Bronchial adenocarcinoma: the value of attempts to exclude other primary tumors for randomized studies in an epidemiologic material.

Abstract:

:To collect an unselected total bronchial carcinoma population as a basis for randomized therapy studies during 1971-1976, 537 patients with suspected bronchial carcinoma were investigated. Of these, 109 were found to have an adenocarcinoma in the lung. Of the 109, 10 had been initially diagnosed as not having adenocarcinoma; 11 had a history of previous carcinoma, and 1 was found not to have bronchial primary on physical examination. The remaining 87 patients were studied with all available methods with the purpose of ruling out all non-bronchial adenocarcinomas as soon as possible. The primary tumor was definitely diagnosed in 86% of the 87 adenocarcinomas. The main non-bronchial tumors were colorectal and renal carcinoma; the main tumors definitely missed were carcinomas of the pancreas. An investigation to rule out non-bronchial primary adenocarcinomas in randomized therapy studies should include: (1) a history of any previous operations on primary carcinomas, histologic comparisons, (2) a careful physical examination, (3) renal investigation, (4) colorectal investigation, (5) gynecologic investigation, and (6) a careful search for symptoms of primary tumors in other organs, especially the pancreas. It is probable, however, that in 10% of cases the condition of the patient will not allow completion of all the investigations, or the real primary tumor will be definitely missed before autopsy.

journal_name

Cancer

journal_title

Cancer

authors

Nõu E

doi

10.1002/1097-0142(19811101)48:9<2121::aid-cncr2820

subject

Has Abstract

pub_date

1981-11-01 00:00:00

pages

2121-5

issue

9

eissn

0008-543X

issn

1097-0142

journal_volume

48

pub_type

临床试验,杂志文章,随机对照试验

相关文献

CANCER文献大全
  • Cisplatin, vindesine and bleomycin (CVB) combination chemotherapy of advanced non-small cell lung cancer.

    abstract::Fifty-four patients with advanced squamous, large-cell or adeno-carcinoma of the lung were treated with a three drug regimen of high-dose cisplatin, vindesine and a four-day bleomycin infusion (CVB). All patients had measurable disease; none had previously received chemotherapy. Of 52 patients evaluable for response, ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830315)51:6<1050::aid-cncr2820

    authors: Itri LM,Gralla RJ,Kelsen DP,Chapman RA,Casper ES,Braun DW Jr,Howard JE,Golbey R,Heelan RT

    更新日期:1983-03-15 00:00:00

  • Quantification of thyroglobulin messenger RNA by in situ hybridization in differentiated thyroid cancers. Difference between well-differentiated and moderately differentiated histologic types.

    abstract::Thyroglobulin messenger RNA (mRNA) was located and quantified in tissue sections of differentiated human thyroid cancers by in situ hybridization using cloned complementary DNA probes. The cells of the well-differentiated follicular and papillary forms contained similar levels of thyroglobulin mRNA, corresponding to a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850715)56:2<345::aid-cncr28205

    authors: Bergé-Lefranc JL,Cartouzou G,De Micco C,Fragu P,Lissitzky S

    更新日期:1985-07-15 00:00:00

  • Low participation rates and disparities in participation in interventional clinical trials for myelodysplastic syndromes.

    abstract:BACKGROUND:The development of novel therapies for the myelodysplastic syndromes (MDS) is hampered by inadequate trial recruitment. Factors contributing to low trial accrual are incompletely understood. METHODS:This study analyzed a pooled patient database from institutions of the US MDS Clinical Research Consortium to...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33105

    authors: Brierley CK,Zabor EC,Komrokji RS,DeZern AE,Roboz GJ,Brunner AM,Stone RM,Sekeres MA,Steensma DP

    更新日期:2020-11-01 00:00:00

  • Psychometric validation of the Female Sexual Function Index (FSFI) in cancer survivors.

