Physical activity and survival of postmenopausal, hormone receptor-positive breast cancer patients: results of the Tamoxifen Exemestane Adjuvant Multicenter Lifestyle study.

Abstract:

BACKGROUND:Physical activity has been related to improved breast cancer outcomes. Especially in the older breast cancer population, physical activity may be important because old age is associated with comorbidities and decreased physical function. The purpose of this study was to investigate the relation between physical activity and overall survival, breast cancer-specific survival, and recurrence in several age groups of postmenopausal breast cancer patients. METHODS:The Tamoxifen Exemestane Adjuvant Multinational Lifestyle study was a side study of the Tamoxifen Exemestane Adjuvant Multinational trial and prospectively investigated lifestyle habits of postmenopausal, hormone receptor-positive breast cancer patients. The relations between prediagnosis and postdiagnosis physical activity and overall survival, breast cancer-specific survival, and recurrence-free survival were assessed with Cox regression and competing risk regression models. RESULTS:Among 521 patients, high levels of physical activity before and after the diagnosis were associated with better overall survival (the multivariate hazard ratios were 0.50 [95% confidence interval = 0.26-0.98] and 0.57 (95% confidence interval = 0.26-1.40] for patients who were very active before and after the diagnosis, respectively, in comparison with inactive patients). This was most evident in patients who were 65 years old or older. Physical activity was not significantly associated with breast cancer-specific survival or the relapse-free period. CONCLUSIONS:Overall survival was better for patients who were active before and after the diagnosis. In contrast with previous studies, breast cancer survival and the risk of recurrence were not significantly associated with physical activity. These findings confirmed the need for more studies investigating the use of physical activity to supplement breast cancer treatment in older patients.

journal_name

Cancer

journal_title

Cancer

authors

de Glas NA,Fontein DB,Bastiaannet E,Pijpe A,De Craen AJ,Liefers GJ,Nortier HJ,de Haes HJ,van de Velde CJ,van Leeuwen FE

doi

10.1002/cncr.28783

subject

Has Abstract

pub_date

2014-09-15 00:00:00

pages

2847-54

issue

18

eissn

0008-543X

issn

1097-0142

journal_volume

120

pub_type

杂志文章,多中心研究,随机对照试验

相关文献

CANCER文献大全
  • Expression of c-erbB-2 oncoprotein in gastric carcinoma. Immunoreactivity for c-erbB-2 protein is an independent indicator of poor short-term prognosis in patients with gastric carcinoma.

    abstract::Correlations of c-erbB-2 protein expression with clinical outcomes of gastric carcinomas were studied in 189 gastric carcinomas. There were 23 (12.2%) carcinomas with evidence of c-erbB-2 protein in which the reaction was localized to the cell membrane. There was no significant association between c-erbB-2 staining an...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910601)67:11<2914::aid-cncr282

    authors: Yonemura Y,Ninomiya I,Ohoyama S,Kimura H,Yamaguchi A,Fushida S,Kosaka T,Miwa K,Miyazaki I,Endou Y

    更新日期:1991-06-01 00:00:00

  • The value of combined-modality therapy in elderly patients with stage III nonsmall cell lung cancer.

    abstract:BACKGROUND:The objective of this study was to assess the value of combined-modality therapy in elderly patients by comparing the differences in outcome between patients who received radiotherapy (RT) alone and patients who received RT plus chemotherapy for stage III nonsmall cell lung cancer (NSCLC). METHODS:The North...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22780

    authors: Schild SE,Mandrekar SJ,Jatoi A,McGinnis WL,Stella PJ,Deming RL,Jett JR,Garces YI,Allen KL,Adjei AA,North Central Cancer Treatment GroupThis study was conducted as a collaborative trial of the North Central Cancer Treatment Group and

    更新日期:2007-07-15 00:00:00

  • Plasma insulin-like growth factor I and its binding proteins 1 and 3 in postmenopausal patients with breast cancer receiving long term tamoxifen.

