Cumulative evaluation of a quantitative immunochemical fecal occult blood test to determine its optimal clinical use.

Abstract:

BACKGROUND:Quantified, human hemoglobin (Hb)-specific, immunochemical fecal occult blood test (IFOBT) measurements are now used for colorectal cancer (CRC) screening. The objective was to evaluate sensitivity and specificity for CRC and advanced adenomatous polyps (APs) by the fecal Hb threshold used to determine a positive test and the number of IFOBTs prepared per test, so as to determine the least number of colonoscopies required to detect a neoplasm. METHODS:Cumulative data were analyzed from a prospective cross-sectional double-blind study of 1682 consecutive, ambulatory, nonbleeding colonoscopy patients who volunteered for IFOBTs, most of above average risk, from 3 ambulatory-endoscopy centers. Fecal Hb was measured in 3 samples and analyzed by an automated instrument, and the highest result >or=50 ng Hb/mL of buffer was related to findings. RESULTS:Colonoscopy identified CRC in 20 patients and advanced APs in 129. Sensitivity for either was best when any of 3 tests had >or=50 ng Hb/mL of buffer; sensitivity was 61.1% (95% confidence interval [CI], 53.2-68.9), and specificity was 87.8% (95% CI, 86.2-89.4). Positive tests identified 100% of CRCs and 55% of advanced APs every 3.1 colonoscopies. Sensitivity of a single test at the commonly used 100-ng Hb/mL threshold was lower at 31.5% (95% CI, 24.1-39.0) (P<.001), but specificity was higher at 96.4% (95% CI, 95.5-97.3) (P<.001). Positive tests identified 65% of CRCs and 26.4% of advanced APs every 2.2 colonoscopies. CONCLUSIONS:The fecal Hb cutoff chosen by the screener and the number of samples collected per patient determine sensitivity and specificity for CRC/advanced AP; these factors determine the number of colonoscopies needed for positive tests and neoplasia yield. This information provides guidelines for IFOBT screening. Limitations are 1-time screening and most examinees not being at average risk for CRC.

journal_name

Cancer

journal_title

Cancer

authors

Rozen P,Comaneshter D,Levi Z,Hazazi R,Vilkin A,Maoz E,Birkenfeld S,Niv Y

doi

10.1002/cncr.25012

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

2115-25

issue

9

eissn

0008-543X

issn

1097-0142

journal_volume

116

pub_type

杂志文章

相关文献

CANCER文献大全
  • Nickel-related cancers of the respiratory tract.

    abstract::Nickel-related cancers of the respiratory tract have been recognized for nearly 50 years and represent a unique opportunity for prevention among refinery workers. Studies of exposed employees have been conducted in which evaluations were made of the histopathologic changes in the respiratory mucosa and the body burden...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800615)45:12<3061::aid-cncr282

    authors: Barton RT,Hogetveit AC

    更新日期:1980-06-15 00:00:00

  • Multiple early gastric carcinomas. Clinicopathologic features and histogenesis.

    abstract:BACKGROUND:Multiple early gastric carcinomas were found in 5-15% of patients with early gastric carcinoma. The goals of this study were to clarify the clinicopathologic features of multiple early gastric carcinomas and to investigate their histogenesis. METHODS:Of 724 patients with early gastric carcinoma, there were ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Isozaki H,Okajima K,Hu X,Fujii K,Sako S

    更新日期:1996-11-15 00:00:00

  • Diploid predominance in hereditary nonpolyposis colorectal carcinoma evaluated by flow cytometry.

    abstract::Fifty-nine colorectal carcinomas of patients with verified cancer family syndrome (CFS) were analyzed for DNA ploidy using flow cytometry. Sixty-eight percent of the tumors were diploid, and 32% were aneuploid. The aneuploid tumors had a median DNA index of 1.24 (range, 1.12-1.97). In 90% of all tumors the DNA index w...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900415)65:8<1825::aid-cncr2820

    authors: Kouri M,Laasonen A,Mecklin JP,Järvinen H,Franssila K,Pyrhönen S

    更新日期:1990-04-15 00:00:00

  • Wide local excision of recurrent breast cancer in the thoracic wall.

