Translocation renal cell carcinoma: lack of negative impact due to lymph node spread.

abstract：BACKGROUND:Elderly people constitute a heterogeneous group and are at an increased risk for the development of cancer. It is not clear whether comorbid conditions and functional status influence clinical decisions and the pattern of referral in elderly cancer patients. The current study investigated functional status m...

journal_title：Cancer

authors： Repetto L,Venturino A,Vercelli M,Gianni W,Biancardi V,Casella C,Granetto C,Parodi S,Rosso R,Marigliano V

更新日期：1998-02-15 00:00:00

abstract：BACKGROUND:p53 gene mutation and p53 protein accumulation are common in human cancer. However, their clinical significance is controversial and p53 accumulation may not correlate with gene mutation. The current study investigates the occurrence of p53 alterations in esophageal carcinoma, the correlation between the ana...

journal_title：Cancer

authors： Coggi G,Bosari S,Roncalli M,Graziani D,Bossi P,Viale G,Buffa R,Ferrero S,Piazza M,Blandamura S,Segalin A,Bonavina L,Peracchia A

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Hypercalcemia of malignancy (HM) is one of the commonest metabolic complications associated with cancer. Plasma parathyroid hormone-related peptide (PTH-rp) is known to cause hypercalcemia in the vast majority of patients with HM. METHODS:Fifty-two patients with HM were treated with a single infusion of 60 ...

journal_title：Cancer

authors： Wimalawansa SJ

更新日期：1994-04-15 00:00:00

abstract：:The cytologic results of 34 fine-needle aspiration (FNA) biopsies of the central nervous system (CNS) are reported. There were 31 intraoperative biopsies performed at the time of craniotomy. All the cases were diagnosed using direct smear preparations stained with Papanicolaou and Diff-Quik (Harleco, NJ) stains. The s...

journal_title：Cancer

authors： Silverman JF,Timmons RL,Leonard JR 3rd,Hardy IM,Harris LS,O'Brien K,Norris HT

更新日期：1986-09-01 00:00:00

abstract：:Initial biopsy and resection specimens from 78 cerebral astrocytomas with anaplastic foci occurring in adults were examined for the presence of five specific histologic features traditionally considered indicative of anaplasia. Anaplastic astrocytomas with foci of tumor necrosis had been classified as glioblastoma mul...

journal_title：Cancer

authors： Fulling KH,Garcia DM

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:Poor accrual to cancer clinical trials may contribute to the lower improvement in survival observed for adolescents and young adults (AYAs) (those aged 15-39 years) with cancer. This has been difficult to quantify without reliable mechanisms to link incident cases with study enrollments. Using unique resourc...

journal_title：Cancer

authors： Collins CL,Malvar J,Hamilton AS,Deapen DM,Freyer DR

更新日期：2015-12-15 00:00:00

abstract：BACKGROUND:Cyclins, cyclin dependent kinases (cdks), and their inhibitors act in combination to regulate progression through the cell cycle and often are dysregulated in carcinoma. The authors hypothesized that cyclin E plays an important role in ovarian carcinogenesis and that its overexpression may be an indicator of...

journal_title：Cancer

authors： Rosen DG,Yang G,Deavers MT,Malpica A,Kavanagh JJ,Mills GB,Liu J

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Parathyroid hormone-related protein (PTHrP) has been shown to be the principal cause of humoral hypercalcemia associated with renal cell carcinoma (RCC). Recent studies have demonstrated that the amino-terminal region of PTHrP has growth factor-like activities, suggesting it may play a role in the developmen...

journal_title：Cancer

authors： Iwamura M,Wu W,Muramoto M,Ohori M,Egawa S,Uchida T,Baba S

更新日期：1999-09-15 00:00:00

abstract：:To determine the efficacy of adjuvant chemotherapy in patients with advanced head and neck squamous carcinoma, the National Cancer Institute initiated a multi-institutional, prospective randomized trial termed the Head and Neck Contracts Program. Between 1978 and 1982, 462 patients with resectable Stage III or IV canc...

journal_title：Cancer

authors：

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:The regulation of parathyroid hormone-related protein (PTH-rP) mRNA levels and immunoreactive (ir)PTH-rP formation by peptide growth factors, particularly transforming growth factor-beta (TGF-beta) and epidermal growth factor (EGF), in squamous cell carcinomas of gynecologic origin is largely unknown. METHO...

