A clinical trial of biochemical modulation of 5-fluorouracil with N-phosphonoacetyl-L-aspartate and thymidine in advanced gastric and anaplastic colorectal cancer.

abstract：BACKGROUND:In the phase 3 MARIANNE trial, trastuzumab emtansine (T-DM1) with or without pertuzumab showed noninferior progression-free survival and better tolerability than trastuzumab plus a taxane (HT) for the first-line treatment of human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer. Thi...

journal_title：Cancer

authors： Perez EA,Barrios C,Eiermann W,Toi M,Im YH,Conte P,Martin M,Pienkowski T,Pivot XB,Burris HA 3rd,Petersen JA,De Haas S,Hoersch S,Patre M,Ellis PA

更新日期：2019-11-15 00:00:00

abstract：:A patient with a 17-year course of metastatic lobular carcinoma of the breast is described who developed large numbers of circulating carcinoma cells which were easily detectable in several routine peripheral blood smears shortly before death. This rare complication of carcinoma has been called "carcinocythemia." Carc...

journal_title：Cancer

authors： Myerowitz RL,Edwards PA,Sartiano GP

更新日期：1977-12-01 00:00:00

abstract：BACKGROUND:Little is known about the natural growth characteristics of untreated glioblastoma before surgical or therapeutic intervention, because patients are rapidly treated after preliminary radiographic diagnosis. Understanding the growth characteristics of uninhibited human glioblastoma may be useful for character...

journal_title：Cancer

authors： Ellingson BM,Nguyen HN,Lai A,Nechifor RE,Zaw O,Pope WB,Yong WH,Nghiemphu PL,Liau LM,Cloughesy TF

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:The incidence, risk factors, time course, and impact on survival of venous thromboembolism (VTE) in a large, population-based study of patients with bladder cancer have not been identified previously. METHODS:The California Cancer Registry was merged with the California Patient Discharge Data Set to determi...

journal_title：Cancer

authors： Sandhu R,Pan CX,Wun T,Harvey D,Zhou H,White RH,Chew HK

更新日期：2010-06-01 00:00:00

abstract：:The observation, in 1980, of a rapid increase in platelet counts as a result of administration of intravenous immunoglobulin (IVIG) in a patient with immune thrombocytopenic purpura (ITP) was followed by clinical studies confirming the efficacy of this new treatment alternative in ITP. Simultaneously, new sensitive as...

journal_title：Cancer

authors： Imbach P

更新日期：1991-09-15 00:00:00

abstract：BACKGROUND:The goal of the current study was to define the clinical features and outcome of recurrent osteosarcoma (OS) in children and young adults initially treated with contemporary chemotherapy. METHODS:The authors reviewed the clinical features, therapy, and outcome for 59 patients from the Mayo Clinic (Rochester...

journal_title：Cancer

authors： Hawkins DS,Arndt CA

更新日期：2003-12-01 00:00:00

abstract：:Proviral DNA of adult T-cell leukemia virus (HTLV-I) was examined by the standard Southern blotting method in lymph nodes of 45 patients with anti-HTLV-I antibody (ATLA)-positive adult T-cell leukemia/lymphoma (ATLL). Six of these patients revealed no monoclonal proviral HTLV-I DNA in tumor cells. These six patients s...

journal_title：Cancer

authors： Yoshida T,Kikuchi M,Ooshima K,Takeshita M,Kimura N,Kozuru M,Satoh H

更新日期：1989-12-15 00:00:00

abstract：:A 65-year-old woman had pancytopenia, splenomegaly, and an inaspirable bone marrow. Diagnostic evaluation demonstrated that she had both leukemic reticuloendotheliosis (LRE), or hairy cell leukemia, and an additional lympho-reticular neoplasm, most likely a "histiocytic" lymphoma. The diagnosis of LRE was based on the...

journal_title：Cancer

authors： Adler SS,Shetty J,Golomb HM

更新日期：1979-05-01 00:00:00

abstract：:Twenty patients with malignant hepatoma were treated with sequential intraarterial doxorubicin (72-hour continuous infusion) followed by systemic 5-fluorouracil (5-FU) and semustine (methyl CCNU). Objective tumor responses were seen in three patients (15%). The durations of response were 6, 19, and 27+ months, respect...

journal_title：Cancer

authors： O'Connell MJ,Hahn RG,Rubin J,Moertel CG

更新日期：1988-09-15 00:00:00

abstract：:As the toll taken by breast cancer continues unabated, screening programs are widely perceived to play a critical role to improve diagnosis and successful treatment. Breast cancer screening programs are increasingly promoted to women; however, the economic implications of mass screening is a subject of much health pol...

