The prognosis of patients with stage III melanoma. Prospective long-term study of 286 patients of the Fachklinik Hornheide.

abstract：:The correlation between clinicopathologic findings and point mutation in codon 12 of c-Ki-ras gene was examined in primary lung adenocarcinomas using polymerase chain reaction and oligonucleotide hybridization techniques. The mutation was detected in ten of 67 cases (15%). Microscopically, mutation-positive cases reve...

journal_title：Cancer

authors： Kobayashi T,Tsuda H,Noguchi M,Hirohashi S,Shimosato Y,Goya T,Hayata Y

更新日期：1990-07-15 00:00:00

abstract：:Jaundice and hepatomegaly developed in a boy with Fanconi anemia after he had undergone treatment with oxymetholone for nine years. A liver scan showed patchy uptake consistent with the presence of space-occupying lesions. After oxymetholone treatment was stopped, the jaundice resolved, the liver size decreased, and t...

journal_title：Cancer

authors： Obeid DA,Hill FG,Harnden D,Mann JR,Wood BS

更新日期：1980-09-15 00:00:00

abstract：BACKGROUND:In a previous clinical trial, the authors disclosed that the expression of tumor cell motility factor gp78hAMFR correlates with tumor progression in patients with bladder carcinoma. This study was initiated to evaluate whether the combination of cytostatic drugs with an antimotility factor has an effect on c...

journal_title：Cancer

authors： Otto T,Bex A,Krege S,Walz PH,Rübben H

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:Several investigators have reported the ability to establish xenografts in nude mice from children with neuroblastomas, but a correlation of prognosis with this establishment and the growth patterns of the neuroblastomas has not been reported. METHODS:Tumor specimens from 58 children with neuroblastomas wer...

journal_title：Cancer

authors： George BA,Yanik G,Wells RJ,Martin LW,Soukup S,Ballard ET,Gartside PS,Lampkin BC

更新日期：1993-12-01 00:00:00

abstract：:Four cell lines were derived from childhood malignancies: rhabdomyosarcoma, sarcoma, lymphosarcoma and an American Burkitt's lymphoma. Cells of the four lines formed tumors in immunosuppressed newborn hamsters. The tumors had a microscopic appearance like that of the tumors from which the cell lines were derived. No ...

journal_title：Cancer

authors： McAllister RM,Nelson-Rees WA,Peer M,Laug WE,Isaacs H Jr,Gilden RV,Rongey RW,Gardner MB

更新日期：1975-11-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA) was measured in 147 patients at diagnosis of small cell lung cancer; 17% of patients with limited disease and 51% with extensive disease had an abnormal CEA level (greater than 10 ng/ml). The median level was higher in extensive than in limited disease (11 ng/ml and 5.8 ng/ml, respective...

journal_title：Cancer

authors： Laberge F,Fritsche HA,Umsawasdi T,Carr DT,Welch S,Murphy WK,Chiuten DF,Dhingra HM,Farha P,Spitzer G

更新日期：1987-06-15 00:00:00

abstract：BACKGROUND:Outcomes have improved significantly in multiple myeloma (MM), but racial disparities in health care access and survival exist. A comprehensive analysis exploring MM care and racial disparities is warranted. METHODS:Patients with MM from 1991 to 2010 in the Surveillance, Epidemiology, and End Results-Medica...

journal_title：Cancer

authors： Ailawadhi S,Frank RD,Sharma M,Menghani R,Temkit M,Paulus S,Khera N,Hashmi S,Advani P,Swaika A,Paulus A,Aslam N,Sher T,Roy V,Colon-Otero G,Chanan-Khan A

更新日期：2018-04-15 00:00:00

abstract：BACKGROUND:Hemangiopericytomas and malignant solitary fibrous tumors (HPC/SFT) are rare, closely related sarcomas with unpredictable behavior that respond infrequently to chemotherapy. An optimal systemic treatment strategy for advanced HPC/SFT has not yet been identified. METHODS:We retrospectively analyzed the recor...

journal_title：Cancer

authors： Park MS,Patel SR,Ludwig JA,Trent JC,Conrad CA,Lazar AJ,Wang WL,Boonsirikamchai P,Choi H,Wang X,Benjamin RS,Araujo DM

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:The current study was conducted to characterize the epidemiology, histology, and radiographic features of as well as the surgical approach to pediatric and adolescent renal cell carcinoma (pRCC). METHODS:pRCC cases prospectively enrolled on the Children's Oncology Group study AREN03B2 underwent central path...

journal_title：Cancer

authors： Geller JI,Ehrlich PF,Cost NG,Khanna G,Mullen EA,Gratias EJ,Naranjo A,Dome JS,Perlman EJ

更新日期：2015-07-15 00:00:00

abstract：BACKGROUND:Cisplatin and carboplatin are essential to management of advanced-stage epithelial ovarian carcinoma. No published data exist regarding carboplatin dose intensity importance in ovarian cancer, nor are there data for the effect of age on the ability to deliver dose-intensive carboplatin. METHODS:Retrospectiv...

