Dose intensity analysis of high-dose carboplatin in refractory ovarian carcinoma relative to age.

Abstract:

BACKGROUND:Cisplatin and carboplatin are essential to management of advanced-stage epithelial ovarian carcinoma. No published data exist regarding carboplatin dose intensity importance in ovarian cancer, nor are there data for the effect of age on the ability to deliver dose-intensive carboplatin. METHODS:Retrospective dose intensity analyses were performed for 93 patients with advanced-stage refractory ovarian carcinoma, who received single-agent, high-dose carboplatin chemotherapy (800 mg/m2/35 days of 160 mg/m2/week). These patients had been treated on one of three high-dose carboplatin studies conducted in the Medicine Branch of the National Cancer Institute during the 1980s. Eligibility criteria required age greater than or equal to 18 years, good end organ function, and good performance status. RESULTS:Patients 60 years of age or older comprised 33% of the cohort and patients 70 years of age or older comprised 8% of the cohort. Administered dose intensity of carboplatin did not differ among age groups. Patients of age < or = 39 years received a dose intensity of 136 +/- 28 mg/m2/week, those of age 40-59 years received 129 +/- 33, those of age > or = 60 years received 134 +/- 24, and those of age > or = 70 years received 129 +/- 19. Further, the administered carboplatin dose intensity did not differ among clinical response groups. Dose intensity in complete responders was 138 +/- 18 mg/m2/week; in partial responders, 121 +/- 29; and in nonresponders, 134 +/- 30. The age distribution of responders matched the age distribution of the cohort. CONCLUSIONS:These data demonstrate that elderly patients with good end organ function and good performance status tolerate the same level of dose-intensive platinum therapy as younger patients. Age alone should not be a determinant for carboplatin dose modification in the treatment of ovarian carcinoma.

journal_name

Cancer

journal_title

Cancer

authors

Cornelison TL,Reed E

doi

10.1002/cncr.2820710225

subject

Has Abstract

pub_date

1993-01-15 00:00:00

pages

650-5

issue

2 Suppl

eissn

0008-543X

issn

1097-0142

journal_volume

71

pub_type

临床试验,杂志文章

相关文献

CANCER文献大全
  • Early hypofractionated salvage radiotherapy for postprostatectomy biochemical recurrence.

    abstract:BACKGROUND:Postprostatectomy adjuvant or salvage radiotherapy, when using standard fractionation, requires 6.5 to 8 weeks of treatment. The authors report on the safety and efficacy of an expedited radiotherapy course for salvage prostate radiotherapy. METHODS:A total of 108 consecutive patients were treated with salv...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25824

    authors: Kruser TJ,Jarrard DF,Graf AK,Hedican SP,Paolone DR,Wegenke JD,Liu G,Geye HM,Ritter MA

    更新日期:2011-06-15 00:00:00

  • Barriers to health care contribute to delays in follow-up among women with abnormal cancer screening: Data from the Patient Navigation Research Program.

    abstract:BACKGROUND:There is limited understanding of the association between barriers to care and clinical outcomes within patient navigation programs. METHODS:Secondary analyses of data from the intervention arms of the Patient Navigation Research Program were performed, which included navigated participants with abnormal br...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29607

    authors: Ramachandran A,Snyder FR,Katz ML,Darnell JS,Dudley DJ,Patierno SR,Sanders MR,Valverde PA,Simon MA,Warren-Mears V,Battaglia TA,Patient Navigation Research Program Investigators.