    abstract:BACKGROUND:The Female Sexual Function Index (FSFI) is the most commonly used self-report instrument to measure sexual functioning among women cancer survivors. Despite this, the validity and reliability of the FSFI for use in cancer populations has not been established. METHODS:Data were combined from 3 separate insti...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26739

    authors: Baser RE,Li Y,Carter J

    更新日期:2012-09-15 00:00:00

  • Erectile function, incontinence, and other quality of life outcomes following proton therapy for prostate cancer in men 60 years old and younger.

    abstract:BACKGROUND:This study sought to evaluate patient-reported health-related quality of life following proton therapy for prostate cancer in men ≤ 60 years old. METHODS:Between August 2006 and January 2010, 262 hormone-naive men ≤ 60 years old were treated with definitive proton therapy for prostate cancer. Before treatme...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27398

    authors: Hoppe BS,Nichols RC,Henderson RH,Morris CG,Williams CR,Costa J,Marcus RB Jr,Mendenhall WM,Li Z,Mendenhall NP

    更新日期:2012-09-15 00:00:00

  • Role of cancer survivor health and health service use in spouses' use of mental health-related care.

    abstract:BACKGROUND:Spouses of cancer survivors are at an increased risk of poor mental health outcomes but are known to underuse supportive services. The objective of the current study was to determine how the health and health care use of cancer survivors were associated with depression and anxiety-related health care use in ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33345

    authors: Litzelman K,Choi H,Maher ME,Harnish A

    更新日期:2020-12-08 00:00:00

  • Management of adult acute leukemia. A Southwest Oncology Group study.

    abstract::Five hundred forty three adult patients with acute leukemia were entered on the study designed to: (1) test efficacy of vincristine and prednisone used as primary drug therapy in patients with good prognosis as judged by a circulating blast cell count less than 30,000 cm2; (2) investigate the use of either simultaneou...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830915)52:6<958::aid-cncr28205

    authors: McCredie KB,Gehan EA,Freireich EJ,Hewlett JS,Coltman CA Jr,Hussein KK,Balcerzak SP,Chen TT

    更新日期:1983-09-15 00:00:00

  • Alpha-fetoprotein and human chorionic gonadotropin in a patient with a primary intracranial germ cell tumor.

    abstract::A 17 year old man with a primary intracranial germ cell tumor in the pituitary region is reported. Both serum alpha-fetoprotein (AFP) and serum human chorionic gonadotropin (hCG) were found elevated preoperatively. Normal levels of serum AFP and hCG were found after operation and radiotherapy. By indirect immunofluore...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197806)41:6<2315::aid-cncr282041

    authors: Nørgaard-Pedersen B,Lindholm J,Albrechtsen R,Arends J,Diemer NH,Riishede J

    更新日期:1978-06-01 00:00:00

  • Public attitudes toward cancer pain.

    abstract::This study examined public attitudes toward pain associated with cancer and its treatment. A variety of issues were assessed, including the extent to which pain is associated with cancer, fear of pain as a factor in the decision to delay seeking treatment, and concerns about the use of narcotic analgesics for pain con...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851101)56:9<2337::aid-cncr2820

    authors: Levin DN,Cleeland CS,Dar R

    更新日期:1985-11-01 00:00:00

  • Comparison of dynamic and conventional computed tomography, angiography, and ultrasonography in the staging of renal cell carcinoma.

    abstract::A prospective study was carried out on 22 patients to assess the diagnostic ability to stage renal cell carcinoma by computed tomography, dynamic computed tomography, arteriography, ultrasonography, and radionuclide scanning. Dynamic computed tomography remedied the most consequential diagnostic shortcomings of conven...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841115)54:10<2205::aid-cncr282

    authors: Lang EK

    更新日期:1984-11-15 00:00:00

  • The prognostic value of histologic subtypes in primary extremity liposarcoma.