journal_title：Cancer

authors： Mushlin AI,Fintor L

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:A combination regimen comprised of docetaxel, gemcitabine, and granulocyte-colony stimulating factor (G-CSF) was studied in patients with advanced nonsmall cell lung carcinoma (NSCLC) to determine its antitumor efficacy and tolerance. METHODS:Thirty-four patients with advanced measurable NSCLC (3 patients w...

journal_title：Cancer

authors： Hejna M,Kornek GV,Raderer M,Ulrich-Pur H,Fiebiger WC,Marosi L,Schneeweiss B,Greul R,Scheithauer W

更新日期：2000-08-01 00:00:00

abstract：:If radical surgery is the only rational policy for most cases of rectal cancer, the problem of local treatment in poor surgical risk patients should be discussed in selected cases. Only limited, fairly-well-differentiated tumors, still confined to the rectal wall may have a sufficiently low probability of lymphatic sp...

journal_title：Cancer

authors： Papillon J

更新日期：1975-08-01 00:00:00

abstract：:Cases of systemic lupus erythematosus, systemic sclerosis, periarteritis nodosa, and dermato- and polymyositis autopsied in Japan during a recent, 7-year period (1972-1978) were studied to assess the incidence of cancer as a complication. In comparison with the other three groups, cases of dermato- and polymyositis (D...

journal_title：Cancer

authors： Okayasu I,Mizutani H,Kurihara H,Yanagisawa F

更新日期：1984-11-01 00:00:00

abstract：:Data from 133 patients with cancer and suspected compression of the spinal cord or cauda equina was reviewed. Although there were differences in presenting symptoms and signs between the group of 62 patients with compression and the 71 without, no single symptom or sign discriminated adequately between the two groups....

journal_title：Cancer

authors： Bernat JL,Greenberg ER,Barrett J

更新日期：1983-05-15 00:00:00

abstract：:Effective screening for occult ovarian cancer will require a strategy that is both sensitive and specific. Preliminary data suggest that CA 125 is elevated at diagnosis in a majority of patients with ovarian cancer. Although CA 125 is sufficiently specific to prompt its evaluation as one component of a strategy to det...

journal_title：Cancer

authors： Bast RC Jr,Knauf S,Epenetos A,Dhokia B,Daly L,Tanner M,Soper J,Creasman W,Gall S,Knapp RC

更新日期：1991-10-15 00:00:00

abstract：:Breast cancer is the most common malignant tumor among women in the world. In 2005, there were approximately 272,000 new cases diagnosed and more than 70,000 deaths from breast cancer in China. Of the patients who are newly diagnosed with breast cancer each year, approximately 3% to 10% have distant metastases at the ...

journal_title：Cancer

authors： Xu B,Hu X,Feng J,Geng C,Jin F,Li H,Li M,Li Q,Liao N,Liu D,Liu J,Liu Q,Lu J,Liu Z,Ma F,Ouyang Q,Pan Y,Shen K,Sun T,Teng Y,Tong Z,Wang B,Wang H,Wang S,Wang S,Wang T,Wang X,Wang X,Wang Y,Wang Z,Wu

更新日期：2020-08-15 00:00:00

abstract：:Lymphoblasts from "null cell" acute lymphocytic leukemia (ALL) were analyzed for the pattern of proliferation displayed in a mixed lymphocyte reaction (MLR), the presence of a B cell surface antigen, and for the presence of intracytoplasmic immunoglobulin (ICIg). "Null cell" ALL was defined by cytologic and cytochemic...

journal_title：Cancer

authors： Davey FR,Dock NL,Wolos JA,Terzian JA,Gottlieb AJ

更新日期：1979-11-01 00:00:00

abstract：BACKGROUND:There is considerable evidence that one of the strongest risk factors for breast carcinoma can be assessed from the mammographic appearance of the breast. However, the magnitude of the risk factor and the reliability of the prediction depend on the method of classification. Subjective classification requires...

journal_title：Cancer

authors： Byng JW,Yaffe MJ,Lockwood GA,Little LE,Tritchler DL,Boyd NF

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Several studies have reported inverse associations between folate intake and colorectal carcinoma risk. Few were prospective studies and none evaluated the association between the intake of individual folate vitamers and colorectal carcinoma risk. METHODS:The aim of the current study was to investigate the ...

journal_title：Cancer

authors： Konings EJ,Goldbohm RA,Brants HA,Saris WH,van den Brandt PA

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Radiofrequency (RF) ablation is an increasingly applied technique. Promising results of hepatic RF ablation raised expectations of its capabilities for treatment of primary and secondary lung tumors. Because of different thermal and electrical properties of lung tissue, compared with liver tissue, a simple a...

journal_title：Cancer

authors： Clasen S,Krober SM,Kosan B,Aebert H,Fend F,Bomches A,Claussen CD,Pereira PL