    更新日期:2015-11-15 00:00:00

  • Prostate cancer outcomes for men aged younger than 65 years with Medicaid versus private insurance.

    abstract:BACKGROUND:In the current national debate regarding private insurance versus Medicaid expansion, understanding how insurance is associated with racial disparities in prostate cancer (CaP) outcomes has broad policy implications. In the current study, the authors examined the association between insurance status, race, a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31106

    authors: Mahal AR,Mahal BA,Nguyen PL,Yu JB

    更新日期:2018-02-15 00:00:00

  • Splenic alterations in hairy-cell leukemia: II. an electron microscopic study.

    abstract::Spleen from nine patients with hairy-cell leukemia (HCL) were studied for ultrastructural alterations. In all cases, hairy cells with typical ultrastructural characteristics were observed within splenic cords and sinuses. Hairy cells had numerous cytoplasmic processes that interdigitated with cytoplasmic processes of ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820415)49:8<1617::aid-cncr2820

    authors: Pilon VA,Davey FR,Gordon GB,Jones DB

    更新日期:1982-04-15 00:00:00

  • Evaluation of the quality of radiotherapy randomized trials for painful bone metastases.

    abstract:BACKGROUND:The quality of randomized radiotherapy studies investigating the palliation of painful bone metastases has been questioned, with some authors recognizing the potential impact of bias on result interpretation. However, there has been no published comprehensive evaluation of quality assessment. The goals of th...

    journal_title:Cancer

    pub_type: 杂志文章,meta分析

    doi:10.1002/cncr.20993

    authors: Shakespeare TP,Thiagarajan A,Gebski V

    更新日期:2005-05-01 00:00:00

  • Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy.

    abstract::Since June 1978, 57 patients with primary osteogenic sarcoma of an extremity were treated with high-dose methotrexate (HDMTX) and citrovorum factor rescue (CFR), Adriamycin, and the combination of bleomycin, cyclophosphamide and dactinomycin (BCD) given for 4-16 weeks prior to definitive surgery. Histologic examinatio...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820315)49:6<1221::aid-cncr2820

    authors: Rosen G,Caparros B,Huvos AG,Kosloff C,Nirenberg A,Cacavio A,Marcove RC,Lane JM,Mehta B,Urban C

    更新日期:1982-03-15 00:00:00

  • The role of radiation therapy in the multidisciplinary management of recurrent and metastatic breast cancer.

    abstract::Carcinoma of the breast is a disease that is associated with 10-year recurrence rates of 25% in operable patients with no spread to the axillary nodes and 75% in patients in whom the tumor has extended to the axillary nodes. Locoregional recurrence rates of close to 50% have been reported in patients with Stage III di...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.2820741334

    authors: Marcial VA

    更新日期:1994-07-01 00:00:00

  • Improved detection of focal lesions with computerized tomographic examination of the liver using ethiodized oil emulsion (EOE-13) liver contrast.

    abstract::A prospective study of computerized tomography (CT) of the liver using a liver contrast agent compared to conventional CT was undertaken. CT scanning without contrast agents (NC-CT), CT with water-soluble contrast (WSC-CT), and CT with ethiodized oil emulsion (EOE-CT) were performed on patients with possible or probab...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841015)54:8<1489::aid-cncr2820

    authors: Sugarbaker PH,Vermess M,Doppman JL,Miller DL,Simon R

    更新日期:1984-10-15 00:00:00

  • Detection of bone marrow relapse in patients with small cell carcinoma of the lung.

    abstract::From a total of 874 patients with small cell lung cancer (SCC), a series of 104 patients were reviewed to determine if bone marrow relapses are detectable by routine clinical investigations. Autopsy, including microscopical bone marrow examination, was performed in all the 104 patients and bone metastases were disclos...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19861201)58:11<2538::aid-cncr282

    authors: Kristjansen PE,Osterlind K,Hansen M

    更新日期:1986-12-01 00:00:00

  • The impact of cancer on spouses' labor earnings: a population-based study.

    abstract:BACKGROUND:Cancer affects patients' incomes, but to the authors' knowledge few studies to date have examined how the income of the patients' spouses may be influenced. In this population-based study from Norway, the effects of cancer on both partners' earnings are analyzed. METHODS:The difference between labor earning...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24582

    authors: Syse A,Tretli S,Kravdal O

    更新日期:2009-09-15 00:00:00

  • Comparison of 5-fluorouracil with 5-fluorouracil, cyclophosphamide, and methotrexate in metastatic colorectal carcinoma.

