Abstract:
:Between 1968 and 1985, 28 patients with recurrent gestational trophoblastic disease (GTD) were treated at the Southeastern Regional Trophoblastic Disease Center. Sixteen patients received primary therapy at this center and had recurrence diagnosed by re-elevation of human chorionic gonadotropin (hCG) levels after three consecutive negative levels: five (2.5%) of 204 patients with nonmetastatic GTD, three (3.7%) of 81 with good prognosis metastatic disease, and eight (13%) of 61 with poor prognosis disease. The remaining 12 patients were referred for therapy after receiving primary therapy elsewhere. All episodes of recurrence were observed within 36 months of remission with 50% and 85% before 3 and 18 months, respectively. Fourteen (56%) of 25 patients who achieved secondary remission developed a second recurrence and five (45%) of 11 surviving a second recurrence developed one or more further episodes of recurrent GTD. Nineteen patients (68%) have sustained remission 18 months following therapy for recurrent GTD. Factors relating to development and survival of recurrent disease include: poor prognosis metastatic disease, inadequate initial staging and therapy, lack of adequate maintenance chemotherapy beyond the first negative hCG level, and prolonged intervals between cycles of chemotherapy. Recent regimens introduced have contributed to an increasing salvage rate: 15 of 18 patients treated since 1978 are without evidence of disease whereas only four of ten treated prior to 1978 are currently in remission (P = 0.03).
journal_name
Cancerjournal_title
Cancerauthors
Mutch DG,Soper JT,Babcock CJ,Clarke-Pearson DL,Hammond CBdoi
10.1002/1097-0142(19900901)66:5<978::aid-cncr28206subject
Has Abstractpub_date
1990-09-01 00:00:00pages
978-82issue
5eissn
0008-543Xissn
1097-0142journal_volume
66pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Survivors of childhood leukemia/lymphoma are at increased risk for reduced bone mineral density (BMD). The authors sought to determine the frequency of reduced BMD detected by off-therapy surveillance, factors associated with reduced BMD, and the association of reduced BMD with fractures. METHODS:This cross...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32512
更新日期:2020-01-01 00:00:00
abstract::The mitogen-activated protein kinase/extracellular signal-regulated (MAPK/ERK) pathway is activated by upstream genomic events and/or activation of multiple signaling events in which information coalesces at this important nodal pathway point. This pathway is tightly regulated under normal conditions by phosphatases a...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.28864
更新日期:2014-11-15 00:00:00
abstract::In this study of 454 colorectal carcinoma colectomy specimens, (289 were associated with and 165 were unassociated with schistosomiasis. Schistosome infestation was found to play an etiologic role in bowel malignancy in patients having diffuse involvement of the large intestine and a history of ten years or more of co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801001)46:7<1661::aid-cncr2820
更新日期:1980-10-01 00:00:00
abstract:BACKGROUND:Breast conservation is now established treatment for patients with small breast cancers. The authors reviewed a large series of patients with long term follow-up who underwent conservative treatment. Clinical and pathologic factors were analyzed to identify patients at an increased risk of relapse in the bre...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19951201)76:11<2260::aid-cncr282
更新日期:1995-12-01 00:00:00
abstract::The clinical, patient-oriented focus of medicine and psychology is contrasted with the epidemiologic (public health) approach in assessing the role of life-style factors and health promotion in cancer research. The unifying host-agent-environment epidemiologic paradigm is applied to contemporary cancer prevention issu...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19910201)67:3+<808::aid-cncr2820
更新日期:1991-02-01 00:00:00
abstract::In 25 patients under treatment or during follow-up for acute lymphoblastic leukemia magnetic resonance imaging (MRI) of both knees was compared to history and physical examination to detect osteonecrosis. Results of MRI were classified as: O, normal bone marrow (BM); 1, diffuse decrease in signal intensity; 2, circums...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871215)60:12<2994::aid-cncr282
更新日期:1987-12-15 00:00:00
abstract:BACKGROUND:The objective of this study was to evaluate the efficacy and toxicity of a high-dose 5-fluorouracil and actinomycin D regimen (the FA regimen) as salvage chemotherapy for patients with high-risk gestational trophoblastic tumors (GTTs). METHODS:From 1985 to 1997, 10 patients with refractory, high-risk GTTs w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10790
更新日期:2002-09-01 00:00:00
abstract::Forty-nine patients with transitional urothelial tract tumors received methotrexate: 0.5-1.0 mg/kg I.V. Q W (40 patients) or 250 mg/M2 in a 2-hour infusion with citrovorum factor rescue 24 hours later (nine patients). Eleven (26%, 95% confidence limits 13-39%) of 42 patients with bidimensionally measurable metastases ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810315)47:6<1246::aid-cncr2820
