Patients' willingness to participate in symptom-related and disease-modifying research: results of a research screening initiative in a palliative care clinic.

abstract：BACKGROUND:Bortezomib is active in heavily pretreated multiple myeloma patients; the dose-limiting toxicity is peripheral neuropathy (PN). METHODS:The authors retrospectively reviewed the incidence, severity, and risk factors for PN in 78 patients who received bortezomib. The median age was 57 years (range, 33-80 year...

journal_title：Cancer

authors： Badros A,Goloubeva O,Dalal JS,Can I,Thompson J,Rapoport AP,Heyman M,Akpek G,Fenton RG

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:This randomized pilot trial investigated whether primary chemotherapy was feasible in terms of efficacy, survival, toxicity profile, and quality of life compared with whole-brain radiotherapy (WBRT) given first in chemotherapy-naive patients nonsmall cell lung cancer (NSCLC) with synchronous brain metastasis...

journal_title：Cancer

authors： Lee DH,Han JY,Kim HT,Yoon SJ,Pyo HR,Cho KH,Shin SH,Yoo H,Lee SH,Lee JS

更新日期：2008-07-01 00:00:00

abstract：:An 11-year-old female with a large embryonal carcinoma of the left ovary was treated by unilateral salpingo-oophorectomy combined with a systemic chemotherapy of a total dose of 1.9 mg of dactinomycin. The preoperative serum alpha-fetoprotein (AFP) level of 70,350 ng/ml decreased to 270 ng/ml 5 weeks after the operati...

journal_title：Cancer

authors： Nakakuma K,Tashiro S,Uemura K,Takayama K

更新日期：1983-10-15 00:00:00

abstract：:Chondrosarcoma of the foot is a very unusual entity. A case arising from a solitary osteocartilagenous exostosis is presented and the literature is reviewed and discussed. ...

journal_title：Cancer

authors： Lewis MM,Marcove RC,Bullough PG

更新日期：1975-08-01 00:00:00

abstract：:Indirect data supporting a preexisting immunologic impairment in patients with Hodgkin's disease (HD) have been presented in recent years. These immunologic defects are supposed to be related to genetic and/or environmental factors. In this study, 65 first-degree relatives and 12 spouses of 21 consecutive patients wit...

journal_title：Cancer

authors： Merk K,Björkholm M,Tullgren O,Mellstedt H,Holm G

更新日期：1990-11-01 00:00:00

abstract：:The current report describes a secondary malignancy developing in a retroperitoneal mature residual lesion 6 years after chemotherapeutic treatment of a disseminated nonseminomatous testicular tumor. The histologically malignant component was not present in the primary tumor and consisted of polygonal and fusiform cel...

journal_title：Cancer

authors： Molenaar WM,Oosterhuis JW,Meiring A,Sleyfer DT,Schraffordt Koops H,Cornelisse CJ

更新日期：1986-07-15 00:00:00

abstract：:This study characterized the fine structure of melanosomes in melanocytes of the dysplastic nevi in six cases with lentiginous melanocytic dysplasia and one case with epithelioid-cell melanocytic dysplasia, and compared that structure with those of common melanocytic nevi and malignant melanoma. It was found that: fin...

journal_title：Cancer

authors： Takahashi H,Horikoshi T,Jimbow K

更新日期：1985-07-01 00:00:00

abstract：:With nearly 80% of childhood cancer patients achieving cure, there are more adult survivors living now than at any other time in history. Because they are at risk for developing complications of treatment years later, it is recommended that survivors undergo systematic, regular monitoring into young adulthood and beyo...

journal_title：Cancer

authors： Freyer DR,Kibrick-Lazear R

更新日期：2006-10-01 00:00:00

abstract：:A prospective study of four cycles of etoposide with ifosfamide and cisplatin (VIP) chemotherapy was conducted in 42 germ cell tumor (GCT) patients who were refractory to cisplatin with etoposide/vinblastine-based therapy. Forty patients were evaluable for response. Ten patients (25%) had a complete response: seven to...

journal_title：Cancer

authors： Motzer RJ,Cooper K,Geller NL,Bajorin DF,Dmitrovsky E,Herr H,Morse M,Fair W,Sogani P,Russo P

更新日期：1990-12-15 00:00:00

abstract：BACKGROUND:Electrochemotherapy (ECT) is a new antitumor approach that combines systemic bleomycin (BLM) with electric pulses (EP) delivered locally at the tumor site. These EP permeabilize the cells in the tissue, allow BLM delivery inside the cells, and increase BLM cytotoxicity. As an extension of our initial Phase I...

