PEG-IFN-alpha-2b therapy in BCR-ABL-negative myeloproliferative disorders: final result of a phase 2 study.

abstract：BACKGROUND:Previous reports suggesting a correlation between lymphoproliferative disease and serum levels of beta-2-microglobulin (beta-2M) and in vitro data indicating a role of cytokines in the production of beta-2M prompted a study of serum and urine beta-2M concentration in patients with hemophagocytic syndrome (HP...

journal_title：Cancer

authors： Hibi S,Ikushima S,Fujiwara F,Hashida T,Tsunamoto K,Todo S,Imashuku S

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Allogeneic hematopoietic cell transplantation (HCT) is a curative therapy for patients with acute myeloid leukemia (AML). However, post-HCT relapse and regimen-related toxicity remain significant barriers to long-term survival. In recent years, new conditioning regimens have been explored to improve transpla...

journal_title：Cancer

authors： Nagler A,Labopin M,Beelen D,Ciceri F,Volin L,Shimoni A,Foá R,Milpied N,Peccatori J,Polge E,Mailhol A,Mohty M,Savani BN

更新日期：2017-07-15 00:00:00

abstract：BACKGROUND:Data suggest that vitamin D plays a role in the treatment and prevention of prostate cancer. The combination of high-dose, intermittent calcitriol (1,25 dihydroxyvitamin D3) plus dexamethasone was studied based on evidence that dexamethasone potentiates the antitumor effects of calcitriol and ameliorates hyp...

journal_title：Cancer

authors： Trump DL,Potter DM,Muindi J,Brufsky A,Johnson CS

更新日期：2006-05-15 00:00:00

abstract：BACKGROUND:The purpose of the study was to determine the utility of quantitation of the extracellular domain (ECD) of the HER-2/neu receptor in the serum for predicting response to treatment in patients with primary breast cancer receiving neoadjuvant therapy. METHODS:HER-2/neu ECD was measured in sera obtained from 3...

journal_title：Cancer

authors： Mazouni C,Hall A,Broglio K,Fritsche H,Andre F,Esteva FJ,Hortobagyi GN,Buzdar AU,Pusztai L,Cristofanilli M

更新日期：2007-02-01 00:00:00

abstract：:The acquisition by tumor cells of the ability to metastasize is the critical event in the clinical course of most human neoplastic disease. While metastasis plays a pivotal role in the ultimate success of failure of therapy, it is in fact a result of a more insidious malignant process termed tumor progression. It is t...

journal_title：Cancer

authors： Frost P,Fidler IJ

更新日期：1986-07-15 00:00:00

abstract：BACKGROUND:Recently, a 23-gene signature was developed to produce a melanoma diagnostic score capable of differentiating malignant and benign melanocytic lesions. The primary objective of this study was to independently assess the ability of the gene signature to differentiate melanoma from benign nevi in clinically re...

journal_title：Cancer

authors： Clarke LE,Flake DD 2nd,Busam K,Cockerell C,Helm K,McNiff J,Reed J,Tschen J,Kim J,Barnhill R,Elenitsas R,Prieto VG,Nelson J,Kimbrell H,Kolquist KA,Brown KL,Warf MB,Roa BB,Wenstrup RJ

更新日期：2017-02-15 00:00:00

abstract：BACKGROUND:The uptake of thallium-201 (T1-201) in malignant tumors is associated with malignant potential (metastatic potential and proliferative activity). The grade of accumulation of T1-201 in malignant tumors may provide information regarding prognosis. METHODS:A T1-201 single photon emission computed tomography w...

journal_title：Cancer

authors： Takekawa H,Takaoka K,Tsukamoto E,Kanegae K,Miller F,Kawakami Y

更新日期：1997-07-15 00:00:00

abstract：BACKGROUND:Although grading has prognostic significance for many tumor types, a prognostically significant grading system for lung adenocarcinoma has not yet been established. The aim of this study was to evaluate histologic characteristics included in tumor grading systems, establish optimal cutoff values that have th...

journal_title：Cancer

authors： Barletta JA,Yeap BY,Chirieac LR

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumors (GISTs) historically were grouped with leiomyosarcomas (LMSs) based on their morphologic similarities; however, recently, GIST was established unequivocally as a distinct type of sarcoma based on its molecular features and response to imatinib treatment. METHODS:To gain furth...

journal_title：Cancer

authors： Ylipää A,Hunt KK,Yang J,Lazar AJ,Torres KE,Lev DC,Nykter M,Pollock RE,Trent J,Zhang W

更新日期：2011-01-15 00:00:00

abstract：BACKGROUND:The objective of this article was to assess the clinimetric properties of the International Federation of Gynecology and Obstetrics (FIGO) staging system of cervical carcinoma to determine whether it is an adequate prognostic tool for the survival of patients with cervical carcinoma. METHODS:The FIGO stagin...

