Prognostic significance of grading in lung adenocarcinoma.

Abstract:

BACKGROUND:Although grading has prognostic significance for many tumor types, a prognostically significant grading system for lung adenocarcinoma has not yet been established. The aim of this study was to evaluate histologic characteristics included in tumor grading systems, establish optimal cutoff values that have the strongest association with overall survival, and develop a grading system incorporating the histopathologic characteristics that the authors found to have prognostic significance in patients with lung adenocarcinoma. METHODS:The authors studied lung adenocarcinomas from 85 consecutive patients, and evaluated the percentage of solid pattern (as a reflection of tumor architecture), the degree of cytologic atypia, and the mitotic count. RESULTS:In univariate analysis, overall survival was associated significantly with sex (P = .045), age (P = .0008), tumor status (P < .0001), lymph node status (P = .02), solid pattern (P = .046), and cytologic atypia (P = .01), but not with mitotic count (P = .26). On the basis of optimal cutoff values, the authors found that a solid pattern > or = 90% and severe cytologic atypia were the best discriminators of worse outcome. A grading score, computed as the sum of the architecture score and cytologic atypia score (2 = well differentiated, 3 = moderately differentiated, 4 = poorly differentiated), was a significant predictor of overall survival in univariate analysis (median overall survival times, 72.4, 39.5, and 8.7 months for well, moderately, and poorly differentiated adenocarcinoma, respectively; P = .0001). Moreover, grading was an independent predictor of survival in multivariate analysis (P = .002). CONCLUSIONS:The authors describe a grading system that incorporates the percentage of solid pattern and degree of the cytologic atypia that is an independent predictor of survival in patients with lung adenocarcinoma.

journal_name

Cancer

journal_title

Cancer

authors

Barletta JA,Yeap BY,Chirieac LR

doi

10.1002/cncr.24831

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

659-69

issue

3

eissn

0008-543X

issn

1097-0142

journal_volume

116

pub_type

杂志文章

相关文献

CANCER文献大全
  • Bone scanning in patients with early breast carcinoma: should it be a routine staging procedure?

    abstract::Bone scanning is a sensitive test for the detection of metastatic breast cancer, but not all abnormal findings on bone scan are diagnostic of skeletal metastasis. Recent studies have found a relatively low rate (less than or equal to 5%) of abnormal scans in patients with Stage I and II breast cancers, and only half o...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19810201)47:3<486::aid-cncr28204

    authors: Lee YT

    更新日期:1981-02-01 00:00:00

  • Wilms' tumor: prognostic factors for patients without metastases at diagnosis: results of the National Wilms' Tumor Study.

    abstract::Multivariate statistical analyses are used to evaluate a wide range of factors in predicting relapse and survival for 429 children enrolled in the National Wilms' Tumor Study. Anaplastic or sarcomatous histology, specimen weight over 250 grams, positive regional lymph nodes, treatment with only a single drug and age o...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197804)41:4<1577::aid-cncr282041

    authors: Breslow NE,Palmer NF,Hill LR,Buring J,D'Angio GJ

    更新日期:1978-04-01 00:00:00

  • Molecular epidemiology of HTLV-I-associated non-Hodgkin's lymphomas in Jamaica.

    abstract::As part of epidemiologic studies of human T-lymphotropic virus (HTLV)-I-associated malignancies in Jamaica, the authors evaluated 26 patients with non-Hodgkin's lymphoma for the presence of integrated HTLV-I provirus in their malignant cells. Fifteen of 26 patients had integrated provirus. All 15 also were HTLV-I anti...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880401)61:7<1477::aid-cncr2820

    authors: Clark JW,Gurgo C,Franchini G,Gibbs WN,Lofters W,Neuland C,Mann D,Saxinger C,Gallo RC,Blattner WA

    更新日期:1988-04-01 00:00:00

  • Sequential development of peripheral T-cell lymphoma in the course of chronic myelogenous leukemia.