    abstract:BACKGROUND:Insulin-like growth factor I (IGF-I) is a potent mitogen for breast cancer cells. The majority of IGF-I in plasma is bound to IGF binding proteins (IGFBPs), which modulate the biologic effects of IGF-I. METHODS:Plasma concentrations of IGF-I, IGFBP-I, and IGFBP-3 were compared between 40 postmenopausal brea...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940715)74:2<618::aid-cncr28207

    authors: Lahti EI,Knip M,Laatikainen TJ

    更新日期:1994-07-15 00:00:00

  • Neurohormonal peptides in ovarian carcinoids: an immunohistochemical study of 81 primary carcinoids and of intraovarian metastases from six mid-gut carcinoids.

    abstract::Eighty-one primary ovarian carcinoids and intraovarian metastases from six mid-gut carcinoids were examined for the presence of tumor cells immunoreactive with antisera raised against various neurohormonal peptides, mostly of gastroenteropancreatic (GEP) origin. Twenty of the primary and two of the metastatic carcinoi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820101)49:1<68::aid-cncr282049

    authors: Sporrong B,Falkmer S,Robboy SJ,Alumets J,Håkanson R,Ljungberg O,Sundler F

    更新日期:1982-01-01 00:00:00

  • Silent cirrhosis in patients with hepatocellular carcinoma. Implications for screening in high-incidence and low-incidence areas.

    abstract::We assessed the frequency of silent (i.e., clinically asymptomatic) cirrhosis among 305 patients with hepatocellular carcinoma (HCC) and cirrhosis in relation to the patients' country of birth, the cause of the cirrhosis, clinical features, and hepatitis B surface antigen (HBsAg) status. Overall, 56% of the patients h...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900401)65:7<1607::aid-cncr2820

    authors: Zaman SN,Johnson PJ,Williams R

    更新日期:1990-04-01 00:00:00

  • The emerging role of retinoids and retinoic acid metabolism blocking agents in the treatment of cancer.

    abstract:BACKGROUND:Although significant advances have been made in the treatment of some malignancies, the prognosis of patients with metastatic tumors remains poor. Differentiating agents redirect cells toward their normal phenotype and therefore may reverse or suppress evolving malignant lesions or prevent cancer invasion. I...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-0142(19981015)83:8<1471::aid-cn

    authors: Miller WH Jr

    更新日期:1998-10-15 00:00:00

  • The Save our Sisters Project. A social network strategy for reaching rural black women.

    abstract::Why are older black women screened less for breast cancer? What can be done to narrow the racial gap in mammography screening? These are the questions addressed by the Save Our Sisters (SOS) Project, a pilot demonstration study funded by the National Cancer Institute in a rural county of North Carolina. The target pop...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19930801)72:3+<1071::aid-cncr282

    authors: Eng E

    更新日期:1993-08-01 00:00:00

  • Radition therpay control of nine patients with malignant thymoma.

    abstract::Malignant thymoma is a relatively rare condition and a review of the literature reveals approximately 100 reported cases. Only a small percentage of these have been treated with megavoltage radiation therapy; therefore, it is difficult to find the necessary information to establish a proper time-dose relationship for ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197801)41:1<117::aid-cncr2820410

    authors: Marks RD Jr,Wallace KM,Pettit HS

    更新日期:1978-01-01 00:00:00

  • Colon carcinoma in children and adolescents. A review of 30 cases.

    abstract::Carcinoma of the large bowel is rare in persons under the age of 30, and generally presents with advanced stages of disease. From 1964 to 1984, 30 patients presented with nonfamilial large bowel malignancies. Seventeen patients were male, and 13 female (age range, 8-25 years). In 15 patients the primary was in the rig...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850315)55:6<1322::aid-cncr2820

    authors: Rao BN,Pratt CB,Fleming ID,Dilawari RA,Green AA,Austin BA

    更新日期:1985-03-15 00:00:00

  • Metastatic melanoma to the liver: a contemporary and comprehensive review of surgical, systemic, and regional therapeutic options.