journal_title：Cancer

authors： Domenge C,Orlowski S,Luboinski B,De Baere T,Schwaab G,Belehradek J Jr,Mir LM

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Disparities in treatment and mortality for colorectal cancer (CRC) may reflect differences in access to specialized care or other characteristics of the area where an individual lives. METHODS:Surveillance, Epidemiology and End Results Program-Medicare data for seniors diagnosed with CRC were linked to area...

journal_title：Cancer

authors： Haas JS,Brawarsky P,Iyer A,Fitzmaurice GM,Neville BA,Earle C

更新日期：2011-09-15 00:00:00

abstract：:Fifty-three patients with advanced lymphocytic lymphoma were randomly assigned to treatment with the combination cyclophosphamide, vincristine, and prednisone (CVP) or the same agents used successively in maximal doses (C-V-P). Complete remissions occurred in 68% with CVP and 48% with C-V-P. For patients with nodular ...

journal_title：Cancer

authors： Kennedy BJ,Bloomfield CD,Kiang DT,Vosika G,Peterson BA,Theologides A

更新日期：1978-01-01 00:00:00

abstract：:Renal cell carcinoma (RCC) has remained refractory to substantive change of its natural history despite intervention with a number of therapeutic modalities. Alpha interferons leukocyte interferon alpha [HuIFN-alpha (Le)] and lymphoblastoid interferon alpha [HuIFN-alpha (Ly)] initially were shown to produce regression...

journal_title：Cancer

authors： Neidhart JA

更新日期：1986-04-15 00:00:00

abstract：:Skin cancers originating in areas of chronic injury (Marjolin's ulcers) are thought to behave in a more aggressive fashion than those due to other causes. The initial surgical treatment, especially the management of the regional lymph nodes, remains controversial. This review of 37 patients with Marjolin's ulcer evalu...

journal_title：Cancer

authors： Barr LH,Menard JW

更新日期：1983-07-01 00:00:00

abstract：:Fluorescence polarization was performed on 82 individuals: 32 patients with malignant diseases, 30 apparently healthy individuals, and 20 patients with nonmalignant diseases. The blood lymphocytes from these cases were isolated and challenged with cancer basic protein (CaBP). Stimulation occurred in the majority of th...

journal_title：Cancer

authors： Schnuda ND

更新日期：1980-09-01 00:00:00

abstract：BACKGROUND:Neurofibroma of the urinary bladder is rare. Only isolated case reports have appeared. Information regarding the long term follow-up of patients with neurofibroma is limited. METHODS:The authors studied 4 cases of neurofibroma of the bladder diagnosed at Mayo Clinic from 1965 through 1990. Immunostains for ...

journal_title：Cancer

authors： Cheng L,Scheithauer BW,Leibovich BC,Ramnani DM,Cheville JC,Bostwick DG

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumors (GISTs) historically were grouped with leiomyosarcomas (LMSs) based on their morphologic similarities; however, recently, GIST was established unequivocally as a distinct type of sarcoma based on its molecular features and response to imatinib treatment. METHODS:To gain furth...

journal_title：Cancer

authors： Ylipää A,Hunt KK,Yang J,Lazar AJ,Torres KE,Lev DC,Nykter M,Pollock RE,Trent J,Zhang W

更新日期：2011-01-15 00:00:00

abstract：:A case of sinus histiocytosis with massive lymphadenopathy (SHML) in which cranial nerve function was impaired is described. Severe paraparesis due to an epidural block at the C2 and C5-T2 levels was also present. Treatment with cytotoxic agents resulted in a dramatic decrease in the size of the involved lymph nodes a...

journal_title：Cancer

authors： Haas RJ,Helmig MS,Prechtel K

更新日期：1978-07-01 00:00:00

abstract：BACKGROUND:The objective of this study was to determine the potential economic implications resulting from using exemestane (EXE), a new steroidal, irreversible aromatase inactivator, compared with megestrol acetate (MA) in patients with advanced breast carcinoma. METHODS:The model used the clinical results from the m...

journal_title：Cancer

authors： Hillner BE,Radice D

更新日期：2001-02-01 00:00:00

abstract：:A new human extrahepatic bile duct carcinoma cell line (KMBC) was established from a serially transplanted tumor in nude mice that originated from a surgically resected tumor from a 73-year-old Japanese man; the cell line has been maintained for 5 five years. KMBC cells proliferate in a monolayered sheet with a popula...