    abstract::A patient is described with chronic myelogenous leukemia (CML) and an unusual karyotype 46XY,t(Y;12) (q11;p12), whose clinical course was complicated by T-cell lymphoma 5 years later. At that time bone marrow cells showed an additional karyotypic abnormality 46XY,t(Y;12) (q11;p12) del(7) (pter-p21), which remained unc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900915)66:6<1198::aid-cncr2820

    authors: Blonk MC,van der Valk P,Beverstock GC,Ossenkoppele GJ

    更新日期:1990-09-15 00:00:00

  • Multiple myeloma and family history of cancer. A case-control study.

    abstract::A hospital-based case-control study was done to examine the hypothesis that persons with a family history of multiple myeloma (MM) or other cancers are at increased risk of multiple myeloma. Study members were 439 cases of multiple myeloma and 1317 matched controls seen at the Duke University Medical Center. Only 3 ca...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851015)56:8<2133::aid-cncr2820

    authors: Bourguet CC,Grufferman S,Delzell E,DeLong ER,Cohen HJ

    更新日期:1985-10-15 00:00:00

  • Coexistence of leukemic reticuloendotheliosis and histiocytic lymphoma: a case report.

    abstract::A 65-year-old woman had pancytopenia, splenomegaly, and an inaspirable bone marrow. Diagnostic evaluation demonstrated that she had both leukemic reticuloendotheliosis (LRE), or hairy cell leukemia, and an additional lympho-reticular neoplasm, most likely a "histiocytic" lymphoma. The diagnosis of LRE was based on the...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197905)43:5<1872::aid-cncr282043

    authors: Adler SS,Shetty J,Golomb HM

    更新日期:1979-05-01 00:00:00

  • A safe and effective method for converting patients from transdermal to intravenous fentanyl for the treatment of acute cancer-related pain.

    abstract:BACKGROUND:The delayed effects (12-16 hours) of transdermal fentanyl make dose titration difficult during acute exacerbations of cancer pain. Patients at the authors' institution routinely are switched from transdermal to intravenous (IV) fentanyl using a 1:1 (transdermal:IV) conversion during severe episodes of pain. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11457

    authors: Kornick CA,Santiago-Palma J,Schulman G,O'Brien PC,Weigand S,Payne R,Manfredi PL

    更新日期:2003-06-15 00:00:00

  • Flow cytometry of low stage bladder tumors: correlation with cytologic and cystoscopic diagnosis.

    abstract::Flow cytometry examinations (FCM) were carried out on 110 bladder irrigation specimens from 84 urologic outpatients who had had prior conservative treatment for low stage bladder tumors. The specimens were easily obtained, and adequately cellular in all cases. Of 60 examinations on patients with no cytoscopic abnormal...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820101)49:1<109::aid-cncr28204

    authors: Devonec M,Darzynkiewicz Z,Kostyrka-Claps ML,Collste L,Whitmore WF Jr,Melamed MR

    更新日期:1982-01-01 00:00:00

  • Integrative genomic characterization and a genomic staging system for gastrointestinal stromal tumors.

    abstract:BACKGROUND:Gastrointestinal stromal tumors (GISTs) historically were grouped with leiomyosarcomas (LMSs) based on their morphologic similarities; however, recently, GIST was established unequivocally as a distinct type of sarcoma based on its molecular features and response to imatinib treatment. METHODS:To gain furth...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25594

    authors: Ylipää A,Hunt KK,Yang J,Lazar AJ,Torres KE,Lev DC,Nykter M,Pollock RE,Trent J,Zhang W

    更新日期:2011-01-15 00:00:00

  • Inhibition of radiogenic mammary carcinoma in rats by estriol or tamoxifen.

    abstract::Mammary carcinomas have been induced by 3.5 Gy whole-body gamma radiation administered at age 40 to 50 days to virgin female Sprague-Dawley rats. In 142 irradiated controls carcinoma incidence averaged 7.8% in survivors observed less than 300 days and 38.3% of those surviving longer (P less than 0.001 by t test). Mamm...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900501)63:9<1685::aid-cncr2820

    authors: Lemon HM,Kumar PF,Peterson C,Rodriguez-Sierra JF,Abbo KM

    更新日期:1989-05-01 00:00:00

  • Human pancreatic ribonuclease 1: expression and distribution in pancreatic adenocarcinoma.

