Chemotherapy of malignant hepatomas with sequential intraarterial doxorubicin and systemic 5-fluorouracil and semustine.


:Twenty patients with malignant hepatoma were treated with sequential intraarterial doxorubicin (72-hour continuous infusion) followed by systemic 5-fluorouracil (5-FU) and semustine (methyl CCNU). Objective tumor responses were seen in three patients (15%). The durations of response were 6, 19, and 27+ months, respectively. Median patient survival was 7 months. A variety of problems were encountered with the use of transcutaneous angiographic catheters for doxorubicin administration, including inability to adequately perfuse the liver, sepsis, and catheter dislodgement during chemotherapy infusion. Although some patients experienced palliation of reasonable duration, we do not believe that the overall results warrant further studies of this regimen.






O'Connell MJ,Hahn RG,Rubin J,Moertel CG




Has Abstract


1988-09-15 00:00:00














  • Head and neck aspergillosis in patients undergoing bone marrow transplantation. Report of four cases and review of the literature.

    abstract::Aspergillus infection can be a major cause of morbidity in immunocompromised patients, especially when there is pulmonary involvement. Diagnosis of aspergillosis is often complicated by the varied clinical presentation and compromised medical status of such patients. Four cases of head and neck Aspergillus infections ...


    pub_type: 杂志文章


    authors: Schubert MM,Peterson DE,Meyers JD,Hackman R,Thomas ED

    更新日期:1986-03-15 00:00:00

  • OKM1-positive T-cell leukemias. Relationships among morphologic features, phenotype, and functional activities.

    abstract::The morphologic features, phenotype, and functions of OKM1+ leukemic T-cells were studied. The leukemic T-cells in two patients with chronic lymphocytic leukemia (CLL) had specific features of large granular lymphocytes (LGL), and those in two patients with acute lymphocytic leukemia (ALL) had L2 morphologic character...


    pub_type: 杂志文章


    authors: Tagawa S,Taniguchi N,Tokumine Y,Tamaki T,Konishi I,Kanayama Y,Inoue R,Machii T,Kitani T

    更新日期:1986-04-15 00:00:00

  • Influence of p53 status on prognosis in preoperatively irradiated rectal carcinoma.

    abstract:BACKGROUND:Even when they are analogous in microscopic and macroscopic appearance, tumors vary in their response rates to radiotherapy. Cell culture and xenograft experiments with colorectal cell lines have demonstrated that wild-type p53 increases radiosensitivity. Hence, the authors investigated, in a well-defined po...


    pub_type: 杂志文章


    authors: Nehls O,Klump B,Holzmann K,Lammering G,Borchard F,Gruenagel HH,Gaco V,Gregor M,Porschen R

    更新日期:1999-06-15 00:00:00

  • Stomach cancer survival in the United States by race and stage (2001-2009): Findings from the CONCORD-2 study.

    abstract:BACKGROUND:Stomach cancer was a leading cause of cancer-related deaths early in the 20th century and has steadily declined over the last century in the United States. Although incidence and death rates are now low, stomach cancer remains an important cause of morbidity and mortality in black, Asian and Pacific Islander...


    pub_type: 杂志文章


    authors: Jim MA,Pinheiro PS,Carreira H,Espey DK,Wiggins CL,Weir HK

    更新日期:2017-12-15 00:00:00

  • Obesity is associated with breast cancer in African-American women but not Hispanic women in South Los Angeles.

    abstract:BACKGROUND:Obesity is considered a risk factor for breast cancer. Modifying life styles that reduce obesity offers the potential for prevention and improved outcomes from cancer. The effects of obesity and breast cancer among African-American women and Hispanic women have been explored in a limited number of studies. T...


    pub_type: 杂志文章


    authors: Sarkissyan M,Wu Y,Vadgama JV

    更新日期:2011-08-15 00:00:00

  • Risk perception and concern among brothers of men with prostate carcinoma.

    abstract:BACKGROUND:It is important for clinicians, researchers, and others who shape public health policy to understand the demographic correlates and psychologic factors that drive health behaviors, such as screening for early detection of cancer, particularly among individuals at high risk for developing the disease. METHOD...


    pub_type: 杂志文章


    authors: Beebe-Dimmer JL,Wood DP Jr,Gruber SB,Chilson DM,Zuhlke KA,Claeys GB,Cooney KA

    更新日期:2004-04-01 00:00:00

  • The prognostic significance of ploidy analysis in operable breast cancer.