journal_title：Cancer

authors： Kupets R,Covens A

更新日期：2001-08-15 00:00:00

abstract：BACKGROUND:In the current study, the authors investigated the incidence of moderate to severe chemotherapy-induced peripheral neuropathy (CIPN) for chemotherapy regimens commonly used in current clinical practice for the treatment of patients with early breast cancer. Patient-reported and clinician-assessed CIPN severi...

journal_title：Cancer

authors： Nyrop KA,Deal AM,Reeder-Hayes KE,Shachar SS,Reeve BB,Basch E,Choi SK,Lee JT,Wood WA,Anders CK,Carey LA,Dees EC,Jolly TA,Kimmick GG,Karuturi MS,Reinbolt RE,Speca JC,Muss HB

更新日期：2019-09-01 00:00:00

abstract：:A bolus intravenous dose of 5-fluorouracil of 600 mg/M2 was added exactly 1 hour after methotrexate administration in an established combination program including bleomycin and cisplatin for advanced squamous cell cancer of the head and neck. Results were no better than those observed previously with the three drugs, ...

journal_title：Cancer

authors： Vogl SE,Komisar A,Kaplan BH,Engstrom PF,Kasule OH,Stolbach L,Lerner H,Muggia F

更新日期：1986-02-15 00:00:00

abstract：:The difficulties encountered in establishing a diagnosis of a malignant peritoneal mesothelioma are emphasized in a patient who developed the lesion 16 years after radiation therapy for a seminoma of the testis. Historically, histologically, electron microscopically, and by microincineration, there was no evidence of ...

journal_title：Cancer

authors： Stock RJ,Fu YS,Carter JR

更新日期：1979-09-01 00:00:00

abstract：BACKGROUND:Radiofrequency (RF) ablation is an increasingly applied technique. Promising results of hepatic RF ablation raised expectations of its capabilities for treatment of primary and secondary lung tumors. Because of different thermal and electrical properties of lung tissue, compared with liver tissue, a simple a...

journal_title：Cancer

authors： Clasen S,Krober SM,Kosan B,Aebert H,Fend F,Bomches A,Claussen CD,Pereira PL

更新日期：2008-12-01 00:00:00

abstract：:The cellular DNA content of 15 benign and 34 malignant primary bone tumors was analyzed by means of flow cytophotometry. All benign tumors except one of questionable histologic type exhibited a normal DNA content (diploid), whereas 23 of 34 malignant tumors showed an abnormal DNA content (aneuploid). Closer analysis r...

journal_title：Cancer

authors： Kreicbergs A,Silvferswärd C,Tribukait B

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:The association of Langerhans cell histiocytosis (LCH) with a malignant neoplasm is rare and generally has been the subject of isolated case reports. METHODS:A recent case of LCH seen at the University of Minnesota in combination with acute lymphoblastic leukemia led the authors to review their own charts f...

journal_title：Cancer

authors： Egeler RM,Neglia JP,Puccetti DM,Brennan CA,Nesbit ME

更新日期：1993-02-01 00:00:00

abstract：:Clinically benign whole, untrimmed prostates and pelvic lymph nodes were obtained from 105 patients at autopsy. All 105 patients had premortem serum from which prostate-specific antigen (PSA) levels were obtained. Sixty-eight did not have carcinoma of the prostate (CAP), 28 had CAP less than 1 ml and 9 had CAP larger ...

journal_title：Cancer

authors： Brawn PN,Speights VO,Kuhl D,Riggs M,Spiekerman AM,McCord RG,Coffield KS,Stewart DT,Lind ML

更新日期：1991-10-01 00:00:00

abstract：:Vitamin B6 is involved in many biological processes of potential relevance to carcinogenesis and tumor growth, including DNA synthesis and maintenance of immunocompetence, yet very little information exists on B6 nutritional status in childhood leukemia. Using a radioenzymatic assay, the authors measured plasma pyrido...

journal_title：Cancer

authors： Pais RC,Vanous E,Hollins B,Faraj BA,Davis R,Camp VM,Ragab AH

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Previous studies in the literature have suggested that radiolabeled F(ab')2 fragments might be superior to whole immunoglobulin G (IgG) for imaging and therapy of cancer because of their greater penetration in tumors. To test this hypothesis, the authors compared tumor and normal tissue uptake along with pla...

journal_title：Cancer

authors： Murray JL,Rosenblum MG,Zhang HZ,Podoloff DA,Kasi LP,Curley SA,Chan JC,Roh M,Hohn DC,Brewer H

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Parathyroid hormone-related protein (PTHrP) has been shown to be the principal cause of humoral hypercalcemia associated with renal cell carcinoma (RCC). Recent studies have demonstrated that the amino-terminal region of PTHrP has growth factor-like activities, suggesting it may play a role in the developmen...