更新日期:1981-03-15 00:00:00
abstract:BACKGROUND:Novel approaches to increasing the therapeutic efficacy of targeted radiotherapy of cancer are required. One strategy to achieve this goal is to induce high-level expression of a receptor on the surface of tumor cells that can be targeted with a radiolabeled peptide. The objectives of this study were to 1) i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10300
更新日期:2002-02-15 00:00:00
abstract:BACKGROUND:Ovarian surface epithelial cells are positionally organized as a single cell layer by a sheet of basement membrane. It is believed that the contact of the ovarian surface epithelial cells with the basement membrane regulates cell growth and ensures the organization of the epithelium. Disabled-2 (Dab2), a sig...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10870
更新日期:2002-10-15 00:00:00
abstract::Cancer tissues from 30 patients with squamous cell carcinoma of the oral cavity were examined immunohistopathologically as to the responsiveness of the host against its own cancer cells in both biopsy and surgically resected specimens from the same patients. Subpopulations of the infiltrating lymphocytes in cancer tis...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840601)53:11<2456::aid-cncr282
更新日期:1984-06-01 00:00:00
abstract::Treatment with BCG (Bacillus Calmette-Guérin) followed by irradiation was attempted to improve response to therapy by cutaneous metastases from malignant skin melanomas. Both agents were applied in low doses, known to cause minimal side effects. Nineteen patients, divided into three groups, entered the clinical trial....
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820915)50:6<1100::aid-cncr2820
更新日期:1982-09-15 00:00:00
abstract:BACKGROUND:A feasibility study examining the effects of supervised aerobic exercise training on cardiopulmonary and quality of life (QOL) endpoints among postsurgical nonsmall cell lung cancer (NSCLC) patients was conducted. METHODS:Using a single-group design, 20 patients with stage I-IIIB NSCLC performed 3 aerobic c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23967
更新日期:2008-12-15 00:00:00
abstract:BACKGROUND:Although ascites cytology is important for therapeutic strategies, it is difficult to distinguish cancer infiltration from reactive mesothelial proliferation in some patients. In this study, the authors applied CDX2 immunocytochemistry to improve diagnostic accuracy. METHODS:The authors examined the distrib...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21840
更新日期:2006-04-25 00:00:00
abstract:BACKGROUND:Meeting quality of care standards in oncology is recognized as important by physicians, professional organizations, and payers. Data from a population-based cohort of patients with prostate cancer were used to examine whether receipt of care was consistent with published consensus metrics and whether receivi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30315
更新日期:2017-01-01 00:00:00
abstract::Three hundred fifteen radioisotopic bone scans ranging from initial scan only to nine scans per patient, performed on 114 patients with adenocarcinoma of the prostate between 1979 and 1984, were reviewed. Seventeen patients had positive scans, ten on initial scan and seven at follow-up. Nine patients had bone pain at ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880615)61:12<2453::aid-cncr282
更新日期:1988-06-15 00:00:00
abstract:BACKGROUND:The current study was performed to describe patient characteristics, treatment patterns, survival, health care resource use (HRU), and costs among older women in the United States with advanced (American Joint Committee on Cancer stage III/IV) triple-negative breast cancer (TNBC) in the Surveillance, Epidemi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31299
更新日期:2018-05-15 00:00:00
abstract::Ultrasonographic examinations and measurements of CA 19-9 and elastase 1 were done simultaneously in 14 patients with resectable pancreatic cancer of less than 3.0 cm in longest diameter and 48 patients with pancreatitis. Although a pancreatic mass was detected ultrasonically in only six (42.9%) of the patients with t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860515)57:10<1947::aid-cncr282
更新日期:1986-05-15 00:00:00
abstract::Forty-one previously untreated patients with a diagnosis of acute myelogenous leukemia (AML) were entered on a study using early intensification followed by a short-term maintenance chemotherapy. Induction and early intensification consisted of three to four cycles of doxorubicin, vincristine, cytosine arabinoside (Ar...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861015)58:8<1603::aid-cncr2820
更新日期:1986-10-15 00:00:00
abstract:BACKGROUND:The current study was conducted to expedite international standardized reporting of bone marrow disease in children with neuroblastoma and to improve equivalence of care. METHODS:A multidisciplinary International Neuroblastoma Response Criteria Bone Marrow Working Group was convened by the US National Cance...
