Abstract:
:The concept of second-look surgery was introduced by Wangensteen 25 years ago, and 17% of patients were reported to be converted to a cancer-free state. Instead of an arbitrary time interval for reoperation, serial CEA values were used as the indicator of colon cancer recurrence and second-look operation. Twenty-two retrospective and 18 prospective patients were evaluable. There was no operative mortality. The CEA Nomogram was used to determine whether the CEA change was significant. All patient-samples were analyzed in duplicate, stored, and compared with the most recent sample; therefore, each patient served as his own control. The prospective results emphasize the importance of minimizing the time delay between a significant change in CEA values and reoperation. Equally important are the frequency of serial determinations (every one or two months), a thorough understanding of the limitations of the CEA radioimmunoassay, and the clinical condition of the patient.
journal_name
Cancerjournal_title
Cancerauthors
Minton JP,Martin EW Jrdoi
10.1002/1097-0142(197809)42:3+<1422::aid-cncr28204subject
Has Abstractpub_date
1978-09-01 00:00:00pages
1422-7issue
3 Suppleissn
0008-543Xissn
1097-0142journal_volume
42pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Peritoneal metastases are one reason for the poor prognosis of scirrhous gastric cancer. However, the mechanism of peritoneal metastasis remains unclear. We therefore investigated the interaction between gastric cancer cells and peritoneal fibroblasts, in vivo and in vitro. METHODS:A human scirrhous gastric...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960415)77:8<1668::AID-CN
更新日期:1996-04-15 00:00:00
abstract:BACKGROUND:Neurofibroma of the urinary bladder is rare. Only isolated case reports have appeared. Information regarding the long term follow-up of patients with neurofibroma is limited. METHODS:The authors studied 4 cases of neurofibroma of the bladder diagnosed at Mayo Clinic from 1965 through 1990. Immunostains for ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Sunitinib malate is an orally bioavailable tyrosine kinase inhibitor that is active against many tyrosine kinase receptors involving crucial pathways in both healthy tissues and malignant tissues. Because its use in clinical practice is quite recent, many of its possible side effects remain unknown. In this ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26435
更新日期:2012-06-15 00:00:00
abstract::Sixty patients with advanced prostatic carcinoma were treated with monthly subcutaneous injections of a depot formulation of goserelin, a luteinizing hormone-releasing hormone (LHRH) analogue (Zoladex, ICI Pharma, Destelbergen, Belgium). All patients were regularly evaluated with measurements of luteinizing hormone (L...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910201)67:3<557::aid-cncr28206
更新日期:1991-02-01 00:00:00
abstract:BACKGROUND:The current study examines 1) the sensitivity of detection and 2) sampling and screening/diagnostic error in the cytologic diagnosis of adenocarcinoma in situ (AIS) of the cervix. The data were taken from public and private sector screening laboratories reporting 25,000 and 80,000 smears, respectively, each ...
journal_title:Cancer
pub_type: 评论,杂志文章
doi:10.1002/cncr.10886
更新日期:2002-12-25 00:00:00
abstract::Because Forssman antigen, one of the most well-known heteroantigens, has been noted in certain cancerous tissues, it would seem that the serum levels of the Forssman antibody of patients with these cancers would be low, owing to the absorption of the naturally occurring antibody by the Forssman antigen-containing canc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890415)63:8<1528::aid-cncr2820
更新日期:1989-04-15 00:00:00
abstract:BACKGROUND:Theoretical considerations have raised the suspicion that transurethral resection of the prostate (TURP) may increase the risk of developing prostate cancer in clinically benign prostate glands. Previous studies have not shown an increased risk among men who had undergone TURP for benign prostatic hyperplasi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19941015)74:8<2347::aid-cncr2820
更新日期:1994-10-15 00:00:00
abstract:BACKGROUND:RUNX3 is a tumor suppressor that plays important roles in cell proliferation, apoptosis, and metastasis. The authors investigated the role of RUNX3 in melanoma pathogenesis and analyzed the prognostic impact of RUNX3 expression in a large series of melanoma patients. METHODS:Two sets of tissue microarrays w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25838
更新日期:2011-06-15 00:00:00
abstract:BACKGROUND:Tamoxifen and aminoglutethimide are two hormone therapies reported to be effective palliative approaches for patients with metastatic breast cancer. The current trial was designed to evaluate their relative therapeutic effectiveness. METHODS:Two hundred forty-nine postmenopausal women with advanced breast c...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/1097-0142(19940115)73:2<354::aid-cncr28207
更新日期:1994-01-15 00:00:00
abstract::In an article published in this issue of Cancer, D'Arcy et al link the incidence of cancer among recipients of solid organ transplantation (SOT) in the Scientific Registry of Transplant Recipients with data from regional and statewide cancer registries to examine cancer-specific mortality for common malignancies in SO...
journal_title:Cancer
pub_type: 评论,杂志文章
doi:10.1002/cncr.31963
更新日期:2019-03-15 00:00:00
abstract::The authors discovered some errors regarding reference group labels in Table 2. The corrected table is attached. The authors regret these errors. ...