    abstract:BACKGROUND:Human pancreatic ribonuclease (RNase 1) is a pancreatic enzyme that is present at high levels in the serum of most patients with pancreatic adenocarcinoma. For this reason, the authors studied its patterns of expression at the single-cell level in pancreatic adenocarcinoma tissues by immunohistochemical anal...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Peracaula R,Cleary KR,Lorenzo J,de Llorens R,Frazier ML

    更新日期:2000-09-15 00:00:00

  • Primary tumors of the trachea. Results of radiation therapy.

    abstract::From 1959 to 1986, 24 patients with primary malignant tumors of the trachea received radiotherapy as all or part of treatment. Common presentations included respiratory symptoms in 20 patients and hemoptysis in 15. Thirteen patients had squamous carcinomas with undifferentiated and adenoid cystic cancers in five and f...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890615)63:12<2429::aid-cncr282

    authors: Fields JN,Rigaud G,Emami BN

    更新日期:1989-06-15 00:00:00

  • Neoadjuvant chemotherapy, surgery, and postoperative radiation therapy for invasive thymoma.

    abstract::Between January 1988 and June 1990, seven previously untreated patients with histologically confirmed and clinically staged IIIa invasive thymoma (IT) were enrolled in a prospective, single treatment arm study of neoadjuvant chemotherapy (NC) followed by surgery and postoperative radiation therapy (4600 to 6000 cGy). ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910815)68:4<706::aid-cncr28206

    authors: Macchiarini P,Chella A,Ducci F,Rossi B,Testi C,Bevilacqua G,Angeletti CA

    更新日期:1991-08-15 00:00:00

  • Detection of recurrent or persistent nasopharyngeal carcinomas after radiotherapy with technetium-99m methoxyisobutylisonitrile single photon emission computed tomography and computed tomography: comparison with 18-fluoro-2-deoxyglucose positron emission

    abstract:BACKGROUND:The diagnostic accuracy of technetium-99m methoxyisobutylisonitrile (Tc-MIBI) single photon emission computed tomography (SPECT) and computed tomography (CT) of the head and neck for differentiating recurrent or residual nasopharyngeal carcinomas (NPC) from benign lesions after radiotherapy was compared with...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/cncr.10400

    authors: Kao CH,Shiau YC,Shen YY,Yen RF

    更新日期:2002-04-01 00:00:00

  • Sequential chemotherapy (etoposide, vinblastine, and doxorubicin) and subtotal lymph node radiation for patients with localized Hodgkin disease and unfavorable prognostic features: A phase II Cancer and Leukemia Group B Study (9051).

    abstract:BACKGROUND:The aim of this study was to evaluate a regimen of sequential chemotherapy and radiotherapy for patients with Hodgkin disease. METHODS:The Cancer and Leukemia Group B conducted a Phase II study of three cycles of etoposide, vinblastine, and doxorubicin (EVA) chemotherapy followed by subtotal lymph node radi...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-0142(19991015)86:8<1590::aid-cn

    authors: Wasserman TH,Petroni GR,Millard FE,Chung CT,Barcos M,Johnson JL,Canellos GP,Peterson BA

    更新日期:1999-10-15 00:00:00

  • Intrahepatic infusional therapy for metastatic ovarian carcinoma.

    abstract::Twenty-four women with ovarian carcinoma that had metastasized to the liver were treated with intrahepatic infusional therapy. No consistent drug regimen was used. There were no complete responders; however, 33% had a partial response. All responses were noticed after the first course of therapy. The median length of ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870601)59:11<1866::aid-cncr282

    authors: Malone JM Jr,Gershenson DM,Carrasco CH,Charansangavej C,Copeland LJ,Larson DM,Kavanagh JJ,Edwards CL,Wallace S

    更新日期:1987-06-01 00:00:00

  • Aberrant, highly hyperdiploid cells in human papillomavirus-positive, abnormal cytologic samples are associated with progressive lesions of the uterine cervix.