journal_title：Cancer

authors： Iwamura M,Wu W,Muramoto M,Ohori M,Egawa S,Uchida T,Baba S

更新日期：1999-09-15 00:00:00

abstract：BACKGROUND:Active surveillance (AS) with deferred treatment is an established management option for patients with prostate cancer and favorable clinical parameters. The impact of repeat biopsy after diagnosis was examined in a cohort of men with prostate cancer on AS. METHODS:In all, 186 men with prostate cancer with ...

journal_title：Cancer

authors： Al Otaibi M,Ross P,Fahmy N,Jeyaganth S,Trottier H,Sircar K,Bégin LR,Souhami L,Kassouf W,Aprikian A,Tanguay S

更新日期：2008-07-15 00:00:00

abstract：BACKGROUND:Radiotherapy (RT) has been a risk factor for development of soft tissue sarcomas (STS). The objective of the current study was to quantify the risk of STS after RT and surgery for breast cancer (BCa), assess time trends, and compare long-term survival of patients with RT-associated and non-RT-associated angi...

journal_title：Cancer

authors： Mery CM,George S,Bertagnolli MM,Raut CP

更新日期：2009-09-15 00:00:00

abstract：:In 230 cases of chronic lymphocytic leukemia (CLL), marker analysis was performed with rosette techniques and a panel of xeno-antisera. A monoclonal B-cell proliferation was found in the majority of cases (94%). In most cases, the B-cells carried IgM, with or without IgD. Cytoplasmic immunoglobulin-inclusion bodies we...

journal_title：Cancer

authors： van der Reijden HJ,van der Gaag R,Pinkster J,Rümke HC,van't Veer MB,Melief CJ,von dem Borne AE

更新日期：1982-12-15 00:00:00

abstract：:Currently, there is a "divide" between cancer survivorship initiatives and minority participation. The level of participation is nearly nonexistent in many cancer support and control initiatives. Cancer survivorship resources that facilitate access to treatment, psychosocial interventions, clinical trials, and researc...

journal_title：Cancer

authors： Guidry JJ,Torrence W,Herbelin S

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Bortezomib is a proteasome inhibitor with manageable clinical toxicity and laboratory evidence of anti-melanoma activity. Therefore, it was considered for clinical testing in patients with metastatic melanoma. METHODS:Patients with metastatic melanoma and adequate hematologic, renal, and hepatic function we...

journal_title：Cancer

authors： Markovic SN,Geyer SM,Dawkins F,Sharfman W,Albertini M,Maples W,Fracasso PM,Fitch T,Lorusso P,Adjei AA,Erlichman C

更新日期：2005-06-15 00:00:00

abstract：:Central nervous system (CNS) recurrence continues to be a significant complication in the treatment of adult patients with acute lymphoblastic leukemia (ALL). Preventing CNS recurrence has been a therapeutic challenge and has not been addressed critically in many clinical trials. Adult studies modeled on childhood ALL...

journal_title：Cancer

authors： Jabbour E,Thomas D,Cortes J,Kantarjian HM,O'Brien S

更新日期：2010-05-15 00:00:00

abstract：:Sixty-four adult patients with refractory acute lymphocytic leukemia (ALL) received salvage therapy with the vincristine, doxorubicin (Adriamycin, Adria Laboratories, Columbus, OH), and dexamethasone (VAD) regimen consisting of induction chemotherapy with the three agents followed by multiple-agent maintenance therapy...

journal_title：Cancer

authors： Kantarjian HM,Walters RS,Keating MJ,Barlogie B,McCredie KB,Freireich EJ

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:A diagnosis of cancer provides a teachable moment in which a physician can counsel or teach the patient. The Cancer and Leukemia Group B hypothesized that this teachable moment could also be used to encourage counseling of the patients' relatives who smoke. The authors' first study sought to determine the fe...

journal_title：Cancer

authors： Schilling A,Conaway MR,Wingate PJ,Atkins JN,Berkowitz IM,Clamon GH,DiFino SM,Vinciguerra V

更新日期：1997-01-01 00:00:00

abstract：:Jaundice and hepatomegaly developed in a boy with Fanconi anemia after he had undergone treatment with oxymetholone for nine years. A liver scan showed patchy uptake consistent with the presence of space-occupying lesions. After oxymetholone treatment was stopped, the jaundice resolved, the liver size decreased, and t...

journal_title：Cancer

authors： Obeid DA,Hill FG,Harnden D,Mann JR,Wood BS

更新日期：1980-09-15 00:00:00

abstract：BACKGROUND:The American Joint Committee on Cancer (AJCC) 7th edition introduced major changes in the staging of lung cancer, including the tumor (T), node (N), metastasis (M)-TNM-system and new stage/prognostic site-specific factors (SSFs), collected under the Collaborative Stage Version 2 (CSv2) Data Collection System...

journal_title：Cancer

authors： Chen VW,Ruiz BA,Hsieh MC,Wu XC,Ries LA,Lewis DR

更新日期：2014-12-01 00:00:00