The prognostic value of histologic subtypes in primary extremity liposarcoma.

Abstract:

:Patients with a localized primary liposarcoma of the extremity who were treated in Memorial Sloan-Kettering Cancer Center between 1968 and 1978 were studied. The prognosis of patients with extremity liposarcoma was analyzed according to histopathologic subtypes. A system of five subtypes was used; well-differentiated, myxoid, fibroblastic, lipoblastic, and pleomorphic liposarcomas. The 5-year treatment failure rates and survival rates were, respectively, 30% and 100% for well-differentiated, 25% and 88% for myxoid, 60% and 58% for fibroblastic, 100% and 40% for lipoblastic, and 64% and 56% for pleomorphic liposarcomas. Although local recurrence was present in all five subtypes, a significant increment in local failure was seen in patients with high-grade liposarcomas. Distant metastasis after the initial operation was not found in patients with well-differentiated liposarcoma and rare in the patients with myxoid liposarcoma. In contrast, 50% of the patients with fibroblastic, lipoblastic, and pleomorphic liposarcoma had a distant relapse within 5 years.

journal_name

Cancer

journal_title

Cancer

authors

Chang HR,Hajdu SI,Collin C,Brennan MF

doi

10.1002/1097-0142(19891001)64:7<1514::aid-cncr2820

subject

Has Abstract

pub_date

1989-10-01 00:00:00

pages

1514-20

issue

7

eissn

0008-543X

issn

1097-0142

journal_volume

64

pub_type

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