    abstract::The nuclear DNA content of 98 operable breast cancers was determined by flow cytometric analysis using paraffin-embedded tissue. All patients were on follow-up and failure of treatment or recurrences were identified. DNA ploidy data in the form of ploidy status and DNA index (DI) has been correlated with various clini...


    pub_type: 杂志文章


    authors: Sharma S,Mishra MC,Kapur BM,Verma K,Nath I

    更新日期:1991-12-15 00:00:00

  • Manipulating the chemokine-chemokine receptor network to treat cancer.

    abstract::Chemokines are chemoattractant cytokines that regulate the trafficking and activation of leukocytes and other cell types under a variety of inflammatory and noninflammatory conditions. Over the past few years, studies have increasingly shown that chemokines play an important role in several aspects of tumor progressio...


    pub_type: 杂志文章,评审


    authors: Ruffini PA,Morandi P,Cabioglu N,Altundag K,Cristofanilli M

    更新日期:2007-06-15 00:00:00

  • High-dose tamoxifen and sulindac as first-line treatment for desmoid tumors.

    abstract:BACKGROUND:Desmoid tumors are mesenchymal nonmetastasizing neoplasms. Although rare in the general population, they are a common extracolonic manifestation of familial adenomatous polyposis (FAP). Because of high tumor recurrence rates, surgery has been less than satisfactory in the treatment of desmoid tumors. In the ...


    pub_type: 杂志文章


    authors: Hansmann A,Adolph C,Vogel T,Unger A,Moeslein G

    更新日期:2004-02-01 00:00:00

  • Feasibility and early results of accelerated radiotherapy for head and neck carcinoma in the elderly.

    abstract:BACKGROUND:Accelerated radiotherapy (RT) represents a promising method with which to improve the treatment outcome in patients with head and neck carcinoma. However, its applicability to elderly patients has not been well established. This study assessed treatment toxicities, patient compliance, and oncologic results i...


    pub_type: 杂志文章


    authors: Allal AS,Maire D,Becker M,Dulguerov P

    更新日期:2000-02-01 00:00:00

  • Complements as new diagnostic tools of hepatocellular carcinoma in cirrhotic patients.

    abstract::Serum complements, C3, C4, and C3 proactivator (C3PA), were evaluated prospectively for their diagnostic power in detecting hepatocellular carcinoma (HCC) in patients with liver cirrhosis (LC). Sixty-three LC patients, including 36 LC with HCC patients, were recruited for this study during the period from March to Nov...


    pub_type: 杂志文章


    authors: Chang WY,Chuang WL

    更新日期:1988-07-15 00:00:00

  • Chemotherapy-induced peripheral neuropathy: Identifying the research gaps and associated changes to clinical trial design.

    abstract:BACKGROUND:To the authors' knowledge, the empiric identification of agents and interventions to mitigate chemotherapy-induced peripheral neuropathy (CIPN) has resulted in only 1 agent that modestly mitigates it and no agents or interventions that prevent its development. This speaks to the need for a mechanistic unders...


    pub_type: 杂志文章


    authors: St Germain DC,O'Mara AM,Robinson JL,Torres AD,Minasian LM

    更新日期:2020-10-15 00:00:00

  • Prostate carcinoma presentation, diagnosis, and staging: an update form the National Cancer Data Base.

    abstract:BACKGROUND:Based on the 1998 Patient Care Evaluation (PCE) from the American College of Surgeons National Cancer Data Base (NCDB), the authors described contemporary nationwide patterns of prostate carcinoma presentation, diagnosis, and staging. METHODS:The authors reviewed 54,212 cases from the 1998 PCE. Demographics...


    pub_type: 杂志文章


    authors: Miller DC,Hafez KS,Stewart A,Montie JE,Wei JT

    更新日期:2003-09-15 00:00:00

  • Positive impact of the Patient Protection and Affordable Care Act Medicaid expansion on Louisiana women with breast cancer.

    abstract:BACKGROUND:Louisiana is one of the few Southern states that enacted the Medicaid expansion of the Patient Protection and Affordable Care Act (ACA). To the authors' knowledge, the issue of how this has affected the breast cancer landscape in Louisiana is unknown. The authors have postulated that ACA expansion had a posi...


    pub_type: 杂志文章


    authors: Chu QD,Li T,Hsieh MC,Yi Y,Gibbs JF,Lyons JM 3rd,Wu XC

    更新日期:2020-11-03 00:00:00

  • Management of asparaginase induced hemorrhagic pancreatitis complicated by pseudocyst.

