Papillary tumors of large lactiferous ducts.

abstract：:Models play a fundamental role in all sciences. Scientific theories can be understood as "intellectual models" of the relations and interrelations between the elements of the science. Such relational models consider the scientific topics as "systems," and may therefore be called "system models." The basic elements of ...

journal_title：Cancer

authors： Brock N,Schneider B

更新日期：1984-09-15 00:00:00

abstract：BACKGROUND:This study was conducted to evaluate the long-term outcomes in patients with stage IE and IIE mucosa-associated lymphoid tissue (MALT) lymphomas treated with involved field radiotherapy (RT). METHODS:Between 1989 and 2004, 192 patients with stage I and II MALT lymphomas were treated. The report focuses on 1...

journal_title：Cancer

authors： Goda JS,Gospodarowicz M,Pintilie M,Wells W,Hodgson DC,Sun A,Crump M,Tsang RW

更新日期：2010-08-15 00:00:00

abstract：:Two patients fulfilled the clinical and hematologic criteria for B-cell acute lymphoblastic leukemia: the malignant cells had L3 morphology, bore B-cell markers, and carried the specific t(8;14) translocation. The leukemic cells of one patient were tetrasomic for 1q, and those of the other patient showed several separ...

journal_title：Cancer

authors： Morris CM,Fitzgerald PH,Neville MA,Wyld PJ,Beard ME

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:Interferon-alpha (IFN-alpha) has shown significant activity in the treatment of BCR-ABL-negative myeloproliferative disorders (MPDs), particularly essential thrombocythemia (ET) and polycythemia vera (PV). PEG-IFN-alpha-2b is a pegylated IFN-alpha-2b with a significant advantage over nonpegylated form in tha...

journal_title：Cancer

authors： Jabbour E,Kantarjian H,Cortes J,Thomas D,Garcia-Manero G,Ferrajoli A,Faderl S,Richie MA,Beran M,Giles F,Verstovsek S

更新日期：2007-11-01 00:00:00

abstract：:Exposure of tumor cells to reduced folates before or with the fluoropyrimidines, 5-fluorouracil or 5-fluoro-2'deoxyuridine, results in a substantial increase in the activity of these drugs. Available evidence suggests that the mechanism of this synergism is a kinetic stabilization of complex formed between thymidylate...

journal_title：Cancer

authors： Morgan RG

更新日期：1989-03-15 00:00:00

abstract：:The relation of gastric acid-secreting function to the gross and histological types and locations of carcinomas was examined in 53 patients with early gastric carcinomas. Studies were made by the endoscopic Congo red test developed in this clinic. Results indicated a close correlation between the gross and histologica...

journal_title：Cancer

authors： Tatsuta M,Okuda S,Taniguchi H,Tamura H

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:The epidophyllotoxin VM 26 has been shown to have single-agent activity in patients with diffuse aggressive lymphoma. In an attempt to determine its activity in combination with other agents known to be effective in lymphoma, a Phase II trial of a novel chemotherapy regimen was conducted. METHODS:Forty-two ...

journal_title：Cancer

authors： Gordon LI,Andersen J,Gregory S,Mazza J,Chervenick P,Hahn RG,O'Connell MJ

更新日期：1993-01-15 00:00:00

abstract：:A system for staging the clinical status of patients with soft tissue sarcomas is presented, based on the clinical characteristics of the primary tumor (size, extension), the involvement of lymph nodes, the presence of metastases, and the grade of the tumor. This represents the TNM system with grade of tumor (G) added...

journal_title：Cancer

authors： Russell WO,Cohen J,Enzinger F,Hajdu SI,Heise H,Martin RG,Meissner W,Miller WT,Schmitz RL,Suit HD

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:Breast carcinoma is one of the leading causes of excess mortality rates in Harlem, an inner-city neighborhood with the highest mortality rates and worst life expectancy in New York City. This study reports the results of a breast carcinoma screening and diagnostic program in Harlem. METHODS:Retrospective re...

journal_title：Cancer

authors： Liberman L,Freeman HP,Chandra S,Stein AL,McCord C,Godfrey D,Dershaw DD

更新日期：2002-07-01 00:00:00

abstract：:Four cases of childhood hepatic angiosarcoma (HAS), representing the malignant form of infantile hemangioendothelioma, are described. The morphologic appearance of childhood HAS differs from the adult form in the following features: the associated presence of benign infantile hemangioendothelioma; the presence of dyso...