    abstract::Thirty-eight patients with metastatic colorecal carcinoma were treated with 5-fluorouracil (5-FU), and 38 patients were treated with the combination of 5-FU, cyclophosphamide, and methotrexate. In terms of percent response, response duration, and survival there was no apparent difference between the two regimens. Comb...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197511)36:5<1589::aid-cncr282036

    authors: Richards F 2nd,Pajak TL,Cooper MR,Spurr CL

    更新日期:1975-11-01 00:00:00

  • Correlations in mortality data involving cancers of the colorectum and esophagus.

    abstract::Massachusetts vital event data for 1969--1972 were used to develop correlations between mortality rates for malignant diseases and other causes of death over the 34 health planning subdivisions of the state. A significant correlation was found between the mortality rates for cancer of the colon and rectum and ischemic...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197905)43:5<1927::aid-cncr282043

    authors: Lipworth LL,Rice CA

    更新日期:1979-05-01 00:00:00

  • Prostate cancer mortality and metastasis under different biopsy frequencies in North American active surveillance cohorts.

    abstract:BACKGROUND:Active surveillance (AS) is an accepted means of managing low-risk prostate cancer. Because of the rarity of downstream events, data from existing AS cohorts cannot yet address how differences in surveillance intensity affect metastasis and mortality. This study projected the comparative benefits of differen...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32557

    authors: Lange JM,Laviana AA,Penson DF,Lin DW,Bill-Axelson A,Carlsson SV,Newcomb LF,Trock BJ,Carter HB,Carroll PR,Cooperberg MR,Cowan JE,Klotz LH,Etzioni RB

    更新日期:2020-02-01 00:00:00

  • Proposed adjustments to pathologic staging of epithelial malignant pleural mesothelioma based on analysis of 354 cases.

    abstract:BACKGROUND:Several pathologic staging systems for malignant pleural mesothelioma (MPM) have been published, but none of them provide optimal survival stratification or stage distribution among patients treated with surgery. Interpretation of prior studies that correlate pathologic factors with outcome has been confound...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24886

    authors: Richards WG,Godleski JJ,Yeap BY,Corson JM,Chirieac LR,Zellos L,Mujoomdar A,Jaklitsch MT,Bueno R,Sugarbaker DJ

    更新日期:2010-03-15 00:00:00

  • Smoking tobacco, oral snuff, and alcohol in the etiology of squamous cell carcinoma of the head and neck: a population-based case-referent study in Sweden.

    abstract:BACKGROUND:This case-referent study was conducted to elucidate the role of selected exogenous agents in the etiology of head and neck cancer. The factors studied were tobacco smoking, alcohol intake, the use of moist oral snuff, dietary factors, occupational exposures, and oral hygiene. In this first report, the author...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19980401)82:7<1367::aid-cn

    authors: Lewin F,Norell SE,Johansson H,Gustavsson P,Wennerberg J,Biörklund A,Rutqvist LE

    更新日期:1998-04-01 00:00:00

  • Feminizing interstitial cell tumor of the testis: personal observations and a review of the literature.

    abstract::A 28-year-old man with evidence of feminization was demonstrated after 4 years of investigation to have a estrogen-secreting interstitial cell tumor. Such feminizing neoplasms are uncommon, only 37 having been described. They are usually benign and are characterized by gynecomastia, a testicular mass and, with lesser ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197504)35:4<1184::aid-cncr282035

    authors: Gabrilove JL,Nicolis GL,Mitty HA,Sohval AR

    更新日期:1975-04-01 00:00:00

  • The relationship between physical and psychological symptoms and health care utilization in hospitalized patients with advanced cancer.