    abstract:BACKGROUND:Infection with oncogenic-type human papillomavirus (HPV) and consecutive cytologic abnormalities of the uterine cervix precede the evolution of carcinoma. However, the specificity of both changes is too low to predict the true malignant potential of the change in a given time point, because the majority of t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20848

    authors: Bollmann R,Méhes G,Speich N,Schmitt C,Bollmann M

    更新日期:2005-04-25 00:00:00

  • The impact of cancer on spouses' labor earnings: a population-based study.

    abstract:BACKGROUND:Cancer affects patients' incomes, but to the authors' knowledge few studies to date have examined how the income of the patients' spouses may be influenced. In this population-based study from Norway, the effects of cancer on both partners' earnings are analyzed. METHODS:The difference between labor earning...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24582

    authors: Syse A,Tretli S,Kravdal O

    更新日期:2009-09-15 00:00:00

  • Thymic carcinoma. A clinicopathologic study of 60 cases.

    abstract::The clinicopathologic features of 60 patients with thymic carcinoma were studied. Patients ranged in age from 10 to 76 years (mean, 46), of whom 24 were females and 36 were males. Overall survival at 1, 3, and 5 years was 56.6%, 40%, and 33.3%, respectively. The following morphologic features were correlated with surv...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910215)67:4<1025::aid-cncr2820

    authors: Suster S,Rosai J

    更新日期:1991-02-15 00:00:00

  • A novel arterial infusion chemotherapy for the treatment of patients with advanced pancreatic carcinoma after vascular supply distribution via superselective embolization.

    abstract:BACKGROUND:Patients with American Joint Committee on Cancer Stage IV advanced pancreatic carcinoma have been treated by systemic chemotherapy, intraarterial chemotherapy, radiation therapy, and multidisciplinary treatment using a combination of these. However, the outcome has not always been satisfactory. In the curren...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Homma H,Doi T,Mezawa S,Takada K,Kukitsu T,Oku T,Akiyama T,Kusakabe T,Miyanishi K,Niitsu Y

    更新日期:2000-07-15 00:00:00

  • Cytophotometric DNA measurements in medullary thyroid carcinoma.

    abstract::The prognostic significance of objectively measured karyometric variables (ploidy pattern, nuclear roundness, area, elongation, chromatin texture, and nearest nucleus distance) was investigated in relation to clinical (stage and type of disease) and morphologic (histologic patterns) variables in 27 patients with the d...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900515)65:10<2255::aid-cncr282

    authors: Galera-Davidson H,González-Cámpora R,Mora-Marín JA,Matilla-Vincente A,Dytch HE,Bartels PH,Lerma-Puertas E,Andrada-Becerra E,Bibbo M

    更新日期:1990-05-15 00:00:00

  • Immunologic evidence of a strong association between non-Hodgkin lymphoma and simian virus 40.

    abstract:BACKGROUND:Non-Hodgkin lymphoma (NHL), the most common cancer of the lymphatic system, is of unknown etiology. The identification of etiologic factors in the onset of NHL is a key event that could facilitate the prevention and cure of this malignancy. Simian virus 40 (SV40) has been considered an oncogenic agent in the...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29404

    authors: Tognon M,Luppi M,Corallini A,Taronna A,Barozzi P,Rotondo JC,Comar M,Casali MV,Bovenzi M,D'Agostino A,Vinante F,Rigo A,Ferrarini I,Barbanti-Brodano G,Martini F,Mazzoni E

    更新日期:2015-08-01 00:00:00

  • Causes of death in long-term survivors of head and neck cancer.

    abstract:BACKGROUND:Survivors of head and neck squamous cell carcinoma (HNSCC) face excess mortality from multiple causes. METHODS:We used the population-based Surveillance, Epidemiology, and End Results (SEER) cancer registry data to evaluate the causes of death in patients with nonmetastatic HNSCC diagnosed between 1992 and ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28588

    authors: Baxi SS,Pinheiro LC,Patil SM,Pfister DG,Oeffinger KC,Elkin EB

    更新日期:2014-05-15 00:00:00

  • Reverse stage shift at a tertiary care center: escalating risk in men undergoing radical prostatectomy.

