Abstract:
BACKGROUND:Forty-eight patients with resected Stages IIA and IIB melanoma were immunized with two tumor antigen epitope peptides derived from gp100(209-217) (210M) (IMDQVPSFV) and tyrosinase(368-376) (370D) (YMDGTMSQV) emulsified with incomplete Freund's adjuvant (IFA). Patients were assigned randomly to receive either peptides/IFA alone or with 250 microm of granulocyte-macrophage-colony-stimulating factor (GM-CSF) subcutaneously daily for 5 days to evaluate the toxicities and immune responses in either arm. Time to recurrence and survival were secondary end points. METHODS:Immunizations were administered every 2 weeks x 4, then every 4 weeks x 3, and once 8 weeks later. A leukapheresis to obtain peripheral blood mononuclear cells for immune analyses and skin testing with peptides and recall reagents was performed before and after eight vaccinations. RESULTS:Local pain and granuloma formation, fever, and lethargy of Grade 1 or 2 were observed. Transient vaccine-related Grade III and no Grade IV toxicity was observed. Seventeen of the 40 patients for whom posttreatment skin tests were performed developed a positive skin test response to the gp100 peptide, but only 1 of the 40 patients developed a positive skin test response to tyrosinase. Immune responses were measured by release of interferon-gamma (IFN-gamma) in an enzyme-linked immunosorbent assay (ELISA) by effector cells in the presence of peptide-pulsed antigen-presenting cells, by cytokine release of IFN-gamma, GM-CSF, and tumor necrosis factor-alpha in a Luminex assay, or by an antigen-specific tetramer flow cytometry assay. Thirty-four of the 39 patients for whom the ELISA data were performed demonstrated an immune response after vaccination, as did 37 of 42 patients by tetramer assay. Enzyme-linked immunosorbent assay, Luminex, and tetramer responses in the GM-CSF/peptide/IFA group were higher than in the peptide/IFA group. Epitope spreading to the MART-1/MelanA 27-35 and 26-35 (27L) epitopes was detected by tetramer assay in 10 patients. Seven of 48 patients experienced disease recurrence with a median of 24 months of follow-up and 2 patients in this intermediate to high risk group have died. CONCLUSION:These data suggest a significant number of patients with resected melanoma mount an antigen-specific immune response against a peptide vaccine. There is a trend for GM-CSF to modestly increase the immune response and support further development of GM-CSF as a vaccine adjuvant.
journal_name
Cancerjournal_title
Cancerauthors
Weber J,Sondak VK,Scotland R,Phillip R,Wang F,Rubio V,Stuge TB,Groshen SG,Gee C,Jeffery GG,Sian S,Lee PPdoi
10.1002/cncr.11045subject
Has Abstractpub_date
2003-01-01 00:00:00pages
186-200issue
1eissn
0008-543Xissn
1097-0142journal_volume
97pub_type
临床试验,杂志文章,随机对照试验相关文献
CANCER文献大全abstract:BACKGROUND:Paclitaxel currently is administered by prolonged intravenous infusion because of the occurrence of severe hypersensitivity reactions in patients in early clinical trials. However, intensive premedication probably is more important in eliminating allergic reactions than is the length of infusion. The authors...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19940815)74:4<1377::aid-cncr2820
更新日期:1994-08-15 00:00:00
abstract::Tn antigen is the immediate precursor of the carcinoma (CA)-associated T antigen; both are masked in non-CA tissues. Tn antigen was detected by absorption of human anti-Tn antibody in 46 of 50 primary breast CAs and in all 6 metastases originating from Tn-positive primary CAs. Thirteen of 25 (52%) anaplastic CAs, but ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850201)55:3<561::aid-cncr28205
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND:The behavior of diffuse peritoneal mesotheliomas in women and the possible relation between tumor morphology and outcome are uncertain. Reported survival has ranged from < 1 month to > 14 years, and a previous study found that tumor morphology could not be used reliably for predicting outcome. The authors ex...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10209
更新日期:2002-01-15 00:00:00
abstract:BACKGROUND:The objective of this study was to determine whether a very low presenting prostate-specific antigen (PSA) level was associated with greater prostate cancer-specific mortality (PCSM) among men with a Gleason score (GS) of 8 to 10. METHODS:The Surveillance, Epidemiology, and End Results program was used to i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29691
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Prior studies raise concern about gender bias in cancer research, including insufficient inclusion of women or men, or studying women and men differently. The 1993 National Institutes of Health Revitalization Act aimed to eliminate gender bias in medicine. To examine changes in medical and psychological lite...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27432
更新日期:2012-10-01 00:00:00
abstract::Few epidemiologic studies have been undertaken to investigate the etiology of cancer of the vulva. To identify risk factors associated with this cancer, a case-control study was conducted in 149 patients with histologically proven vulvar carcinoma and the same number of control patients matched for age, race, marital ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850415)55:8<1843::aid-cncr2820
