Abstract:
:In an article published in this issue of Cancer, D'Arcy et al link the incidence of cancer among recipients of solid organ transplantation (SOT) in the Scientific Registry of Transplant Recipients with data from regional and statewide cancer registries to examine cancer-specific mortality for common malignancies in SOT recipients. This analysis helps to illuminate the role of immune surveillance across a broad range of malignancies and compares the incidence of cancers due to virally mediated oncogenesis (lymphoma, squamous cell carcinoma of the aerodigestive epithelium, and hepatitis-induced liver cancer) with the incidence of other malignancies. The authors' central finding is that cancer-specific mortality is significantly increased in SOT recipients in comparison with nontransplant recipients for multiple cancers, and the increased cancer incidence is not limited to the effects of viral oncogenesis. The authors document a significant increase in common epithelial malignancies that are currently treated with immune checkpoint antibodies, including melanoma, bladder cancer, colorectal cancer, cancers of the oral cavity/pharynx, kidney cancer, and lung cancer, and this supports the hypothesis that post-SOT immunosuppression affects immune surveillance in these cancers. Provocatively, the authors also document increases in the incidence and mortality of cancers not typically responsive to immune checkpoint therapies, including breast cancer and pancreatic cancer. The findings of D'Arcy et al suggest that immune surveillance controls oncogenesis and tumor progression in a broad range of malignancies and that breast cancer and pancreatic cancer could be sensitive to drugs targeting immune surveillance pathways other than those treated with currently Food and Drug Administration-approved antibodies to CTLA4 and PD-1/PD-L1.
journal_name
Cancerjournal_title
Cancerauthors
Koff JL,Waller EKdoi
10.1002/cncr.31963subject
Has Abstractpub_date
2019-03-15 00:00:00pages
838-842issue
6eissn
0008-543Xissn
1097-0142journal_volume
125pub_type
评论,杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Allelic deletions are frequent genetic alterations in patients with hepatocellular carcinoma (HCC). METHODS:To evaluate the allelic losses on chromosome 8p in HCC patients and define their clinicopathologic significance, we performed high-density allelotyping on 8p in 60 patients with HCC and analyzed the c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10612
更新日期:2002-06-15 00:00:00
abstract:BACKGROUND:Intensity-modulated radiation therapy (IMRT) is a novel approach to the planning and delivery of radiation therapy. The prevalence of IMRT use among radiation oncologists in the U.S. appears to be increasing, despite limited data evaluating its risks and benefits. METHODS:A random sample of radiation oncolo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21284
更新日期:2005-09-15 00:00:00
abstract:BACKGROUND:Despite extensive investigation, the role of MDR of human cancer remains unclear. Canine lymphoma is a spontaneously arising correlate of human non-Hodgkin's lymphoma that may complement other in vivo models for investigation of issues related to MDR. METHODS:Immunoreactivity of primary antibodies to the hu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960501)77:9<1892::AID-CN
更新日期:1996-05-01 00:00:00
abstract::We measured des-gamma-carboxyglutamic acid prothrombin (protein induced by vitamin K absence or antagonist-Factor II: [PIVKA-II]) in plasmas of normal subjects, patients with thrombotic disease, those with hepatic disease including hepatocellular carcinoma, and those with carcinoma of other tissues, and compared the r...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891215)64:12<2546::aid-cncr282
更新日期:1989-12-15 00:00:00
abstract:BACKGROUND:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only treatment with a curative potential for myelodysplastic syndrome (MDS) patients. Allo-HSCT has substantial risks, particularly in the elderly, and its role for older MDS patients has yet to be defined. METHODS:We analyzed 88 MDS pati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30632
更新日期:2017-07-15 00:00:00
abstract:BACKGROUND:Microphthalmia transcription factor (MITF)-associated (MiT) tumors are a family of rare malignancies, including alveolar soft part sarcoma (ASPS), clear cell sarcoma (CCS), and translocation-associated renal cell carcinoma (tRCC) that have dysregulated expression of oncogenic MITF family proteins. The MET re...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.27582
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:The clinical dose of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitro- sourea hydrochloride (ACNU) is limited by the bone marrow suppression it produces. The authors investigated whether bone marrow transplantation (BMT) associated with a high dose of ACNU could alleviate marrow toxicity ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930115)71:2<364::aid-cncr28207
更新日期:1993-01-15 00:00:00
