Abstract:
BACKGROUND:Active surveillance (AS) with deferred treatment is an established management option for patients with prostate cancer and favorable clinical parameters. The impact of repeat biopsy after diagnosis was examined in a cohort of men with prostate cancer on AS. METHODS:In all, 186 men with prostate cancer with favorable parameters or who refused treatment were conservatively managed by AS. Of these, 92 patients had at least 1 biopsy after diagnosis. Patients were followed every 3 to 6 months with prostate-specific antigen (PSA) and physical examination and were offered rebiopsy annually or if there were any changes on physical examination or in the PSA value. Disease progression while on AS was defined as having > or =1 of the following: > or =cT2b disease, > or =3 positive cores, >50% of cancer in at least 1 core, or a predominant Gleason pattern of 4 in rebiopsies. RESULTS:The median age of the patients at the time of diagnosis was 67 years (range, 49-78 years). The median follow-up was 76 months (range, 20-169 months). Of the 92 patients who underwent repeat biopsies, 42 patients, 25 patients, 13 patients, 10 patients, and 2 patients had 1, 2, 3, 4, and 5 rebiopsies, respectively. A total of 34 patients (36%) demonstrated disease progression on rebiopsy. The first rebiopsy was positive for cancer in 48 patients (52.2%) and negative in 44 patients (47.8%). The 5-year actuarial progression-free probability was 82% for patients with a negative first repeat biopsy compared with 50% for patients with a positive first rebiopsy (P = .02). A PSA doubling time <67 months was associated an increased risk of disease progression on biopsy. CONCLUSIONS:Negative rebiopsy in patients with prostate cancer on AS is associated with low-volume disease. The result of first repeated biopsy appears to have a strong impact on disease progression. Patients with a positive first repeated biopsy should be considered for treatment. An intensive biopsy protocol within the first 2 years is required to identify and treat those patients.
journal_name
Cancerjournal_title
Cancerauthors
Al Otaibi M,Ross P,Fahmy N,Jeyaganth S,Trottier H,Sircar K,Bégin LR,Souhami L,Kassouf W,Aprikian A,Tanguay Sdoi
10.1002/cncr.23575subject
Has Abstractpub_date
2008-07-15 00:00:00pages
286-92issue
2eissn
0008-543Xissn
1097-0142journal_volume
113pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Germ cell tumors (GCTs) in adolescent and young males are very sensitive to cisplatin-based chemotherapy. However, 10-20% of the patients cannot be cured by currently available therapeutic options. Once a tumor does not respond to cisplatin, current therapeutic modalities offer only a chance for short pallia...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10671
更新日期:2002-07-15 00:00:00
abstract::The American Cancer Society estimates that nearly a million new cases of cancer will occur and that approximately a half million lives will be lost in 1987. These figures may double by the year 2000 primarily because of our aging population, with age being the leading risk factor for cancer. It is believed that the ma...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880601)61:11+<2382::aid-cncr28
更新日期:1988-06-01 00:00:00
abstract::The trends in head and neck cancer incidence and smoking prevalence are reviewed, discussing where such trends parallel but also how and why they may not. In the U.S., public health efforts at tobacco control and education have successfully reduced the prevalence of cigarette smoking, resulting in a lower incidence of...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.22963
更新日期:2007-10-01 00:00:00
abstract::The monitoring utility of serial patterns of a single marker (carcinoembryonic antigen) level and multiple marker (three carbohydrates-fucose, mannose and galactose) levels in patients with small cell carcinoma of the lung was investigated using a quantitative approach. A serial multiple regression (SMR) model was for...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19811001)48:7<1633::aid-cncr2820
更新日期:1981-10-01 00:00:00
abstract::A marked increase in specific immunogenicity of tumor cells is induced upon incorporation of cholesteryl hemisuccinate (CHS) into the cell membrane, which presumably promotes the expression of latent tumor-associated antigens. Immunotherapy with CHS-treated and irradiated tumor cells as vaccine was found to be very ef...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19860801)58:3<650::aid-cncr28205
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:Colorectal cancer incidence rates vary widely internationally, by race and gender, and have changed over time. Investigation of the patterns by subsite within the colorectum may suggest clues of possible etiologic significance for further study. METHODS:Using population-based data on more than 120,000 cases...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930615)71:12<3819::aid-cncr282
更新日期:1993-06-15 00:00:00
abstract::The establishment of a cell culture system for the clonal development of hematopoietic cells has made it possible to discover the proteins that control growth and differentiation of different hematopoietic cell lineages and the molecular basis of normal and abnormal cell development in blood-forming tissues. A model s...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19900515)65:10<2196::aid-cncr282