    abstract:BACKGROUND:Patients with advanced cancer often experience frequent and prolonged hospitalizations; however, the factors associated with greater health care utilization have not been described. We sought to investigate the relation between patients' physical and psychological symptom burden and health care utilization. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30912

    authors: Nipp RD,El-Jawahri A,Moran SM,D'Arpino SM,Johnson PC,Lage DE,Wong RL,Pirl WF,Traeger L,Lennes IT,Cashavelly BJ,Jackson VA,Greer JA,Ryan DP,Hochberg EP,Temel JS

    更新日期:2017-12-01 00:00:00

  • Malignant mesenchymoma of the bladder.

    abstract::A case of malignant mesenchymoma of the bladder, containing fibroleiomyomatous, myxomatous, osteoid, and cartilaginous components is presented. The primary pedunculated tumor measuring 18 X 10 X 9 cm and weighing 934 g, arose from the anterior wall of the bladder and was treated by partial cystectomy. Six months after...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19870815)60:4<858::aid-cncr28206

    authors: Terada Y,Saito I,Morohoshi T,Niijima T

    更新日期:1987-08-15 00:00:00

  • Myoepithelial cell-rich neoplasms: cytologic features of benign and malignant lesions.

    abstract:BACKGROUND:Lesions that contain abundant myoepithelial cells may present as a diagnostic challenge in fine-needle aspiration (FNA) specimens. Potential diagnostic problems may arise due to morphologic heterogeneity of myoepithelial cell-rich lesions and difficulty in predicting malignancy in FNA specimens. An accurate ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20642

    authors: Darvishian F,Lin O

    更新日期:2004-12-25 00:00:00

  • Total RNA yield and microarray gene expression profiles from fine-needle aspiration biopsy and core-needle biopsy samples of breast carcinoma.

    abstract:BACKGROUND:Gene expression profiling should be applicable to needle biopsy samples if microarray technology is to become practically useful for clinical research or management of breast carcinoma. This study compared gene expression profiles derived from fine-needle aspiration biopsy (FNAB) and from core needle biopsy ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11435

    authors: Symmans WF,Ayers M,Clark EA,Stec J,Hess KR,Sneige N,Buchholz TA,Krishnamurthy S,Ibrahim NK,Buzdar AU,Theriault RL,Rosales MF,Thomas ES,Gwyn KM,Green MC,Syed AR,Hortobagyi GN,Pusztai L

    更新日期:2003-06-15 00:00:00

  • The National Cancer Data Base report on breast carcinoma characteristics and outcome in relation to age.

    abstract:BACKGROUND:Previous data from the National Cancer Data Base have examined time trends in stage of disease, treatment patterns, and survival for selected cancers. The most current (1993) data for breast carcinoma are described here. METHODS:Five Calls for Data have yielded a total of 508,724 breast cancer cases diagnos...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19961015)78:8<1838::aid-cn

    authors: Winchester DP,Osteen RT,Menck HR

    更新日期:1996-10-15 00:00:00

  • Percutaneous tumor ablation with radiofrequency.

    abstract:BACKGROUND:Radiofrequency thermal ablation (RFA) is a new minimally invasive treatment for localized cancer. Minimally invasive surgical options require less resources, time, recovery, and cost, and often offer reduced morbidity and mortality, compared with more invasive methods. To be useful, image-guided, minimally i...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.10234

    authors: Wood BJ,Ramkaransingh JR,Fojo T,Walther MM,Libutti SK

    更新日期:2002-01-15 00:00:00

  • Anatomic distribution of periprostatic adipose tissue: a mapping study of 100 radical prostatectomy specimens.

    abstract:BACKGROUND:Because the prostatic capsule is often indistinct, recognition of extraprostatic extension by carcinoma depends heavily on the identification of carcinoma cells in the periprostatic adipose tissue. However, the distribution of adipose tissue along the prostatic surfaces has not been studied extensively. MET...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11231

    authors: Hong H,Koch MO,Foster RS,Bihrle R,Gardner TA,Fyffe J,Ulbright TM,Eble JN,Cheng L