    abstract:BACKGROUND:Local recurrence is one of the major problems in treatment of breast cancer. Approximately 20% of patients who have radical or modified radical mastectomy have a local recurrence. METHODS:The records of 98 women with locally recurrent breast cancer treated with wide local excision, in the years 1983-1987, w...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930801)72:3<774::aid-cncr28207

    authors: Dahlstrøm KK,Andersson AP,Andersen M,Krag C

    更新日期:1993-08-01 00:00:00

  • Pediatric melanoma in melanoma-prone families.

    abstract:BACKGROUND:In the United States, only approximately 0.4% of all melanomas are diagnosed in patients aged <20 years. To the authors' knowledge, melanoma in pediatric members of melanoma-prone families has not been fully investigated to date. The objective of the current study was to evaluate pediatric patients with mela...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31641

    authors: Goldstein AM,Stidd KC,Yang XR,Fraser MC,Tucker MA

    更新日期:2018-09-15 00:00:00

  • Utilization of a human tumor cloning system to monitor for bone marrow involvement in children with non-hodgkin's lymphoma.

    abstract::The objective of this study was to evaluate the sensitivity of two methods for determining bone marrow involvement with non-Hodgkin's lymphoma. These methods were histologic review of bone marrow aspirates, and clot sections versus in vitro growth of lymphoma colonies on soft agar. Forty-two bone marrow aspirates were...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840415)53:8<1724::aid-cncr2820

    authors: Smith SD,Kisker S,Bush L,Trueworthy RC

    更新日期:1984-04-15 00:00:00

  • Physical activity and survival of postmenopausal, hormone receptor-positive breast cancer patients: results of the Tamoxifen Exemestane Adjuvant Multicenter Lifestyle study.

    abstract:BACKGROUND:Physical activity has been related to improved breast cancer outcomes. Especially in the older breast cancer population, physical activity may be important because old age is associated with comorbidities and decreased physical function. The purpose of this study was to investigate the relation between physi...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/cncr.28783

    authors: de Glas NA,Fontein DB,Bastiaannet E,Pijpe A,De Craen AJ,Liefers GJ,Nortier HJ,de Haes HJ,van de Velde CJ,van Leeuwen FE

    更新日期:2014-09-15 00:00:00

  • Radiation for bone metastases: conventional techniques and the role of systemic radiopharmaceuticals.

    abstract::Pain management often is difficult in patients with bone metastases. Metastatic disease represents >40% of oncologic practice, and >70% of patients with metastatic disease have uncontrolled cancer-related pain. Significant morbidity caused by pathologic fracture and spinal cord compression can result from untreated bo...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-0142(19971015)80:8+<1628::aid-c

    authors: Janjan NA

    更新日期:1997-10-15 00:00:00

  • Non-Hodgkin's lymphoma of Waldeyer's ring and nasal cavity. Clinical and immunologic aspects.

    abstract::Twenty-nine cases of non-Hodgkin's lymphoma of Waldeyer's ring (W-NHL) and nasal cavity or paranasal sinus (N-NHL) were studied for tumor-surface marker phenotype and histopathologic correlation with clinical features. Immunostaining procedures on tissue sections by using xenoantisera and monoclonal antibodies to huma...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850815)56:4<768::aid-cncr28205

    authors: Yamanaka N,Harabuchi Y,Sambe S,Shido F,Matsuda F,Kataura A,Ishii Y,Kikuchi K

    更新日期:1985-08-15 00:00:00

  • Biologic distinctions between cure and time to death in 2892 patients with intraocular melanoma.

    abstract:BACKGROUND:For certain types of cancer, resection alone rarely achieves a cure, but patients nevertheless tend to have a prolonged survival before they die of the tumor. For other types of cancer, the opposite scenario prevails, suggesting that those biologic mechanisms that allow a curative resection are not identical...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930401)71:7<2299::aid-cncr2820

    authors: Gamel JW,McLean IW,McCurdy JB

    更新日期:1993-04-01 00:00:00

  • Proliferative activity of early gastric cancer measured by in vitro and in vivo bromodeoxyuridine labeling.

