How will we recruit, train, and retain physicians and scientists to conduct translational cancer research?

abstract：BACKGROUND:The observed seasonal and geographic variations in the incidence of immunoproliferative small intestinal disease (IPSID) suggest that environmental factors contribute to its pathogenesis. One such environmental factor, the Epstein-Barr virus (EBV), has been associated with other B-cell lymphoproliferative di...

journal_title：Cancer

authors： Baddoura FK,Unger ER,Mufarrij A,Nassar VH,Zaki SR

更新日期：1994-09-15 00:00:00

abstract：BACKGROUND:The development of new chelating agents and radiolabeling protocols is essential to progress in radioimmunotherapy with antibody-chelate conjugates. METHODS:Immunoconjugates of four polyazamacrocycles with N-bonded acetate groups were prepared by conjugation via 2-iminothiolane to Lym-1, a murine antilympho...

journal_title：Cancer

authors： Kukis DL,Diril H,Greiner DP,DeNardo SJ,DeNardo GL,Salako QA,Meares CF

更新日期：1994-02-01 00:00:00

abstract：:The adolescent and young adult (AYA) oncology population has seen inferior progress in cancer survival compared with younger children and older adults over the past 25 years. Previously, AYAs had the best survival rates due to the prevalence of highly curable diseases including Hodgkin lymphoma and germ cell tumors, y...

journal_title：Cancer

authors： Burke ME,Albritton K,Marina N

更新日期：2007-12-01 00:00:00

abstract：:Since June 1978, 57 patients with primary osteogenic sarcoma of an extremity were treated with high-dose methotrexate (HDMTX) and citrovorum factor rescue (CFR), Adriamycin, and the combination of bleomycin, cyclophosphamide and dactinomycin (BCD) given for 4-16 weeks prior to definitive surgery. Histologic examinatio...

journal_title：Cancer

authors： Rosen G,Caparros B,Huvos AG,Kosloff C,Nirenberg A,Cacavio A,Marcove RC,Lane JM,Mehta B,Urban C

更新日期：1982-03-15 00:00:00

abstract：BACKGROUND:Radiofrequency (RF)-induced tissue coagulation represents a new approach for the thermal destruction of tumors within the liver. The purpose of the current study was to 1) assess technique safety; 2) determine the extent and evolution of induced cellular damage; and 3) correlate the observed pathologic effec...

journal_title：Cancer

authors： Goldberg SN,Gazelle GS,Compton CC,Mueller PR,Tanabe KK

更新日期：2000-06-01 00:00:00

abstract：:The current results of trials testing combined surgery and chemotherapy in patients with breast cancer is reviewed. Information concerning eight trials utilizing nine single-agent regimens was obtained. The results at this time are conflicting. There appear to be differences among the regimens utilized in the various ...

journal_title：Cancer

authors： Tormey DC

更新日期：1975-09-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to present planning, feasibility, toxicity, and outcome of helical tomotherapy for spinal cord-sparing reirradiation of spinal metastases and tumors. METHODS:Thirty-six patients with spinal metastases and tumors who had undergone previous radiotherapy were reirradiated with hel...

journal_title：Cancer

authors： Sterzing F,Hauswald H,Uhl M,Herm H,Wiener A,Herfarth K,Debus J,Krempien R

更新日期：2010-08-15 00:00:00

abstract：:Estrogen receptors in breast tumors were assayed in 55 premenopausal women undergoing bilateral oophorectomy and in 120 postmenopausal women undergoing bilateral adrenalectomy for treatment of metastatic breast cancer. The data show that 20 (60%) of the 32 patients with estrogen receptor-positive (ER+) tumors had obje...

journal_title：Cancer

authors： Dao TL,Nemoto T

更新日期：1980-12-15 00:00:00

abstract：BACKGROUND:This study was undertaken to determine whether the use of intermediate dose methotrexate in combination with vinblastine, doxorubicin, and cisplatin as first-line therapy increases the proportion of major responders and overall survival in patients with unresectable or metastatic transitional cell carcinoma ...

journal_title：Cancer

authors： Dodd PM,McCaffrey JA,Mazumdar M,Scher H,Vlamis V,Higgins G,Herr H,Bajorin DF

更新日期：1999-03-01 00:00:00

abstract：:Because chronic lymphocytic leukemia is a heterogeneous disease, there are considerable efforts underway to develop increasingly accurate and precise analytics with which to estimate the probability of future events such as the need for and probability of response to therapy, progression-free survival, and survival. T...