journal_title：Cancer

authors： Cornelison TL,Reed E

更新日期：1993-01-15 00:00:00

abstract：:All patients with a diagnosis of cutaneous malignant melanoma (CMM) in Western Australia from 1980 to 1981 were observed for up to 6 years to determine vital status and to detect the development of local recurrences of the primary lesion. Approximately 35% of all patients had their tumors excised with surgical margins...

journal_title：Cancer

authors： Heenan PJ,English DR,Holman CD,Armstrong BK

更新日期：1992-01-15 00:00:00

abstract：:Five hundred and sixty-six patients with either Stage III or IV Hodgkin's disease were prospectively randomized to test whether CCNU and/or vinblastine are more effective than mechlorethamine and/or vincristine with procarbazine and prednisone. The combination of CCNU, vinblastine, procarbazine, and prednisone (CVPP) ...

journal_title：Cancer

authors： Cooper MR,Pajak TF,Nissen NI,Stutzman L,Brunner K,Cuttner J,Falkson G,Grunwald H,Bank A,Leone L,Seligman BR,Silver RT,Weiss RB,Haurani F,Blom J,Spurr CL,Glidewell OJ,Gottlieb AJ,Holland JF

更新日期：1980-08-15 00:00:00

abstract：:Since June 1978, 57 patients with primary osteogenic sarcoma of an extremity were treated with high-dose methotrexate (HDMTX) and citrovorum factor rescue (CFR), Adriamycin, and the combination of bleomycin, cyclophosphamide and dactinomycin (BCD) given for 4-16 weeks prior to definitive surgery. Histologic examinatio...

journal_title：Cancer

authors： Rosen G,Caparros B,Huvos AG,Kosloff C,Nirenberg A,Cacavio A,Marcove RC,Lane JM,Mehta B,Urban C

更新日期：1982-03-15 00:00:00

abstract：:Two cases of primary non-Hodgkin's lymphomas of the breast were studied with light and electron microscopy. By light microscopy, according to Rappaport's classification, one was a poorly differentiated lymphocytic lymphoma, the other a diffuse histiocytic lymphoma. However, the ultrastructural features of the latter w...

journal_title：Cancer

authors： Navas JJ,Battifora H

更新日期：1977-05-01 00:00:00

abstract：:Long-term survival of 1986 consecutive patients with infiltrating duct carcinoma of the breast treated at the National Cancer Institute of Milano (Italy) in two periods of time (1971 to 1972 and 1977 to 1978) was comparatively evaluated to verify if the evolving concepts in the management of breast cancer had an impac...

journal_title：Cancer

authors： Cascinelli N,Greco M,Morabito A,Bufalino R,Testori A,Baldini MT,Andreola S,Leo E,Galluzzo D,Rilke F

更新日期：1991-07-15 00:00:00

abstract：BACKGROUND:The authors attempted to obtain shared proteins among lung carcinoma cells by column chromatographies. A glycoprotein with approximately 500 kDa isolated from QG56 cells showed an identical amino acid sequence to 90K/Mac-2 binding protein (M2BP). This protein has been reported to be highly expressed and to m...

journal_title：Cancer

authors： Ozaki Y,Kontani K,Hanaoka J,Chano T,Teramoto K,Tezuka N,Sawai S,Fujino S,Yoshiki T,Okabe H,Ohkubo I

更新日期：2002-11-01 00:00:00

abstract：:Since 1975, clinical studies have been carried out to determine whether radiation when combined with localized hyperthermia evokes improved tumor control compared to that achieved with radiation alone. Local tumor hyperthermia was achieved using radiofrequency inductive heating at 27.12 MHz. In bulky lesions (greater ...

journal_title：Cancer

authors： Kim JH,Hahn EW,Ahmed SA

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:Transplantation of donor-derived malignancies during organ transplantation fortunately is very rare. Discontinuation of immunosuppressive medications under these circumstances has previously resulted in complete tumor rejection. Ectopic adrenocorticotropic hormone (ACTH) production may result in Cushing synd...

journal_title：Cancer

authors： Bodvarsson S,Burlingham W,Kusaka S,Hafez GR,Becker BN,Pintar T,Sollinger HW,Albertini MR

更新日期：2001-11-01 00:00:00

abstract：:The National Wilms' Tumor Study (NWTS) was initiated in 1969. One of its objectives was to modulate treatments according to risk factors to minimize the number and severity of treatment-related short-term and long-term iatrogenic complications. The NWTS has therefore incorporated a Long Term Follow-up Study (LTFS) wit...

journal_title：Cancer

authors： Evans AE,Norkool P,Evans I,Breslow N,D'Angio GJ

更新日期：1991-01-15 00:00:00

abstract：:Until recently the prognosis of childhood non-Hodgkin's lymphoma has been poor. A program of combination chemotherapy and involved area radiotherapy was instituted in the Department of Pediatrics at Roswell Park Memorial Institute in 1971. Thirty-one biopsy proven untreated children entered this study. There were 4 St...