    abstract::Forty seven patients with early gastric cancer received a 30-minute intravenous injection of bromodeoxyuridine (BrdU), 1000 mg each 1 hour before laparotomy, to label tumor cells in the S phase. In 13 of 47 patients, specimens obtained by endoscopic biopsy were cultured in vitro at 37 degrees C for 1 hour under three ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891015)64:8<1665::aid-cncr2820

    authors: Kamata T,Yonemura Y,Sugiyama K,Ooyama S,Kosaka T,Yamaguchi A,Miwa K,Miyazaki I

    更新日期:1989-10-15 00:00:00

  • Racial disparities in the use of and indications for colorectal procedures in Medicare beneficiaries.

    abstract:BACKGROUND:African Americans are diagnosed more frequently with colorectal carcinoma at a later stage compared with Caucasians. One potential reason for the disparity is a lower rate of screening examinations. METHODS:Using Outpatient and Physician-Supplier claims for all Medicare beneficiaries age > or = 65 years in ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20014

    authors: Cooper GS,Koroukian SM

    更新日期:2004-01-15 00:00:00

  • Virilizing adrenocortical tumors in adult women. Report of 10 patients, 2 of whom each had a tumor secreting only testosterone.

    abstract:BACKGROUND:Virilizing adrenocortical tumors are uncommon in adult women. These lesions generally secrete dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS), but not testosterone, which usually is produced by ovarian tumors. Exceptionally, adrenal growths may give off testosterone and no other asse...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930915)72:6<1997::aid-cncr2820

    authors: Del Gaudio AD,Del Gaudio GA

    更新日期:1993-09-15 00:00:00

  • A clinical trial of biochemical modulation of 5-fluorouracil with N-phosphonoacetyl-L-aspartate and thymidine in advanced gastric and anaplastic colorectal cancer.

    abstract::A novel sequential administration schedule of PALA (N-phosphonoacetyl-L-aspartate) and thymidine to enhance the cytotoxic effect of 5-fluorouracil (5FU) was tested in 36 patients with advanced gastric cancer and 21 patients with advanced poorly differentiated (anaplastic) colorectal cancer. The potency of 5FU was dram...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19900901)66:5<853::aid-cncr28206

    authors: Windschitl HE,O'Connell MJ,Wieand HS,Krook JE,Rubin J,Moertel CG,Kugler JW,Pfeifle DM,Goldberg RM,Laurie JA

    更新日期:1990-09-01 00:00:00

  • Beta-glucuronidase activity in prostatic carcinoma and benign prostatic hyperplasia.

    abstract::Beta-glucuronidase activity was extracted from prostatic carcinomas and hyperplastic prostates. It was 3.6-fold higher (P less than 0.0001) in prostatic carcinoma than in prostatic hyperplasia. Analysis for isoenzymes of prostatic beta-glucuronidase by disc-gel electrophoresis in nondenaturing polyacrylamide gels demo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890815)64:4<911::aid-cncr28206

    authors: Pearson JP,Pretlow TP,Bradley EL Jr,McGinnis MC,Pretlow TG

    更新日期:1989-08-15 00:00:00

  • Malignant fibrous histiocytoma induced by intra-articular injection of 9,10-dimethyl-1,2-benzanthracene in the rat. Pathological and enzyme histochemical studies.

    abstract::Malignant fibrous histiocytoma (MFH) was produced by injection of 9,10-dimethyl-1,2-benzanthracene (DMBA) into the rat knee joint. The tumor was observed in or around the knee in nearly all the animals 13 to 36 weeks after the initial DMBA administration. Histologically, these lesions were of the storiform-pleomorphic...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860615)57:12<2313::aid-cncr282

    authors: Sakamoto K

    更新日期:1986-06-15 00:00:00

  • Prognostic factors for lymphedema after primary treatment of breast carcinoma.

