extraintestinal malignancy in Lynch syndrome (LS) and often is the sentinel malignancy, yet there is no consensus regarding LS-EC detection algorithms. In this study, the authors determined the efficacy of family/personal history and tumor morphology in predicting L...


    pub_type: 杂志文章


    authors: Ryan P,Mulligan AM,Aronson M,Ferguson SE,Bapat B,Semotiuk K,Holter S,Kwon J,Kalloger SE,Gilks CB,Gallinger S,Pollett A,Clarke BA

    更新日期:2012-02-01 00:00:00

  • Reproductive history and prognosis in patients with operable breast cancer.

    abstract:BACKGROUND:Late menarche, early menopause, high parity, and early first birth decrease the risk of development of breast cancer. The influence of these factors on the survival of breast cancer patients has not been explained. METHODS:A group of 1885 patients with operable breast cancer was studied retrospectively. A u...


    pub_type: 杂志文章


    authors: Korzeniowski S,Dyba T

    更新日期:1994-09-01 00:00:00

  • Adriamycin cardiotoxicity in children: case reports, literature review, and risk factors.

    abstract::Two children with Wilms' tumor and prior thoracic radiation developed congestive heart failure at cumulative adriamycin doses of 350 mg/m2 and 400 mg/m2. Details of these two cases and a summary of previously reported adriamycin cardiotoxicity in children are presented. Dose recommendations and predictive tests are di...


    pub_type: 杂志文章,评审


    authors: Prout MN,Richards MJ,Chung KJ,Joo P,Davis HL Jr

    更新日期:1977-01-01 00:00:00

  • Clinical impact of molecular genetic diagnosis, genetic counseling, and management of hereditary cancer. Part I: Studies of cancer in families.

    abstract::Hereditary cancer represents approximately 5-10% of the total cancer burden and may account for 60,000 to 120,000 new cancer occurrences this year in the United States. New developments in molecular genetics and the cloning of cancer-prone genes have intensely fueled interest in dealing with hereditary forms of cancer...


    pub_type: 杂志文章


    authors: Lynch HT,Watson P,Shaw TG,Lynch JF,Harty AE,Franklin BA,Kapler CR,Tinley ST,Liu B

    更新日期:1999-12-01 00:00:00

  • The frequency of founder mutations in the BRCA1, BRCA2, and APC genes in Australian Ashkenazi Jews: implications for the generality of U.S. population data.

    abstract:BACKGROUND:Several studies have shown that Ashkenazi Jews in the United States and Israel have a high prevalence of the founder mutations BRCA1 185delAG, BRCA1 5382insC, BRCA2 6174delT, and APC I1307K at frequencies of 1.0--1.1%, 0.2--0.3%, 0.6--1.4%, and 6.1--7.0%, respectively. The objective of this study was to comp...


    pub_type: 杂志文章


    authors: Bahar AY,Taylor PJ,Andrews L,Proos A,Burnett L,Tucker K,Friedlander M,Buckley MF

    更新日期:2001-07-15 00:00:00

  • Reliability of computer image analysis of pigmented skin lesions of Australian adolescents.

    abstract:BACKGROUND:The diagnosis of melanomas at an early stage is associated with improved survival, so the recognition of changes in pigmented skin lesions over time is important. We have developed a computer imaging system with the aim of assisting clinicians in differentiating early melanomas from benign pigmented skin les...


    pub_type: 杂志文章


    authors: Aitken JF,Pfitzner J,Battistutta D,O'Rourke PK,Green AC,Martin NG

    更新日期:1996-07-15 00:00:00

  • Intrahepatic infusional therapy for metastatic ovarian carcinoma.

    abstract::Twenty-four women with ovarian carcinoma that had metastasized to the liver were treated with intrahepatic infusional therapy. No consistent drug regimen was used. There were no complete responders; however, 33% had a partial response. All responses were noticed after the first course of therapy. The median length of ...


    pub_type: 杂志文章


    authors: Malone JM Jr,Gershenson DM,Carrasco CH,Charansangavej C,Copeland LJ,Larson DM,Kavanagh JJ,Edwards CL,Wallace S

    更新日期:1987-06-01 00:00:00

  • Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapy.

