Chemotherapy of malignant hepatomas with sequential intraarterial doxorubicin and systemic 5-fluorouracil and semustine.

Abstract:

:Twenty patients with malignant hepatoma were treated with sequential intraarterial doxorubicin (72-hour continuous infusion) followed by systemic 5-fluorouracil (5-FU) and semustine (methyl CCNU). Objective tumor responses were seen in three patients (15%). The durations of response were 6, 19, and 27+ months, respectively. Median patient survival was 7 months. A variety of problems were encountered with the use of transcutaneous angiographic catheters for doxorubicin administration, including inability to adequately perfuse the liver, sepsis, and catheter dislodgement during chemotherapy infusion. Although some patients experienced palliation of reasonable duration, we do not believe that the overall results warrant further studies of this regimen.

journal_name

Cancer

journal_title

Cancer

authors

O'Connell MJ,Hahn RG,Rubin J,Moertel CG

doi

10.1002/1097-0142(19880915)62:6<1041::aid-cncr2820

subject

Has Abstract

pub_date

1988-09-15 00:00:00

pages

1041-3

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

62

pub_type

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