The use of serial CEA determinations to predict recurrence of colon cancer and when to do a second-look operation.

Abstract:

:The concept of second-look surgery was introduced by Wangensteen 25 years ago, and 17% of patients were reported to be converted to a cancer-free state. Instead of an arbitrary time interval for reoperation, serial CEA values were used as the indicator of colon cancer recurrence and second-look operation. Twenty-two retrospective and 18 prospective patients were evaluable. There was no operative mortality. The CEA Nomogram was used to determine whether the CEA change was significant. All patient-samples were analyzed in duplicate, stored, and compared with the most recent sample; therefore, each patient served as his own control. The prospective results emphasize the importance of minimizing the time delay between a significant change in CEA values and reoperation. Equally important are the frequency of serial determinations (every one or two months), a thorough understanding of the limitations of the CEA radioimmunoassay, and the clinical condition of the patient.

journal_name

Cancer

journal_title

Cancer

authors

Minton JP,Martin EW Jr

doi

10.1002/1097-0142(197809)42:3+<1422::aid-cncr28204

subject

Has Abstract

pub_date

1978-09-01 00:00:00

pages

1422-7

issue

3 Suppl

eissn

0008-543X

issn

1097-0142

journal_volume

42

pub_type

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