Abstract:
:The potential of using a blood test enumerating oncofetal ferritin-bearing lymphocytes (FBL) as a biomarker for early breast cancer was further explored. Nine hundred women attending a high-risk breast cancer clinic and 2500 normal-risk women were physically examined and their blood drawn for FBL determination using a newly developed radioimmunoassay. The FBL test results were compared to clinically or histopathologically diagnosed breast disease and to known breast cancer risk factors. A gradual increase in the mean FBL ratio was seen from normal risk disease-free women to those with in situ or early stage breast cancer. The percentage of women with positive FBL was 13.6% for the normal risk group, 19% and 25.7% for clinically and histopathologically diagnosed benign breast disease, respectively, and 100, 77.8, and 66.7% for in situ, Stage I, and Stage II breast cancer, respectively. In locally advanced disease (Stage III) the percentage of positive women was only 17.2%. It was further found that a negative FBL result in known breast cancer patients at Stage I, II of the disease was a bad prognostic marker indicating a shorter disease-free survival. The follow-up of patients after surgery by periodical clinical examination and the FBL test revealed that the positive FBL was declining after removal of the precancerous or malignant tumor and that it was highly sensitive (100%) in predicting tumor development and recurrence. Using a logistic regression analysis, an FBL-positive test indicated a significant association with risk of early breast cancer (odds ratio = 2.9; 95% confidence interval = 1.4-5.8). Being a measure of the immune response the positive FBL was associated with early breast cancer and good prognosis. Since patients with locally advanced cancer and poor prognosis were FBL negative but such patients were shown to have increased serum ferritin levels. It is suggested to use the FBL and serum ferritin assays for screening and diagnosis of breast cancer.
journal_name
Cancerjournal_title
Cancerauthors
Moroz C,Kahn M,Ron E,Luria H,Chaimoff Cdoi
10.1002/1097-0142(19890801)64:3<691::aid-cncr28206subject
Has Abstractpub_date
1989-08-01 00:00:00pages
691-7issue
3eissn
0008-543Xissn
1097-0142journal_volume
64pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:: The purpose of this study was to evaluate the impact of postmastectomy breast reconstruction on the timing of chemotherapy. METHODS:: The authors included stage I-III breast cancer patients from 8 National Comprehensive Cancer Network institutions for whom guidelines recommended chemotherapy. Surgery type...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24891
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Hepatic artery administration of iodine-131-Lipiodol serves as a modality that delivers targeted radiation therapy to hepatocellular carcinoma. Its efficacy has been promising according to trials conducted in the adjuvant setting after hepatic resection. Further investigation of its role in the palliative se...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25283
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:The current study sought to delineate prospectively the rates and clinical course of emotional distress, cognitive impairment, and quality of life (QOL) in chemotherapy-naive patients with cancer and to consider the determinants of global QOL. METHODS:Patients who consented to participate were administered ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20385
更新日期:2004-07-15 00:00:00
abstract:BACKGROUND:Low-grade gliomas (LGGs) and low-grade glioneuronal tumors (LGGNTs) diagnosed during the first year of life carry unique clinical characteristics and challenges in management. However, data on the treatment burden, outcomes, and morbidities are lacking. METHODS:A retrospective study of LGGs and LGGNTs diagn...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31918
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:In 1991, the Italian Association for Pediatric Hematology-Oncology and the National Council of Research (CNR) initiated an Italian Cooperative Study (SE 91-CNR Protocol) with the main objective of improving the overall survival (SUR) and the event free survival (EFS) of children and young adults with localiz...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/(sici)1097-0142(19990801)86:3<421::aid-cnc
更新日期:1999-08-01 00:00:00
abstract::Meningeal myeloid metaplasia (MM) is very rarely observed in patients with myelofibrosis. We report the occurrence of meningeal MM causing exophthalmus and fever in a patient with myelofibrosis secondary to polycythemia vera. A computerized tomography (CT) scan showed multiple intracranial and intraorbital enhancing m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881201)62:11<2346::aid-cncr282