    abstract::Effective management of hepatic metastases from ocular and cutaneous melanoma remains a major therapeutic challenge. Treatment options include hepatic resection, hepatic intra-arterial (HIA) chemotherapy, chemoembolization, and hepatic perfusions. Evaluating the efficacy of these interventions is limited by the retros...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.28480

    authors: Agarwala SS,Eggermont AM,O'Day S,Zager JS

    更新日期:2014-03-15 00:00:00

  • Quantitative imaging of cancer in the postgenomic era: Radio(geno)mics, deep learning, and habitats.

    abstract::Although cancer often is referred to as "a disease of the genes," it is indisputable that the (epi)genetic properties of individual cancer cells are highly variable, even within the same tumor. Hence, preexisting resistant clones will emerge and proliferate after therapeutic selection that targets sensitive clones. He...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.31630

    authors: Napel S,Mu W,Jardim-Perassi BV,Aerts HJWL,Gillies RJ

    更新日期:2018-12-15 00:00:00

  • Accuracy of advanced cancer patients' life expectancy estimates: The role of race and source of life expectancy information.

    abstract:BACKGROUND:The objective of this study was to examine the source of advanced cancer patients' information about their prognosis and determine whether this source of information could explain racial disparities in the accuracy of patients' life expectancy estimates (LEEs). METHODS:Coping With Cancer was a prospective, ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30001

    authors: Trevino KM,Zhang B,Shen MJ,Prigerson HG

    更新日期:2016-06-15 00:00:00

  • Prognostic factors in gliomas. A multivariate analysis of clinical, pathologic, flow cytometric, cytogenetic, and molecular markers.

    abstract:BACKGROUND:The ability to divide subsets of patients with glial neoplasms into prognostic groups currently is limited because only a few clinical and pathologic variables are available. The goal of this investigation was to identify biologic factors of potential prognostic value in patients with cerebral gliomas. METH...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940801)74:3<920::aid-cncr28207

    authors: Ganju V,Jenkins RB,O'Fallon JR,Scheithauer BW,Ransom DT,Katzmann JA,Kimmel DW

    更新日期:1994-08-01 00:00:00

  • Estimating the magnitude of colorectal cancers prevented during the era of screening: 1976 to 2009.

    abstract:BACKGROUND:Ideally, screening detects cancer at a more curable stage and, as a result, decreases the rate of subsequent diagnosis at a late stage. Although it is suggested that some cancer screening tests have led to substantial increases in early-stage incidence with only marginal reductions in late-stage incidence (e...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28794

    authors: Yang DX,Gross CP,Soulos PR,Yu JB

    更新日期:2014-09-15 00:00:00

  • Analysis of stage and clinical/prognostic factors for lung cancer from SEER registries: AJCC staging and collaborative stage data collection system.

    abstract:BACKGROUND:The American Joint Committee on Cancer (AJCC) 7th edition introduced major changes in the staging of lung cancer, including the tumor (T), node (N), metastasis (M)-TNM-system and new stage/prognostic site-specific factors (SSFs), collected under the Collaborative Stage Version 2 (CSv2) Data Collection System...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29045

    authors: Chen VW,Ruiz BA,Hsieh MC,Wu XC,Ries LA,Lewis DR

    更新日期:2014-12-01 00:00:00

  • Non-small cell lung cancer. Neuroresection of the solitary intracranial metastasis followed by radiochemotherapy.

    abstract::Fifteen selected patients with advanced intrathoracic non-small cell lung cancer and solitary metastasis were treated by a combined program including craniotomy, brain and chest irradiation, and systemic chemotherapy. One patient died because of cerebral hemorrhage after the operation. Five patients failed to achieve ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851201)56:11<2569::aid-cncr282

    authors: Tummarello D,Porfiri E,Rychlicki F,Miseria S,Cellerino R

    更新日期:1985-12-01 00:00:00

  • Analysis of prognostic factors in patients with isolated chest wall recurrence of breast cancer.