journal_title：Cancer

authors： Montserrat E,Gale RP

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:The goal of the current study was to assess the toxicity, safety, and efficacy of pentostatin in patients with T-cell lymphoid malignancies. METHODS:Patients were eligible if they had biopsy-proven T-cell lymphoma or leukemia and failure to respond to previous therapy or an expected complete response rate t...

journal_title：Cancer

authors： Tsimberidou AM,Giles F,Duvic M,Fayad L,Kurzrock R

更新日期：2004-01-15 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated an association between a diagnosis of cancer and the risk of suicide; however, they failed to account for psychiatric care before a cancer diagnosis, which may confound this relationship. The objective of this study was to assess the effect of a cancer diagnosis on the risk...

journal_title：Cancer

authors： Klaassen Z,Wallis CJD,Chandrasekar T,Goldberg H,Sayyid RK,Williams SB,Moses KA,Terris MK,Nam RK,Urbach D,Austin PC,Kurdyak P,Kulkarni GS

更新日期：2019-08-15 00:00:00

abstract：:One hundred eighty-three patients with malignant skeletal (83) or soft tissue sarcoma (100) were entered into the multimodality preoperative limb salvage protocol. Local recurrences were observed in 5 of 183 (2.7%). Six patients required amputation because of complications, and 13 patients died within 1 year from meta...

journal_title：Cancer

authors： Eilber FR,Morton DL,Eckardt J,Grant T,Weisenburger T

更新日期：1984-06-15 00:00:00

abstract：:We report on an 89-year-old female admitted with signs of intestinal obstruction in whom three independent adenocarcinomas of the proximal jejunum were found. Multiple foci of pyloric gland metaplasia, glandular hyperplasia and dysplasia, carcinoma-in-situ, and several varieties of adenocarcinoma were identified on mi...

journal_title：Cancer

authors： Warner TF,Peralta J

更新日期：1979-09-01 00:00:00

abstract：BACKGROUND:Lesions of the thyroid gland composed of Hurthle cells encompass pathologic entities ranging from hyperplastic nodules with Hurthle cell metaplasia to Hurthle cell carcinomas. The cytologic distinction between these entities can be diagnostically challenging. Many cytologic features of Hurthle cell lesions t...

journal_title：Cancer

authors： Elliott DD,Pitman MB,Bloom L,Faquin WC

更新日期：2006-04-25 00:00:00

abstract：BACKGROUND:The clinical significance of atypical glandular cells of undetermined significance (AGUS) remains poorly understood, and patient management is not standardized. The authors evaluated the rate, qualification, and follow-up (FU) findings of AGUS patients. METHODS:Computerized records from the authors' institu...

journal_title：Cancer

authors： Soofer SB,Sidawy MK

更新日期：2000-08-25 00:00:00

abstract：:In a 3 1/2 year cytogenetic study of 107 leukemia patients diagnosed in childhood and adloescence, 8 presented with chronic myelogenous leukemia (CML). Seven of the 8 had chromosomal abnormalities. Six had the Ph1 chromosome; 5 had the usual 9;22 translocation. Two patients had involvement with chromosome 15; one had ...

journal_title：Cancer

authors： Hays T,Morse H,Peakman D,Rose B,Robinson A

更新日期：1979-07-01 00:00:00

abstract：BACKGROUND:This study was conducted to investigate the influence of therapeutic parameters on local control (LC) in the sphincter-conserving treatment of T2-T3 anal carcinoma. METHODS:From 1976 to 1993, 137 patients with anal carcinoma classified as T2 (85 patients) or T3 (52 patients) were treated curatively by radio...

journal_title：Cancer

authors： Allal AS,Mermillod B,Roth AD,Marti MC,Kurtz JM

更新日期：1997-06-15 00:00:00

abstract：:On the basis of previous findings at this institution, VM-26 and Cytosine Arabinoside (ara-C) were used in combination to treat 33 children with refractory acute lymphocytic leukemia (ALL). Chemotherapy was given by vein twice a week for four weeks at dosage of 300 mg/m2 for ara-C and 50, 75, 110, 165, or 200 mg/m2 fo...

journal_title：Cancer

authors： Rivera G,Aur RJ,Dahl GV,Pratt CB,Wood A,Avery TL

更新日期：1980-03-15 00:00:00

abstract：BACKGROUND:Although studies comparing conventional imaging modalities with (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) for the detection of lymphoma and although the relations between (18)F-FDG-PET and histologic types were reported previously, most studies were not systematic and involved rel...

