Myeloproliferative disorder with unusual marrow chromosome constitution.

Abstract:

:This report describes a patient referred at 14 years in 1971, after one year's surveillance by the family physician, for a persistently elevated erythrocyte sedimentation rate, leukopenia, and relative lymphocytosis. Despite the documented myeloproliferative syndrome of seven years, significant physiologic impairment precluding strenuous ranching and rodeo work appeared only in the last six to nine months. Throughout the clinical course characterized by pancytopenia, refractory and somewhat megaloblastic anemia partially responsive to oxymetholone, and subacute myeloblastic leukemia, he showed a persistent double trisomy--48, XY, +8, +21 in bone marrow. This report reiterates the value of chromosome analysis in the study of hematologic disorders and, in addition, emphasizes the need to individualize each patient's prognosis.

journal_name

Cancer

journal_title

Cancer

authors

Whaun JM,Lin CC,Biederman B,Cornish SJ,Dundas JB

doi

10.1002/1097-0142(19810901)48:5<1164::aid-cncr2820

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

1164-9

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

48

pub_type

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