更新日期:1990-05-15 00:00:00
abstract:BACKGROUND:DNA ploidy and S-phase fraction measured by DNA flow cytometry were shown to correlate with several clinicopathologic characteristics in several types of tumors. METHODS:DNA flow cytometry was performed on 329 samples (164 normal mucosa, 165 tumors) obtained from 165 patients (112 men) with stomach cancer, ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930915)72:6<1819::aid-cncr2820
更新日期:1993-09-15 00:00:00
abstract:BACKGROUND:The aims of this study were to compare human epidermal growth factor receptor 2 (HER2) results between immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), and to investigate the clinicopathological characteristics and outcomes according to their results. METHODS:Using consecutive tissu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26406
更新日期:2012-02-15 00:00:00
abstract:BACKGROUND:: Although platinum-based combinations are considered the best option of care for patients with advanced nonsmall cell lung cancer (NSCLC), single-agent therapy is the preferred treatment for older patients. Since the late 1990s, various combinations of third-generation agents (gemcitabine [G], vinorelbine, ...
journal_title:Cancer
pub_type: 杂志文章,meta分析
doi:10.1002/cncr.24207
更新日期:2009-05-01 00:00:00
abstract::Fifty-eight patients with 62 pathologic fractures secondary to metastatic disease were admitted to a rehabilitation hospital during a 5-year period. Thirty-four patients were discharged home, 7 were transferred to other facilities, and 17 died. The average hospital stay for the patients who went home (37 days) was onl...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920101)69:1<98::aid-cncr282069
更新日期:1992-01-01 00:00:00
abstract::Two cases of primary non-Hodgkin's lymphomas of the breast were studied with light and electron microscopy. By light microscopy, according to Rappaport's classification, one was a poorly differentiated lymphocytic lymphoma, the other a diffuse histiocytic lymphoma. However, the ultrastructural features of the latter w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197705)39:5<2025::aid-cncr282039
更新日期:1977-05-01 00:00:00
abstract:BACKGROUND:National and international bodies acknowledge the benefit of exercise for people with cancer, yet limited accessibility to related programing remains. Given their involvement in managing the disease, cancer centers can play a central role in delivering exercise-oncology services. The authors developed and im...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32297
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:The authors analyzed the secretion of extracellular matrix-degrading proteinases, including urinary-type plasminogen activator (u-PA), matrix metalloproteinase-2 (MMP-2, gelatinase A), and MMP-9 (gelatinase B), by short term primary cultures of epithelial ovarian carcinoma cells derived from primary ovarian ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971015)80:8<1457::aid-cn
更新日期:1997-10-15 00:00:00
abstract::A prospective study of computerized tomography (CT) of the liver using a liver contrast agent compared to conventional CT was undertaken. CT scanning without contrast agents (NC-CT), CT with water-soluble contrast (WSC-CT), and CT with ethiodized oil emulsion (EOE-CT) were performed on patients with possible or probab...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841015)54:8<1489::aid-cncr2820
更新日期:1984-10-15 00:00:00
abstract:BACKGROUND:In cholangiocarcinoma, no established method of analysis of lymph node metastasis has been reported with respect to the surgical outcome. METHODS:The authors retrospectively examined the pattern of lymph node metastasis and the surgical outcome with reference to the International Union Against Cancer (UICC)...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract::Two cases of occult seminoma were observed which showed left-sided lymph node metastases without clinically demonstrable testicular tumors. The peculiar histology of the lymph node metastases, namely PAS-positive tumor cells with clear cytoplasm together with a granulomatous stromal reaction, was highly suggestive of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197907)44:1<245::aid-cncr2820440
更新日期:1979-07-01 00:00:00
abstract::The properties of two classes of nonhistone nuclear proteins (NHNP) whose appearance has been correlated with the process of carcinogenesis in the colonic epithelium of rats given 1,2-dimethylhydrazine (DMH) have been investigated. NHNP isolated from adenocarcinomas of the colon were tested for their binding to homolo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197711)40:5+<2584::aid-cncr28204
更新日期:1977-11-01 00:00:00
abstract::Two children with cancer that persisted after multiple exploratory laparotomies, external beam radiation therapy, and multidrug chemotherapy had gold 198 (198Au) seeds implanted into their localized but unresectable tumor. Both children are alive, are receiving no therapy, and are disease-free more than 2 years later....