    abstract::A retrospective analysis of a series of 162 patients treated for isolated chest wall recurrence of breast cancer after mastectomy was undertaken. Cumulative survival, distant relapse-free survival, and freedom from local progression after 5 years from the diagnosis of recurrence were 34%, 28%, and 45% respectively. Fi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870715)60:2<240::aid-cncr28206

    authors: Magno L,Bignardi M,Micheletti E,Bardelli D,Plebani F

    更新日期:1987-07-15 00:00:00

  • Basaloid squamous cell carcinoma of floor of mouth.

    abstract:BACKGROUND:Only five cases of basaloid squamous cell carcinoma (BSCC), a rare tumor of head and neck, have been reported to involve the floor of mouth. METHODS:Clinicopathologic and immunohistochemical features of eight BSCC of floor of mouth were studied to evaluate the significance of the basaloid features. RESULTS...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19931015)72:8<2299::aid-cncr2820

    authors: Coppola D,Catalano E,Tang CK,Elfenbein IB,Harwick R,Mohr R

    更新日期:1993-10-15 00:00:00

  • MET amplification is not rare and predicts unfavorable clinical outcomes in patients with recurrent/metastatic gastric cancer after chemotherapy.

    abstract:BACKGROUND:Several large studies have reported an extremely low incidence of MET gene amplification (GA) in patients with radically resected gastric cancer. This study was conducted to evaluate the prevalence and prognostic role of MET in patients with recurrent=metastatic gastric cancer who received chemotherapy. MET...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28454

    authors: An X,Wang F,Shao Q,Wang FH,Wang ZQ,Wang ZQ,Chen C,Li C,Luo HY,Zhang DS,Xu RH,Li YH

    更新日期:2014-03-01 00:00:00

  • Superior vena cava syndrome secondary to an angiotropic large cell lymphoma.

    abstract:BACKGROUND:Angiotropic large cell lymphoma (ALCL) is characterized by the intravascular proliferation of malignant lymphoid cells in small and medium-sized blood vessels. In the current study, the authors report an unusual case in which the initial presentation of the ALCL was that of superior vena cava (SVC) syndrome....

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20001215)89:12<2515::aid-cncr1>3

    authors: Savarese DM,Zavarin M,Smyczynski MS,Rohrer MJ,Hutzler MJ

    更新日期:2000-12-15 00:00:00

  • Seminoma at Roswell Park, 1970 to 1979. An analysis of treatment failures.

    abstract::A retrospective study of all cases of seminoma treated at Roswell Park Memorial Institute from 1970 through 1979 was conducted. Fifty-six evaluable patients treated initially with radiation therapy were seen during this period, and the overall survival rate at an average follow-up period of 52 months was 82%. The surv...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840401)53:7<1451::aid-cncr2820

    authors: Huben RP,Williams PD,Pontes JE,Panahon AM,Murphy GP

    更新日期:1984-04-01 00:00:00

  • Prognostic significance of serum osteoprotegerin levels in patients with bladder carcinoma.

    abstract:BACKGROUND:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plays an important role in the process of lymphocyte-mediated cytotoxicity against malignant cells. Osteoprotegerin (OPG) is a soluble decoy receptor for TRAIL, and circulating OPG has been implicated in the protection of cells from TRAIL-mediat...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20550

    authors: Mizutani Y,Matsubara H,Yamamoto K,Nan Li Y,Mikami K,Okihara K,Kawauchi A,Bonavida B,Miki T

    更新日期:2004-10-15 00:00:00

  • Late regrowth of pituitary adenomas after irradiation and/or surgery. Hazard function analysis.

    abstract::A retrospective analysis was performed on all patients with pituitary adenomas treated at the Radiation Oncology Center, Mallinckrodt Institute of Radiology, St. Louis, Missouri. Of 210 patients treated from April 1954 through December 1982, 70 were treated with radiotherapy alone (RT), 121 received immediate postoper...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890401)63:7<1308::aid-cncr2820

    authors: Grigsby PW,Simpson JR,Fineberg B

    更新日期:1989-04-01 00:00:00

  • Nutrition and breast cancer.

