Severe hypertension in a child with ganglioneuroblastoma.

Abstract:

:A 26-month-old boy with Stage III abdominal ganglioneuroblastoma had tachycardia and hypertension. The hypertension increased following the institution of chemotherapy and necessitated the use of both alpha and beta adrenergic blocking agents to control the effects of the marked catecholamine production. After excision of the residual tumor, the blood pressure and urinary catecholamine excretion returned to normal. Histologic examination of this tissue under light microscopy revealed some sections of ganglioneuroblastoma as well as large areas of ganglioneuroma. Examination by electron microscopy demonstrated a moderate number of dense core neurosecretory-type granules in the cell bodies of the ganglion-like cells and an abundance of the same type of granules in the bundles of the interwoven cytoplasmic neural processes. To data, 32 months after diagnosis and 20 months off chemotherapy, the patient remains free of tumor and is in excellent general health. We postulate that the large number of secretory granules in this tumor permitted storage and release of markedly increased quantities of norepinephrine and resulted in a clinical profile similar to that associated with pheochromocytoma.

journal_name

Cancer

journal_title

Cancer

authors

Kedar A,Glassman M,Voorhess ML,Fisher J,Allen J,Jenis E,Freeman AI

doi

10.1002/1097-0142(19810415)47:8<2077::aid-cncr2820

subject

Has Abstract

pub_date

1981-04-15 00:00:00

pages

2077-80

issue

8

eissn

0008-543X

issn

1097-0142

journal_volume

47

pub_type

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