    abstract::Patients with a localized primary liposarcoma of the extremity who were treated in Memorial Sloan-Kettering Cancer Center between 1968 and 1978 were studied. The prognosis of patients with extremity liposarcoma was analyzed according to histopathologic subtypes. A system of five subtypes was used; well-differentiated,...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891001)64:7<1514::aid-cncr2820

    authors: Chang HR,Hajdu SI,Collin C,Brennan MF

    更新日期:1989-10-01 00:00:00

  • Improving cancer-specific outcomes in solid organ transplant recipients: Where to begin?

    abstract::In an article published in this issue of Cancer, D'Arcy et al link the incidence of cancer among recipients of solid organ transplantation (SOT) in the Scientific Registry of Transplant Recipients with data from regional and statewide cancer registries to examine cancer-specific mortality for common malignancies in SO...

    journal_title:Cancer

    pub_type: 评论,杂志文章

    doi:10.1002/cncr.31963

    authors: Koff JL,Waller EK

    更新日期:2019-03-15 00:00:00

  • Mesoblastic nephroma--a report from the Gesellschaft fur Pädiatrische Onkologie und Hämatologie (GPOH).

    abstract:BACKGROUND:Surgery alone is the appropriate first-line treatment for patients with mesoblastic nephroma (MN). Nevertheless, there are reports of local recurrences and metastasis, especially in the cellular subtype. The authors evaluated the outcome of patients with MN who were enrolled in either the International Socie...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21836

    authors: Furtwaengler R,Reinhard H,Leuschner I,Schenk JP,Goebel U,Claviez A,Kulozik A,Zoubek A,von Schweinitz D,Graf N,Gesellschaft fur Pädiatrische Onkologie und Hämatologie (GPOH) Nephroblastoma Study Group.

    更新日期:2006-05-15 00:00:00

  • Choroid plexus carcinoma of childhood.

    abstract::The presentation, growth patterns, and response to therapy of 11 consecutive children with choroid plexus carcinomas were analyzed, and the results were compared with the outcome reported in other series. Patients were a median of 26 months of age at diagnosis. Two patients had thalamic tumors, one had a posterior fos...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19920115)69:2<580::aid-cncr28206

    authors: Packer RJ,Perilongo G,Johnson D,Sutton LN,Vezina G,Zimmerman RA,Ryan J,Reaman G,Schut L

    更新日期:1992-01-15 00:00:00

  • Influence of the time between surgery and radiotherapy on local recurrence in patients with lymph node-positive, early-stage, invasive breast carcinoma undergoing breast-conserving surgery: results of the French Adjuvant Study Group.

    abstract:BACKGROUND:Radiotherapy (RT) after breast-conserving surgery (BCS) has produced significant reductions in ipsilateral breast carcinoma (BC) recurrence. It was shown previously that a delay in the initiation of RT resulted in a higher local recurrence (LR) rate. In the current retrospective analysis, the authors investi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21161

    authors: Benchalal M,Le Prisé E,de Lafontan B,Berton-Rigaud D,Belkacemi Y,Romestaing P,Peignaux K,Courdi A,Monnier A,Montcuquet P,Goudier MJ,Marchal C,Chollet P,Abadie-Lacourtoisie S,Datchary J,Veyret C,Kerbrat P

    更新日期:2005-07-15 00:00:00

  • Bronchogenic carcinoma and secondary aspergillosis--common yet unexplored: evaluation of the role of bronchoalveolar lavage-polymerase chain reaction and some nonvalidated serologic methods to establish early diagnosis.

    abstract:BACKGROUND:More cases of bronchogenic carcinoma have been reported in recent years, and these patients are more prone to secondary aspergillosis. However, the frequency of secondary aspergillosis in bronchogenic carcinoma still has not been defined clearly in the literature. METHODS:The current study population was co...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23570

    authors: Shahid M,Malik A,Bhargava R

    更新日期:2008-08-01 00:00:00

  • Multiple biologic markers in the monitoring of treatment for patients with small cell carcinoma of the lung: the use of serial levels of plasma CEA and serum carbohydrates.