abstract::The exact nature of the association between hormones and the development of breast cancer remains uncertain. Studies of endogenous hormone levels and breast cancer suggest a possible role of estrogens and androgens in the cause of breast cancer. Numerous studies have been conducted to assess the risk of breast cancer ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19951115)76:10+<2059::aid-cncr28
更新日期:1995-11-15 00:00:00
abstract:BACKGROUND:Ewing's sarcomas, osteosarcomas, and rhabdomyosarcomas are significantly more responsive to chemotherapy than other sarcomas. Adjuvant chemotherapy is used routinely based on data from randomized trials. Although a percentage of children with locally advanced or metastatic tumors remain curable, few data exi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:There is accumulating evidence that galanin receptors (GALRs) may be tumor suppressors in head and neck squamous cell carcinoma (HNSCC). Promoter methylation status and gene expression were assessed in a large panel of head and neck primary tumors, based on the hypothesis that cytosine-guanine dinucleotide (...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28411
更新日期:2014-01-15 00:00:00
abstract::The authors retrospectively reviewed 50 episodes of spinal epidural tumor that occurred in 42 patients with metastatic prostate cancer and were treated with external-beam radiation. Treatment response was evaluated in terms of symptoms, neurologic status, and, in most cases, reduction of tumor on repeat myelography. A...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921101)70:9<2319::aid-cncr2820
更新日期:1992-11-01 00:00:00
abstract::Until recently the prognosis of childhood non-Hodgkin's lymphoma has been poor. A program of combination chemotherapy and involved area radiotherapy was instituted in the Department of Pediatrics at Roswell Park Memorial Institute in 1971. Thirty-one biopsy proven untreated children entered this study. There were 4 St...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197805)41:5<1997::aid-cncr282041
更新日期:1978-05-01 00:00:00
abstract::From 1975 until 1984 37 children with newly diagnosed Hodgkin's disease were treated with six mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) courses with or without involved field radiotherapy (25 Gy) independent of the stage of their disease. Patients with small lymph node tumors (less than 4 cm) r...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870601)59:11<1870::aid-cncr282
更新日期:1987-06-01 00:00:00
abstract::In a series of 643 patients with small cell lung cancer (SCLC), 55 patients (8.6%) had signs or symptoms of superior vena caval obstruction syndrome (SVCO). Relatively long intervals from the onset of the first symptoms of SVCO to the start of therapy were observed, and invasive diagnostic procedures were safely perfo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860215)57:4<847::aid-cncr28205
更新日期:1986-02-15 00:00:00
abstract:BACKGROUND:Data from the Health Care Financing Administration's (HCFA) Medicare Health Outcomes Survey (MHOS) of patients enrolled in managed care services through Medicare were analyzed. The MHOS provided baseline estimates of quality of life of cancer survivors in comparison to a frequency age-matched cohort of nonca...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11085
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:Patient safety is a critical concern in clinical oncology, but the ability to measure adverse events (AEs) across cancer care is limited by a narrow focus on treatment-related toxicities. The objective of this study was to assess the nature and extent of AEs among cancer patients across inpatient and outpati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30916
更新日期:2017-12-01 00:00:00
abstract::Risk factors associated with local recurrences were analyzed from a series of 3445 clinical Stage I melanoma patients. In single-factor analysis, tumor thickness, ulceration, and increasing age were highly significantly predictive of recurrence (p less than 0.00001). After 5 years of follow-up, local recurrence rates ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850315)55:6<1398::aid-cncr2820
更新日期:1985-03-15 00:00:00
abstract:BACKGROUND:Cisplatin and carboplatin are essential to management of advanced-stage epithelial ovarian carcinoma. No published data exist regarding carboplatin dose intensity importance in ovarian cancer, nor are there data for the effect of age on the ability to deliver dose-intensive carboplatin. METHODS:Retrospectiv...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.2820710225
更新日期:1993-01-15 00:00:00
abstract::Multifocal osteosarcoma with unique patho-biological features in a 23-year old white male is reported. The natural history and classification of multiple osteosarcomas are reviewed. A proposal is presented for evaluation of the multicentric origin in future cases. ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197911)44:5<1897::aid-cncr282044
更新日期:1979-11-01 00:00:00
abstract:BACKGROUND:Oral mucositis (OM) is a frequent complication of mucotoxic cancer therapy, causing significant oral pain, increased infection risk, and impaired functioning. The efficacy and safety of Saforis (glutamine) powder in UpTec for oral suspension was evaluated for the prevention and treatment of OM. METHODS:Thre...