journal_title：Cancer

authors： Tait DL,MacDonald PC,Casey ML

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Ovarian dysplasia has been defined by histologic and morphometric studies focusing on architectural and nuclear profile changes. A new technique is used to enhance the accuracy of this diagnosis by a quantitative evaluation of the nuclear texture that represents the nuclear chromatin pattern on which convent...

journal_title：Cancer

authors： Deligdisch L,Miranda C,Barba J,Gil J

更新日期：1993-12-01 00:00:00

abstract：:Carcinomas of the pancreas with giant cells are not rare, but those containing osteoclast-like tumor cells are quite unusual. This report documents a pancreatic neoplasm comprising both easily recognizable well-differentiated adenocarcinoma and osteoclast-like tumor. The literature on the "osteoclastoma" of the pancre...

journal_title：Cancer

authors： Trepeta RW,Mathur B,Lagin S,LiVolsi VA

更新日期：1981-11-01 00:00:00

abstract：BACKGROUND:The bone destruction in myeloma patients is largely responsible for the clinical features of the disease. However, only recently has attention focused on identifying and developing drugs targeted specifically at the osteolysis. Receptor activator of NF-kappaB ligand (RANKL), macrophage inflammatory protein (...

journal_title：Cancer

authors： Oyajobi BO,Mundy GR

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:The role of adjuvant therapy in the management of patients with malignant mixed Müllerian tumors (MMMT) of the uterus has not been defined. The outcome of planned multimodality therapy for patients with apparent early stage disease was assessed. METHODS:A pilot study was performed on 38 patients with clinic...

journal_title：Cancer

authors： Manolitsas TP,Wain GV,Williams KE,Freidlander M,Hacker NF

更新日期：2001-04-15 00:00:00

abstract：BACKGROUND:To evaluate the prevalence and significance of abnormal ovarian findings in asymptomatic postmenopausal women, screening for ovarian cancer with color Doppler ultrasound was performed. METHODS:One thousand three hundred sixty-four asymptomatic women aged 56-61 years (mean, 59 years) were examined by color D...

journal_title：Cancer

authors： Vuento MH,Pirhonen JP,Mäkinen JI,Laippala PJ,Grönroos M,Salmi TA

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Patients age > or = 75 years with acute myeloid leukemia (AML) generally are offered palliative treatments instead of induction chemotherapy. The authors conducted a retrospective study comparing the outcomes among these elderly patients with the outcomes among younger patients to assess the impact of intens...

journal_title：Cancer

authors： Vey N,Coso D,Bardou VJ,Stoppa AM,Braud AC,Bouabdallah R,Sainty D,Mozziconacci MJ,Lafage M,Damaj G,Blaise D,Gastaut JA,Maraninchi D

更新日期：2004-07-15 00:00:00

abstract：BACKGROUND:The value of surgical staging and treatment of the axillary lymph nodes with either surgery or radiotherapy in the initial management of patients with Stage I or II invasive breast cancer is controversial. METHODS:A review of retrospective and prospective clinical studies was performed to assess the risks o...

journal_title：Cancer

authors： Recht A,Houlihan MJ

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:This study was performed to determine the incidence of central venous device-related blood stream infection and thrombosis in patients treated with moderate dose continuous-infusion interleukin-2 (IL-2). METHODS:The records of 160 consecutive patients treated at the University of Wisconsin Hospital and Clin...

journal_title：Cancer

authors： Eastman ME,Khorsand M,Maki DG,Williams EC,Kim K,Sondel PM,Schiller JH,Albertini MR

更新日期：2001-02-15 00:00:00

abstract：:In a retrospective review (1950-1975) of the Mayo Clinic experience with seminomas (483 cases), twelve patients (2.5%) were found to have a retroperitoneal seminoma without evidence of testicular involvement. The mean age was 47 years (range, 31-67). Eleven patients were treated by radiation alone, with doses ranging ...

journal_title：Cancer

authors： Buskirk SJ,Evans RG,Farrow GM,Earle JD

更新日期：1982-05-01 00:00:00

abstract：:Light microscopic, immunocytochemical and ultrastructural studies were performed on chondrosarcomas which contained a second, noncartilagenous mesenchymal component. Attention was focused on the nonchondroid portion of each tumor in an attempt to elucidate the histogenesis of this mixed variant of chondrosarcoma. The ...