    abstract:BACKGROUND:The objective of this study was to evaluate changes in clinical and pathologic characteristics of prostate cancer in patients who underwent surgery at a large tertiary care center in the context of increased use of active surveillance (AS) and minimally invasive surgery (MIS). METHODS:The authors retrospect...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26132

    authors: Silberstein JL,Vickers AJ,Power NE,Fine SW,Scardino PT,Eastham JA,Laudone VP

    更新日期:2011-11-01 00:00:00

  • Prostate carcinoma incidence and patient mortality: the effects of screening and early detection.

    abstract:BACKGROUND:Screening for and the aggressive treatment of prostate carcinoma are controversial, but they are nevertheless being practiced in the U.S. Current clinical studies of the effectiveness of screening will take years to complete. Meanwhile, screening for prostate carcinoma is already having an effect on society....

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19971101)80:9<1857::aid-cn

    authors: Brawley OW

    更新日期:1997-11-01 00:00:00

  • The treatment of chronic lymphocytic leukemia with COP chemotherapy.

    abstract::Since single drug therapy of chronic lymphocytic leukemia (CLL) has not resulted in prolonged remissions of advanced disease, we initiated a program of combination chemotherapy, COP (cycloposphamide, vincristine sulfate, prednisone) for CLL patients with increasing adenopathy, spenomegaly, and/or signs of marrow failu...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197805)41:5<1664::aid-cncr282041

    authors: Liepman M,Votaw ML

    更新日期:1978-05-01 00:00:00

  • Parathyroid hormone-related protein expression in gynecic squamous carcinoma cells.

    abstract:BACKGROUND:The regulation of parathyroid hormone-related protein (PTH-rP) mRNA levels and immunoreactive (ir)PTH-rP formation by peptide growth factors, particularly transforming growth factor-beta (TGF-beta) and epidermal growth factor (EGF), in squamous cell carcinomas of gynecologic origin is largely unknown. METHO...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940301)73:5<1515::aid-cncr2820

    authors: Tait DL,MacDonald PC,Casey ML

    更新日期:1994-03-01 00:00:00

  • Adjuvant chemotherapy for advanced nasopharyngeal carcinoma in childhood.

    abstract::Seven children with advanced nasopharyngeal carcinoma younger than 20 years of age diagnosed between 1975 and 1986 (inclusive) were treated with a uniform adjuvant chemotherapy regimen, which consisted of vincristine (1.5 mg/m2; day 1), doxorubicin (45 mg/m2; day 1), 5-fluorouracil (8 mg/kg; days 1 through 5), and cyc...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19890515)63:10<1922::aid-cncr282

    authors: Kim TH,McLaren J,Alvarado CS,Wyly JB,Crocker I,Winn K,Singhapakdi S,Ragab A

    更新日期:1989-05-15 00:00:00

  • Organ modeling in the quantitation of planar images for distribution studies.

    abstract:BACKGROUND:The advantage of whole-body imaging for distribution studies is that it accounts for all activities. The problem, however, is that the classic approach to determining distribution from planar images does not accommodate overlapping structures. That approach assumes implicitly that the sampling region is a pr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940201)73:3+<919::aid-cncr2820

    authors: Goris ML,Knox SA,Nielsen KR,Bouillant O

    更新日期:1994-02-01 00:00:00

  • Experimental models for gastric leiomyosarcoma. The effects of N-methyl-N'-nitro-N-nitrosoguanidine in combination with stress, aspirin, or sodium taurocholate.

    abstract::A series of experiments was devised to determine possible modifying effects of stress, aspirin, and sodium taurocholate on the activity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in the Buffalo rat stomach. MNNG is a well known, direct-reacting carcinogen, and has been a reliable agent for the experimental product...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840301)53:5<1088::aid-cncr2820

    authors: Cohen A,Geller SA,Horowitz I,Toth LS,Werther JL

    更新日期:1984-03-01 00:00:00