journal_title：Cancer

authors： Brecher ML,Sinks LF,Thomas RR,Freeman AI

更新日期：1978-05-01 00:00:00

abstract：BACKGROUND:Older age has historically been an adverse prognostic factor in pediatric acute myeloid leukemia (AML). To the authors' knowledge, the impact of age relative to that of other prognostic factors on the outcome of patients treated in recent trials is unknown. METHODS:Clinical outcome and causes of treatment f...

journal_title：Cancer

authors： Rubnitz JE,Pounds S,Cao X,Jenkins L,Dahl G,Bowman WP,Taub JW,Pui CH,Ribeiro RC,Campana D,Inaba H

更新日期：2012-12-15 00:00:00

abstract：BACKGROUND:Cyclin D1 expression has been reported in a subset of patients with diffuse large B-cell leukemia (DLBCL), but studies have been few and generally small, and they have demonstrated no obvious clinical implications attributable to cyclin D1 expression. METHODS:The authors reviewed 1435 patients who were diag...

journal_title：Cancer

authors： Ok CY,Xu-Monette ZY,Tzankov A,O'Malley DP,Montes-Moreno S,Visco C,Møller MB,Dybkaer K,Orazi A,Zu Y,Bhagat G,Richards KL,Hsi ED,Han van Krieken J,Ponzoni M,Farnen JP,Piris MA,Winter JN,Medeiros LJ,Young KH

更新日期：2014-06-15 00:00:00

abstract：:During the period 1955 to 1975, 63 consecutive cases of apical lung carcinoma were treated in the Radiation Therapy Division of the University of Michigan Medical Center (UMMC). Supervoltage external radiation alone or combination of radiation and surgery were the main modalities of treatment used in these patients. O...

journal_title：Cancer

authors： Ahmad K,Fayos JV,Kirsh MM

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:Although marital distress has been implicated in difficulties with adjustment to a breast cancer diagnosis, its long-term effects, especially on physical recovery, are unknown. METHODS:Longitudinal data from newly diagnosed breast cancer patients (N=100) who were married or cohabiting were used. Patients we...

journal_title：Cancer

authors： Yang HC,Schuler TA

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Infection with oncogenic-type human papillomavirus (HPV) and consecutive cytologic abnormalities of the uterine cervix precede the evolution of carcinoma. However, the specificity of both changes is too low to predict the true malignant potential of the change in a given time point, because the majority of t...

journal_title：Cancer

authors： Bollmann R,Méhes G,Speich N,Schmitt C,Bollmann M

更新日期：2005-04-25 00:00:00

abstract：BACKGROUND:This study was designed to assess the toxicity of pelvic radiation therapy, 5-fluorouracil (5-FU) administered by protracted venous infusion, and leucovorin. METHODS:Pelvic radiation therapy consisted of 50.4-54 gray (Gy) administered in 28-30 fractions. Systemic treatment consisted of leucovorin (10 mg dai...

journal_title：Cancer

authors： Martenson JA,Shanahan TG,O'Connell MJ,Cobau CD,Schroeder G,Burch PA,Levitt R,Rowland KM Jr

更新日期：1999-08-15 00:00:00

abstract：:A nonfunctioning strumal carcinoid arising in a 49-year-old woman was studied by histochemical and immunocytochemical techniques. All tumor cells, irrespective of their architectural arrangement, showed properties of neuroendocrine-programmed cells, without any evidence of thyroid follicular cell differentiation. Foci...

journal_title：Cancer

authors： Dayal Y,Tashjian AH Jr,Wolfe HJ

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND:Bone morphogenetic proteins (BMP) induce ectopic bone formation in vivo and may play a role in normal bone development. In addition, bone morphogenetic activity, as measured in a bone-forming assay in immunodeficient, athymic nu/nu mice, is present in a proportion of osteosarcomas; this activity, which may b...

journal_title：Cancer

authors： Yoshikawa H,Rettig WJ,Takaoka K,Alderman E,Rup B,Rosen V,Wozney JM,Lane JM,Huvos AG,Garin-Chesa P

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:The authors tested a biotherapy regimen involving recombinant interferon-alpha-2a (rIFN-alpha-2a) and recombinant human interleukin-2 (rhIL-2), given in a "decrescendo" schedule over 5 days, for its activity and toxicity in 21 patients who previously had received chemotherapy for advanced melanoma. METHODS:...

journal_title：Cancer

authors： Eton O,Buzaid AC,Bedikian AY,Smith TM,Papadopoulos NE,Ellerhorst JA,Hibberts JL,Legha SS,Benjamin RS

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Sacituzumab govitecan (IMMU-132), an antitrophoblastic cell-surface antigen (anti-Trop-2) humanized antibody-SN-38 conjugate, had encouraging efficacy in the phase 1 clinical trial. This report further examines the pharmacokinetics and safety of multiple cycles of IMMU-132 at doses of 8 or 10 mg/kg in patien...

journal_title：Cancer

authors： Ocean AJ,Starodub AN,Bardia A,Vahdat LT,Isakoff SJ,Guarino M,Messersmith WA,Picozzi VJ,Mayer IA,Wegener WA,Maliakal P,Govindan SV,Sharkey RM,Goldenberg DM

更新日期：2017-10-01 00:00:00