    abstract::The monitoring utility of serial patterns of a single marker (carcinoembryonic antigen) level and multiple marker (three carbohydrates-fucose, mannose and galactose) levels in patients with small cell carcinoma of the lung was investigated using a quantitative approach. A serial multiple regression (SMR) model was for...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19811001)48:7<1633::aid-cncr2820

    authors: Woo KB,Waalkes P,Abeloff MD,Ettinger DS,McNitt KL,Gehrke CW

    更新日期:1981-10-01 00:00:00

  • A phase II study of "decrescendo" interleukin-2 plus interferon-alpha-2a in patients with progressive metastatic melanoma after chemotherapy.

    abstract:BACKGROUND:The authors tested a biotherapy regimen involving recombinant interferon-alpha-2a (rIFN-alpha-2a) and recombinant human interleukin-2 (rhIL-2), given in a "decrescendo" schedule over 5 days, for its activity and toxicity in 21 patients who previously had received chemotherapy for advanced melanoma. METHODS:...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Eton O,Buzaid AC,Bedikian AY,Smith TM,Papadopoulos NE,Ellerhorst JA,Hibberts JL,Legha SS,Benjamin RS

    更新日期:2000-04-01 00:00:00

  • Estrogen receptors in patients with malignant melanoma.

    abstract::We detected cytoplasmic estrogen receptors (ER) in only 4 of 34 (12%) patients with malignant melanoma. The titers as assayed by the dextran-coated charcoal method were 3, 3, 4, and 5 fmol/mg, respectively. Our data indicate that the incidence of melanoma with detectable ER is low, which suggests that any potential cl...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19801015)46:8<1785::aid-cncr2820

    authors: Creagan ET,Ingle JN,Woods JE,Pritchard DJ,Jiang NS

    更新日期:1980-10-15 00:00:00

  • The treatment of ejaculation disorders after retroperitoneal lymph node dissection.

    abstract::In 14 patients by bilateral retroperitoneal lymph node dissection for nonseminoma tumors of the testes, several sexual functions before and after node dissection were compared. All patients had normal sexual function before the operation. After the operation, antegrade ejaculation was found to have disappeared complet...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19821215)50:12<2967::aid-cncr282

    authors: Nijman JM,Jager S,Boer PW,Kremer J,Oldhoff J,Koops HS

    更新日期:1982-12-15 00:00:00

  • Platinum analogue combination chemotherapy: cisplatin, carboplatin, and methotrexate in patients with metastatic urothelial tract tumors. A phase II trial with evaluation of prognostic factors.

    abstract:BACKGROUND:Cisplatin is one of the single drugs that has shown the best documented effect in treating patients with locally recurrent or metastatic urothelial cancer. To the authors' knowledge, the effect of the combination of different platinum analogues in treating transitional cell carcinoma has not been evaluated p...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19951115)76:10<1797::aid-cncr282

    authors: Sengeløv L,Nielsen OS,Kamby C,von der Maase H

    更新日期:1995-11-15 00:00:00

  • Chemical carcinogenesis.

    abstract::The field of chemical carcinogenesis is reviewed, with emphasis on three aspects: 1) environmental chemicals are a major cause of human cancer; 2) most chemical carcinogens require metabolic activation by mixed-function oxidases to electrophilic metabolites that form strong covalent chemical bonds with cellular macrom...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197707)40:1+<430::aid-cncr282040

    authors: Heidelberger C

    更新日期:1977-07-01 00:00:00

  • Primary retroperitoneal seminoma.

    abstract::In a retrospective review (1950-1975) of the Mayo Clinic experience with seminomas (483 cases), twelve patients (2.5%) were found to have a retroperitoneal seminoma without evidence of testicular involvement. The mean age was 47 years (range, 31-67). Eleven patients were treated by radiation alone, with doses ranging ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820501)49:9<1934::aid-cncr2820

    authors: Buskirk SJ,Evans RG,Farrow GM,Earle JD

    更新日期:1982-05-01 00:00:00

  • The prevalence of unsuspected thyroid pathology in 300 sequential autopsies, with special reference to the incidental carcinoma.