    abstract::Asparaginase induced hemorrhagic pancreatitis is a rare but serious development occurring in less than 0.5% of patients treated with this drug. Severe pancreatitis with progressive abdominal distention, toxemia, hypotension and respiratory insufficiency occurred in an 18-year-old patient with acute lymphoblastic leuke...


    pub_type: 杂志文章


    authors: Greenstein R,Nogeire C,Ohnuma T,Greenstein A

    更新日期:1979-02-01 00:00:00

  • Surgical treatment of phyllodes tumors of the breast.

    abstract::Eighty-one female patients with phyllodes tumors of the breast, surgically treated from 1974 to 1983, were studied. Their age ranged from 9 to 88 years. According to histology, the series was divided into three groups, of 28 (34.5%) benign tumors, 32 (39.5%) border-line tumors, and 21 (25.9%) malignant tumors. Because...


    pub_type: 杂志文章


    authors: Salvadori B,Cusumano F,Del Bo R,Delledonne V,Grassi M,Rovini D,Saccozzi R,Andreola S,Clemente C

    更新日期:1989-06-15 00:00:00

  • Serum acute phase reactants and prognosis in renal cell carcinoma.

    abstract:BACKGROUND:Inflammatory parameters as acute phase proteins commonly are elevated in patients with renal cell carcinoma. Some of these acute phase reactants have been proposed to influence survival. METHODS:In 170 patients with renal cell carcinoma, the authors studied six acute phase reactant parameters (erythrocyte s...


    pub_type: 杂志文章


    authors: Ljungberg B,Grankvist K,Rasmuson T

    更新日期:1995-10-15 00:00:00

  • Prognostic implications of patterns of failure for gastrointestinal leiomyosarcomas.

    abstract::One hundred ninety-one patients with gastrointestinal leiomyosarcomas were analyzed to determine the prevalence in patterns of failure and the factors predicting those at higher risk of relapse at specific sites. Of 100 assessable patients who died of disease, 89% were found to have peritoneal tumor, 78% had liver met...


    pub_type: 杂志文章


    authors: Ng EH,Pollock RE,Romsdahl MM

    更新日期:1992-03-15 00:00:00

  • The spectrum of cytologic features in nonproliferative breast lesions.

    abstract:BACKGROUND:The reliability of cytologic criteria to classify nonproliferative breast lesions (NPBL) is still debated. Sampling error and heterogeneity of breast lesions complicates the histologic correlation of fine-needle aspiration results further. METHODS:To provide optimal cytohistologic correlation, two smears (o...


    pub_type: 杂志文章


    authors: Sidawy MK,Tabbara SO,Bryan JA,Poprocky LA,Frost AR

    更新日期:2001-04-25 00:00:00

  • Glycosaminoglycan in malignant pleural mesothelioma.

    abstract::The quantitative analysis on glycosaminoglycan (GAG) in the tumor tissues of five patients with malignant pleural mesothelioma and in the pleural fluid of two patients was performed with the use of biochemical methods. In the tumor tissues, it was found that the average of the total amount of GAG was more than 7.9 tim...


    pub_type: 杂志文章


    authors: Nakano T,Fujii J,Tamura S,Amuro Y,Nabeshima K,Horai T,Hada T,Higashino K

    更新日期:1986-01-01 00:00:00

  • Role of repeated biopsy of the prostate in predicting disease progression in patients with prostate cancer on active surveillance.

    abstract:BACKGROUND:Active surveillance (AS) with deferred treatment is an established management option for patients with prostate cancer and favorable clinical parameters. The impact of repeat biopsy after diagnosis was examined in a cohort of men with prostate cancer on AS. METHODS:In all, 186 men with prostate cancer with ...


    pub_type: 杂志文章


    authors: Al Otaibi M,Ross P,Fahmy N,Jeyaganth S,Trottier H,Sircar K,Bégin LR,Souhami L,Kassouf W,Aprikian A,Tanguay S

    更新日期:2008-07-15 00:00:00

  • The effect of 5-fluorouracil and adriamycin on heterotransplantation of Noble rat prostatic tumors in congenitally athymic (nude) mice.

    abstract::The Nb rat prostatic adenocarcinoma is a well-characterized, hormonally induced family of tumors that are all readily transplantable into congenitally athymic (nude) mice. Because of this versatile heterotransplantation model, multiple replicate copies of individual tumors can be studied "in rodent." We have extended ...


    pub_type: 杂志文章


    authors: Drago JR,Maurer RE,Gershwin ME,Eckels D,Palmer JM

    更新日期:1979-08-01 00:00:00

  • Utilization and expense of adjuvant cancer therapies following radical prostatectomy.