    更新日期:2003-04-01 00:00:00

  • Artificial neural networks: opening the black box.

    abstract::Artificial neural networks now are used in many fields. They have become well established as viable, multipurpose, robust computational methodologies with solid theoretic support and with strong potential to be effective in any discipline, especially medicine. For example, neural networks can extract new medical infor...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(20010415)91:8+<1615::aid-cncr117

    authors: Dayhoff JE,DeLeo JM

    更新日期:2001-04-15 00:00:00

  • Primary reticulum cell sarcoma of testis in a 12-year-old.

    abstract::A 12-year-old boy with primary reticulum cell sarcoma of the testis who is alive and free of tumor 32 months after orchiectomy, radiation therapy to inguinal, iliac and retroperitoneal lymph nodes and chemotherapy is reported. Seven previously documented cases of childhood primary testicular lymphoma are reviewed. The...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197602)37:2<935::aid-cncr2820370

    authors: Weitzner S,Gropp A

    更新日期:1976-02-01 00:00:00

  • Social class and colon cancer survival in Finland.

    abstract::METHODS. Social class differences in colon cancer survival were studied in 3147 patients with colon cancer diagnosed in Finland from 1979-1982. Of these patients, 2969 were eligible for survival analysis. RESULTS. A clear social class gradient in colon cancer survival was detected. The difference in the age-adjusted r...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920715)70:2<402::aid-cncr28207

    authors: Auvinen A

    更新日期:1992-07-15 00:00:00

  • Sentinel lymph node biopsy in patients with papillary thyroid carcinoma.

    abstract:BACKGROUND:It remains controversial whether modified radical neck dissection (MRND) for patients with papillary thyroid carcinoma improves prognosis. However, it is highly probable that the incidence of local recurrence is reduced by lymph node dissection. Sentinel lymph node (SLN) biopsy (SLNB) for patients with melan...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20011201)92:11<2868::aid-cncr101

    authors: Fukui Y,Yamakawa T,Taniki T,Numoto S,Miki H,Monden Y

    更新日期:2001-12-01 00:00:00

  • Findings from NSABP Protocol No. B-04: comparison of radical mastectomy with alternative treatments. II. The clinical and biologic significance of medial-central breast cancers.

    abstract::Findings from 1665 women with primary breast cancer, treated at 34 NSABP institutions in Canada and the United States, have failed to demonstrate that patients with medial-central tumors had a greater probability of developing distant metastases or dying than did those with lateral tumors despite the greater incidence...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19811015)48:8<1863::aid-cncr2820

    authors: Fisher B,Wolmark N,Redmond C,Deutsch M,Fisher ER

    更新日期:1981-10-15 00:00:00

  • Disparities in access to care at high-volume institutions for uro-oncologic procedures.

    abstract:BACKGROUND:Socioeconomic status represents an established barrier to health care access. Age, sex, and race may also play a role. The authors examined whether these affect the access to high-volume hospitals for uro-oncologic procedures in the United States. METHODS:Within the Nationwide Inpatient Sample (NIS), the au...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27440

    authors: Trinh QD,Sun M,Sammon J,Bianchi M,Sukumar S,Ghani KR,Jeong W,Dabaja A,Shariat SF,Perrotte P,Agarwal PK,Rogers CG,Peabody JO,Menon M,Karakiewicz PI

    更新日期:2012-09-15 00:00:00

  • Radiation therapy at the end of life in patients with incurable nonsmall cell lung cancer.

    abstract:BACKGROUND:Receipt of chemotherapy at the end of life (EOL) is considered an indicator of poor quality of care for medical oncology. The objective of this study was to characterize the use of radiotherapy (RT) in patients with nonsmall cell lung cancer (NSCLC) during the same period. METHODS:Treatment characteristics ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27401

    authors: Kapadia NS,Mamet R,Zornosa C,Niland JC,D'Amico TA,Hayman JA

    更新日期:2012-09-01 00:00:00