    abstract:BACKGROUND:Lymphedema of the arm is a serious consequence of breast carcinoma treatment. Postmastectomy lymphedema of the upper limb usually is related to certain risk factors such as axillary surgery, radiotherapy, obesity, venous outflow obstruction, delayed wound healing, and infection. The objective of the current ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20011001)92:7<1783::aid-cncr1694

    authors: Herd-Smith A,Russo A,Muraca MG,Del Turco MR,Cardona G

    更新日期:2001-10-01 00:00:00

  • Long-term outcomes and clinicopathologic differences of African-American versus white patients treated with breast conservation therapy for early-stage breast cancer.

    abstract:BACKGROUND:African-American (AA) and white patients with early-stage disease who were treated with breast conservation therapy (BCT) were examined to detect differences in clinicopathologic features and outcomes as a function of race. METHODS:Clinical data from the charts of 2164 white and 207 AA patients treated with...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23881

    authors: Moran MS,Yang Q,Harris LN,Jones B,Tuck DP,Haffty BG

    更新日期:2008-11-01 00:00:00

  • Leukemic iritis with hypopyon.

    abstract::A patient with acute lymphoblastic leukemia who had received CNS sanctuary treatment with cranial X-irradiation and intrathecal methotrexate displayed his first sign of relapse as iritis with malignant hypopyon. Treatment included topical and subconjunctival corticosteroids and local X-irradiation. Leukemic infiltrati...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197910)44:4<1511::aid-cncr282044

    authors: Gruenewald RL,Perry MC,Henry PH

    更新日期:1979-10-01 00:00:00

  • The clinical and pathogenetic significance of estrogen receptor-beta expression in chronic liver diseases and liver carcinoma.

    abstract:BACKGROUND:Estrogen receptor-alpha (ERalpha) is variably expressed in hepatocellular carcinoma (HCC) and is believed to be correlated with prognosis and survival. Recently, another estrogen receptor (ERbeta) has been identified, but its relevance in liver diseases is unknown. METHODS:The expression of ERbeta in the li...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11528

    authors: Iavarone M,Lampertico P,Seletti C,Francesca Donato M,Ronchi G,del Ninno E,Colombo M

    更新日期:2003-08-01 00:00:00

  • Spinal epidural tumor in patients with prostate cancer. Clinical and radiographic predictors of response to radiation therapy.

    abstract::The authors retrospectively reviewed 50 episodes of spinal epidural tumor that occurred in 42 patients with metastatic prostate cancer and were treated with external-beam radiation. Treatment response was evaluated in terms of symptoms, neurologic status, and, in most cases, reduction of tumor on repeat myelography. A...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19921101)70:9<2319::aid-cncr2820

    authors: Zelefsky MJ,Scher HI,Krol G,Portenoy RK,Leibel SA,Fuks ZY

    更新日期:1992-11-01 00:00:00

  • Breast carcinoma with noninflammatory skin involvement (T4b): time to abandon an historic relic from the TNM classification.

    abstract:BACKGROUND:In this study, the authors evaluated the clinical presentation of patients with T4b breast carcinoma, analyzed the impact of noninflammatory skin involvement on long-term survival, and addressed the question whether the T4 tumor category still has any justification. METHODS:The clinical course of a study gr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21394

    authors: Guth U,Wight E,Schotzau A,Langer I,Dieterich H,Rochlitz C,Herberich L,Holzgreve W,Singer G

    更新日期:2005-11-01 00:00:00

  • Breast carcinoma presenting as axillary metastases without evidence of a primary tumor.

    abstract:BACKGROUND:Sixty cases of axillary metastases from clinically occult breast cancer were analyzed. All cases had histologic evidence of metastatic nodes compatible with breast carcinoma. METHODS:Thirty-three patients underwent breast surgery at the time of histologic diagnosis of the axillary metastases, 6 patients wer...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920715)70:2<504::aid-cncr28207

    authors: Merson M,Andreola S,Galimberti V,Bufalino R,Marchini S,Veronesi U

    更新日期:1992-07-15 00:00:00

  • Pancreatic carcinoma in azaserine-treated rats: induction, classification and dietary modulation of incidence.