journal_title：Cancer

authors： Tsukamoto N,Kojima M,Hasegawa M,Oriuchi N,Matsushima T,Yokohama A,Saitoh T,Handa H,Endo K,Murakami H

更新日期：2007-08-01 00:00:00

abstract：:Twenty-four women with ovarian carcinoma that had metastasized to the liver were treated with intrahepatic infusional therapy. No consistent drug regimen was used. There were no complete responders; however, 33% had a partial response. All responses were noticed after the first course of therapy. The median length of ...

journal_title：Cancer

authors： Malone JM Jr,Gershenson DM,Carrasco CH,Charansangavej C,Copeland LJ,Larson DM,Kavanagh JJ,Edwards CL,Wallace S

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:The epidophyllotoxin VM 26 has been shown to have single-agent activity in patients with diffuse aggressive lymphoma. In an attempt to determine its activity in combination with other agents known to be effective in lymphoma, a Phase II trial of a novel chemotherapy regimen was conducted. METHODS:Forty-two ...

journal_title：Cancer

authors： Gordon LI,Andersen J,Gregory S,Mazza J,Chervenick P,Hahn RG,O'Connell MJ

更新日期：1993-01-15 00:00:00

abstract：BACKGROUND:Postgastrectomy patients undergoing chemoradiation risk chemoradiation-induced liver disease (CRILD). The objectives of this study were to investigate dosimetric implications and assess biologic susceptibility to CRILD in these patients. METHODS:Sixty-two patients with Stage IB-IV gastric/gastroesophageal a...

journal_title：Cancer

authors： Cheng JC,Liu MC,Tsai SY,Fang WT,Jer-Min Jian J,Sung JL

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor-C (VEGF-C) plays an important role in lymphangiogenesis and activates VEGF receptor-3 (VEGFR-3). Lymphatic spread is an important prognostic factor in patients with lung adenocarcinoma. The aim of the current study was to determine whether the expression of VEGF-C and VEGFR...

journal_title：Cancer

authors： Kojima H,Shijubo N,Yamada G,Ichimiya S,Abe S,Satoh M,Sato N

更新日期：2005-10-15 00:00:00

abstract：BACKGROUND:Breast carcinoma commonly metastasizes to the skeleton in patients with advanced disease to cause bone destruction and the associated pain, hypercalcemia, fracture, and nerve-compression syndromes. In this scenario, the bone destruction is mediated by the osteoclast. Tumor-produced parathyroid hormone-relate...

journal_title：Cancer

authors： Guise TA

更新日期：2000-06-15 00:00:00

abstract：:The establishment of a maturation-induction model using human colon cancer cells as targets is reported. Two colon carcinoma cell lines were established from human tumors; one line was heterogeneous and was cloned into two distant subpopulations. Cells from these lines and clones and cells from an established human co...

journal_title：Cancer

authors： Dexter DL,Hager JC

更新日期：1980-03-15 00:00:00

abstract：:The presence of receptors for estrogen, glucocorticoid and progesterone was determined in the cytosol of two breast angiosarcomas. Estrogen and glucocorticoid receptors were present in both of them. Progesterone receptors were present in one of the two tumors assayed. Occupied nuclear estrogen receptors have been foun...

journal_title：Cancer

authors： Brentani MM,Pacheco MM,Oshima CT,Nagai MA,Lemos LB,Góes JC

更新日期：1983-06-01 00:00:00

abstract：:Sixteen cases of clear cell adenocarcinoma of the cervix and vagina in young women were studied by electron microscopy and the observations were compared with the light microscopic appearance. Ultrastructurally, the neoplastic cells were found to be of the same basic type, regardless of whether light microscopy disclo...

journal_title：Cancer

authors： Dickersin GR,Welch WR,Erlandson R,Robboy SJ

更新日期：1980-04-01 00:00:00

abstract：BACKGROUND:An increase in resting energy expenditure (REE) is considered to contribute to the weight loss experienced by patients with cancer. However, alternations in basal metabolism vary among patients with different neoplasms. REE in patients with hepatocellular carcinoma (HCC), a common malignant tumor in Taiwan, ...

journal_title：Cancer

authors： Chen WJ,Chung YC

更新日期：1994-02-01 00:00:00

abstract：:The unique characteristics of tumor vasculature represent an attractive target that may be exploited by vascular-targeting anticancer agents. A promising strategy involves the selective disruption of established tumor blood vessels by tumor-vascular disrupting agents (tumor-VDAs), which exhibit antivascular activity, ...

journal_title：Cancer

authors： McKeage MJ,Baguley BC

更新日期：2010-04-15 00:00:00