更新日期:1985-04-15 00:00:00
abstract:BACKGROUND:Pericolorectal tumor deposits (TDs) are associated with adverse outcomes in patients with colorectal cancer, and the seventh edition of the American Joint Committee on Cancer (AJCC) staging system recently classified TDs without regional lymph node metastasis as category N1c. However, the definition of TDs h...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25968
更新日期:2011-09-01 00:00:00
abstract::A leukocyte migration procedure was utilized to test cellular hypersensitivity of breast cancer patients' leukocytes to autologous and homologous breast cancer tissues and to murine milk containing murine mammary tumor virus (MuMTV). The in vitro responsiveness of the leukocytes and the antigenicity of breast cancer t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197501)35:1<121::aid-cncr2820350
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:Childhood cancer survivors are at risk for cardiovascular disease (CVD) because of intensive cancer therapies often accompanied by an unhealthy lifestyle. This study was aimed at 1) describing modifiable CVD risk factors in survivors and 2) investigating the association between different aspects of physical ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33351
更新日期:2021-01-06 00:00:00
abstract::The evaluation of serial plasma carcinoembryonic antigen (CEA) levels is one of the most important parameter used to establish the prognosis of surgically cured colorectal cancer patients. Carcinoembryonic antigen is particularly useful in the identification of recurrences and metastasis. However, to improve the usefu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850601)55:11<2624::aid-cncr282
更新日期:1985-06-01 00:00:00
abstract::A clinicopathologic analysis of 35 cases of lymphocyte predominance Hodgkin's disease (LPHD) was performed, and the relationship between various histologic features and stage at presentation was examined. The series comprised 31 male and 4 female patients with a median age of 32 years. Twenty patients had Ann Arbor St...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870101)59:1<99::aid-cncr282059
更新日期:1987-01-01 00:00:00
abstract::Between January 1988 and June 1990, seven previously untreated patients with histologically confirmed and clinically staged IIIa invasive thymoma (IT) were enrolled in a prospective, single treatment arm study of neoadjuvant chemotherapy (NC) followed by surgery and postoperative radiation therapy (4600 to 6000 cGy). ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910815)68:4<706::aid-cncr28206
更新日期:1991-08-15 00:00:00
abstract::Between 1968 and 1985, 28 patients with recurrent gestational trophoblastic disease (GTD) were treated at the Southeastern Regional Trophoblastic Disease Center. Sixteen patients received primary therapy at this center and had recurrence diagnosed by re-elevation of human chorionic gonadotropin (hCG) levels after thre...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900901)66:5<978::aid-cncr28206
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:The unusual clinical picture of transitional cell carcinoma (TCC) in Taiwan appears to be different from that reported elsewhere. METHODS:The authors reviewed their experience of 135 cases of pathologically proven TCC of the upper urinary tract. Data regarding the gender ratio and clinical presentation were...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1999-03-15 00:00:00
abstract:BACKGROUND:Studies of colorectal adenocarcinoma (CRC) indicate a higher mortality rate for African Americans compared with Caucasians in the United States. In the current study, the authors evaluated the racial differences in survival based on tumor location and pathologic stage between African-American patients and Ca...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20337
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:As an organized screening program, the national Breast and Cervical Cancer Early Detection Program (BCCEDP) was launched in the early 1990s to improve breast cancer outcomes among underserved women. To analyze the impact of the BCCEDP on breast cancer outcomes in Ohio, this study compared cancer stages and m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30720
更新日期:2017-08-15 00:00:00
abstract:BACKGROUND:Previous studies have shown that low levels of p27(Kip1), an inhibitor of G1 cyclin-dependent kinases, are associated with high aggressiveness and poor prognosis in a variety of cancers. Decreased levels of p27 are caused, at least in part, by acceleration of the rate of its ubiquitin-mediated degradation. I...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010501)91:9<1745::aid-cncr1193
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Conditional survival (CS) has emerged as a clinically relevant measure of prognosis for cancer survivors. The objective of this analysis was to provide melanoma-specific CS estimates to help clinicians promote more informed patient decision making. METHODS:Patients with melanoma and at least 5 years of foll...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24966
