Abstract:
:This report describes a patient referred at 14 years in 1971, after one year's surveillance by the family physician, for a persistently elevated erythrocyte sedimentation rate, leukopenia, and relative lymphocytosis. Despite the documented myeloproliferative syndrome of seven years, significant physiologic impairment precluding strenuous ranching and rodeo work appeared only in the last six to nine months. Throughout the clinical course characterized by pancytopenia, refractory and somewhat megaloblastic anemia partially responsive to oxymetholone, and subacute myeloblastic leukemia, he showed a persistent double trisomy--48, XY, +8, +21 in bone marrow. This report reiterates the value of chromosome analysis in the study of hematologic disorders and, in addition, emphasizes the need to individualize each patient's prognosis.
journal_name
Cancerjournal_title
Cancerauthors
Whaun JM,Lin CC,Biederman B,Cornish SJ,Dundas JBdoi
10.1002/1097-0142(19810901)48:5<1164::aid-cncr2820subject
Has Abstractpub_date
1981-09-01 00:00:00pages
1164-9issue
5eissn
0008-543Xissn
1097-0142journal_volume
48pub_type
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