    abstract::Pancreatic carcinomas have been induced in Wistar and W/LEW rats by administration of total azaserine doses of 150-520 mg/kg by injection or oral routes over periods of 5-52 weeks. The latent period for development of invasive carcinomas was 1-2 years, but focal abnormalities in acinar cells appear earlier. The incide...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810315)47:6+<1562::aid-cncr282

    authors: Longnecker DS,Roebuck BD,Yager JD Jr,Lilja HS,Siegmund B

    更新日期:1981-03-15 00:00:00

  • HER-2/neu and p53 overexpression as biomarkers of breast carcinoma in women age 30 years and younger.

    abstract:BACKGROUND:Although p53 and HER-2/neu overexpression are found in 30% of breast carcinomas in women of all ages and are associated with high rates of lymph node metastases, their role in women age < 30 years has not been studied extensively. METHODS:The institutional breast cancer data base was searched to identify yo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20850

    authors: Maru D,Middleton LP,Wang S,Valero V,Sahin A

    更新日期:2005-03-01 00:00:00

  • Influence of compartmental involvement on the patterns of morbidity in soft tissue sarcoma of the thigh.

    abstract:BACKGROUND:The authors sought to determine whether differences existed in patterns of outcome and morbidity between the 3 thigh compartments after limb-sparing surgery and postoperative radiation therapy (RT). METHODS:A total of 255 patients with primary soft tissue sarcoma (STS) of the thigh were identified in our sa...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23975

    authors: Rimner A,Brennan MF,Zhang Z,Singer S,Alektiar KM

    更新日期:2009-01-01 00:00:00

  • Antibody response to Epstein-Barr virus Rta protein in patients with nasopharyngeal carcinoma: a new serologic parameter for diagnosis.

    abstract:BACKGROUND:Nasopharyngeal carcinoma (NPC) is associated closely with Epstein-Barr virus (EBV). The authors previously reported that an EBV immediate-early gene, BRLF1, was expressed frequently in NPC tumors, and a significant elevation in immunoglobulin G (IgG) antibodies directed against BRLF1 gene product Rta was det...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20011001)92:7<1872::aid-cncr1704

    authors: Feng P,Chan SH,Soo MY,Liu D,Guan M,Ren EC,Hu H

    更新日期:2001-10-01 00:00:00

  • Adherence to endocrine therapy including ovarian suppression: A large observational cohort study of US women with early breast cancer.

    abstract:BACKGROUND:Recent clinical trials support adding ovarian suppression (OS) to oral endocrine therapy (ET) for premenopausal women with early breast cancer. The adoption of OS among real-world populations and the impact of OS on ET adherence have not been evaluated. METHODS:This study examined a retrospective, observati...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33367

    authors: Reeder-Hayes KE,Mayer SE,Lund JL

    更新日期:2021-01-28 00:00:00

  • Squamous cell carcinoma antigen in the diagnosis and treatment follow-up of oral and facial squamous cell carcinoma.

    abstract::The squamous cell carcinoma (SCC) antigen was determined by radioimmunoassay in the serum of 40 untreated patients with SCC of the oromaxillofacial region. The mean (+/- SEM) serum concentration for these patients (3.8 +/- 0.8 ng/ml) was significantly higher than that of 52 disease-free patients coming to routine post...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900315)65:6<1321::aid-cncr2820

    authors: Fischbach W,Meyer T,Barthel K

    更新日期:1990-03-15 00:00:00

  • Detection of circulating prostate carcinoma cells via an enhanced reverse transcriptase-polymerase chain reaction assay in patients with early stage prostate carcinoma. Independence from other pretreatment characteristics.

    abstract:BACKGROUND:Circulating prostate cells can be detected in the venous blood of patients with clinically localized prostate carcinoma by applying reverse transcriptase-polymerase chain reaction (RT-PCR) techniques using primers specific for the prostate specific antigen (PSA) gene. This study evaluates whether the detecti...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19970615)79:12<2402::aid-c

    authors: Ennis RD,Katz AE,de Vries GM,Heitjan DF,O'Toole KM,Rubin M,Buttyan R,Benson MC,Schiff PB

    更新日期:1997-06-15 00:00:00