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND:Children diagnosed with medulloblastoma whose tumor involves the brain stem or has spread through the cerebrospinal fluid pathways to other areas of the brain or spinal cord have a poor prognosis despite therapy with surgery, craniospinal irradiation (CSI), and chemotherapy. Preradiation chemotherapy may imp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931101)72:9<2755::aid-cncr2820
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:The growth of cancer symptom management research has been limited by challenges of slow recruitment and under-enrollment. One potential solution to this problem is the use of screening questions that identify patients who are interested in participating in research. The goal of this study was to evaluate thi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11329
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:The widespread use of anthracycline chemotherapy has contributed to improved outcomes in children with cancer. The most feared complication of the anthracyclines is cardiotoxicity. Routine echocardiographic monitoring typically is used before, during, and after treatment to minimize cardiotoxicity. The ideal...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26481
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Intralesional radioimmunotherapy (RAIT) may improve the management of malignant gliomas whose prognosis is, at present, very poor. Current treatment modalities (e.g., surgery, radiotherapy, and chemotherapy) may prolong survival by a few months but cannot prevent tumor recurrence. METHODS:Following one or m...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19940201)73:3+<1076::aid-cncr282
更新日期:1994-02-01 00:00:00
abstract::The East Harlem Partnership for Cancer Awareness (EHPCA) was formed in 1999 to reduce disparities in cancer screening and prevention among medically underserved minorities residing in a large urban community (East Harlem, New York City) by increasing awareness of cancer risk, prevention, and treatment, and promoting g...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22153
更新日期:2006-10-15 00:00:00
abstract:BACKGROUND:Gastric carcinoids are uncommon, and are unlike carcinoids at other gastrointestinal sites, clinically and pathologically. METHODS:The authors studied specimens from 104 patients with gastric carcinoid, with study emphasis being placed on pathologic features, immunohistochemistry, clinical associations, and...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940415)73:8<2053::aid-cncr2820
更新日期:1994-04-15 00:00:00
abstract::Proficiency testing in cytopathology and in other disciplines should be based on firm statistical and scientific foundations, because test theory in general is a heavily statistical subject. Statistical considerations have demonstrated that the design of "short" proficiency tests in cytopathology, including the curren...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23154
更新日期:2007-12-25 00:00:00
abstract::The clinical and laboratory features of nine patients with chronic myelomonocytic leukemia are described. Hepatic or splenic enlargement accompanied by an absolute monocytosis in an older patient with an elevated serum or urine lysozyme and serum vitamin B12 levels were characteristic of the majority of patients in th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197912)44:6<2249::aid-cncr282044
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND:The use of adjuvant tamoxifen to treat postmenopausal breast carcinoma patients as an adjunct to primary surgery is well established. The current study reports the long term results for a low risk stratum in a randomized trial of adjuvant tamoxifen. The main focus of this analysis was to determine whether ta...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1998-06-01 00:00:00
abstract::A human liposarcoma cell line COLO 222, derived from a primary tumor in a 62-year-old male, elaborates hyaluronic acid. COLO 222 is characterized on the basis of histochemical, ultramorphological, and cytogenetic properties, along with isozyme phenotype and cell products. A chromosome mode of 53 predominates and uniqu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800315)45:6<1400::aid-cncr2820
更新日期:1980-03-15 00:00:00
abstract:BACKGROUND:After the introduction of a mammography screening program, the incidence of late-stage breast cancer is expected to decrease. The objective of the current study was to evaluate variations in the total incidence of breast cancer and in the incidence of breast cancers with a pathologic tumor (pT) classificatio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28014
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the results of thyroid fine-needle aspiration (FNA) and to determine the reasons for the discrepancies between the cytologic and histologic diagnoses. METHODS:The authors evaluated the cytologic and histologic results of 133 FNAs obtained from 92 patients who underw...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970825)81:4<253::aid-cnc
更新日期:1997-08-25 00:00:00