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860301)57:5<951::aid-cncr28205
更新日期:1986-03-01 00:00:00
abstract:BACKGROUND:To explore the potential role of infiltrating benign B cells in classic Hodgkin disease (HD) lesions in supporting the survival of malignant Hodgkin and Reed-Sternberg (H/RS) cells, the authors initiated a pilot study of rituximab. Rituximab is used to primarily deplete normal B cells from HD lesions. METHO...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.11511
更新日期:2003-07-15 00:00:00
abstract::A large lipoma and a large angiomyolipoma of the liver, one case each, are described. In the first case, a 24 X 14-cm homogeneous mass demonstrated a fatty density (-96H) on computed tomography (CT), echogenicity on sonography, and fine neovascular vessels on angiography in the right lobe of the liver. Histopathologic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870301)59:5<916::aid-cncr28205
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:The behavior of diffuse peritoneal mesotheliomas in women and the possible relation between tumor morphology and outcome are uncertain. Reported survival has ranged from < 1 month to > 14 years, and a previous study found that tumor morphology could not be used reliably for predicting outcome. The authors ex...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10209
更新日期:2002-01-15 00:00:00
abstract:BACKGROUND:Adequate prediction of survival is important in deciding on treatment for patients with symptomatic spinal metastases. The authors reviewed 342 patients with painful spinal metastases without neurologic impairment who were treated conservatively within a large, prospectively randomized radiotherapy trial. Re...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/cncr.20756
更新日期:2005-01-15 00:00:00
abstract::Acute non-lymphocytic leukemia occurred in eight women following long-term treatment with Treosulfan (= dihydroxybusulfan) for ovarian carcinoma. The leukemia developed from 21 to 58 months (median 50 months) after the institution of chemotherapy. At the time when the leukemia appeared seven of the patients were in co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800101)45:1<19::aid-cncr282045
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Ependymomas account for 2% of all intracranial tumors in adults. Supratentorial ependymomas are less common than their infratentorial counterparts. To the authors' knowledge to date, the predictive values of surgery, histology, and patient-related prognostic factors for these tumors remain unresolved. The au...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23530
更新日期:2008-07-01 00:00:00
abstract::Routinely embedded tumors (116 cases) were screened immunohistochemically for the thyroid-associated antigens, thyroglobulin and calcitonin, and for carcinoembryonic antigen (CEA). Also the influence of different fixatives, decalcification, and embedding procedures were studied. All follicular and papillary carcinomas...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840715)54:2<274::aid-cncr28205
更新日期:1984-07-15 00:00:00
abstract:BACKGROUND:Meningeal melanocytomas are rare, benign central nervous system lesions with a high probability of recurrence. To the authors' knowledge, approximately 100 cases have been reported since 1972, when the entity first was described. In the current study, four therapies were compared with regard to local control...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20296
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Thalidomide is an antiangiogenic agent with immune modulating potential. The objective of this study was to determine response rates among women who were treated for recurrent ovarian cancer using topotecan with or without thalidomide. METHODS:Women were enrolled in this multicenter, prospective, randomized...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.23164
更新日期:2008-01-15 00:00:00
abstract::In a series of 25 patients with head and neck cancer who had severe pain, the type and cause of the pain were analyzed. There were two types of pain: nociceptive and non-nociceptive. Nineteen (76%) patients had nociceptive pain that could be subdivided into actual nociceptive pain (9 patients), nociceptive nerve pain ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920701)70:1<178::aid-cncr28207
更新日期:1992-07-01 00:00:00
abstract::Of a total of 1561 patients registered in the Intergroup Rhabdomyosarcoma Study (IRS) as of May 1983, 78 patients (5%) were younger than 1 year of age. These infants did not differ from the older children (1-20 years of age) in male/female ratio, clinical grouping, or survival rates. Infants younger than 1 year of age...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861215)58:12<2606::aid-cncr282
更新日期:1986-12-15 00:00:00