更新日期:2010-05-01 00:00:00
abstract::The pancreatographic appearance and the clinical presentation of ten patients presenting with adenocarcinoma of the head of the pancreas coexisting with chronic pancreatitis were compared with those of 45 patients with chronic pancreatitis (CP), without malignancy, investigated at the same time period. All ten patient...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900215)65:4<893::aid-cncr28206
更新日期:1990-02-15 00:00:00
abstract:BACKGROUND:The p53 tumor suppressor gene encodes a nuclear phosphoprotein that is thought to be important to cell cycle regulation and DNA repair and that also may regulate induction of apoptosis by ionizing radiation. Somatic p53 gene mutations occur in 30-50% of breast carcinomas and are associated with poor prognosi...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::During the period 1955 to 1975, 63 consecutive cases of apical lung carcinoma were treated in the Radiation Therapy Division of the University of Michigan Medical Center (UMMC). Supervoltage external radiation alone or combination of radiation and surgery were the main modalities of treatment used in these patients. O...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840901)54:5<913::aid-cncr28205
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND:The Centers for Disease Control and Prevention (CDC) initiated the Colorectal Cancer Screening Demonstration Program (CRCSDP) to explore the feasibility of establishing a large-scale colorectal cancer screening program for underserved populations in the United States. The authors of the current report provid...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.28158
更新日期:2013-08-01 00:00:00
abstract::Delayed cutaneous hypersensitivity to 2,3-dinitrochlorobenzene (DNCB) was tested in 419 patients with malignant melanoma to determine whether DNCB reactivity was associated with prognosis. At the time of definitive surgery, a positive DNCB test was seen in 82% of the patients in State I (regional lymph node histologic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810515)47:10<2446::aid-cncr282
更新日期:1981-05-15 00:00:00
abstract:BACKGROUND:Studies postulate that certain religious beliefs related to medical care influence the end-of-life (EOL) medical decision making and care of patients with advanced cancer. Because to the best of the authors' knowledge no current measure explicitly assesses such beliefs, in the current study the authors intro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31946
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:The relationships between psychological and behavioral variables and patient outcomes after hematopoietic stem cell transplantation (HSCT) are not known definitively but have great potential importance, since this lifesaving procedure is used increasingly to treat a variety of malignancies. The objective of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20431
更新日期:2004-08-15 00:00:00
abstract:BACKGROUND:For patients who have chondrosarcoma with unresectable disease, because of tumor location, tumor size, or extensive metastatic disease, treatment options are very limited because of their relative resistance to radiotherapy and chemotherapy. The overall survival of this patient population is poor; however, s...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.28845
更新日期:2014-10-15 00:00:00
abstract::The endocrine action of medroxyprogesterone acetate (MPA) has been claimed to be of a glucocorticoid-like nature. Upon clinical observation, MPA has been shown to improve life quality and overall well-being in patients with advanced breast cancer, renal carcinoma, prostatic carcinoma, and uterine adenocarcinoma. The a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19901101)66:9<1949::aid-cncr2820
更新日期:1990-11-01 00:00:00
abstract::Fifty-four patients with advanced squamous, large-cell or adeno-carcinoma of the lung were treated with a three drug regimen of high-dose cisplatin, vindesine and a four-day bleomycin infusion (CVB). All patients had measurable disease; none had previously received chemotherapy. Of 52 patients evaluable for response, ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830315)51:6<1050::aid-cncr2820
更新日期:1983-03-15 00:00:00
abstract::A patient with a primary adenohypophyseal neoplasm who had a long course marked by multiple surgical resections, radiation therapy, and high-dose dopamine agonist therapy developed local invasion as well as cranial and extracranial osseous metastatic lesions. The serum prolactin levels were greatly elevated, and immun...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850201)55:3<598::aid-cncr28205
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND:Prognostic factors for patients with stage III melanoma are still controversial. METHODS:Two hundred eighty-six patients with solitary cutaneous malignant melanoma of the skin in Stage III (International Union Against Cancer [UICC]) were followed up for as long as 11 years. RESULTS:Patients in risk group p...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930215)71:4<1239::aid-cncr2820
更新日期:1993-02-15 00:00:00