journal_title:Cancer
pub_type: 共识发展会议,杂志文章,评审
doi:10.1002/cncr.30380
更新日期:2017-04-01 00:00:00
abstract::This trial was conducted to determine if the reported superiority of tamoxifen (TAM) plus prednisolone (PRDLN) over TAM alone in postmenopausal women with metastatic breast cancer could be corroborated. A total of 326 patients were randomized on a double-blind trial to TAM (10 mg twice daily) plus placebo or TAM plus ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/1097-0142(19910701)68:1<34::aid-cncr282068
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:Chemoradiotherapy has become the standard of care for head and neck squamous cell carcinoma; however, those patients often experience multiple treatment-related symptoms or symptom clusters. Two symptom clusters have been identified for this population. Little is known about the risk factors of these symptom...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.28500
更新日期:2014-03-15 00:00:00
abstract::C57B1/6 mice were given intravenous tumor cells on day O. Mice were then given either a brief exposure to halothane anesthesia or given halothane and then underwent a hind limb amputation. Immune testing was done at varying time intervals and correlated with the development of artificial pulmonary metastases. The effe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197803)41:3<827::aid-cncr2820410
更新日期:1978-03-01 00:00:00
abstract:BACKGROUND:Cisplatin (CDDP) administration concomitant with radiotherapy (RT) for the treatment of locally advanced cervical cancer has evolved from an inpatient 5-day every 21-day regimen to a weekly outpatient regimen. This study was designed to test for differences in progression-free survival (PFS) and toxicity bet...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22369
更新日期:2007-01-01 00:00:00
abstract::Currently, there is a "divide" between cancer survivorship initiatives and minority participation. The level of participation is nearly nonexistent in many cancer support and control initiatives. Cancer survivorship resources that facilitate access to treatment, psychosocial interventions, clinical trials, and researc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21251
更新日期:2005-12-01 00:00:00
abstract::Seven adults had a distinct clinicopathologic type of lymphoproliferative disorder of the bone marrow. All patients presented with weakness and pancytopenia; no evidence of gross extramedullary involvement was found. In 5 cases severe and prolonged bone marrow hypoplasia was associated with combination chemotherapy; 1...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801015)46:8<1767::aid-cncr2820
更新日期:1980-10-15 00:00:00
abstract:BACKGROUND:Receipt of chemotherapy at the end of life (EOL) is considered an indicator of poor quality of care for medical oncology. The objective of this study was to characterize the use of radiotherapy (RT) in patients with nonsmall cell lung cancer (NSCLC) during the same period. METHODS:Treatment characteristics ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27401
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Proliferating cell nuclear antigen (PCNA) is an intranuclear protein that is linked closely to the cell cycle. An immunohistochemical study was performed on the expression of PCNA in various sized hepatocellular carcinomas (HCCs) to determine the relation between the proliferative activity of cancer cells an...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950801)76:3<399::aid-cncr28207
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Little is known about cellular level genetic alterations in preinvasive breast lesions, particularly lobular carcinoma in situ. METHODS:We employed fluorescence in situ hybridization (FISH) using pericentromeric (alpha satellite) probes to assess numerical alterations of chromosomes 1, 7, 8, 16, 17, and X i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960115)77:2<315::AID-CNC
更新日期:1996-01-15 00:00:00
abstract:BACKGROUND:Image-directed biopsies may be collected as histologic or cytologic specimens. METHODS:In 34 patients, the results of aspiration cytologic examination were compared prospectively with core tissue biopsy findings obtained and diagnosed independently using the same image-guided procedure. RESULTS:Cytologic e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921015)70:8<2187::aid-cncr2820
更新日期:1992-10-15 00:00:00