journal_title：Cancer

authors： Falk H,Herbert JT,Edmonds L,Heath CW Jr,Thomas LB,Popper H

更新日期：1981-01-15 00:00:00

abstract：:A 58-year-old patient with metastatic prostatic carcinoma had two well-documented episodes of disseminated intravascular coagulation (DIC) occurring 1 year apart and resolving without heparin therapy. This case illustrates that DIC need not have a poor prognosis and may resolve spontaneously despite progressive cancer...

journal_title：Cancer

authors： Alving BM,Abeloff MD,Bell W

更新日期：1976-02-01 00:00:00

abstract：:The authors studied 11 pediatric intrathoracic neoplasms that share clinicopathologic features and constitute a specific tumor in children. These neoplasms were intrapulmonary, mediastinal, or pleural-based masses. A common histologic feature was the presence of small, primitive cells with blastematous qualities separ...

journal_title：Cancer

authors： Manivel JC,Priest JR,Watterson J,Steiner M,Woods WG,Wick MR,Dehner LP

更新日期：1988-10-15 00:00:00

abstract：:Since 1981, 20 patients with anaplastic giant cell carcinoma of the thyroid have been prospectively treated according to a combination regimen of chemotherapy and external beam radiation therapy. Two types of chemotherapy were used every 4 weeks, depending on the patient's age. For those younger than 65 years, a combi...

journal_title：Cancer

authors： Schlumberger M,Parmentier C,Delisle MJ,Couette JE,Droz JP,Sarrazin D

更新日期：1991-02-01 00:00:00

abstract：:Cutaneous atypical fibroxanthoma (AFX) occurs in elderly persons as a small nodule or ulcernodule in actinically damaged skin of the head and neck area. The vast majority of AFX behave in a benign manner, and metastasis is rare. Eight examples of metastasizing AFX are reported. Factors that portend aggressive behavior...

journal_title：Cancer

authors： Helwig EB,May D

更新日期：1986-01-15 00:00:00

abstract：BACKGROUND:The authors investigated how lymphopenia and low serum albumin levels correlate with the prognosis of patients with carcinoma of unknown primary (CUP). METHODS:Univariate and multivariate prognostic factor analyses were conducted in a population of 317 consecutive patients with CUP who were evaluated at the...

journal_title：Cancer

authors： Seve P,Ray-Coquard I,Trillet-Lenoir V,Sawyer M,Hanson J,Broussolle C,Negrier S,Dumontet C,Mackey JR

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Oral leukoplakia is a premalignant lesion, but the genetic changes in the foci of early cancerization in leukoplakia have not been studied. METHODS:Loss of heterozygosity (LOH) was successively investigated in 13 cases in the leukoplakia and foci of early cancerization in the same leukoplakia. The authors m...

journal_title：Cancer

authors： Jiang WW,Fujii H,Shirai T,Mega H,Takagi M

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Several studies have shown that lysophosphatidic acid (LPA), a phospholipidic chemical mediator, is relevant to the pathogenesis of ovarian carcinoma. Higher plasma levels of LPA have been reported in patients with ovarian carcinoma than in healthy patients, and LPA is known to activate ovarian carcinoma cel...

journal_title：Cancer

authors： Tokumura A,Tominaga K,Yasuda K,Kanzaki H,Kogure K,Fukuzawa K

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Recently, the number and morphologic features of argyrophilic nucleolar organizer regions (AgNOR), silver-stained nucleolar organizer regions, were thought to reflect the cellular proliferative activity and the grade of malignancy. In liver diseases, it has been reported that AgNOR scores for hepatocellular ...

journal_title：Cancer

authors： Shiro T,Seki T,Naitoh Y,Inoue K,Okamura A

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Abnormalities in chromosome 11q13 regions have been frequently found in head and neck squamous carcinoma. Recent studies indicate that the PRAD-1 (also CCND1), which encodes cyclin D1, is a putative oncogene that is an important component of this region. METHODS:DNA was extracted from 32 snap-frozen specime...

journal_title：Cancer

authors： Callender T,el-Naggar AK,Lee MS,Frankenthaler R,Luna MA,Batsakis JG

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:A diagnosis of cancer provides a teachable moment in which a physician can counsel or teach the patient. The Cancer and Leukemia Group B hypothesized that this teachable moment could also be used to encourage counseling of the patients' relatives who smoke. The authors' first study sought to determine the fe...

journal_title：Cancer

authors： Schilling A,Conaway MR,Wingate PJ,Atkins JN,Berkowitz IM,Clamon GH,DiFino SM,Vinciguerra V

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Results from numerous trials have indicated that breast-conserving therapy (BCT) produces outcomes equivalent to those produced by mastectomy in terms of both locoregional control and survival. However, conservative treatment has resulted in the dilemma of how best to address recurrences when they appear in ...