journal_title:Cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/cncr.22384
更新日期:2007-01-15 00:00:00
abstract:BACKGROUND:A study was undertaken to evaluate results of surgery and radiotherapy (RT) for high-risk extracranial chondrosarcomas. METHODS:Between 1986 and 2006, 60 patients underwent surgery and RT for extracranial high-risk chondrosarcoma. Preoperative RT (median, 50 gray [Gy]) and postoperative RT (median, 60 Gy) w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25806
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:TRAIL (tumor necrosis factor related apoptosis-inducing ligand) is involved in tumor immune surveillance and, thus, may be a potential cancer therapy. TRAIL expression in the tumor microenvironment has been shown to impact cancer survival in multiple tumor types, including ovarian cancer. We studied TRAIL ex...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25504
更新日期:2011-03-15 00:00:00
abstract::Results from the standpoint of survival rates and locoregional failures are compared in three series of patients having had a radical mastectomy for breast cancer: (1) radical mastectomy alone for the patients who had essentially outer quadrant lesions and a negative axilla; (2) postoperative irradiation when the axil...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19830415)51:8<1388::aid-cncr2820
更新日期:1983-04-15 00:00:00
abstract:BACKGROUND:Whereas the role of specific symptoms, such as pain and fatigue, for quality of life (QOL) is unquestioned, their relative importance for long-lasting impairments in QOL in cancer patients has rarely been assessed quantitatively. The authors, therefore, aimed to identify symptoms most predictive of limitatio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22274
更新日期:2006-11-15 00:00:00
abstract:BACKGROUND:Carboplatin-based regimens have demonstrated activity in pediatric patients with low-grade glioma (LGG). However, carboplatin hypersensitivity reaction (Cb HSR) represents a common and limiting factor for the continuation of therapy. METHODS:The objectives of this study were to describe the prevalence, char...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.23249
更新日期:2008-02-15 00:00:00
abstract:BACKGROUND:An increased incidence of cancer, especially hematopoietic in origin, has long been suspected but never established in patients with Gaucher disease. METHODS:To determine whether patients with Gaucher disease have an increased risk of cancer, the authors conducted a retrospective cohort study, comparing the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930701)72:1<219::aid-cncr28207
更新日期:1993-07-01 00:00:00
abstract::The ability to noninvasively discriminate the most common types of renal cell carcinoma (RCC) based on their magnetic resonance imaging (MRI) appearances or their magnetic resonance phenotypes is achievable. Intracellular lipids, a histologic characteristic of the clear cell RCC, can be identified on chemical shift MR...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.24237
更新日期:2009-05-15 00:00:00
abstract::Paraneoplastic nervous system syndromes are being identified with increasing frequency because of greater physician awareness and the availability of serodiagnostic tests for some syndromes. Frequently, paraneoplastic syndromes develop in the setting of an indolent, limited stage, or otherwise occult malignancy. As a ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19940101)73:1<168::aid-cncr28207
更新日期:1994-01-01 00:00:00
abstract::Although improvements in the management of adults with acute leukemia have lagged behind those seen in the treatment of children, there are clear reasons for optimism. Combination chemotherapy for acute myeloblastic leukemia (AML) and acute lymphoblastic leukemia (ALL) in adults results in complete remissions in 50-85...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830615)51:12+<2460::aid-cncr28
更新日期:1983-06-15 00:00:00
abstract:BACKGROUND:African Americans are diagnosed more frequently with colorectal carcinoma at a later stage compared with Caucasians. One potential reason for the disparity is a lower rate of screening examinations. METHODS:Using Outpatient and Physician-Supplier claims for all Medicare beneficiaries age > or = 65 years in ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20014
更新日期:2004-01-15 00:00:00