Steroid receptors and response to endocrine ablations in women with metastatic cancer of the breast.

Abstract:

:Estrogen receptors in breast tumors were assayed in 55 premenopausal women undergoing bilateral oophorectomy and in 120 postmenopausal women undergoing bilateral adrenalectomy for treatment of metastatic breast cancer. The data show that 20 (60%) of the 32 patients with estrogen receptor-positive (ER+) tumors had objective remission after oophorectomy, and 44 (51%) of the 87 patients with ER+ tumors responded to adrenalectomy. In contrast, of those patients with estrogen receptor-negative (ER-) tumors, only 3% had an objective remission following oophorectomy and 9% following adrenalectomy. It is concluded that major endocrine ablative procedures are not justified in patients with ER- tumors. The data also conclusively demonstrate the significance of 4S receptors in predicting the response to endocrine therapy. In this study, it was found that although the response rate to endocrine ablation was substantially higher (71-83%) in patients whose tumors contained both estradiol and progesterone receptors, between 50 and 60% of ER+ tumors lacking progesterone receptors had objective remission after endocrine ablative therapy.

journal_name

Cancer

journal_title

Cancer

authors

Dao TL,Nemoto T

doi

10.1002/1097-0142(19801215)46:12+<2779::aid-cncr28

subject

Has Abstract

pub_date

1980-12-15 00:00:00

pages

2779-82

issue

12 Suppl

eissn

0008-543X

issn

1097-0142

journal_volume

46

pub_type

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