journal_title：Cancer

authors： Yano H,Maruiwa M,Iemura A,Mizoguchi A,Kojiro M

更新日期：1992-04-01 00:00:00

abstract：:Advances in clinical medicine require effective translational research. Ideally, this research will be performed by multidisciplinary teams that include both physicians and basic scientists. However, the current system does not appropriately train either physicians or basic scientists for these careers. In addition, t...

journal_title：Cancer

authors： Pickering CR,Bast RC Jr,Keyomarsi K

更新日期：2015-03-15 00:00:00

abstract：BACKGROUND:Despite Helicobacter pylori (HP) eradication, individuals can still develop gastric cancer (GC). Prior studies have demonstrated that nonaspirin nonsteroidal anti-inflammatory drugs (NA-NSAIDs) reduce the risk of GC, but this may be caused by immortal time bias and failure to adjust for HP status. The object...

journal_title：Cancer

authors： Li B,Cheung KS,Wong IY,Leung WK,Law S

更新日期：2021-01-20 00:00:00

abstract：BACKGROUND:Medical records of 50 patients with malignant mesothelioma were reviewed to determine the clinical features and factors influencing survival. METHODS:Charts of all patients whose conditions were diagnosed as malignant mesothelioma were abstracted and analyzed by statistical software. RESULTS:The male-to-fe...

journal_title：Cancer

authors： Sridhar KS,Doria R,Raub WA Jr,Thurer RJ,Saldana M

更新日期：1992-12-15 00:00:00

abstract：BACKGROUND:Human pancreatic ribonuclease (RNase 1) is a pancreatic enzyme that is present at high levels in the serum of most patients with pancreatic adenocarcinoma. For this reason, the authors studied its patterns of expression at the single-cell level in pancreatic adenocarcinoma tissues by immunohistochemical anal...

journal_title：Cancer

authors： Peracaula R,Cleary KR,Lorenzo J,de Llorens R,Frazier ML

更新日期：2000-09-15 00:00:00

abstract：:Previous studies and those of the authors have reported about raised levels of lipid-bound sialic acid (LSA) in sera of patients with various neoplasms. Most authors have used the method of Katopodis and Stock for isolating serum LSA. Because of the discrepancy of the amount of extracted LSA with the content of pure g...

journal_title：Cancer

authors： Voigtmann R,Pokorny J,Meinshausen A

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:Cell cycle proteins are important markers in predicting tumor behavior in urothelial carcinoma of the bladder. The objectives of this study were 1) to determine the expression levels of some of those markers in a series of patients with bladder carcinoma, 2) to define their value in distinguishing T1a (minim...

journal_title：Cancer

authors： Mhawech P,Greloz V,Oppikofer C,Szalay-Quinodoz I,Herrmann F

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:National and international bodies acknowledge the benefit of exercise for people with cancer, yet limited accessibility to related programing remains. Given their involvement in managing the disease, cancer centers can play a central role in delivering exercise-oncology services. The authors developed and im...

journal_title：Cancer

authors： Santa Mina D,Au D,Auger LE,Alibhai SMH,Matthew AG,Sabiston CM,Oh P,Ritvo PG,Chang EB,Jones JM

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:In a cohort including 5112 prostate cancer (pCa) patients, the authors investigated associations among triglycerides (TG), total cholesterol (TC), and pCa while taking into account glucose. METHODS:A cohort (n = 200,660) based on 4 groups of men, according to age at cohort entry, with TG, TC, and glucose me...

journal_title：Cancer

authors： Van Hemelrijck M,Garmo H,Holmberg L,Walldius G,Jungner I,Hammar N,Lambe M

更新日期：2011-05-15 00:00:00

abstract：BACKGROUND:Prostate carcinoma metastasizes frequently to the skeleton, causing significant morbidity, particularly severe bone pain. Metastatic lesions typically are osteosclerotic, but there is experimental, histologic, and biochemical evidence of increased bone resorption. Furthermore, bone resorption rates appear to...

journal_title：Cancer

authors： Papapoulos SE,Hamdy NA,van der Pluijm G

更新日期：2000-06-15 00:00:00

abstract：BACKGROUND:Full-scale implementation of lung cancer screening in the United States will increase detection of early stages. This study was aimed at assessing the capacity required for treating those cancers. METHODS:A well-established microsimulation model was extended with treatment data from the National Cancer Data...

journal_title：Cancer

authors： Blom EF,Ten Haaf K,Arenberg DA,de Koning HJ

更新日期：2019-06-15 00:00:00