journal_title:Cancer
pub_type: 已发布勘误
doi:10.1002/cncr.29118
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:The spontaneous formation of neutralizing antibodies (inhibitors) to factor VIII (FVIII) in patients with cancer is a well known phenomenon. However, to the authors' knowledge there is lack of information in the literature with respect to the clinical course of these patients and the nature of the associatio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010315)91:6<1067::aid-cncr1101
更新日期:2001-03-15 00:00:00
abstract::An unusual upper esophageal polypoid tumor was found to be predominantly a carcinoid tumor and in part a mucin-producing adenocarcinoma. A review of literature showed this to be a unique tumor in this location. ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197911)44:5<1853::aid-cncr282044
更新日期:1979-11-01 00:00:00
abstract::The records of 51 patients with esophageal carcinoma were reviewed. Twenty-two patients underwent attempted curative resection with a mean survival of 7.7 months. Twenty patients underwent primary radiotherapy (mean survival, 4.3 months). Nine patients received palliative therapy alone (mean survival, 2.8 months). Sur...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840901)54:5<918::aid-cncr28205
更新日期:1984-09-01 00:00:00
abstract::Patients with cancer experience a much higher than expected incidence of thromboembolic disorders, commonly referred as Trousseau syndrome. Although this association has been well documented, the etiology of the hypercoagulable state is not known. The expression on tumor cells of tissue factor (TF), a membrane-bound l...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920901)70:5<1194::aid-cncr2820
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Nodal status is one of the most important prognostic factors for distal bile duct cancer. The pattern of lymphatic spread of distal bile duct cancer was analyzed by determining the frequency of involvement of various lymph nodes. MATERIALS AND METHODS:From 1973 to 1991, 29 patients with distal bile duct can...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931001)72:7<2112::aid-cncr2820
更新日期:1993-10-01 00:00:00
abstract::The mitogen-activated protein kinase/extracellular signal-regulated (MAPK/ERK) pathway is activated by upstream genomic events and/or activation of multiple signaling events in which information coalesces at this important nodal pathway point. This pathway is tightly regulated under normal conditions by phosphatases a...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.28864
更新日期:2014-11-15 00:00:00
abstract::This study is based on 38 patients, each of whom had a malignant lymphoma in which the gonad was the site of the main tumor mass at the time of diagnosis. Histiocytic lymphoma was the predominant type in the 27 male patients; in the 11 female patients, poorly differentiated lymphocytic lymphoma was the most frequent t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800201)45:3<561::aid-cncr28204
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:Quantified, human hemoglobin (Hb)-specific, immunochemical fecal occult blood test (IFOBT) measurements are now used for colorectal cancer (CRC) screening. The objective was to evaluate sensitivity and specificity for CRC and advanced adenomatous polyps (APs) by the fecal Hb threshold used to determine a pos...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25012
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Compared with free drug, sterically stabilized liposomal drug has prolonged circulation time and, thereby, higher tumor selectivity and antitumor activity. The stability in plasma is an important consideration in the formulation of clinically useful liposomal drug. A Phase I study of a stable liposomal doxor...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:The incidence of adenocarcinoma of the cervix did not decline in Western countries in the 1970s and 1980s despite the availability and use of cervical cytologic screening. The impact of improved endocervical sampling and better recognition of the cytologic precursors to adenocarcinoma during the 1990s in red...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11835
更新日期:2003-12-25 00:00:00
abstract::The continuity that exists between Hodgkin's disease and the fibrohistiocytoses has only recently been recognized. Four cases are presented that illustrate this phenomenon. The fibrohistiocytic component of the Hodgkin's lesion may lag behind the lymphoreticular component, may be present in equal proportion, or may as...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860115)57:2<264::aid-cncr28205
更新日期:1986-01-15 00:00:00
abstract:BACKGROUND:The objective of this study was to evaluate the efficacy and toxicity of a high-dose 5-fluorouracil and actinomycin D regimen (the FA regimen) as salvage chemotherapy for patients with high-risk gestational trophoblastic tumors (GTTs). METHODS:From 1985 to 1997, 10 patients with refractory, high-risk GTTs w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10790
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:A combination regimen comprised of docetaxel, gemcitabine, and granulocyte-colony stimulating factor (G-CSF) was studied in patients with advanced nonsmall cell lung carcinoma (NSCLC) to determine its antitumor efficacy and tolerance. METHODS:Thirty-four patients with advanced measurable NSCLC (3 patients w...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND:The identification of high risk patients with endometrial carcinoma is considered essential for individualized therapy to improve prognosis and avoid overtreatment. The goal of the current study was to investigate the prognostic value of nuclear morphometry, particularly for patients with localized endometri...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:Sequential systematic biopsies after radiotherapy (RT) for prostate carcinoma were evaluated with respect to radiation effect, tumor differentiation, and prostate specific antigen (PSA) staining, and these histopathologic parameters were correlated with local outcome. METHODS:Since 1990, transrectal ultraso...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Historically, patients with nonmetastatic renal cell carcinoma (RCC) involving adjacent organs have been considered inoperable and incurable. The oncologic efficacy of an aggressive surgical approach was evaluated in a selected subpopulation of RCC patients. Further, an attempt was made to define the clinica...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22629
更新日期:2007-05-15 00:00:00
abstract::Pain management often is difficult in patients with bone metastases. Metastatic disease represents >40% of oncologic practice, and >70% of patients with metastatic disease have uncontrolled cancer-related pain. Significant morbidity caused by pathologic fracture and spinal cord compression can result from untreated bo...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19971015)80:8+<1628::aid-c
更新日期:1997-10-15 00:00:00
abstract:BACKGROUND:Carfilzomib improves survival in patients with recurrent myeloma. Given the strict eligibility criteria in clinical trials, the actual frequency of cardiac adverse events (CAEs) and pulmonary adverse events (PAEs) and the risk factors associated with these AEs in the general population need to be established...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32601
更新日期:2020-02-15 00:00:00
abstract:BACKGROUND:National Cancer Institute (NCI)/National Comprehensive Cancer Network (NCCN)-designated cancer centers (CCs) offer patients state-of-the-art treatment, but their impact on multiple myeloma (MM) patient outcomes has not been evaluated. METHODS:Adult MM patients diagnosed between 1973 and 2011 were identified...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29771
更新日期:2016-02-15 00:00:00