    abstract::Three-hundred whole thyroid glands were collected at autopsy from patients who had no known clinical history of thyroid disease, and who varied from 13 to 82 years of age; 200 were male and 100 female. Thyroid glands were weighed, measured, and examined after previous formalin fixation. Histologic examination was done...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19891101)64:9<1888::aid-cncr2820

    authors: Bisi H,Fernandes VS,de Camargo RY,Koch L,Abdo AH,de Brito T

    更新日期:1989-11-01 00:00:00

  • Depressed adenoma of the stomach, revisited. Histologic, histochemical, and immunohistochemical profiles.

    abstract::For 52 patients with depressed adenomas of the stomach, histopathologic studies were done on 56 tumors and for 43 of them, histochemical and immunohistochemical features were examined. In addition, nondepressed adenomas (n = 57) and the depressed type of early gastric adenocarcinomas of the well-differentiated variety...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910501)67:9<2382::aid-cncr2820

    authors: Xuan ZX,Ambe K,Enjoji M

    更新日期:1991-05-01 00:00:00

  • Idiopathic giant cell myocarditis after autologous hematopoietic stem cell transplantation and interleukin-2 immunotherapy: a case report.

    abstract:BACKGROUND:Interleukin-2 (IL-2) is used in the treatment of solid tumors and hematologic malignancies. Sudden death is a rare complication of IL-2 treatment. METHODS:A patient with lymphoma underwent chemoradiotherapy myeloablation and autologous stem cell transplantation. The stem cells were cultured in IL-2 (6000 IU...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19980915)83:6<1231::aid-cn

    authors: Truica CI,Hansen CH,Garvin DF,Meehan KR

    更新日期:1998-09-15 00:00:00

  • Cancers of the large bowel: associated disorders in individuals.

    abstract::The individual medical histories in the files of the Oxford Record Linkage Study for the years 1963 to 1967 were analyzed to ascertain any previously unsuspected associations between cancers of the large bowel and other diseases in individuals, and to quantify the relative risks of disorders already known to be associ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197906)43:6<2553::aid-cncr282043

    authors: Adelstein P,Baldwin JA,Fedrich J

    更新日期:1979-06-01 00:00:00

  • Primary malignant fibrous histiocytoma of bone.

    abstract::A review of over 400 primary bone tumors yielded 11 lesions with features allowing classification as malignant fibrous histiocytoma on a purely histological basis. Correlation with roentgenograms and clinical data indicated that these tumors occurred as osteolytic lesions associated with a high incidence of pathologic...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.2820360925

    authors: Spanier SS,Enneking WF,Enriquez P

    更新日期:1975-12-01 00:00:00

  • Expression of alpha-3/4-monofucosylated polylactosaminoglycan epitope, as defined by monoclonal antibody FW6, is a marker of the colorectal adenoma-carcinoma sequence.

    abstract:BACKGROUND:The expression of a distinct alpha-3/4-monofucosylated polylactosaminoglycan epitope, which is detected by monoclonal antibody FW6, was investigated by comparative immunohistochemical analysis of colorectal tissue specimens exhibiting different grades of premalignant and malignant transformation. The presenc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950915)76:6<954::aid-cncr28207

    authors: Baldus SE,Vierbuchen M,Hanisch FG,Schwonzen M,Fischer R

    更新日期:1995-09-15 00:00:00

  • Cancer and total mortality among active Mormons.

    abstract::Based on Church records for 15,500 California Mormons during 1968 to 1975 and for 55,000 Utah Mormons during 1970 and 1975, the ratio of age-adjusted death rates for religiously active Mormon males compared with U.S. white males is 38% for ages 35 to 64 years and 50% for ages 35 years and above. The remaining life exp...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197810)42:4<1943::aid-cncr282042

    authors: Enstrom JE

    更新日期:1978-10-01 00:00:00