    abstract:BACKGROUND:We sought to identify the costs of adjuvant therapies following radical prostatectomy (RP) and factors associated with their receipt. METHODS:We used SEER-Medicare data from 2004-2006 to identify 4247 men who underwent RP, of whom 600 subsequently received adjuvant therapies. We used Cox regression to ident...


    pub_type: 杂志文章


    authors: Williams SB,Gu X,Lipsitz SR,Nguyen PL,Choueiri TK,Hu JC

    更新日期:2011-11-01 00:00:00

  • Cisplatin combination chemotherapy in advanced seminoma.

    abstract::Thirty-one patients were treated with cisplatin combination chemotherapy for advanced seminoma (26 Stage III or bulky Stage II testicular, and five disseminated extragonadal). Seventeen (89%) of 19 patients not previously pretreated and four (80%) of five who had received only abdominal irradiation entered continuous ...


    pub_type: 杂志文章


    authors: Pizzocaro G,Salvioni R,Piva L,Zanoni F,Milani A,Faustini M

    更新日期:1986-10-15 00:00:00

  • A prospective, observational cohort study comparing cancer clinical trial availability and enrollment between early adolescents/young adults and children.

    abstract:BACKGROUND:Poor enrollment of adolescents and young adults (AYAs) (ages 15-39 years) onto cancer clinical trials (CCTs) may contribute to inferior survival gains compared with children. In this study, the authors assessed whether differences in CCT availability would explain lower CCT enrollment for early AYAs (eAYAs) ...


    pub_type: 杂志文章


    authors: Thomas SM,Malvar J,Tran H,Shows J,Freyer DR

    更新日期:2018-03-01 00:00:00

  • Clinical and radiologic features of hepatocellular carcinoma originating in the caudate lobe.

    abstract::Five patients with hepatocellular carcinoma in the caudate lobe were evaluated. Computed tomography (CT) scan and/or angiography clearly demonstrated multiple intrahepatic metastases in four (80%), and tumor thrombi in the portal vein in two (40%), and in the inferior vena cava in one. Even though there was no recogni...


    pub_type: 杂志文章


    authors: Takayasu K,Muramatsu Y,Shima Y,Goto H,Moriyama N,Yamada T,Makuuchi M,Kaneko A,Itabashi M,Shimamura Y

    更新日期:1986-10-01 00:00:00

  • Radiographic evaluation of metastatic melanoma.

    abstract::Malignant melanoma can potentially involve any organ system in the body once it metastasizes beyond the regional lymph nodes. A survey of the radiographic and associated clinical manifestations of metastatic melanoma is presented. The findings from 74 autopsies of patients who died of metastatic melanoma are included....


    pub_type: 杂志文章


    authors: Meyer JE

    更新日期:1978-07-01 00:00:00

  • Familial bilateral papillary cystadenoma of the epididymis: report of three cases in siblings.

    abstract::This paper describes an unusual, familial bilateral papillary cystadenoma of the epididymis found in three siblings. The histological characteristics of the tumor were: 1) papillary proliferation of clear cells, consisting of both tall columnar and round ovoid cells, in the efferent duct epithelium; and 2) cystic dila...


    pub_type: 杂志文章


    authors: Tsuda H,Fukushima S,Takahashi M,Hikosaka Y,Hayashi K

    更新日期:1976-04-01 00:00:00

  • Local environmental influences on uveal melanoma: vitreous humor promotes uveal melanoma invasion, whereas the aqueous can be inhibitory.

    abstract:BACKGROUND:Uveal melanomas of the choroid and ciliary body are aggressive tumors causing the death of approximately 50% of patients. In contrast, iris melanomas only infrequently metastasize; why these differences exist is not known. The local environment can regulate cancer growth and development, and it is probable t...


    pub_type: 杂志文章


    authors: Canovas D,Rennie IG,Nichols CE,Sisley K

    更新日期:2008-04-15 00:00:00

  • Identification of novel immunogenic human leukocyte antigen-A 2402-binding epitopes of human papillomavirus type 16 E7 for immunotherapy against human cervical cancer.

    abstract:BACKGROUND:A study was undertaken to identify new immunogenic human leukocyte antigen (HLA)-A 2402-restricted epitopes from human papillomavirus (HPV) type 16 E7 protein for immunotherapy against cervical cancer. METHODS:Synthetic overlapping peptides were screened by measuring the frequency of CD8(+) cytotoxic T lymp...


    pub_type: 杂志文章


    authors: Jang S,Kim YT,Chung HW,Lee KR,Lim JB,Lee K

    更新日期:2012-04-15 00:00:00