abstract:BACKGROUND:It has previously been shown that heparanase-1 (HPR1), an endoglycosidase, is up-regulated in pancreatic carcinoma. The purpose of this study was to test whether serum HPR1 levels in pancreatic carcinoma patients are elevated, and whether higher serum HPR1 levels are associated with a shortened survival. ME...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21648
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Inferior vena cava obstruction (IVCO) is a poorly characterized complication of metastatic germ cell tumor (GCT). The authors identified 31 cases to describe the clinical features, radiologic findings, complications, and treatment of this clinical entity. METHODS:Patients with GCT and IVCO were identified f...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1999-02-15 00:00:00
abstract::A lifetime history of analgesics and tobacco consumption was obtained by a questionnaire completed at interview from 67 patients with carcinoma of the renal pelvis (40 women, 27 men) and 180 control subjects drawn from two sources, friends of patients and persons attending a health screening clinic. Regular consumptio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820615)49:12<2617::aid-cncr282
更新日期:1982-06-15 00:00:00
abstract:BACKGROUND:Previous reports based on small patient numbers suggested that changes in serum HER-2/neu levels may predict response or lack of response to trastuzumab-based therapies in metastatic breast cancer (MBC). The objectives of this study were to pool data from 307 patients with MBC from 7 medical institutions to ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.23689
更新日期:2008-09-15 00:00:00
abstract::The authors report three patients who developed fatal respiratory failure after limited or unilateral thoracic radiation therapy for neoplasms. The respiratory failure was characteristic of the adult respiratory distress syndrome (ARDS) with refractory hypoxemia and diffuse bilateral infiltrates including areas of lun...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860515)57:10<1941::aid-cncr282
更新日期:1986-05-15 00:00:00
abstract:BACKGROUND:Approximately 5-10% of patients with rhabdomyosarcomas (RMS) are diagnosed during the first year of life, and their clinical characteristics have been well documented. However, because RMS rarely occurs during the neonatal period, little is known about neonatal RMS. METHODS:Four patients with neonatal RMS w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010915)92:6<1613::aid-cncr1487
更新日期:2001-09-15 00:00:00
abstract:BACKGROUND:The Akt/mammalian target of the rapamycin (mTOR) signaling pathway represents a promising target for cancer therapy. The phosphorylation status of Akt and of mTOR's phosphorylation target eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) is often used to assess the activity of Akt and mTOR signaling...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23456
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:In the current national debate regarding private insurance versus Medicaid expansion, understanding how insurance is associated with racial disparities in prostate cancer (CaP) outcomes has broad policy implications. In the current study, the authors examined the association between insurance status, race, a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31106
更新日期:2018-02-15 00:00:00
abstract::A case of squamous cell carcinoma of the tongue in a 26-year-old man developing nine years after renal transplantation is presented. This is the first such case to be reported. Within seven months, widespread tumor metastases resulted in death. Pathologic examination of the transplanted kidney demonstrated neither re-...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197801)41:1<1::aid-cncr282041010
更新日期:1978-01-01 00:00:00
abstract::Two studies were performed to evaluate the safety, tolerability, and efficacy of irinotecan (CPT-11) in the treatment of adults with malignant glioma. Patients with progressive or recurrent malignant gliomas were enrolled. In the first study, CPT-11 was administered once every 3 weeks as a 90-minute intravenous infusi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11306
更新日期:2003-05-01 00:00:00
abstract::Review of the consultation records of the Gastrointestinal Surgical Oncology service at Roswell Park Memorial Institute from 1982 to 1987 revealed 22 patients with a clinical diagnosis of neutropenic enterocolitis. Ninety-one percent of the patients had hematologic malignancies, and 95% were receiving cytotoxic chemot...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920101)69:1<17::aid-cncr282069
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Although >70% of younger women with nonmetastatic breast cancer (BC) received adjuvant chemotherapy, only approximately 15% to 20% of elderly women with BC received chemotherapy. The decision to treat may be associated with nonmedical factors, such as patient, physician, or practice characteristics. In the c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24448
更新日期:2009-09-01 00:00:00