    abstract:BACKGROUND:The goal of the current study was to define the clinical features and outcome of recurrent osteosarcoma (OS) in children and young adults initially treated with contemporary chemotherapy. METHODS:The authors reviewed the clinical features, therapy, and outcome for 59 patients from the Mayo Clinic (Rochester...


    pub_type: 杂志文章


    authors: Hawkins DS,Arndt CA

    更新日期:2003-12-01 00:00:00

  • Malignant epithelial tumors in the minor salivary glands, the submandibular gland, and the sublingual gland. Prognostic factors and treatment results.

    abstract::Ninety-five malignant tumors in the submandibular gland, the sublingual gland, and the minor salivary glands seen in a 25-year period were reviewed. The patients were retrospectively staged using the Union Internationale Contre le Cancer (UICC) classification. The most frequent tumor was adenoid cystic carcinoma, foll...


    pub_type: 杂志文章


    authors: Andersen LJ,Therkildsen MH,Ockelmann HH,Bentzen JD,Schiødt T,Hansen HS

    更新日期:1991-12-01 00:00:00

  • Focal, high dose, and fractionated modified stereotactic radiation therapy for lung carcinoma patients: a preliminary experience.

    abstract:BACKGROUND:Stereotactic radiation therapy is highly effective in the treatment of small brain metastases, regardless of the histology. This suggests that small extracranial malignancies may be curable with similar radiation therapy. The authors developed a novel treatment unit for administering such therapy. METHODS:T...


    pub_type: 杂志文章


    authors: Uematsu M,Shioda A,Tahara K,Fukui T,Yamamoto F,Tsumatori G,Ozeki Y,Aoki T,Watanabe M,Kusano S

    更新日期:1998-03-15 00:00:00

  • Comparison of clinical staging algorithms and 111indium-capromab pendetide immunoscintigraphy in the prediction of lymph node involvement in high risk prostate carcinoma patients.

    abstract:BACKGROUND:The pretherapy prediction of occult lymph node involvement and the avoidance of otherwise futile and potentially morbid definitive local therapy is paramount in men with newly diagnosed prostate carcinoma. To identify patients with prostate carcinoma who likely have lymph node involvement and would benefit f...


    pub_type: 临床试验,杂志文章


    authors: Polascik TJ,Manyak MJ,Haseman MK,Gurganus RT,Rogers B,Maguire RT,Partin AW

    更新日期:1999-04-01 00:00:00

  • Phase II trial of 4'-0-tetrahydropyranyladriamycin (pirarubicin) in head and neck carcinoma.

    abstract:BACKGROUND:4'-0-tetrahydropyranyladriamycin (Pirarubicin, Meiji Seika (USA) Inc., New York, NY) may be less toxic than doxorubicin. METHODS:A Phase II trial of Pirarubicin was done in 26 patients who had not previously had chemotherapy and who had measurable and incurable head and neck carcinoma. All patients received...


    pub_type: 临床试验,杂志文章


    authors: Sridhar KS,Hussein AM,Benedetto P,Ardalan B,Savaraj N,Richman SP

    更新日期:1992-09-15 00:00:00

  • Breast cancers presenting luminal B subtype features show higher discordant human epidermal growth factor receptor 2 results between immunohistochemistry and fluorescence in situ hybridization.

    abstract:BACKGROUND:The aims of this study were to compare human epidermal growth factor receptor 2 (HER2) results between immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), and to investigate the clinicopathological characteristics and outcomes according to their results. METHODS:Using consecutive tissu...


    pub_type: 杂志文章


    authors: Park S,Park HS,Koo JS,Yang WI,Kim SI,Park BW

    更新日期:2012-02-15 00:00:00

  • A prospective pilot study of curative-intent stereotactic body radiation therapy in patients with 5 or fewer oligometastatic lesions.

    abstract:BACKGROUND:It is hypothesized that oligometastatic disease represents a state of potentially curable, limited metastases. Stereotactic body radiation therapy (SBRT) is an option for patients who are not amenable to or do not want resection. METHODS:From 2001 to 2006, 121 patients with < or =5 detectable metastases wer...


    pub_type: 临床试验,杂志文章


    authors: Milano MT,Katz AW,Muhs AG,Philip A,Buchholz DJ,Schell MC,Okunieff P

    更新日期:2008-02-01 00:00:00