Feminizing interstitial cell tumor of the testis: personal observations and a review of the literature.

Abstract:

:A 28-year-old man with evidence of feminization was demonstrated after 4 years of investigation to have a estrogen-secreting interstitial cell tumor. Such feminizing neoplasms are uncommon, only 37 having been described. They are usually benign and are characterized by gynecomastia, a testicular mass and, with lesser frequency, by decreased libido and potency and poor semen quality. The urinary excretion and plasma levels of estrogen are increased and, by selective testicular catheterization, the site of increased estrogen production can be localized. Secondary histologic changes occur in the nontumorous portions of the testis as well as in the contralateral testis; they are most marked in the area immediately adjacent to the tumor. Postoperatively, the gynecomastia regresses, the excessive levels of estrogen return to normal, libido improves, and the sperm count increases to normal.

journal_name

Cancer

journal_title

Cancer

authors

Gabrilove JL,Nicolis GL,Mitty HA,Sohval AR

doi

10.1002/1097-0142(197504)35:4<1184::aid-cncr282035

subject

Has Abstract

pub_date

1975-04-01 00:00:00

pages

1184-202

issue

4

eissn

0008-543X

issn

1097-0142

journal_volume

35

pub_type

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