Sequential development of peripheral T-cell lymphoma in the course of chronic myelogenous leukemia.

Abstract:

:A patient is described with chronic myelogenous leukemia (CML) and an unusual karyotype 46XY,t(Y;12) (q11;p12), whose clinical course was complicated by T-cell lymphoma 5 years later. At that time bone marrow cells showed an additional karyotypic abnormality 46XY,t(Y;12) (q11;p12) del(7) (pter-p21), which remained unchanged until blastic transformation of the CML 8 months later. The bone marrow biopsy specimen, which revealed the blastic transformation of the CML, also showed evidence for localization of T-cell lymphoma. This case, added to two previously reported cases of the concurrence of CML and T-cell lymphoma, suggests a relationship between the two diseases, which is discussed.

journal_name

Cancer

journal_title

Cancer

authors

Blonk MC,van der Valk P,Beverstock GC,Ossenkoppele GJ

doi

10.1002/1097-0142(19900915)66:6<1198::aid-cncr2820

subject

Has Abstract

pub_date

1990-09-15 00:00:00

pages

1198-203

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

66

pub_type

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