    abstract::International comparisons have provided striking correlations between fat consumption and risk of breast cancer, but these comparisons do not often consider variations in life style. Case-control studies carried out in several countries showed no real association between fat intake and breast cancer. There is some evi...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19900915)66:14+<1321::aid-cncr28

    authors: Kritchevsky D

    更新日期:1990-09-15 00:00:00

  • Imaging in gynecologic malignancies.

    abstract::Cross-sectional imaging is often a useful complement to clinical examination in patients with gynecologic malignancies. Patients with ovarian cancer will benefit less from the use of computed tomography and magnetic resonance imaging (MRI); however, extensive intraperitoneal disease may be evaluated and followed with ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.2820710431

    authors: Bragg DG,Hricak H

    更新日期:1993-02-15 00:00:00

  • Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapy.

    abstract:BACKGROUND:The goal of the current study was to define the clinical features and outcome of recurrent osteosarcoma (OS) in children and young adults initially treated with contemporary chemotherapy. METHODS:The authors reviewed the clinical features, therapy, and outcome for 59 patients from the Mayo Clinic (Rochester...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11799

    authors: Hawkins DS,Arndt CA

    更新日期:2003-12-01 00:00:00

  • Type Ia glycogenosis associated with hepatocellular carcinoma.

    abstract::The predisposition of preexisting cirrhotic metabolic liver disease to the development of hepatocellular carcinoma is well established. However, the association between glycogenoses (a form of noncirrhotic metabolic liver disease) and the formation of benign and malignant liver tumors is less well known. The sixth cas...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19920315)69:6<1320::aid-cncr2820

    authors: Conti JA,Kemeny N

    更新日期:1992-03-15 00:00:00

  • Granulocyte-macrophage-colony-stimulating factor added to a multipeptide vaccine for resected Stage II melanoma.

    abstract:BACKGROUND:Forty-eight patients with resected Stages IIA and IIB melanoma were immunized with two tumor antigen epitope peptides derived from gp100(209-217) (210M) (IMDQVPSFV) and tyrosinase(368-376) (370D) (YMDGTMSQV) emulsified with incomplete Freund's adjuvant (IFA). Patients were assigned randomly to receive either...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/cncr.11045

    authors: Weber J,Sondak VK,Scotland R,Phillip R,Wang F,Rubio V,Stuge TB,Groshen SG,Gee C,Jeffery GG,Sian S,Lee PP

    更新日期:2003-01-01 00:00:00

  • PTH mRNA transcription analysis in infantile tumors associated with hypercalcemia.

    abstract::The ability of infantile hypercalcemic tumors (three rhabdoid renal tumors, one cellular mesoblastic nephroma, and one hepatoblastoma) to produce parathyroid hormone (PTH) was tested using RNA-DNA hybridization. Results were compared with those obtained in one lung epidermoid carcinoma and one parathyroid adenoma from...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880715)62:2<303::aid-cncr28206

    authors: Rousseau-Merck MF,de Keyzer Y,Bourdeau A,Cournot G,Mercier F,Nezelof C

    更新日期:1988-07-15 00:00:00

  • Retroperitoneal lymphadenectomy and aggressive chemotherapy in nonbulky clinical Stage II nonseminomatous germinal testis tumors.

    abstract::In a former series of 60 resected Stage II nonseminomatous germinal testis tumors the authors succeeded in demonstrating that adjuvant cisplatin, vinblastine, and bleomycin (PVB) was able to significantly improve survival (100% in 11 treated versus 28.5% in 7 historical controls, P less than 0.01) only in patients wit...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840315)53:6<1363::aid-cncr2820

    authors: Pizzocaro G,Zanoni F,Milani A,Piva L,Salvioni R,Pasi M,Pilotti S,Monfardini S

    更新日期:1984-03-15 00:00:00