journal_title：Cancer

authors： Têtu B,Ordóñez NG,Ayala AG,Mackay B

更新日期：1986-07-15 00:00:00

abstract：BACKGROUND:False-positive cancer screening results may affect a patient's willingness to obtain future screening. METHODS:The authors conducted logistic regression analysis of 450,484 person-years of electronic medical records (2006-2015) in 92,405 individuals aged 50 to 75 years. Exposures were false-positive breast,...

journal_title：Cancer

authors： Taksler GB,Keating NL,Rothberg MB

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:The local control rates of T1 and T2 supraglottic carcinoma treated with radiation alone were reported as 71% to 92% and 59% to 83%, respectively. The factors that affect the local control rate for early supraglottic carcinoma were investigated. METHODS:From 1967 through 1985, 100 cases with early supraglot...

journal_title：Cancer

authors： Inoue T,Matayoshi Y,Inoue T,Ikeda H,Teshima T,Murayama S

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:The current study was designed to evaluate the efficacy and toxicity of the continuous oral administration of a combination of cyclophosphamide (50 mg/day given in the morning) and dexamethasone (1 mg/day given in the evening) in patients with prostate specific antigen (PSA) progression despite single or mul...

journal_title：Cancer

authors： Glode LM,Barqawi A,Crighton F,Crawford ED,Kerbel R

更新日期：2003-10-15 00:00:00

abstract：BACKGROUND:Modern cancer treatments can cure or prolong patients' lives. However, the associated physical and psychosocial problems can detrimentally affect patients' compliance with treatment and, ultimately, their outcomes. Therefore, oncologists need to recognize the problems experienced by their patients and, when ...

journal_title：Cancer

authors： Newell S,Sanson-Fisher RW,Girgis A,Bonaventura A

更新日期：1998-10-15 00:00:00

abstract：:The platinum-free interval is the most important predictive factor of a response to subsequent lines of chemotherapy and the most important prognostic factor for progression-free and overall survival in patients with recurrent epithelial ovarian cancer. A nonplatinum regimen is generally considered the most appropriat...

journal_title：Cancer

authors： Tomao F,D'Incalci M,Biagioli E,Peccatori FA,Colombo N

更新日期：2017-09-15 00:00:00

abstract：BACKGROUND:Desmoid tumors are mesenchymal nonmetastasizing neoplasms. Although rare in the general population, they are a common extracolonic manifestation of familial adenomatous polyposis (FAP). Because of high tumor recurrence rates, surgery has been less than satisfactory in the treatment of desmoid tumors. In the ...

journal_title：Cancer

authors： Hansmann A,Adolph C,Vogel T,Unger A,Moeslein G

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:The objective of this study was to determine the clinical characteristics, treatment response, and frequency of p53 overexpression in Ashkenazi Jewish women with hereditary ovarian carcinoma. METHODS:Seventy-one Jewish women with epithelial ovarian carcinoma (EOC) were tested for the three BRCA founder muta...

journal_title：Cancer

authors： Cass I,Baldwin RL,Varkey T,Moslehi R,Narod SA,Karlan BY

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Ovarian cancer patients frequently receive chemotherapy near the end of life. The purpose of the current study was to develop indicators that characterize those ovarian cancer patients who have a short life span. METHODS:The medical charts of deceased epithelial ovarian cancer patients were retrospectively ...

journal_title：Cancer

authors： von Gruenigen V,Daly B,Gibbons H,Hutchins J,Green A

更新日期：2008-05-15 00:00:00

abstract：:Forty-nine patients with regionally confined recurrent malignancy were treated with intra-arterial cis-diamminedichloro platinum II in a Phase I-II trial. A safe starting dose of 120 mg/m2 was established. An overall response rate of 45% was noted with significant responses observed among patients with melanoma, sarco...

journal_title：Cancer

authors： Calvo DB 3rd,Patt YZ,Wallace S,Chuang VP,Benjamin RS,Pritchard JD,Hersh EM,Bodey GP Sr,Mavligit GM

更新日期：1980-03-15 00:00:00

abstract：BACKGROUND:Despite extensive investigation, the role of MDR of human cancer remains unclear. Canine lymphoma is a spontaneously arising correlate of human non-Hodgkin's lymphoma that may complement other in vivo models for investigation of issues related to MDR. METHODS:Immunoreactivity of primary antibodies to the hu...

journal_title：Cancer

authors： Lee JJ,Hughes CS,Fine RL,Page RL

更新日期：1996-05-01 00:00:00