更新日期：2008-12-01 00:00:00

abstract：:The monitoring utility of serial patterns of a single marker (carcinoembryonic antigen) level and multiple marker (three carbohydrates-fucose, mannose and galactose) levels in patients with small cell carcinoma of the lung was investigated using a quantitative approach. A serial multiple regression (SMR) model was for...

journal_title：Cancer

authors： Woo KB,Waalkes P,Abeloff MD,Ettinger DS,McNitt KL,Gehrke CW

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND:Pediatric renal cell carcinoma (RCC) is clinically distinct from adult RCC. Characterization of the unique biological and clinical features of pediatric RCC are required. METHODS:A retrospective review and biological analysis of all RCC cases presenting to Cincinnati Children's Hospital Medical Center (CCHM...

journal_title：Cancer

authors： Geller JI,Argani P,Adeniran A,Hampton E,De Marzo A,Hicks J,Collins MH

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Prostate carcinoma metastasizes frequently to the skeleton, causing significant morbidity, particularly severe bone pain. Metastatic lesions typically are osteosclerotic, but there is experimental, histologic, and biochemical evidence of increased bone resorption. Furthermore, bone resorption rates appear to...

journal_title：Cancer

authors： Papapoulos SE,Hamdy NA,van der Pluijm G

更新日期：2000-06-15 00:00:00

abstract：:Aggressive nutritional support of the cancer patient undergoing treatment has become widespread standard practice. In order to evaluate the effect of total parenteral nutrition (TPN) on protein metabolism, 11 patients with localized squamous cell carcinoma of the distal esophagus were studied in the postabsorptive sta...

journal_title：Cancer

authors： Burt ME,Stein TP,Schwade JG,Brennan MF

更新日期：1984-03-15 00:00:00

abstract：BACKGROUND:The high recurrence rate of hepatocellular carcinoma (HCC) determines the long-term prognosis for patients with HCC. In the current study, the authors tested the effects of menatetrenone, a vitamin K2 analog, on recurrent HCC and survival after curative treatment. METHODS:Sixty-one patients who were diagnos...

journal_title：Cancer

authors： Mizuta T,Ozaki I,Eguchi Y,Yasutake T,Kawazoe S,Fujimoto K,Yamamoto K

更新日期：2006-02-15 00:00:00

abstract：:Twenty-one cases of clear cell adenocarcinoma of the cervix and vagina have been reviewed. Fifteen cases occurred in females under 25 years of age and four in women over 45 years. In seven cases, a positive history of maternal ingestion of diethylstilbestrol (DES) was obtained. One mother gave a history of medication ...

journal_title：Cancer

authors： Nordqvist SR,Fidler WJ Jr,Woodruff JM,Lewis JL Jr

更新日期：1976-02-01 00:00:00

abstract：:This article reports on the diagnostic features, radiographic findings, staging, operative management, treatments, and treatment results for 95 children (mean age, 10 years) with paratesticular sarcoma; they were treated on the Intergroup Rhabdomyosarcoma Study (IRS) I and II protocols. Embryonal rhabdomyosarcoma (RMS...

journal_title：Cancer

authors： Raney RB Jr,Tefft M,Lawrence W Jr,Ragab AH,Soule EH,Beltangady M,Gehan EA

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:None of the commonly used staging criteria accurately determine the prognosis of a patient with adenocarcinoma of Barrett's esophagus. The authors therefore assessed the expression pattern and prognostic impact of CD44 standard and CD44 isoforms CD44v4, v5,v6,v7, and v10 in adenocarcinoma of Barrett's esopha...

journal_title：Cancer

authors： Böttger TC,Youssef V,Dutkowski P,Maschek H,Brenner W,Junginger T

更新日期：1998-09-15 00:00:00

abstract：BACKGROUND:Many trials submitted to scientific meetings are not reported in peer-reviewed journals. Results may vary substantially and the lack of final publication constitutes a form of reporting bias. The authors sought to determine the presentation and publication rates of Phase I trials submitted to a major oncolog...

journal_title：Cancer

authors： Camacho LH,Bacik J,Cheung A,Spriggs DR

更新日期：2005-10-01 00:00:00

abstract：:Granulocyte (PMN) directional locomotion (migration) in vitro and in vivo, resting nitroblue tetrazolium (NBT)-reduction and adherence to nylon wool of polymorphonuclear neutrophils (PMN) were assayed in 7 patients with Hodgkin's disease (HD) and in 11 patients with non-Hodgkin's lymphoma (NHL) prior to therapy. In mo...

journal_title：Cancer

authors： Von Fliedner V,Salvatori V,Higby DJ,Stutzman L,Park BH

更新日期：1980-02-01 00:00:00