journal_title：Cancer

authors： Vicini FA,Antonucci JV,Goldstein N,Wallace M,Kestin L,Krauss D,Kunzmann J,Gilbert S,Schell S

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Failure to obtain the requisite follow-up of patients with abnormal mammograms may delay cancer diagnosis and impact outcome. Up to 20% of women do not receive timely recommended follow-up. The current study tested the accuracy of the linkage of payer claims and clinical data to identify the appropriate trea...

journal_title：Cancer

authors： Eberl MM,Watroba N,Reinhardt M,Pomerantz J,Serghany J,Broffman G,Fox CH,Mahoney MC,Edge SB

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:A considerable body of evidence supports the concept that a significant number of cutaneous malignant melanomas progress through a precursor lesion or dysplastic melanocytic nevi (DN). Tumor angiogenesis likely plays a critical role in early development of melanoma, and intermediate biomarkers of angiogenesi...

journal_title：Cancer

authors： Einspahr JG,Thomas TL,Saboda K,Nickolof BJ,Warneke J,Curiel-Lewandrowski C,Ranger-Moore J,Duckett L,Bangert J,Fruehauf JP,Alberts DS

更新日期：2007-12-01 00:00:00

abstract：:Breast fluid was collected from 244 nonlactating Finnish women with no known breast disease and analyzed with respect to various epidemiologic and hormonal parameters commonly associated with breast cancer risk. The data obtained permit characterization of women with breast secretory ability and provide fundamental in...

journal_title：Cancer

authors： Wynder EL,Hill P,Laakso K,Littner R,Kettunen K

更新日期：1981-03-15 00:00:00

abstract：BACKGROUND:Aberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic therapy. Decitabine indirectly depletes methylcytosine and causes hypomethylation of target gene promoters. METHODS:A total of 170 patients with...

journal_title：Cancer

authors： Kantarjian H,Issa JP,Rosenfeld CS,Bennett JM,Albitar M,DiPersio J,Klimek V,Slack J,de Castro C,Ravandi F,Helmer R 3rd,Shen L,Nimer SD,Leavitt R,Raza A,Saba H

更新日期：2006-04-15 00:00:00

abstract：BACKGROUND:Patients with advanced cancer often experience frequent and prolonged hospitalizations; however, the factors associated with greater health care utilization have not been described. We sought to investigate the relation between patients' physical and psychological symptom burden and health care utilization. ...

journal_title：Cancer

authors： Nipp RD,El-Jawahri A,Moran SM,D'Arpino SM,Johnson PC,Lage DE,Wong RL,Pirl WF,Traeger L,Lennes IT,Cashavelly BJ,Jackson VA,Greer JA,Ryan DP,Hochberg EP,Temel JS

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:While acute pancreatitis is a recognized complication of numerous drugs, cytarabine's role in causing this complication is controversial. Approximately 15 cases have been reported to the Food and Drug Administration linking cytarabine with pancreas-related toxicities. Previous case reports have been complica...

journal_title：Cancer

authors： McBride CE,Yavorski RT,Moses FM,Robson ME,Solimando DA Jr,Byrd JC

更新日期：1996-06-15 00:00:00

abstract：:Mammary carcinomas have been induced by 3.5 Gy whole-body gamma radiation administered at age 40 to 50 days to virgin female Sprague-Dawley rats. In 142 irradiated controls carcinoma incidence averaged 7.8% in survivors observed less than 300 days and 38.3% of those surviving longer (P less than 0.001 by t test). Mamm...

journal_title：Cancer

authors： Lemon HM,Kumar PF,Peterson C,Rodriguez-Sierra JF,Abbo KM

更新日期：1989-05-01 00:00:00

abstract：:This study examined public attitudes toward pain associated with cancer and its treatment. A variety of issues were assessed, including the extent to which pain is associated with cancer, fear of pain as a factor in the decision to delay seeking treatment, and concerns about the use of narcotic analgesics for pain con...

journal_title：Cancer

authors： Levin DN,Cleeland CS,Dar R

更新日期：1985-11-01 00:00:00

abstract：:A primary fibrosarcoma of the thyroid occurring in a patient with a nodular goiter is described. Light microscopy showed interwoven bundles of spindle cells admixed with plump ovoid cells, and foci of multinucleated giant cells. Remnants of distorted thyroid follicles were found only at the periphery of the tumor. "Tr...

journal_title：Cancer

authors： Shin WY,Aftalion B,Hotchkiss E,Schenkman R,Berkman J

更新日期：1979-08-01 00:00:00